{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:02:36Z","timestamp":1793138556384,"version":"4.5.0"},"reference-count":21,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The diterpene sessein, isolated from Salvia sessei, is a metabolite of interest due to its conjugated p-quinone system, \u03b4-lactone ring, and phenolic hydroxyl in C-12. These functionalities make it an ideal starting point for reactivity studies and semi-synthetic derivatization. In this work, we report the obtainment of two derivatives by selective esterification of phenolic hydroxyl in C-12, through acetylation and benzoylation reactions under mild conditions and with high yields. The structures were characterized by UPLC-MS, FTIR, and NMR spectroscopy 1H, 13C, and 2D, which allowed to precisely confirm the modifications made in the derivatives. These results confirm that hydroxyl in C-12 constitutes a privileged site of reactivity within the royleanone family, consolidating sessein as a versatile nucleus for the generation of derivatives. Finally, the preliminary evaluation of the antimicrobial activity showed that sessein shows a broad spectrum of action against Gram-positive, Gram-negative, and Candida albicans strains. The acetylated derivative showed an increase in activity against gram-negative bacteria, while the benzoyl derivative had a loss of effect at the concentrations evaluated. These findings demonstrate that structural modifications influence the properties of the derivatives with respect to the compound sessein.<\/jats:p>","DOI":"10.3390\/molecules31020286","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:52:57Z","timestamp":1768319577000},"page":"286","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Thorough Characterization of Two Sessein Derivatives with Potential Biological Activity"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7528-4082","authenticated-orcid":false,"given":"Abraham","family":"G\u00f3mez-Rivera","sequence":"first","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica de Ciencias B\u00e1sicas, Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco, Carretera Cunduac\u00e1n-Jalpa Km. 0.5, Cunduac\u00e1n 86690, Tabasco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1522-0384","authenticated-orcid":false,"given":"Cristian Octavio","family":"Barredo-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica de Ciencias B\u00e1sicas, Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco, Carretera Cunduac\u00e1n-Jalpa Km. 0.5, Cunduac\u00e1n 86690, Tabasco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9123-5334","authenticated-orcid":false,"given":"Santiago","family":"Santos-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica de Ciencias B\u00e1sicas, Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco, Carretera Cunduac\u00e1n-Jalpa Km. 0.5, Cunduac\u00e1n 86690, Tabasco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3734-7780","authenticated-orcid":false,"given":"Carlos Ernesto","family":"Lobato-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica de Ciencias B\u00e1sicas, Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco, Carretera Cunduac\u00e1n-Jalpa Km. 0.5, Cunduac\u00e1n 86690, Tabasco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6712-6765","authenticated-orcid":false,"given":"Ammy Joana","family":"Gallegos-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Ciencias B\u00e1sicas e Ingenier\u00eda, Universidad Popular de la Chontalpa, Carretera C\u00e1rdenas-Huimanguillo Km 2 S\/N, Rancher\u00eda, Invitab Paso y Playa, C\u00e1rdenas 86556, Tabasco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2202-8584","authenticated-orcid":false,"given":"Ricardo","family":"L\u00f3pez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica de Ciencias B\u00e1sicas, Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco, Carretera Cunduac\u00e1n-Jalpa Km. 0.5, Cunduac\u00e1n 86690, Tabasco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7464-9898","authenticated-orcid":false,"given":"Laura","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Qu\u00edmicas, Universidad Aut\u00f3noma del Estado de Morelos, Cuernavaca 62209, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5456-0677","authenticated-orcid":false,"given":"Ma Dolores","family":"P\u00e9rez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-1670","authenticated-orcid":false,"given":"Manas\u00e9s","family":"Gonz\u00e1lez-Cortazar","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8036-1580","authenticated-orcid":false,"given":"Jorge Luis","family":"Torres-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorio de Biotecnolog\u00eda, Universidad Polit\u00e9cnica del Centro, Carretera Villahermosa-Teapa Km. 22.5, Tumbulushal, Villahermosa 86290, Tabasco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2447-7036","authenticated-orcid":false,"given":"Eric Jaziel","family":"Medrano-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica de Ciencias B\u00e1sicas, Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco, Carretera Cunduac\u00e1n-Jalpa Km. 0.5, Cunduac\u00e1n 86690, Tabasco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural Products in Drug Discovery: Advances and Opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. 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