{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T19:53:44Z","timestamp":1781726024831,"version":"3.54.5"},"reference-count":30,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>(1) Pome fruits (apples and pears) are among the most frequently consumed fruits in Europe and may contribute to dietary exposure to pesticide residues. Although residue levels generally comply with maximum residue limits (MRLs), even low concentrations may cumulatively contribute to chronic health risks under conditions of frequent and long-term consumption. This study aimed to quantitatively assess dietary exposure and the potential non-carcinogenic health risks associated with pesticide residues in apples and pears, using representative monitoring and consumption data. (2) The assessment was based on results of the Polish national official monitoring program for pesticide residues in food, specifically apples and pears sampled in 2022, as reported by the National Institute of Public Health (NIZP-PZH). These data were combined with age- and body weight-specific consumption scenarios derived from FAO\/WHO GEMS\/Food cluster diets and national Polish statistics. For the most frequently detected pesticides (captan, flonicamid, acetamiprid and fosetyl-Al in apples; captan and acetamiprid in pears), the mean and 95th percentile concentrations were used to estimate the estimated daily intake (EDI). Non-carcinogenic risk was characterized using the hazard quotient (HQ = EDI\/ADI) and the cumulative Hazard Index (HI). The hazard quotient (HQ) was calculated as the ratio of estimated daily intake to the acceptable daily intake (HQ = EDI\/ADI), while the Hazard Index (HI) was defined as the sum of individual HQ values for pesticides detected in a given commodity and exposure scenario (HI = \u03a3HQ). Calculations were performed separately for children and adults under several dietary scenarios (Polish general population, German child, German general population, GEMS\/Food G08). (3) For all pesticides and exposure scenarios, the HQ values were well below 1, indicating no exceedance of the acceptable daily intake (ADI). The highest chronic exposure was observed for apples in children (German child scenario), with the HQ values for captan, flonicamid and acetamiprid in the approximate range of 0.01\u20130.05, while the HI remained &lt; 0.1 even under high-consumption conditions. In adults (Polish and German general populations, GEMS\/Food G08), HQ values were approximately one order of magnitude lower than in children, and the cumulative HI values for both apples and pears were far below 1. The contribution of pears to total exposure was limited, reflecting lower consumption and fewer active substances detected. (4) This quantitative risk assessment, based on Polish monitoring data from 2022, indicates that under current residue levels and consumption patterns, chronic dietary exposure to pesticide residues from apples and pears does not pose a relevant non-carcinogenic health concern for either children or adults. Nevertheless, children consistently showed higher relative exposure than adults, underscoring the importance of age-stratified risk assessment and continued monitoring of residues in commonly consumed fruits. The findings support existing regulatory frameworks while justifying sustained, targeted surveillance of key active substances in pome fruits as part of public health prevention strategies.<\/jats:p>","DOI":"10.3390\/molecules31050767","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:51:29Z","timestamp":1772117489000},"page":"767","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pesticide Residues in Apples and Pears: A Deterministic Assessment of Chronic Exposure and Non-Carcinogenic Risk for European Consumers"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2606-1656","authenticated-orcid":false,"given":"Jaros\u0142aw","family":"Chmielewski","sequence":"first","affiliation":[{"name":"Department of Public Health, Academy of Medical Sciences of Applied and Holistic Sciences, 02-304 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-5888","authenticated-orcid":false,"given":"Barbara","family":"Gworek","sequence":"additional","affiliation":[{"name":"Department of Environmental Chemistry and Risk Assessment, Institute of Environmental Protection-National Research Institute, 02-170 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1489-2399","authenticated-orcid":false,"given":"Magdalena","family":"Florek-\u0141uszczki","sequence":"additional","affiliation":[{"name":"Department of Medical Anthropology, Institute of Rural Health, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3059-0393","authenticated-orcid":false,"given":"Jarogniew J.","family":"\u0141uszczki","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, Medical University, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"ref_1","first-page":"250","article-title":"Toxicity of agrochemicals: Impact on environment and human health","volume":"2","author":"Anjaria","year":"2024","journal-title":"J. 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