{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:29:32Z","timestamp":1779373772479,"version":"3.53.1"},"reference-count":60,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz","doi-asserted-by":"publisher","award":["503\/3-016-03\/503-31-001"],"award-info":[{"award-number":["503\/3-016-03\/503-31-001"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A total of 250 known and novel compounds\u2014ketamine and serotonergic psychedelics or their analogues\u2014designed to target depression, addictions and\/or other mental or neurological disorders and developed as \u201crecreational\u201d (illegal) drugs from three chemical families, ergolines, tryptamines and phenylethylamines, were investigated in the context of their ability to cross the human placenta. Using a novel multivariate model involving compounds\u2019 drug-likeness (according to Lipinski\u2019s Ro5), caco-2 membrane permeability, fraction unbound to plasma proteins, steady-state volume of distribution and the total count of heteroatoms (non-carbon atoms with hydrogens included), it was established that the majority of studied compounds are likely to cross the placenta easily, most probably by the passive diffusion mechanism. Atomic contributions of structural elements of studied compounds were investigated using the Morgan fingerprinting algorithm and it was postulated that the fragments promoting transport of compounds across the placenta are carbonyl, hydroxyl, nitro- and phosphoryloxy groups\u2014rigid polycyclic structures, bulky alkyl\/aryl groups and halogen atoms restrict the trans-placental passage. All studied compounds are expected to be relatively easily obtained by synthetic routes, which makes them an interesting target for manufacturers of illegal drugs and warrants the need to pursue pharmacological studies of these compounds in silico.<\/jats:p>","DOI":"10.3390\/molecules31020212","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:01:29Z","timestamp":1767862889000},"page":"212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Psychedelic Drugs Rediscovered\u2014In Silico Study of Potential Fetal Exposure to Analogues of Psychedelic Drugs During Pregnancy"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1846-9240","authenticated-orcid":false,"given":"Anna W.","family":"Soba\u0144ska","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lodz, 90-151 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7544-365X","authenticated-orcid":false,"given":"Andrzej M.","family":"Soba\u0144ski","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, University of Lodz, 91-403 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1135-7147","authenticated-orcid":false,"given":"El\u017cbieta","family":"Brzezi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lodz, 90-151 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1126\/science.abl8615","article-title":"Structure-Based Discovery of Nonhallucinogenic Psychedelic Analogs","volume":"375","author":"Cao","year":"2022","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16S","DOI":"10.1038\/sj.npp.1395318","article-title":"Serotonin and Hallucinogens","volume":"21","author":"Aghajanian","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6144","DOI":"10.1021\/acs.jmedchem.3c01961","article-title":"Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT2 Receptor Agonist","volume":"67","author":"Varty","year":"2024","journal-title":"J. Med. Chem."},{"key":"ref_4","first-page":"5","article-title":"The Medical History & Use of Psychedelic Drugs","volume":"20","author":"Renshaw","year":"2020","journal-title":"Legacy"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pharmthera.2018.11.010","article-title":"Classic Psychedelics: An Integrative Review of Epidemiology, Therapeutics, Mystical Experience, and Brain Network Function","volume":"197","author":"Johnson","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/1468-0424.12471","article-title":"Psychedelic Birth: Bodies, Boundaries and the Perception of Pain in the 1970s","volume":"32","author":"Kline","year":"2020","journal-title":"Gend. Hist."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fpsyt.2019.00591","article-title":"A Neglected Link Between the Psychoactive Effects of Dietary Ingredients and Consciousness-Altering Drugs","volume":"10","author":"Smalheiser","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000139775","article-title":"Clinical Studies of Lysergic Acid Diethylamide","volume":"128","author":"Anderson","year":"1954","journal-title":"Monatsschr Psychiatr. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Omidian, H., and Omidian, A. (2025). Clinical Research on Lysergic Acid Diethylamide (LSD) in Psychiatry and Neuroscience. Pharmaceuticals, 18.","DOI":"10.3390\/ph18040499"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/pcn.13741","article-title":"Impact of Psilocybin on Cognitive Function: A Systematic Review","volume":"78","author":"Meshkat","year":"2024","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/s41386-023-01744-8","article-title":"Psilocybin Analog 4-OH-DiPT Enhances Fear Extinction and GABAergic Inhibition of Principal Neurons in the Basolateral Amygdala","volume":"49","author":"Kelly","year":"2024","journal-title":"Neuropsychopharmacology"},{"key":"ref_12","unstructured":"Rush, B., Marcus, O., Shore, R., Cunningham, L., Thomson, N., and Rideout, K. (2022). Psychedelic Medicine: A Rapid Review of Therapeutic Applications and Implications for Future Research, Homewood Research Institute."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1021\/acschemneuro.5c00152","article-title":"Classic Psychedelics in Pain Modulation: Mechanisms, Clinical Evidence, and Future Perspectives","volume":"16","author":"Czopek","year":"2025","journal-title":"ACS Chem. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Mastinu, A., Anyanwu, M., Carone, M., Abate, G., Bonini, S.A., Peron, G., Tirelli, E., Pucci, M., Ribaudo, G., and Oselladore, E. (2023). The Bright Side of Psychedelics: Latest Advances and Challenges in Neuropharmacology. