{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:22:30Z","timestamp":1773116550417,"version":"3.50.1"},"reference-count":185,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374073"],"award-info":[{"award-number":["82374073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2025ZYD0025"],"award-info":[{"award-number":["2025ZYD0025"]}]},{"name":"Sichuan Science and Technology Program","award":["2022YFS0607"],"award-info":[{"award-number":["2022YFS0607"]}]},{"name":"Luzhou Science and Technology Program","award":["2025JBH004"],"award-info":[{"award-number":["2025JBH004"]}]},{"name":"Luzhou Science and Technology Program","award":["2023SYF110"],"award-info":[{"award-number":["2023SYF110"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Thrombocytopenia is a common hematological disorder characterized by reduced platelet counts and an increased risk of bleeding, for which current pharmacological treatments are often limited by adverse effects, drug resistance, or high costs. Traditional Chinese medicinal herbs such as ginseng, notoginseng, peony root, and astragalus have long been used for blood-nourishing and qi-tonifying purposes and are frequently prescribed for conditions associated with blood deficiency and hematopoietic dysfunction. This review systematically summarizes glycoside compounds derived from these herbs, focusing on their structural characteristics and pharmacological activities relevant to thrombocytopenia. Accumulating evidence indicates that glycosylation enhances the solubility, bioavailability, and stability of aglycones, thereby influencing their biological effects. Preclinical studies suggest that glycoside compounds may improve the hematopoietic microenvironment through anti-inflammatory, antioxidant, and immunomodulatory actions, potentially reducing immune-mediated platelet destruction. In addition, they may promote thrombopoiesis by modulating hematopoietic signaling pathways, such as PI3K\/AKT, and by restoring immune balance, particularly via regulation of the Treg\/Th17 axis. Collectively, these multi-target effects on hematopoiesis and immune regulation highlight glycoside compounds as promising lead candidates for the development of novel therapeutic approaches to thrombocytopenia.<\/jats:p>","DOI":"10.3390\/molecules31050894","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:49:42Z","timestamp":1773071382000},"page":"894","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycoside Compounds from Blood-Nourishing Chinese Medicinal Herbs: Structural Characteristics, Pharmacological Mechanisms, and Therapeutic Potential for Thrombocytopenia"],"prefix":"10.3390","volume":"31","author":[{"given":"Jianqin","family":"Tang","sequence":"first","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Du","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6136-7469","authenticated-orcid":false,"given":"Jianming","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Du","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/bjh.14664","article-title":"The effect of rituximab on anti-platelet autoantibody levels in patients with immune thrombocytopenia","volume":"178","author":"Arnold","year":"2017","journal-title":"Br. J. Haematol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12185-015-1837-6","article-title":"Integrated analysis of long-term safety in patients with chronic immune thrombocytopaenia (ITP) treated with the thrombopoietin (TPO) receptor agonist romiplostim","volume":"102","author":"Cines","year":"2015","journal-title":"Int. J. Hematol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13054-016-1593-x","article-title":"Is platelet transfusion associated with hospital-acquired infections in critically ill patients?","volume":"21","author":"Aubron","year":"2017","journal-title":"Crit. Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.3324\/haematol.2021.279484","article-title":"Treatment of drug-induced immune thrombocytopenias","volume":"107","author":"Marini","year":"2022","journal-title":"Haematologica"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1200\/JCO.22.02699","article-title":"Eltrombopag for low-risk myelodysplastic syndromes with thrombocytopenia: Interim results of a phase II, randomized, placebo-controlled clinical trial (EQOL-MDS)","volume":"41","author":"Oliva","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1182\/bloodadvances.2019000812","article-title":"Updated international consensus report on the investigation and management of primary immune thrombocytopenia","volume":"3","author":"Provan","year":"2019","journal-title":"Blood Adv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1182\/blood-2011-12-309153","article-title":"How I treat immune thrombocytopenia: The choice between splenectomy or a medical therapy as a second-line treatment","volume":"120","author":"Ghanima","year":"2012","journal-title":"Blood"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.3324\/haematol.2025.287512","article-title":"Splenectomy: Still a life-saving treatment in immune thrombocytopenia","volume":"110","author":"Rodeghiero","year":"2025","journal-title":"Haematologica"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"113000","DOI":"10.1016\/j.jep.2020.113000","article-title":"Integration of organ metabolomics and proteomics in exploring the blood enriching mechanism of Danggui Buxue Decoction in hemorrhagic anemia rats","volume":"261","author":"Shi","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_10","first-page":"1574","article-title":"Study of blood nourishing effects of albiflorin and paeoniflorin on blood deficiency mouse model induced by irradiation of and effect on levels of IL-3, GM-CSF, IL-6 and TNF-\u03b1","volume":"11","author":"Wang","year":"2016","journal-title":"World Chin. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1142\/S0192415X25500612","article-title":"Chinese medicine in regulating immune balance for the treatment of autoimmune diseases","volume":"53","author":"Zhou","year":"2025","journal-title":"Am. J. Chin. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Wiggins, R.W., Woo, J., Cauba, J.N., and Mito, S. (2024). Evaluating the potential of herbal extracts as treatment in immune thrombocytopenia: A review of evidence and limitations. Appl. Biosci., 4.","DOI":"10.3390\/applbiosci4010001"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"109265","DOI":"10.1016\/j.biopha.2019.109265","article-title":"A natural small molecule induces megakaryocytic differentiation and suppresses leukemogenesis through activation of PKC\u03b4\/ERK1\/2 signaling pathway in erythroleukemia cells","volume":"118","author":"Yang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_14","first-page":"555","article-title":"Effects of anhydroicaritin microemulsion formulation on the immunologic bocytopenic purpura mice","volume":"26","author":"Wang","year":"2017","journal-title":"Chin. J. New Drugs"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"12035","DOI":"10.1002\/anie.201606121","article-title":"Targeted delivery and sustained antitumor activity of triptolide through glucose conjugation","volume":"55","author":"He","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_16","first-page":"484","article-title":"Research progress in glycoconjugate prodrugs for targeted cancer therapy","volume":"44","author":"Tan","year":"2020","journal-title":"Prog. Pharm. Sci."},{"key":"ref_17","first-page":"30","article-title":"Glycosylation modification of flavonoids","volume":"39","author":"Xu","year":"2022","journal-title":"Leather Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"105296","DOI":"10.1016\/j.tifs.2025.105296","article-title":"Advances in flavonoid glycosylation: Chemical and biological basis, mechanisms, physicochemical properties, and applications in the food industry","volume":"165","author":"Lai","year":"2025","journal-title":"Trends Food Sci. Technol."},{"key":"ref_19","first-page":"0371","article-title":"Effects of salidroside on hematopoietic recovery in cyclophosphamide-induced marrow injury mice","volume":"24","author":"Wu","year":"2013","journal-title":"Tradit. Chin. Drug Res. Clin. Pharmacol."},{"key":"ref_20","first-page":"1892","article-title":"Effects and mechanism of albiflorin on mouse model of blood deficiency syndrome induced by cyclophosphamide","volume":"31","author":"Zhu","year":"2016","journal-title":"China J. Tradit. Chin. Med. Pharm."},{"key":"ref_21","first-page":"16","article-title":"Syndrome of blood deficiency in Chinese medicine research","volume":"20","author":"Zhang","year":"2013","journal-title":"China Mod. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.12677\/md.2025.151017","article-title":"Advances in modern medical research on the hematopoietic effect of Qi and blood replenishing drugs","volume":"15","author":"Duan","year":"2025","journal-title":"Med. Diagn."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Yang, Y., Ren, J., Yan, G., Yang, L., Wu, X., Kong, L., Sun, H., Han, Y., and Zhang, X. (2024). Chinmedomics strategy for elucidating the effects and effective constituents of Danggui Buxue Decoction in treating blood deficiency syndrome. Front. Mol. Biosci., 11.","DOI":"10.3389\/fmolb.2024.1376345"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4633270","DOI":"10.1155\/2021\/4633270","article-title":"Ginsenoside Rg1 as a potential regulator of hematopoietic stem\/progenitor cells","volume":"2021","author":"He","year":"2021","journal-title":"Stem Cells Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jep.2014.05.008","article-title":"The haematopoietic effect of Panax japonicus on blood deficiency model mice","volume":"154","author":"Zhang","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3892\/etm.2024.12431","article-title":"Therapeutic effect of notoginseng saponins before and after fermentation on blood deficiency rats","volume":"27","author":"Su","year":"2024","journal-title":"Exp. Ther. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Zhang, Y., Gao, M., Cui, X., Yang, Y., van Duijn, B., Wang, M., Hu, Y., Wang, C., and Xiong, Y. (2020). Steamed panax notoginseng attenuates anemia in mice with blood deficiency syndrome via regulating hematopoietic factors and JAK-STAT pathway. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.01578"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jgr.2024.12.005","article-title":"A narrative review of panax notoginseng: Unique saponins and their pharmacological activities","volume":"49","author":"Li","year":"2025","journal-title":"J. Ginseng Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1142\/S0192415X18500155","article-title":"Phytotherapeutic activities of Sanguisorba officinalis and its chemical constituents: A review","volume":"46","author":"Jang","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhou, P., Li, J., Chen, Q., Wang, L., Yang, J., Wu, A., Jiang, N., Liu, Y., Chen, J., and Zou, W. (2021). A comprehensive review of genus sanguisorba: Traditional uses, chemical constituents and medical applications. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.750165"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"110505","DOI":"10.1016\/j.biopha.2020.110505","article-title":"A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects","volume":"130","author":"Zhou","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"112913","DOI":"10.1016\/j.jep.2020.112913","article-title":"Total glucosides of paeony: A review of its phytochemistry, role in autoimmune diseases, and mechanisms of action","volume":"258","author":"Jiang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"155483","DOI":"10.1016\/j.phymed.2024.155483","article-title":"Genus paeonia monoterpene glycosides: A systematic review on their pharmacological activities and molecular mechanisms","volume":"127","author":"Xu","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"114431","DOI":"10.1016\/j.jep.2021.114431","article-title":"Si-Wu-Tang facilitates ovarian function through improving ovarian microenvironment and angiogenesis in a mouse model of premature ovarian failure","volume":"280","author":"Zhou","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1182\/blood.V122.21.4216.4216","article-title":"Astragalus polysaccharide has hematopoietic and thrombopoietic activities in an irradiation mouse model","volume":"122","author":"Yang","year":"2013","journal-title":"Blood"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.ijbiomac.2021.05.120","article-title":"Radix astragali polysaccharide RAP directly protects hematopoietic stem cells from chemotherapy-induced myelosuppression by increasing FOS expression","volume":"183","author":"Bao","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"115809","DOI":"10.1016\/j.biopha.2023.115809","article-title":"Progress of research into the pharmacological effect and clinical application of the traditional Chinese medicine rehmanniae radix","volume":"168","author":"Jia","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"100548","DOI":"10.1016\/j.cjac.2025.100548","article-title":"Mechanisms of radix rehmanniae praeparata in treating blood deficiency: A study on chemistry, metabolomics, and gut microbiota","volume":"53","author":"Gao","year":"2025","journal-title":"Chin. J. Anal. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"116200","DOI":"10.1016\/j.jep.2023.116200","article-title":"A review of hemostatic chemical components and their mechanisms in traditional Chinese medicine and ethnic medicine","volume":"307","author":"Mu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_40","first-page":"92","article-title":"Research progress in processing and extraction technology of ginseng","volume":"4","author":"Feng","year":"2024","journal-title":"Liquor-Mak. Sci. Technol."},{"key":"ref_41","first-page":"415","article-title":"Research progress on extraction, structure, biological activity and application of panax notoginseng saponin","volume":"46","author":"Wei","year":"2024","journal-title":"Sci. Technol. Food Ind."},{"key":"ref_42","first-page":"985","article-title":"Research progress on the components and clinical pharmacological effects of panax notoginseng saponin","volume":"40","author":"Guo","year":"2024","journal-title":"J. Nanjing Univ. Tradit. Chin. Med."},{"key":"ref_43","first-page":"353","article-title":"Advances in study on icariin extraction, separation, and its anti-tumor mechanism","volume":"26","author":"Jiang","year":"2011","journal-title":"Drugs Clin."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Oprita, E.I., Iosageanu, A., and Craciunescu, O. (2022). Progress in composite hydrogels and scaffolds enriched with icariin for osteochondral defect healing. Gels, 8.","DOI":"10.3390\/gels8100648"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1142\/S0192415X25500089","article-title":"Advances in pharmacological research on icaritin: A comprehensive review","volume":"53","author":"Guo","year":"2025","journal-title":"Am. J. Chin. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"107452","DOI":"10.1016\/j.pharmthera.2019.107452","article-title":"Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony","volume":"207","author":"Zhang","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Li, X.Y., Sun, C.X., Zhang, J.Y., Hu, L.Q., Yu, Z.L., Zhang, X.N., Wang, Z.P., Chen, J.Y., Wu, M., and Liu, L.T. (2023). Protective effects of paeoniflorin on cardiovascular diseases: A pharmacological and mechanistic overview. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1122969"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"109268","DOI":"10.1016\/j.cbi.2020.109268","article-title":"Salidroside: A review of its recent advances in synthetic pathways and pharmacological properties","volume":"339","author":"Zhang","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.2147\/DDDT.S160776","article-title":"Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system","volume":"12","author":"Zhong","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8151","DOI":"10.18632\/aging.103131","article-title":"Salidroside inhibits platelet function and thrombus formation through AKT\/GSK3\u03b2 signaling pathway","volume":"12","author":"Wei","year":"2020","journal-title":"Aging"},{"key":"ref_51","first-page":"1445","article-title":"Research progress on the pharmacological action and mechanism of echinacoside","volume":"36","author":"Sun","year":"2024","journal-title":"Nat. Prod. Res. Dev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"106951","DOI":"10.1016\/j.phrs.2023.106951","article-title":"Echinacoside: A promising active natural products and pharmacological agents","volume":"197","author":"Wang","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Liang, Y.T., Chen, B.Q., Liang, D., Quan, X.X., Gu, R.L., Meng, Z.Y., Gan, H., Wu, Z.N., Sun, Y.B., and Liu, S.C. (2023). Pharmacological effects of astragaloside IV: A review. Molecules, 28.","DOI":"10.3390\/molecules28166118"},{"key":"ref_54","first-page":"758","article-title":"Preparation and antioxidant properties of astragaloside IV","volume":"22","author":"Shi","year":"2023","journal-title":"Chin. J. Public Health Eng."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"112895","DOI":"10.1016\/j.jep.2020.112895","article-title":"Astragali radix (Huangqi): A promising edible immunomodulatory herbal medicine","volume":"258","author":"Chen","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_56","first-page":"46","article-title":"Advances in pharmacology of rehmanniaglutinosa","volume":"11","author":"Chen","year":"2019","journal-title":"Chem. Eng."},{"key":"ref_57","first-page":"127","article-title":"Study on extraction process of rehmannioside D in radix rehmanniae and its Content Comparison in Different Processed Products","volume":"48","author":"Zhang","year":"2016","journal-title":"Shandong Agric. Sci."},{"key":"ref_58","first-page":"979","article-title":"Research progress on the main chemical constituents and pharmacological actions of rehmannia glutinosa","volume":"41","author":"Zhang","year":"2024","journal-title":"J. Xinxiang Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"114820","DOI":"10.1016\/j.jep.2021.114820","article-title":"A systematic review on botany, processing, application, phytochemistry and pharmacological action of radix rehmnniae","volume":"285","author":"Li","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_60","first-page":"1874","article-title":"Dietary flavonoid aglycones and their glycosides: Which show better biological significance?","volume":"57","author":"Xiao","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s11655-012-1306-4","article-title":"Panax notoginseng saponins induced up-regulation, phosphorylation and binding activity of MEK, ERK, AKT, PI-3K protein kinases and GATA transcription factors in hematopoietic cells","volume":"19","author":"Sun","year":"2013","journal-title":"Chin. J. Integr. Med."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Xie, L., Deng, Z., Zhang, J., Dong, H., Wang, W., Xing, B., and Liu, X. (2022). Comparison of flavonoid O-glycoside, C-glycoside and their aglycones on antioxidant capacity and metabolism during in vitro digestion and in vivo. Foods, 11.","DOI":"10.3390\/foods11060882"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"125868","DOI":"10.1016\/j.ijpharm.2025.125868","article-title":"Solid-state screening and dry powder inhaler development of ziyuglycoside II sodium salt for enhanced bioavailability","volume":"681","author":"Zhang","year":"2025","journal-title":"Int. J. Pharm."