{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:19:40Z","timestamp":1789647580351,"version":"4.0.0"},"reference-count":147,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dun\u0103rea de Jos University of Gala\u021bi","award":["7957\/31.03.2025;"],"award-info":[{"award-number":["7957\/31.03.2025;"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Imidazole is, from a structural point of view, a heterocycle consisting of three C atoms and two N atoms, belonging to the class of diazoles, having two N atoms at the first and third positions in the aromatic ring. Being a polar and ionizable aromatic compound, it has the role of improving the pharmacological properties of lead molecules, thus being used to optimize their solubility and bioavailability. Imidazole is a constituent of many important biological compounds, like histidine, histamine, and purine compounds, the most widespread heterocyclic compound in nature. In current practice, substituted imidazole derivatives play a major role in antifungal, antibacterial, anti-inflammatory, CNS active compounds, antiprotozoal, as well as anticancer therapy. Thus, imidazole derivatives have demonstrated significant anticancer activities by inhibiting the key metabolic pathways essential for tumor cell growth and survival. Nitroimidazoles, for instance, have been employed as hypoxia-directed therapeutic agents, targeting oxygen-deprived tumor tissues, while mercaptopurine derivatives are well-established in oncological treatments. Structural modifications of the imidazole nucleus have led to the novel compounds exhibiting increased selective cytotoxicity against cancer cells, while sparing normal healthy cells. In accordance with what has been stated, this review highlights recent research on the medicinal and pharmaceutical interest of novel imidazole derivatives, emphasizing their potential in the development of new drugs.<\/jats:p>","DOI":"10.3390\/molecules31030423","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T12:41:16Z","timestamp":1769431276000},"page":"423","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Importance and Involvement of Imidazole Structure in Current and Future Therapy"],"prefix":"10.3390","volume":"31","author":[{"given":"Alexandra Pavel","family":"Burlacu","sequence":"first","affiliation":[{"name":"Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 35 AL Cuza Street, 800010 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9138-1843","authenticated-orcid":false,"given":"Maria","family":"Dr\u0103gan","sequence":"additional","affiliation":[{"name":"Department of II Pharmaceutical Science, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ovidiu","family":"Oniga","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 41 Victor Babe\u0219 Street, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u0103d\u0103lina Nicoleta","family":"Matei","sequence":"additional","affiliation":[{"name":"Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 35 AL Cuza Street, 800010 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7660-9993","authenticated-orcid":false,"given":"Ilioara","family":"Oniga","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, Ion Creang\u0103 Street 12, 400010 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9310-9731","authenticated-orcid":false,"given":"Elena-L\u0103cr\u0103mioara","family":"Lis\u0103","sequence":"additional","affiliation":[{"name":"Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 35 AL Cuza Street, 800010 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia-Simona","family":"Stefan","sequence":"additional","affiliation":[{"name":"Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 35 AL Cuza Street, 800010 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0389-8974","authenticated-orcid":false,"given":"Oana-Maria","family":"Dragostin","sequence":"additional","affiliation":[{"name":"Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 35 AL Cuza Street, 800010 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2174\/1573406414666181005143431","article-title":"Phenolic Imidazole Derivatives with Dual Antioxidant\/Antifungal Activity: Synthesis and Structure-Activity Relationship","volume":"15","author":"Bettencourt","year":"2019","journal-title":"Med. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1007\/s11696-024-03861-0","article-title":"Design, Synthesis, In Vitro and In Silico Anticancer Studies on Amide Derivatives of 1,3,4-Oxadiazole\u2013Isoxazol\u2013Pyridine Benzimidazole","volume":"79","author":"Devi","year":"2025","journal-title":"Chem. Pap."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ejmech.2015.12.013","article-title":"Imidazole-Based Pinanamine Derivatives: Discovery of Dual Inhibitors of the Wild-Type and Drug-Resistant Mutant of the Influenza A Virus","volume":"108","author":"Dong","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1039\/D4OB01717J","article-title":"A Comprehensive Review of the Imidazole, Benzimidazole and Imidazo[1,2-a]Pyridine-Based Sensors for the Detection of Fluoride Ion","volume":"23","author":"Kumari","year":"2025","journal-title":"Org. Biomol. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1016\/j.bmcl.2008.04.039","article-title":"IRAK-4 Inhibitors. Part II: A Structure-Based Assessment of Imidazo[1,2-a]Pyridine Binding","volume":"18","author":"Buckley","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"136166","DOI":"10.1016\/j.molstruc.2023.136166","article-title":"Synthesis, Characterization, DFT Studies, and Molecular Docking Investigation of a Silver Nitrate Complex of 5-Benzimidazole Carboxylic Acid as Targeted Anticancer Agents","volume":"1293","year":"2023","journal-title":"J. Mol. Struct."