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021329"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alves, J., Lu\u00eds, \u00c2., Gallardo, E., and Duarte, A.P. (2021). Psychoactive Substances of Natural Origin: Toxicological Aspects, Therapeutic Properties and Analysis in Biological Samples. Molecules, 26.","DOI":"10.3390\/molecules26051397"},{"key":"ref_16","unstructured":"Collette, K.M. (2025, September 15). Rediscovering Psilocybin and Its Therapeutic Potential. Available online: https:\/\/www.caymanchem.com\/news\/rediscovering-psilocybin-and-its-therapeutic-potential%0A."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Karabulut, S., Kaur, H., and Gauld, J.W. (2023). Applications and Potential of In Silico Approaches for Psychedelic Chemistry. Molecules, 28.","DOI":"10.3390\/molecules28165966"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1021\/acschemneuro.8b00692","article-title":"Chronic, Intermittent Microdoses of the Psychedelic N, N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents","volume":"10","author":"Cameron","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1021\/acschemneuro.9b00493","article-title":"Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression","volume":"11","author":"Hibicke","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1021\/acschemneuro.2c00718","article-title":"5-HT2ARs Mediate Therapeutic Behavioral Effects of Psychedelic Tryptamines","volume":"14","author":"Cameron","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1021\/acsptsci.0c00063","article-title":"Structure-Activity Relationship Analysis of Psychedelics in a Rat Model of Asthma Reveals the Anti-Inflammatory Pharmacophore","volume":"4","author":"Flanagan","year":"2021","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Campara, A., and Kovacic, D. (2024). Exploring Psilocybin as a Tool for Studying Parkinsonism-Related Psychosis: A Narrative Review Supplemented with a Computational Approach. Proceedings of the Mediterranean Conference on Medical and Biological Engineering and Computing (MEDICON) and International Conference on Medical and Biological Engineering (CMBEBIH), Sarajevo, Bosnia, 14\u201316 September 2023, Springer. Conference Paper in IFMBE Proceedings.","DOI":"10.1007\/978-3-031-49068-2_54"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/164_2018_107","article-title":"Serotonergic Psychedelics: Experimental Approaches for Assessing Mechanisms of Action","volume":"252","author":"Canal","year":"2018","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41586-024-07403-2","article-title":"Structural Pharmacology and Therapeutic Potential of 5-Methoxytryptamines","volume":"630","author":"Warren","year":"2024","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"117049","DOI":"10.1016\/j.ejmech.2024.117049","article-title":"Structural Insights into Tryptamine Psychedelics: The Role of Hydroxyl Indole Ring Site in 5-HT2A Receptor Activation and Psychedelic-like Activity","volume":"281","author":"Zhang","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.5114\/bta.2020.94770","article-title":"Molecular Docking and Binding Interaction between Psychedelic Drugs and Human Serum Albumin","volume":"101","author":"Khastar","year":"2020","journal-title":"Biotechnologia"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1021\/acs.jnatprod.1c00087","article-title":"Chemoenzymatic Synthesis of 5-Methylpsilocybin: A Tryptamine with Potential Psychedelic Activity","volume":"84","author":"Fricke","year":"2021","journal-title":"J. Nat. Prod."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1021\/acschemneuro.3c00610","article-title":"Psychedelic-like Activity of Norpsilocin Analogues","volume":"15","author":"Sherwood","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"ref_29","unstructured":"Longueville, A.-J. (2024). Synthesis of Psilocybin Analogues and Other 5-HT Receptor Agonists for Stimulation of Neurotransmission, Universiteit Gent."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1021\/acs.chemrev.3c00375","article-title":"Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants","volume":"124","author":"Duan","year":"2024","journal-title":"Chem. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1039\/D4MD00043A","article-title":"Synthesis and Bioactivity of Psilocybin Analogues Containing a Stable Carbon-Phosphorus Bond","volume":"15","author":"Vandevelde","year":"2024","journal-title":"RSC Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1021\/acsptsci.0c00176","article-title":"Investigation of the Structure-Activity Relationships of Psilocybin Analogues","volume":"4","author":"Klein","year":"2021","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"24888","DOI":"10.1021\/acsomega.2c03476","article-title":"Synthesis, Structural Characterization, and Pharmacological Activity of Novel Quaternary Salts of 4-Substituted Tryptamines","volume":"7","author":"Glatfelter","year":"2022","journal-title":"ACS Omega"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1021\/acsptsci.2c00177","article-title":"Structure\u2212Activity Relationships for Psilocybin, Baeocystin, Aeruginascin, and Related Analogues to Produce Pharmacological Effects in Mice","volume":"5","author":"Glatfelter","year":"2022","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1021\/acsmedchemlett.3c00566","article-title":"Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists","volume":"15","author":"Jayakodiarachchi","year":"2024","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"714","DOI":"10.4045\/tidsskr.15.1278","article-title":"Novel Psychoactive Substances","volume":"136","author":"Krabseth","year":"2016","journal-title":"Tidsskr. Nor. Legeforen"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"102626","DOI":"10.1016\/j.pbi.2024.102626","article-title":"New Frontiers in the Biosynthesis