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"998","DOI":"10.2174\/0113862073299904240416114653","article-title":"Mogroside V promotes osteogenic differentiation of bone marrow mesenchymal stem cells from diabetic mice by altering microRNA profiles","volume":"28","author":"Luo","year":"2025","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e240020","DOI":"10.1530\/JME-24-0020","article-title":"Icariside II protects from marrow adipose tissue (MAT) expansion in estrogen-deficient mice by targeting S100A16","volume":"73","author":"Li","year":"2024","journal-title":"J. Mol. Endocrinol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s10020-021-00404-1","article-title":"DMAG, a novel countermeasure for the treatment of thrombocytopenia","volume":"27","author":"Lin","year":"2021","journal-title":"Mol. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"156597","DOI":"10.1016\/j.phymed.2025.156597","article-title":"Multimodal discovery of bavachinin A: A natural FLT3 agonist for treating thrombocytopenia","volume":"140","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3324\/haematol.2022.282209","article-title":"Targeting a thrombopoietin-independent strategy in the discovery of a novel inducer of megakaryocytopoiesis, DMAG, for the treatment of thrombocytopenia","volume":"108","author":"Wang","year":"2022","journal-title":"Haematologica"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Yang, J., Pan, C., Pan, Y., Hu, A., Zhao, P., Chen, M., Song, H., Li, Y., and Hao, X. (2024). A carbon 21 steroidal glycoside with pregnane skeleton from cynanchum atratum bunge promotes megakaryocytic and erythroid differentiation in erythroleukemia HEL cells through regulating platelet-derived growth factor receptor beta and JAK2\/STAT3 pathway. Pharmaceuticals, 17.","DOI":"10.3390\/ph17050628"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"10712","DOI":"10.1021\/acs.jafc.8b03266","article-title":"Cyanidin-3-O-\u03b2-glucoside, a natural polyphenol, exerts proapoptotic effects on activated platelets and enhances megakaryocytic proplatelet formation","volume":"66","author":"Ya","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Yang, F., Lai, J., Deng, J.Z., Du, J., Du, X., Zhang, X., Wang, Y., Huang, Q., Xu, Q., and Yang, G. (2023). The application of ethnomedicine in modulating megakaryocyte differentiation and platelet counts. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043168"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13045-023-01481-x","article-title":"Hyperhomocysteinemia potentiates megakaryocyte differentiation and thrombopoiesis via GH-PI3K-Akt axis","volume":"16","author":"Lei","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41392-021-00627-y","article-title":"M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity","volume":"6","author":"Zhao","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1248\/bpb.b18-00854","article-title":"Astragaloside IV regulates the PI3K\/Akt\/HO-1 signaling pathway and inhibits H9c2 cardiomyocyte injury induced by hypoxia\u2013reoxygenation","volume":"42","author":"Yang","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"113389","DOI":"10.1016\/j.jep.2020.113389","article-title":"Astragaloside IV, a saponin from astragalus membranaceus var. mongholicus, induces expressions of heme recycle proteins via signaling of Nrf2\/ARE in cultured macrophages","volume":"265","author":"Gong","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Nag, S.A., Qin, J.J., Wang, W., Wang, M.H., Wang, H., and Zhang, R. (2012). Ginsenosides as anticancer agents: In vitro and in vivo activities, structure-activity relationships, and molecular mechanisms of action. Front. Pharmacol., 3.","DOI":"10.3389\/fphar.2012.00025"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e2500612","DOI":"10.1002\/advs.202500612","article-title":"Efficient generation of megakaryocyte progenitors and platelets from HSPCs via JAK2\/STAT3 signaling","volume":"12","author":"Liu","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e574","DOI":"10.1097\/HS9.0000000000000574","article-title":"Immune thrombocytopenia: Recent advances in pathogenesis and treatments","volume":"5","author":"Audia","year":"2021","journal-title":"Hemasphere"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1142\/S0192415X20500275","article-title":"The role of Th17\/Treg axis in the traditional Chinese medicine intervention on immune-mediated inflammatory diseases: A systematic review","volume":"48","author":"Xu","year":"2020","journal-title":"Am. J. Chin. Med."},{"key":"ref_80","first-page":"985","article-title":"Exploration of biological essence of blood heat syndrome and mechanism of blood-cooling traditional Chinese medicine from combination of disease and syndrome","volume":"50","author":"Sun","year":"2025","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1002\/ptr.7875","article-title":"Astragaloside IV attenuates high glucose-induced NF-kappaB-mediated inflammation through activation of PI3K\/AKT-ERK-dependent Nrf2\/ARE signaling pathway in glomerular mesangial cells","volume":"37","author":"Su","year":"2023","journal-title":"Phytother. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"8265","DOI":"10.3892\/mmr.2017.7598","article-title":"Total glucosides of paeony ameliorates TNBS-induced colitis by modulating differentiation of Th17\/Treg cells and the secretion of cytokines","volume":"16","author":"Lin","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"114583","DOI":"10.1016\/j.phytochem.2025.114583","article-title":"Anti-inflammatory glycosides from gomphandra mollis merr.: Structural elucidation and mechanistic insights","volume":"239","author":"Chu","year":"2025","journal-title":"Phytochemistry"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1182\/blood-2018-99-115137","article-title":"18\u03b2-glycyrrhetic acid modulates Th1\/Th17\/Th22\/regulatory T cells homeostasis via HMGB1\/NF-\u03baB signaling pathway in immune thrombocytopenia","volume":"132","author":"Wang","year":"2018","journal-title":"Blood"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1016\/j.bmc.2017.07.042","article-title":"9,19-cycloartenol glycoside G3 from cimicifuga simplex regulates immune responses by modulating Th17\/Treg ratio","volume":"25","author":"Su","year":"2017","journal-title":"Bioorganic Med. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s10787-020-00722-6","article-title":"Paeoniflorin ameliorates ulcerative colitis by modulating the dendritic cell-mediated TH17\/Treg balance","volume":"28","author":"Zheng","year":"2020","journal-title":"Inflammopharmacology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e70048","DOI":"10.1002\/cti2.70048","article-title":"SIRT7 ameliorates Th17\/Treg imbalance by desuccinylation of STAT3 to improve immune thrombocytopenia","volume":"14","author":"Ge","year":"2025","journal-title":"Clin. Transl. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Park, J.I., Bae, H.R., Kim, C.G., Stonik, V.A., and Kwak, J.Y. (2014). Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers. Front. Chem., 2.","DOI":"10.3389\/fchem.2014.00077"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e202402306","DOI":"10.1002\/cbdv.202402306","article-title":"Gentiopicroside: An updated review of its pharmacological activities and mechanisms","volume":"22","author":"Ding","year":"2024","journal-title":"Chem. Biodivers."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"112045","DOI":"10.1016\/j.fct.2021.112045","article-title":"Lack of potential carcinogenicity for steviol glycosides\u2014Systematic evaluation and integration of mechanistic data into the totality of evidence","volume":"150","author":"Chappell","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jgr.2018.07.009","article-title":"Studies of the effects and mechanisms of ginsenoside Re and Rk3 on myelosuppression induced by cyclophosphamide","volume":"43","author":"Han","year":"2019","journal-title":"J. Ginseng Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.yrtph.2017.12.018","article-title":"Acute and sub-chronic toxicological studies of the iridoid glycosides extract of Lamiophlomis rotata (Benth.) Kudo in rats","volume":"92","author":"Zhang","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jpba.2018.08.018","article-title":"Identification of hepatotoxic and nephrotoxic potential markers of triptolide in mice with delayed-type hypersensitivity","volume":"160","author":"Wang","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_94","first-page":"3523","article-title":"Efficacy and safety of total glucosides of paeony in treating primary Sj\u00f6gren\u2019s syndrome: A propensity-matched study","volume":"28","author":"Cui","year":"2024","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Liu, Y., and Lu, K. (2025). Clinical efficacy and safety of Tripterygium wilfordii glycosides in the treatment of idiopathic membranous nephropathy: A systematic review and meta-analysis. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1652789"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Li, M., Li, Y., Xiang, L., and Li, L. (2022). Efficacy and safety of total glucosides of paeony as an add-on treatment in adolescents and adults with chronic urticaria: A systematic review and meta-analysis. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.961371"},{"key":"ref_97","first-page":"312","article-title":"A small-scale in vitro digestion model to examine the stability of flavonoid C-glycosides, O-glycosides, and their aglycons","volume":"89","author":"Heilmann","year":"2023","journal-title":"Planta Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2174\/1389200211209050577","article-title":"Absorption, disposition, and pharmacokinetics of saponins from Chinese medicinal herbs: What do we know and what do we need to know more?","volume":"13","author":"Ke","year":"2012","journal-title":"Curr. Drug Metab."