{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T12:12:14Z","timestamp":1771416734683,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>We report an efficient synthetic method for the preparation of 6H-benzo[c]chromenes from substituted 1-(2\u2032-bromo-[1,1\u2032-biphenyl]-2-yl)-2-phenylethanols. These intermediates were obtained via a TDAE-initiated reaction between new substituted 2\u2032-bromo-[1,1\u2032-biphenyl]-2-carbaldehyde derivatives and substituted nitrobenzylic chlorides. The second step involved a palladium-catalyzed intramolecular O-arylation of the alcohol intermediate under microwave irradiation (110 \u00b0C for 1.5 h). The structure of 6H-benzo[c]chromene derivatives was confirmed by X-ray crystallography of product 5c.<\/jats:p>","DOI":"10.3390\/molecules31040706","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T11:45:58Z","timestamp":1771415158000},"page":"706","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Original Synthesis of Substituted 6H-Benzo[c]chromene Derivatives Using a TDAE and Pd-Catalyzed Cyclization Strategy"],"prefix":"10.3390","volume":"31","author":[{"given":"Donia","family":"Ben Salah","sequence":"first","affiliation":[{"name":"Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage, Hammam-Lif 2050, Tunisia"},{"name":"Faculty of Sciences of Gafsa, University of Gafsa, Gafsa 2100, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3247-0587","authenticated-orcid":false,"given":"Omar","family":"Khoumeri","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo-Bob","family":"Muller","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0110-9588","authenticated-orcid":false,"given":"Naceur","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage, Hammam-Lif 2050, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-4170","authenticated-orcid":false,"given":"Thierry","family":"Terme","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9946-829X","authenticated-orcid":false,"given":"Patrice","family":"Vanelle","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3762\/bjoc.5.1","article-title":"Reduction of arenediazonium salts by tetrakis (dimethylamino) ethylene (TDAE): Efficient formation of products derived from aryl radicals","volume":"5","author":"Mahesh","year":"2009","journal-title":"Beilstein J. 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