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1016\/j.bmc.2012.09.013","article-title":"The Therapeutic Journey of Benzimidazoles: A Review","volume":"20","author":"Bansal","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"117524","DOI":"10.1016\/j.ejmech.2025.117524","article-title":"An Insight into Synthetic, Structural and Medicinal Perspective of Imidazole Analogs: A Review","volume":"290","author":"Yadav","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/00397911.2024.2414201","article-title":"Unlocking the Imidazole Ring: A Comprehensive Review of Synthetic Strategies","volume":"55","author":"Solo","year":"2025","journal-title":"Synth. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e24202","DOI":"10.1016\/j.heliyon.2024.e24202","article-title":"Synthesis and Biological Activity of Imidazole Phenazine Derivatives as Potential Inhibitors for NS2B-NS3 Dengue Protease","volume":"10","author":"Khalili","year":"2024","journal-title":"Heliyon"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"122890","DOI":"10.1016\/j.jorganchem.2023.122890","article-title":"Synthesis, and Study Biological Activity of CuI Complexes Involving Imidazole-2-Selones as Ligands","volume":"1001","author":"Mageed","year":"2023","journal-title":"J. Organomet. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e03240","DOI":"10.1016\/j.heliyon.2020.e03240","article-title":"Effects of Pyrroloquinoline Quinone and Imidazole Pyrroloquinoline on Biological Activities and Neural Functions","volume":"6","author":"Yamada","year":"2020","journal-title":"Heliyon"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"113750","DOI":"10.1016\/j.ejmech.2021.113750","article-title":"Design, Synthesis and Biological Activities of Benzo[d]Imidazo[1,2-a]Imidazole Derivatives as TRPM2-Specfic Inhibitors","volume":"225","author":"Zhao","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1016\/j.bmcl.2010.05.018","article-title":"Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X7 antagonists","volume":"20","author":"Gleave","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1124\/jpet.109.154963","article-title":"Pharmacological Properties of 2-((R-5-Chloro-4-Methoxymethylindan-1-Yl)-1H-Imidazole (PF-3774076), a Novel and Selective \u03b11A-Adrenergic Partial Agonist, in in Vitro and in Vivo Models of Urethral Function","volume":"330","author":"Conlon","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2174\/0115734064248204230919074743","article-title":"Synthesis and Evaluation of Imidazole Derivatives Bearing Imidazo[2,1-b] [1,3,4]Thiadiazole Moiety as Antibacterial Agents","volume":"20","author":"Xu","year":"2024","journal-title":"Med. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.arabjc.2013.11.020","article-title":"One-Pot Synthesis of 1,2,4,5-Tetra Substituted Imidazoles Using Sulfonic Acid Functionalized Silica (SiO2-Pr-SO3H)","volume":"8","author":"Ziarani","year":"2015","journal-title":"Arab. J. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"117946","DOI":"10.1016\/j.bmc.2024.117946","article-title":"Synthesis, Pharmacological Evaluation, and Modeling of Novel Quaternary Ammonium Salts Derived from \u03b2-Carboline Containing an Imidazole Moiety as Angiogenesis Inhibitors","volume":"114","author":"Chen","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"102259","DOI":"10.1016\/j.rechem.2025.102259","article-title":"Design, Synthesis of Imidazole Scaffolds as an Effective Larvicidal Agent against Etiella zinkenella and in Vitro Antibacterial and Antifungal Evaluation against Candida albicans with DFT Calculations, Molecular Docking Technique and Theoretical Biological Potential","volume":"15","author":"Rayate","year":"2025","journal-title":"Results Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.2174\/1389557520999201209213648","article-title":"Imidazole Derivatives and Their Antibacterial Activity\u2014A Mini-Review","volume":"21","author":"Andrei","year":"2021","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.13005\/bpj\/2696","article-title":"Imidazole Scaffold: A Review of Synthetic Strategies and Therapeutic Action","volume":"16","author":"Tripathi","year":"2023","journal-title":"Biomed. Pharmacol. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"134920","DOI":"10.1016\/j.molstruc.2023.134920","article-title":"New Imidazole Derivatives as Aromatase Inhibitor: Design, Synthesis, Biological Activity, Molecular Docking, and Computational ADME-Tox Studies","volume":"1278","author":"Celik","year":"2023","journal-title":"J. Mol. Struct."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2174\/1570193X11666141028235010","article-title":"Trisubstituted Imidazole Synthesis: A Review","volume":"12","author":"Rani","year":"2015","journal-title":"Mini-Rev. Org. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e31253","DOI":"10.1016\/j.heliyon.2024.e31253","article-title":"Various Synthesis and Biological Evaluation of Some Tri-Tetra-Substituted Imidazoles Derivatives: A Review","volume":"10","author":"Hamdi","year":"2024","journal-title":"Heliyon"},{"key":"ref_25","first-page":"7","article-title":"Reaction Strategies for Synthesis of Imidazole Derivatives: A Review","volume":"5","author":"Georgieva","year":"2018","journal-title":"Scr. Sci. Pharm."},{"key":"ref_26","first-page":"1668","article-title":"Routes of synthesis and biological significances of Imidazole derivatives","volume":"3","author":"Chaudhury","year":"2015","journal-title":"World J. Pharm. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Goel, K.K., Thapliyal, S., Kharb, R., Joshi, G., Negi, A., and Kumar, B. (2023). Imidazoles as Serotonin Receptor Modulators for Treatment of Depression: Structural Insights and Structure\u2013Activity Relationship Studies. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15092208"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1039\/D0OB00350F","article-title":"Recent advances in the synthesis of imidazoles","volume":"18","author":"Shabalin","year":"2020","journal-title":"Org. Biomol. Chem."},{"key":"ref_29","first-page":"630","article-title":"Imidazole and Derivatives Drugs Synthesis: A Review","volume":"20","author":"Rani","year":"2022","journal-title":"Curr. Org. Synth."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/15583720903288914","article-title":"Designing Imidazole-Based Ionic Liquids and Ionic Liquid Monomers for Emerging Technologies","volume":"49","author":"Green","year":"2009","journal-title":"Polym. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Wingate, D. (1989). Martindale: The Extra Pharmacopeia, BMJ. [29th ed.].","DOI":"10.1136\/gut.30.12.1804"},{"key":"ref_32","unstructured":"Eicher, T., Hauptmann, S., and Speicher, A. (2013). The Chemistry of Heterocycles: Structures, Reactions, Synthesis, and Applications, Wiley-VCH."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"142096","DOI":"10.1016\/j.molstruc.2025.142096","article-title":"A Novel Hg2+ Ion Chemosensor Based on Dihydro-Pyrano Imidazole Derivatives","volume":"1337","author":"Ziarani","year":"2025","journal-title":"J. Mol. Struct."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"163239","DOI":"10.1016\/j.apsusc.2025.163239","article-title":"Synergistic Mechanism and Synergistic Effect of Two Structurally Complex Imidazole Derivatives Forming a Double Adsorption Layer","volume":"701","author":"Tang","year":"2025","journal-title":"Appl. Surf. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1021\/acs.joc.4c03010","article-title":"Synthesis of diverse imidazole and quinoxaline derivatives via iodine-mediated cyclization reactions","volume":"90","author":"Panneerselvam","year":"2025","journal-title":"J. Org. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"115436","DOI":"10.1016\/j.ejmech.2023.115436","article-title":"New Miconazole-Based Azoles Derived from Eugenol Show Activity against Candida spp. and Cryptococcus gattii by Inhibiting the Fungal Ergosterol Biosynthesis","volume":"256","author":"Reis","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2310828","DOI":"10.1002\/adfm.202310828","article-title":"Imidazole Derivative Assisted Crystallization for High-Efficiency Mixed Sn\u2013Pb Perovskite Solar Cells","volume":"34","author":"Liu","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"112692","DOI":"10.1016\/j.ejmech.2020.112692","article-title":"The Role of Imidazole and Benzimidazole Heterocycles in Chagas Disease: A Review","volume":"206","author":"Alcolea","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0021-9258(18)72045-0","article-title":"Some Biological Effects Produced by Benzimidazole and Their Reversal by Purines","volume":"152","author":"Woolley","year":"1944","journal-title":"J. Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0040-4020(01)92753-X","article-title":"On the Dipole Moments and Chemical Properties of Pyrazole and Imidazole","volume":"18","author":"Hamano","year":"1962","journal-title":"Tetrahedron"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/0731-7085(91)80094-P","article-title":"HPLC Analysis of Imidazole Antimycotic Drugs in Pharmaceutical Formulations","volume":"10","author":"Cavrini","year":"1992","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_42","first-page":"887","article-title":"Biochemical Effects of Miconazole on Fungi. I. Effects on the Uptake and or Utilization of Purines, Pyrimidines, Nucleosides, Amino Acids and Glucose by Candida albicans","volume":"23","year":"1974","journal-title":"Biochem. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1439-0507.1958.tb04016.x","article-title":"Pilzhemmende Wirkung Eines Neuen Benzimidazol-Derivates","volume":"1","author":"Seeliger","year":"1958","journal-title":"Mycoses"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"108341","DOI":"10.1016\/j.compbiolchem.2025.108341","article-title":"In Silico Design and Molecular Dynamics Analysis of Imidazole Derivatives as Selective Cyclooxygenase-2 Inhibitors","volume":"115","author":"Saadh","year":"2025","journal-title":"Comput. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"140148","DOI":"10.1016\/j.molstruc.2024.140148","article-title":"Insight on Development of Oxazole and Imidazole Derivatives as COX Inhibitors with Anti-Inflammatory Effects","volume":"1321","author":"Rayan","year":"2025","journal-title":"J. Mol. Struct."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"117542","DOI":"10.1016\/j.bone.2025.117542","article-title":"The Effect of Celecoxib and muMab911 on Strain Adaptive Bone Remodeling and Fracture Repair in Female Mice: Implications for Rapidly Progressive Osteoarthritis","volume":"198","author":"Ruggiero","year":"2025","journal-title":"Bone"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ejmech.2019.07.019","article-title":"An Insight into the Medicinal Perspective of Synthetic Analogs of Indole: A Review","volume":"180","author":"Thanikachalam","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"116459","DOI":"10.1016\/j.ejmech.2024.116459","article-title":"Synthesis and Evaluation of Diaryl Ether Modulators of the Leukotriene A4 Hydrolase Aminopeptidase Activity","volume":"272","author":"Petruncio","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.jmii.2023.04.009","article-title":"Comparative Safety of Bedaquiline and Delamanid in Patients with Multidrug Resistant Tuberculosis: A Nationwide Retrospective Cohort Study","volume":"56","author":"Kim","year":"2023","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"101437","DOI":"10.1016\/j.nmni.2024.101437","article-title":"Delamanid and Bedaquiline Resistance Patterns in Mycobacterium tuberculosis in Iran: A Cross-Sectional Analysis","volume":"60\u201361","author":"Aghababa","year":"2024","journal-title":"New Microbes New Infect."