of Psychoactive Specialized Metabolites","volume":"82","author":"Li","year":"2024","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Serreau, R., Amirouche, A., Benyamina, A., and Berteina-Raboin, S. (2023). A Review of Synthetic Access to Therapeutic Compounds Extracted from Psilocybe. Pharmaceuticals, 16.","DOI":"10.3390\/ph16010040"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1001\/jama.1972.03210110013004","article-title":"Possible Reproductive Detriment in LSD Users","volume":"222","author":"Jacobson","year":"1972","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1001\/archopht.1978.03910050150009","article-title":"Multiple Ocular Anomalities Associated With Maternal LSD Ingestion","volume":"96","author":"Chan","year":"1978","journal-title":"Arch. Ophthalmol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0140-6736(71)92326-9","article-title":"L.S.D., Intrauterine Amputations, and Amniotic-Band Syndrome","volume":"298","author":"Blanc","year":"1971","journal-title":"Lancet"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1258\/om.2010.100014","article-title":"Illicit Substance Use in Pregnancy\u2014A Review","volume":"3","author":"Scott","year":"2010","journal-title":"Obstet. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0140-6736(70)92673-5","article-title":"Children of Mothers Who Took L.S.D. in Pregnancy","volume":"296","author":"Aase","year":"1970","journal-title":"Lancet"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ntt.2016.01.003","article-title":"Motor Delays in MDMA (Ecstasy) Exposed Infants Persist to 2 Years","volume":"54","author":"Singer","year":"2016","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.tips.2023.08.001","article-title":"A Perspective on Psychedelic Teratogenicity: The Utility of Zebrafish Models","volume":"44","author":"Syed","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"114924","DOI":"10.1016\/j.bbr.2024.114924","article-title":"Exposure to the Psychedelic Substance 25 H-NBOMe Disrupts Maternal Care in Lactating Rats and Subsequently Impairs the Social Play Behavior of the Offspring","volume":"465","author":"Melo","year":"2024","journal-title":"Behav. Brain Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1177\/02698811221093793","article-title":"Postpartum Depression: A Role for Psychedelics?","volume":"36","author":"Jairaj","year":"2022","journal-title":"J. Psychopharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","article-title":"Lead- and Drug-like Compounds: The Rule-of-Five Revolution","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discov. Today Technol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.addr.2016.04.029","article-title":"Rule of Five in 2015 and beyond: Target and Ligand Structural Limitations, Ligand Chemistry Structure and Drug Discovery Project Decisions","volume":"101","author":"Lipinski","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Di Filippo, J.I., Bollini, M., and Cavasotto, C.N. (2021). A Machine Learning Model to Predict Drug Transfer Across the Human Placenta Barrier. Front. Chem., 9.","DOI":"10.3389\/fchem.2021.714678"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1021\/acschemneuro.8b00186","article-title":"DARK Classics in Chemical Neuroscience: Psilocybin","volume":"9","author":"Geiger","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"109294","DOI":"10.1016\/j.neuropharm.2022.109294","article-title":"Mescaline: The Forgotten Psychedelic","volume":"222","author":"Vamvakopoulou","year":"2023","journal-title":"Neuropharmacology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1758-2946-1-8","article-title":"Estimation of Synthetic Accessibility Score of Drug-like Molecules Based on Molecular Complexity and Fragment Contributions","volume":"1","author":"Ertl","year":"2009","journal-title":"J. Cheminform."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1248\/bpb.b14-00883","article-title":"Quantitative Structure-Activity Relationship Model for the Fetal-Maternal Blood Concentration Ratio of Chemicals in Humans","volume":"38","author":"Takaku","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e9562","DOI":"10.7717\/peerj.9562","article-title":"Prediction of Human Fetal\u2013Maternal Blood Concentration Ratio of Chemicals","volume":"8","author":"Wang","year":"2020","journal-title":"PeerJ"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"138649","DOI":"10.1016\/j.chemosphere.2023.138649","article-title":"In Silico Assessment of Risks Associated with Pesticides Exposure during Pregnancy","volume":"329","year":"2023","journal-title":"Chemosphere"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10822-011-9440-2","article-title":"Online Chemical Modeling Environment (OCHEM): Web Platform for Data Storage, Model Development and Publishing of Chemical Information","volume":"25","author":"Sushko","year":"2011","journal-title":"J. Comput. Aided Mol. Des."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: A Free Web Tool to Evaluate Pharmacokinetics, Drug-Likeness and Medicinal Chemistry Friendliness of Small Molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/jcc.21707","article-title":"PaDEL-Descriptor: An Open Source Software to Calculate Molecular Descriptors and Fingerprints","volume":"32","author":"Yap","year":"2011","journal-title":"J. Comput. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2307\/2526185","article-title":"Selection of Regressors","volume":"21","author":"Amemiya","year":"1980","journal-title":"Int. Econ. Rev."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/2\/212\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:02:02Z","timestamp":1767862922000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/2\/212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":60,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["molecules31020212"],"URL":"https:\/\/doi.org\/10.3390\/molecules31020212","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]}}}