{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T19:31:44Z","timestamp":1781292704674,"version":"3.54.1"},"reference-count":57,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"SECIHTI-CONAHCYT-Mexico","doi-asserted-by":"publisher","award":["1318908"],"award-info":[{"award-number":["1318908"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"SECIHTI-CONAHCYT-Mexico","doi-asserted-by":"publisher","award":["593548"],"award-info":[{"award-number":["593548"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A collection of 40 derivatives of 1,2-diphenyl-2-[1,2,3]triazol-1-yl-ethanol was obtained through a sequence of reactions, starting with benzoin as the initial raw material and using the CuAAC reaction as the key step in this process. The structure of a pair of these compounds was ultimately corroborated by single-crystal X-ray diffraction studies, which also reveals important O-H\u00b7\u00b7\u00b7N interactions. The antimicrobial activity of synthesized 1,2,3-triazoles was assessed against strains that include Candida albicans and Staphylococcus aureus. The antiproliferative properties of some of these novel compounds were also tested using a variety of tumor cell lines, including U251 (human glioblastoma), PC-3 (human prostate cancer cell line), K562 (human leukemia), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma), and SKLU (human lung adenocarcinoma).<\/jats:p>","DOI":"10.3390\/molecules31010170","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T09:56:23Z","timestamp":1767347783000},"page":"170","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Use of Benzoin as a Privileged Structure: Synthesis, Characterization, Crystalline Form and an In Vitro Biological Evaluation of 1,2-Diphenyl-2-[1,2,3]triazol-1-yl-ethanol Derivatives"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3655-2425","authenticated-orcid":false,"given":"No\u00e9","family":"Mart\u00ednez-Romero","sequence":"first","affiliation":[{"name":"Centro Conjunto de Investigaci\u00f3n en Qu\u00edmica Sustentable UAEM-UNAM, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Carretera Toluca-Atlacomulco Km 14.5, Toluca 50200, Estado de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7415-203X","authenticated-orcid":false,"given":"Mario","family":"Valle-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro Conjunto de Investigaci\u00f3n en Qu\u00edmica Sustentable UAEM-UNAM, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Carretera Toluca-Atlacomulco Km 14.5, Toluca 50200, Estado de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Garc\u00eda-Eleno","sequence":"additional","affiliation":[{"name":"Centro Conjunto de Investigaci\u00f3n en Qu\u00edmica Sustentable UAEM-UNAM, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Carretera Toluca-Atlacomulco Km 14.5, Toluca 50200, Estado de M\u00e9xico, Mexico"},{"name":"Facultad de Qu\u00edmica, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Paseo Colon esq. 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