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1038\/s41467-023-39300-z","article-title":"DprE2 Is a Molecular Target of the Anti-Tubercular Nitroimidazole Compounds Pretomanid and Delamanid","volume":"14","author":"Abrahams","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"100433","DOI":"10.1016\/j.jctube.2024.100433","article-title":"Concomitant Bedaquiline and Delamanid Therapy in Patients with Drug-Resistant Extra-Pulmonary Tuberculosis in Mumbai, India","volume":"35","author":"Mongia","year":"2024","journal-title":"J. Clin. Tuberc. Other Mycobact. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00044-024-03230-2","article-title":"Recent Pharmacological Insights about Imidazole Hybrids: A Comprehensive Review","volume":"33","author":"Poyraz","year":"2024","journal-title":"Med. Chem. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.ejmech.2017.08.001","article-title":"Substituted Methoxybenzyl-Sulfonyl-1H-Benzo[d]Imidazoles Evaluated as Effective H+\/K+-ATPase Inhibitors and Anti-Ulcer Therapeutics","volume":"139","author":"Rajesh","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_55","first-page":"59","article-title":"Design, Synthesis, and Cytotoxicity Evaluation of New 1,2-Diaryl-4,5,6,7-Tetrahydro-1H-Benzo[d]imidazoles as Tubulin Inhibitors","volume":"14","author":"Amirmostofian","year":"2015","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"102217","DOI":"10.1016\/j.rechem.2025.102217","article-title":"Rational Design, and Synthesis of Imidazole Ring Incorporated Pyridine-1,2,4-Oxadiazole Derivatives: In-Vitro Anticancer Evaluation and in-Silico Molecular Docking Simulations","volume":"15","author":"Vasamsetti","year":"2025","journal-title":"Results Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"140959","DOI":"10.1016\/j.molstruc.2024.140959","article-title":"Development of Novel Imidazole-2-One\/-2-Thione Heterocyclic Derivatives as Antimicrobial and Antiproliferative Agents and Evaluation through Biological Studies and Molecular Modeling Simulations","volume":"1324","author":"Alzahrani","year":"2025","journal-title":"J. Mol. Struct."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"139376","DOI":"10.1016\/j.molstruc.2024.139376","article-title":"Novel Hybrid Motifs of 2-(2-Pyridinyl)-1H-Benzo[d]Imidazole-1,2,3-Triazole: Synthesis, Anticancer Assessment, and in Silico Study","volume":"1318","year":"2024","journal-title":"J. Mol. Struct."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"108271","DOI":"10.1016\/j.bioorg.2025.108271","article-title":"Design, Synthesis and Anticancer Evaluation of Novel 1,3-Imidazole-Type Phenylhistin Derivatives: Dual Mechanism via P53 Induction and Microtubulin Inhibition","volume":"157","author":"Chen","year":"2025","journal-title":"Bioorg. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"28065","DOI":"10.1038\/s41598-024-76533-4","article-title":"Synthesis and Effect of 4-Acetylphenylamine-Based Imidazole Derivatives on Migration and Growth of 3D Cultures of Breast, Prostate and Brain Cancer Cells","volume":"14","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"102313","DOI":"10.1016\/j.rechem.2025.102313","article-title":"Novel Imidazoles from Guanylhydrazone: Synthesis, Computational, and Molecular Docking Studies as \u03b1-Amylase Inhibitors for Type 2 Diabetes Management","volume":"16","author":"Badrey","year":"2025","journal-title":"Results Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"136951","DOI":"10.1016\/j.molstruc.2023.136951","article-title":"Design, Synthesis and Biological Evaluation of Novel Imidazole-Based Benzamide and Hydroxamic Acid Derivatives as Potent Histone Deacetylase Inhibitors and Anticancer Agents","volume":"1297","author":"Nasrollahzadeh","year":"2024","journal-title":"J. Mol. Struct."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1021\/acsinfecdis.0c00910","article-title":"Benzimidazole Derivatives Are Potent against Multiple Life Cycle Stages of Plasmodium falciparum Malaria Parasites","volume":"7","author":"Leshabane","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"104240","DOI":"10.1016\/j.bioorg.2020.104240","article-title":"History of the Development of Antifungal Azoles: A Review on Structures, SAR, and Mechanism of Action","volume":"104","author":"Shafiei","year":"2020","journal-title":"Bioorg. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0014-5793(95)01341-5","article-title":"Ketoconazole and Other Imidazole Derivatives Are Potent Inhibitors of Peroxisomal Phytanic Acid Alpha-Oxidation","volume":"377","author":"Pahan","year":"1995","journal-title":"FEBS Lett."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"109238","DOI":"10.1016\/j.carres.2024.109238","article-title":"Synthesis, Characterization and Antifungal Activity of Imidazole Chitosan Derivatives","volume":"544","author":"Wu","year":"2024","journal-title":"Carbohydr. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"137447","DOI":"10.1016\/j.molstruc.2023.137447","article-title":"Imidazole Derivatives as Novel and Potent Antifungal Agents: Synthesis, Biological Evaluation, Molecular Docking Study, Molecular Dynamic Simulation and ADME Prediction","volume":"1302","author":"Sadeghian","year":"2024","journal-title":"J. Mol. Struct."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Lisa, E.L., Dragostin, O.M., Petroaie, A.D., Gurau, G., Cristea, A., Pavel, A., Bonifate, F., Popa, P.S., and Matei, M. (2022). The Effect of the New Imidazole Derivatives Complexation with Betacyclodextrin, on the Antifungal Activity in Oropharyngeal Infections. Processes, 10.","DOI":"10.3390\/pr10122697"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1016\/j.ejmech.2009.05.021","article-title":"Synthesis and Evaluation of in Vitro Anti-Microbial and Anti-Tubercular Activity of 2-Styryl Benzimidazoles","volume":"44","author":"Shingalapur","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"141289","DOI":"10.1016\/j.molstruc.2024.141289","article-title":"Synthesis, Characterization, Antifungal Evaluation, and in Silico Studies of Novel Imidazole-Pyrazole and Imidazole-Isoxazole Clubbed Scaffolds","volume":"1328","author":"Deshmukh","year":"2025","journal-title":"J. Mol. Struct."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/j.ejmech.2011.02.036","article-title":"Synthesis, Spectral, Crystal Structure and in Vitro Antimicrobial Evaluation of Imidazole\/Benzotriazole Substituted Piperidin-4-One Derivatives","volume":"46","author":"Ramachandran","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S1995-7645(10)60113-7","article-title":"Synthesis and Antibacterial Evaluation of 2\u2013Substituted\u20134,5\u2013Diphenyl\u2013N\u2013Alkyl Imidazole Derivatives","volume":"3","author":"Jain","year":"2010","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41929-022-00904-1","article-title":"Molecular Mechanism of Topoisomerase Poisoning by the Peptide Antibiotic Albicidin","volume":"6","author":"Michalczyk","year":"2023","journal-title":"Nat. Catal."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1093\/nar\/gky181","article-title":"A New Class of Antibacterials, the Imidazopyrazinones, Reveal Structural Transitions Involved in DNA Gyrase Poisoning and Mechanisms of Resistance","volume":"46","author":"Germe","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e202500162","DOI":"10.1002\/chem.202500162","article-title":"Synthesis of Derivatives of the Antibiotic Albicidin: The N-Terminal Fragment as Key to Control Potency and Resistance Mediated by the Binding Protein AlbA","volume":"31","author":"Hommernick","year":"2025","journal-title":"Chem. Eur. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"103277","DOI":"10.1016\/j.bioorg.2019.103277","article-title":"Synthesis and Investigation of Inhibitory Activities of Imidazole Derivatives against the Metallo-\u03b2-Lactamase IMP-1","volume":"92","author":"Arjomandi","year":"2019","journal-title":"Bioorg. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"113965","DOI":"10.1016\/j.ejmech.2021.113965","article-title":"Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-\u03b2-lactamase inhibitors","volume":"228","author":"Yan","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"113985","DOI":"10.1016\/j.microc.2025.113985","article-title":"Environmentally-Friendly Functionalized Carbon Dots for the Detection of Metronidazole and Antibacterial Applications","volume":"214","author":"Li","year":"2025","journal-title":"Microchem. J."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.radcr.2025.02.042","article-title":"A Rare Clinical Presentation of Metronidazole-Induced Dysarthria: A Case Report with Literature Review","volume":"20","author":"Mitra","year":"2025","journal-title":"Radiol. Case Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"112994","DOI":"10.1016\/j.ejmech.2020.112994","article-title":"Metronidazole-Conjugates: A Comprehensive Review of Recent Developments towards Synthesis and Medicinal Perspective","volume":"210","author":"Patel","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"108544","DOI":"10.1016\/j.bioorg.2025.108544","article-title":"Preparation of Water-Soluble Imidazole-Functionalized Pillar[5]Arenes: The Activities of Antibacterial and Antioxidant, Catalytic Reduction of 4-Nitrophenol","volume":"161","author":"Atacan","year":"2025","journal-title":"Bioorg. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1254\/jjp.42.575","article-title":"Effects of a new anti-inflammatory imidazole derivative, fenflumizole, on platelet aggregation in the rabbit","volume":"42","author":"Aono","year":"1986","journal-title":"Jpn. J. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"117286","DOI":"10.1016\/j.ejmech.2025.117286","article-title":"Design, Synthesis, and Evaluation of Carboxylic Acid-Substituted Celecoxib Isosteres as Potential Anti-Inflammatory Agents","volume":"286","author":"Song","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/jphp.13068","article-title":"Imidazole Alkaloids Inhibit the Pro-Inflammatory Mechanisms of Human Neutrophil and Exhibit Anti-Inflammatory Properties in Vivo","volume":"71","author":"Rocha","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.biopha.2019.01.052","article-title":"New Pre-Clinical Evidence of Anti-Inflammatory Effect and Safety of a Substituted Fluorophenyl Imidazole","volume":"111","author":"Munhoz","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"17788","DOI":"10.1021\/acsomega.3c00605","article-title":"Synthesis, In Silico Studies, and In Vitro Anti-Inflammatory Activity of Novel Imidazole Derivatives Targeting P38 MAP Kinase","volume":"8","author":"Awasthi","year":"2023","journal-title":"ACS Omega"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jphs.2024.01.006","article-title":"Sulconazole Induces Pyroptosis Promoted by Interferon-\u03b3 in Monocyte\/Macrophage Lineage Cells","volume":"154","author":"Miyawaki","year":"2024","journal-title":"J. Pharmacol. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Khoshnood, S., Taki, E., Sadeghifard, N., Kaviar, V.H., Haddadi, M.H., Farshadzadeh, Z., Kouhsari, E., Goudarzi, M., and Heidary, M. (2021). Mechanism of Action, Resistance, Synergism, and Clinical Implications of Delamanid Against Multidrug-Resistant Mycobacterium tuberculosis. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.717045"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ejmech.2018.03.016","article-title":"Recent Advances of Imidazole-Containing Derivatives as Anti-Tubercular Agents","volume":"150","author":"Fan","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_90","first-page":"e00441","article-title":"1H-Benzo[d]Imidazole Derivatives Affect MmpL3 in Mycobacterium Tuberculosis","volume":"63","author":"Viljoen","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3390\/biomed4030018","article-title":"Unveiling DprE1 as a Key Target in the Fight against Tuberculosis: Insights and Perspectives on Developing Novel Antimicrobial Agents","volume":"4","author":"Fil","year":"2024","journal-title":"BioMed"},{"key":"ref_92","unstructured":"Johnson, L.R. (2004). Proton pump inhibitors. Encyclopedia of Gastroenterology, Elsevier Academic Press."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.2147\/DDDT.S131797","article-title":"Drug\u2013drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer","volume":"11","author":"Park","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"138657","DOI":"10.1016\/j.molstruc.2024.138657","article-title":"Synthesis, Crystal Structure, Hirshfeld, DFT, Molecular Docking, Dynamics Studies, and Anti-Cancer Activity of 1-Substituted-2-(4-(Diethylamino)-2-Hydroxyphenyl)-1H-Benzo[d]Imidazole-5-Ethyl Carboxylates","volume":"1314","author":"Ganavi","year":"2024","journal-title":"J. Mol. Struct."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"156140","DOI":"10.1016\/j.scitotenv.2022.156140","article-title":"The Overall Assessment of Simultaneous Photocatalytic Degradation of Cimetidine and Amisulpride by Using Chemical and Genotoxicological Approaches","volume":"838","author":"Spyrou","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s40199-021-00427-3","article-title":"Novel Benzimidazole Derivatives; Synthesis, Bioactivity and Molecular Docking Study as Potent Urease Inhibitors","volume":"30","author":"Moghadam","year":"2022","journal-title":"DARU J. Pharm. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"114858","DOI":"10.1016\/j.ejmech.2022.114858","article-title":"Structural Optimization of Imidazo[1, 2-a]Pyridine Derivatives for the Treatment of Gastric Cancer via STAT3 Signaling Pathway","volume":"244","author":"Li","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e200324228067","DOI":"10.2174\/0118715265274067240223040333","article-title":"Imidazo[1,2-A]Pyridine: Potent Biological Activity, SAR and Docking Investigations (2017\u20132022)","volume":"24","author":"Narayan","year":"2024","journal-title":"Infect. Disord. Drug Targets"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.1021\/jm7010063","article-title":"Synthesis and Evaluation of 7H-8,9-Dihydropyrano[2,3-c]Imidazo[1,2-a]Pyridines as Potassium-Competitive Acid Blockers","volume":"50","author":"Palmer","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Shahin, A.I., Zaib, S., Zaraei, S.-O., Kedia, R.A., Anbar, H.S., Younas, M.T., Al-Tel, T.H., Khoder, G., and El-Gamal, M.I. (2023). Design and Synthesis of Novel Anti-Urease Imidazothiazole Derivatives with Promising Antibacterial Activity against Helicobacter Pylori. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0286684"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jare.2018.05.003","article-title":"A Review on the Development of Urease Inhibitors as Antimicrobial Agents against Pathogenic Bacteria","volume":"13","author":"Rego","year":"2018","journal-title":"J. Adv. Res."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Valenzuela-Hormazabal, P., Sep\u00falveda, R.V., Alegr\u00eda-Arcos, M., Vald\u00e9s-Mu\u00f1oz, E., Rojas-P\u00e9rez, V., Gonz\u00e1lez-Bonet, I., Suard\u00edaz, R., Galarza, C., Morales, N., and Leddermann, V. (2024). Unveiling Novel Urease Inhibitors for Helicobacter Pylori: A Multi-Methodological Approach from Virtual Screening and ADME to Molecular Dynamics Simulations. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25041968"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"107106","DOI":"10.1016\/j.bioorg.2024.107106","article-title":"Alpha-Glucosidase Inhibitory and Hypoglycemic Effects of Imidazole-Bearing Thioquinoline Derivatives with Different Substituents: In Silico, in Vitro, and in Vivo Evaluations","volume":"144","author":"Azmi","year":"2024","journal-title":"Bioorg. Chem."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Trifonov, R.E., and Ostrovskii, V.A. (2023). Tetrazoles and Related Heterocycles as Promising Synthetic Antidiabetic Agents. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242417190"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.bioorg.2017.12.014","article-title":"Biological evaluation of new imidazole derivatives tethered with indole moiety as potent \u03b1-glucosidase inhibitors","volume":"76","author":"Naureen","year":"2018","journal-title":"Bioorg. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"106298","DOI":"10.1016\/j.bioorg.2022.106298","article-title":"2,5-Disubstituted Furan Derivatives Containing Imidazole, Triazole or Tetrazole Moiety as Potent \u03b1-Glucosidase Inhibitors","volume":"131","author":"He","year":"2023","journal-title":"Bioorg. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e67007","DOI":"10.2196\/67007","article-title":"Comparative Efficacy of Video Games Versus Midazolam in Reducing Perioperative Anxiety in Pediatric Patients: Systematic Review and Meta-Analysis","volume":"13","author":"Luo","year":"2025","journal-title":"JMIR Serious Games"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"108390","DOI":"10.1016\/j.yebeh.2021.108390","article-title":"Intranasal Midazolam versus Intravenous\/Rectal Benzodiazepines for Acute Seizure Control in Children: A Systematic Review and Meta-Analysis","volume":"125","author":"Chhabra","year":"2021","journal-title":"Epilepsy Behav."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jcrc.2021.04.001","article-title":"A Systematic Review and Meta-Analysis of Propofol versus Midazolam Sedation in Adult Intensive Care (ICU) Patients","volume":"64","author":"Garcia","year":"2021","journal-title":"J. Crit. Care"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"106704","DOI":"10.1016\/j.jddst.2025.106704","article-title":"A Comprehensive Study on Needle-Free Injection Technology Combined with Midazolam Nanosuspension","volume":"106","author":"Zhang","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"106023","DOI":"10.1016\/j.tiv.2025.106023","article-title":"Assessing the Safety of Midazolam: A Comprehensive Analysis of Adverse Events from FAERS","volume":"105","author":"Chen","year":"2025","journal-title":"Toxicol. Vitr."},{"key":"ref_112","unstructured":"National Center for Biotechnology Information (2025, December 09). PubChem Compound Summary for CID 4192, Midazolam, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/4192."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e19327","DOI":"10.1016\/j.heliyon.2023.e19327","article-title":"Novel Hybrid Motifs of 4-Nitroimidazole-Piperazinyl Tagged 1,2,3-Triazoles: Synthesis, Crystal Structure, Anticancer Evaluations, and Molecular Docking Study","volume":"9","author":"Saber","year":"2023","journal-title":"Heliyon"},{"key":"ref_114","first-page":"29","article-title":"Synthesis and antidepressant activity of N-substituted imidazole-5-carboxamides in forced swimming test model","volume":"7","author":"Hadizadeh","year":"2010","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.biopha.2018.06.064","article-title":"Imidazole Bearing Chalcones as a New Class of Monoamine Oxidase Inhibitors","volume":"106","author":"Sasidharan","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"16187","DOI":"10.1039\/D5RA01929J","article-title":"Exploring N-Heterocyclic Linked Novel Hybrid Chalcone Derivatives: Synthesis, Characterization, Evaluation of Antidepressant Activity, Toxicity Assessment, Molecular Docking, DFT and ADME Study","volume":"15","author":"Deshmukh","year":"2025","journal-title":"RSC Adv."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1128\/CMR.14.1.114-128.2001","article-title":"Treatment of Giardiasis","volume":"14","author":"Gardner","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Ansell, B.R.E., McConville, M.J., Ma\u2019ayeh, S.Y., Dagley, M.J., Gasser, R.B., Svard, S.G., and Jex, A.R. (2017). Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.00398"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ejmech.2016.04.064","article-title":"Nitroimidazole Carboxamides as Antiparasitic Agents Targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis","volume":"120","author":"Jarrad","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e00829-19","DOI":"10.1128\/AAC.00829-19","article-title":"Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis","volume":"63","author":"Wijnant","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijpddr.2019.02.002","article-title":"Novel Benzoxaborole, Nitroimidazole and Aminopyrazoles with Activity against Experimental Cutaneous Leishmaniasis","volume":"11","author":"Caridha","year":"2019","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3390\/futurepharmacol4010015","article-title":"Using 5-Nitroimidazole Derivatives against Neglected Tropical Protozoan Diseases: Systematic Review","volume":"4","year":"2024","journal-title":"Future Pharmacol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Rosas, M.E., Quiroz-Cruz, S., Vald\u00e9s-Casillas, A., Rivas-Garc\u00eda, I., Guzm\u00e1n-Delgado, N.E., \u00c1lvarez-Hern\u00e1ndez, A.A., Ram\u00edrez-Mendoza, M.J., Gonz\u00e1lez-Castro, M.A., Ch\u00e1vez-Mungu\u00eda, B., and Reyes-Batlle, M. (2024). Imidazole Carbamates as a Promising Alternative for Treating Trichomoniasis. Molecules, 29.","DOI":"10.3390\/molecules29112585"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3347\/kjp.2021.59.3.189","article-title":"Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: An Update","volume":"59","author":"Chai","year":"2021","journal-title":"Korean J. Parasitol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00423-003-0418-y","article-title":"Echinococcus granulosus infection: Clinical presentation, medical treatment and outcome","volume":"388","author":"Kern","year":"2003","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Guarnaschelli, I., and Koziol, U. (2025). Albendazole specifically disrupts microtubules and protein turnover in the tegument of the cestode Mesocestoides corti. PLoS Pathog., 21.","DOI":"10.1101\/2025.03.04.641463"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11164-021-04601-9","article-title":"An Efficient Synthesis of Rearranged New Biologically Active Benzimidazoles Derived from 2-Formyl Carvacrol","volume":"48","author":"Bhoi","year":"2022","journal-title":"Res. Chem. Intermed."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.2174\/0929867331666230915093928","article-title":"State-of-the-art Review on the Antiparasitic Activity of Benzimidazole-based Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis","volume":"31","author":"Francesconi","year":"2024","journal-title":"Curr. Med. Chem."},{"key":"ref_129","first-page":"224","article-title":"New Benzimidazole Derivative Compounds with In Vitro Fasciolicidal Properties","volume":"17","year":"2024","journal-title":"Parasites Vectors"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"7938","DOI":"10.2174\/0109298673342932241016032905","article-title":"Insights into the Antiparasitic Activity of Pyrazole-benzimidazole against Trypanosoma cruzi","volume":"32","author":"Paes","year":"2025","journal-title":"Curr. Med. Chem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.bmcl.2014.02.041","article-title":"Schiff\u2019s Base Derivatives Bearing Nitroimidazole and Quinoline Nuclei: New Class of Anticancer Agents and Potential EGFR Tyrosine Kinase Inhibitors","volume":"24","author":"Makawana","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1039\/C7MD00067G","article-title":"Imidazoles as Potential Anticancer Agents","volume":"8","author":"Ali","year":"2017","journal-title":"Med. Chem. Commun."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"102300","DOI":"10.1016\/j.redox.2022.102300","article-title":"Cellular mechanism of action of 2-nitroimidazoles as hypoxia-selective therapeutic agents","volume":"52","author":"Rashed","year":"2022","journal-title":"Redox Biol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/CMR.0b013e3283649a97","article-title":"Efficacy and side effects of dacarbazine in comparison with temozolomide in the treatment of malignant melanoma: A meta-analysis consisting of 1314 patients","volume":"23","author":"Teimouri","year":"2013","journal-title":"Melanoma Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3892\/or.2022.8325","article-title":"Bendamustine: A review of pharmacology, clinical use and immunological effects","volume":"47","author":"Aurer","year":"2022","journal-title":"Oncol. Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/bjc.1976.78","article-title":"Metronidazole (Flagyl): Characterization as a cytotoxic drug specific for hypoxic tumour cells","volume":"33","author":"Foster","year":"1976","journal-title":"Br. J. Cancer"},{"key":"ref_137","first-page":"4509","article-title":"Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix","volume":"56","author":"Hockel","year":"1996","journal-title":"Cancer Res."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Sprangers, B., Cosmai, L., and Porta, C. (2020). Conventional chemotherapy. Onco-Nephrology, Elsevier.","DOI":"10.1016\/B978-0-323-54945-5.00025-4"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"129865","DOI":"10.1016\/j.molstruc.2020.129865","article-title":"Potential antiviral and anticancer effect of imidazoles and bridgehead imidazoles generated by HPV-Induced cervical carcinomas via reactivating the P53\/pRb pathway and inhibition of CA IX","volume":"1230","author":"Hassan","year":"2021","journal-title":"J. Mol. Struct."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"104904","DOI":"10.1016\/j.bioorg.2021.104904","article-title":"Design, synthesis and biological evaluation of novel imidazole-chalcone derivatives as potential anticancer agents and tubulin polymerization inhibitors","volume":"112","author":"Rahimzadeh","year":"2021","journal-title":"Bioorg. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"139622","DOI":"10.1016\/j.molstruc.2024.139622","article-title":"Synthesis, QTAIM, Anticancer Activity Analysis of Pyrrole-Imidazole\/Benzimidazole Derivatives and Investigation of Their Reactivity Properties Using DFT Calculations and Molecular Docking","volume":"1321","author":"Ram","year":"2025","journal-title":"J. Mol. Struct."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1016\/j.ejmech.2010.04.015","article-title":"Synthesis of 2-Substituted-N-[4-(1-Methyl-4,5-Diphenyl-1H-Imidazole-2-Yl)Phenyl]Acetamide Derivatives and Evaluation of Their Anticancer Activity","volume":"45","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"100649","DOI":"10.1016\/j.rechem.2022.100649","article-title":"Synthesis and Biological Evaluation of Aryl 1,2,4-Oxadiazole Incorporated (2-(Oxazol)-1H-Imidazoles as Anticancer Agents","volume":"4","author":"Bairi","year":"2022","journal-title":"Results Chem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"139240","DOI":"10.1016\/j.molstruc.2024.139240","article-title":"Imidazole-Based Hydrazones as Potent Anti-Colon Cancer Agents: Design, Synthesis, Biological Evaluation and Computational Studies","volume":"1318","author":"Tapera","year":"2024","journal-title":"J. Mol. Struct."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"106352","DOI":"10.1016\/j.bioorg.2023.106352","article-title":"Structure Optimization, Synthesis, and Biological Evaluation of 6-(2-Amino-1H-Benzo[d]Imidazole-6-Yl)-Quinazolin-4(3H)-One Derivatives as Potential Multi-Targeted Anticancer Agents via Aurora A\/ PI3K\/BRD4 Inhibition","volume":"132","author":"Fan","year":"2023","journal-title":"Bioorg. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"102134","DOI":"10.1016\/j.rechem.2025.102134","article-title":"Green Synthesis and in Vitro Anticancer Evaluation of 1,2-Disubstituted Benzimidazole Derivatives","volume":"14","year":"2025","journal-title":"Results Chem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"100753","DOI":"10.1016\/j.cdc.2021.100753","article-title":"Design, Synthesis and Anticancer Evaluation of 2-(5-(Benzo[d]Thiazol-2-Yl)-1H-Imidazol-1-Yl)-5-Aryl-1H-Benzo[d]Imidazole Derivatives","volume":"35","author":"Edukondalu","year":"2021","journal-title":"Chem. 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