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"111501","DOI":"10.1016\/j.biopha.2021.111501","article-title":"Ex vivo and in vivo chemoprotective activity and potential mechanism of martynoside against 5-fluorouracil-induced bone marrow cytotoxicity","volume":"138","author":"Hong","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Gao, X.Y., Liu, G.C., Zhang, J.X., Wang, L.H., Xu, C., Yan, Z.A., Wang, A., Su, Y.F., Lee, J.J., and Piao, G.C. (2022). Pharmacological properties of ginsenoside Re. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.754191"},{"key":"ref_101","first-page":"195","article-title":"Advances in research on anti-tumor immune regulation of icariin","volume":"47","author":"Jia","year":"2020","journal-title":"Liaoning J. Tradit. Chin. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.exphem.2014.12.008","article-title":"The effects of panaxadiol saponins on megakaryocytic maturation and immune function in a mouse model of immune thrombocytopenia","volume":"43","author":"Lin","year":"2015","journal-title":"Exp. Hematol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.3109\/13880209.2015.1133659","article-title":"Modulation of intracellular expression of IFN\u03b3 and IL-2 in culture of splenic T lymphocytes by some flavonoid glycosides of alchornea floribunda","volume":"54","author":"Okoye","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Guo, Z., Wang, L., Haq, S.U., Wang, L., Guo, W., Luo, Y., and Ijaz, N. (2023). In-vitro evaluation of immunomodulatory activity of sulphation-modified total ginsenosides derivative-3. Front. Vet. Sci., 10.","DOI":"10.3389\/fvets.2023.1068315"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.intimp.2012.11.014","article-title":"Evaluation of the new anti-inflammatory compound ethyl salicylate 2-O-\u03b2-D-glucoside and its possible mechanism of action","volume":"15","author":"Xin","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1002\/tox.24233","article-title":"Hibifolin protected pro-inflammatory response and oxidative stress in LPS-induced acute lung injury through antioxidative enzymes and the AMPK2\/Nrf-2 pathway","volume":"39","author":"Ni","year":"2024","journal-title":"Environ. Toxicol."},{"key":"ref_107","first-page":"964","article-title":"Hesperetin suppresses inflammatory responses in lipopolysaccharide-induced RAW 264.7 cells via the inhibition of NF-\u03baB and activation of Nrf2\/HO-1 pathways","volume":"39","author":"Ren","year":"2016","journal-title":"Inflammation"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1002\/ptr.6364","article-title":"Kaempferitrin inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes","volume":"33","author":"Wang","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1161\/CIRCRESAHA.124.323579","article-title":"What it takes to be a platelet: Evolving concepts in platelet production","volume":"135","author":"Carminita","year":"2024","journal-title":"Circ. Res."},{"key":"ref_110","first-page":"030503","article-title":"A modern overview of the process of platelet formation (thrombocytopoiesis) and its dependence on several factors","volume":"34","year":"2024","journal-title":"Biochem. Med."},{"key":"ref_111","first-page":"154","article-title":"Regulation mechanism of bone marrow niche on hematopoietic stem cell quiescence","volume":"37","author":"Li","year":"2015","journal-title":"Chin. J. Cell Biol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Gao, A., and Gong, Y.M. (2025). Revisiting hematopoietic hierarchy: Emerging insights into megakaryocyte-biased differentiation pathways of hematopoietic stem cells. Curr. Stem Cell Res. Ther., Online ahead of print.","DOI":"10.2174\/011574888X395136250908045533"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Manso, B.A., Rodriguez y Baena, A., and Forsberg, E.C. (2024). From hematopoietic stem cells to platelets: Unifying differentiation pathways identified by lineage tracing mouse models. Cells, 13.","DOI":"10.3390\/cells13080704"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13020-025-01092-3","article-title":"Astragaloside IV accelerates hematopoietic reconstruction by improving the AMPK\/PGC1\u03b1-mediated mitochondrial function in hematopoietic stem cells","volume":"20","author":"Zhang","year":"2025","journal-title":"Chin. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13020-022-00678-5","article-title":"Carbohydrates and ginsenosides in shenmai injection jointly improve hematopoietic function during chemotherapy-induced myelosuppression in mice","volume":"17","author":"Zhang","year":"2022","journal-title":"Chin. Med."},{"key":"ref_116","first-page":"120","article-title":"Proliferation and differentiation of human CD34+ hematopoietic stem\/progenitor cells induced by panax notoginosides","volume":"11","author":"Qian","year":"2003","journal-title":"J. Exp. Hematol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1745-7254.2007.00551.x","article-title":"Effects of notoginosides on proliferation and upregulation of GR nuclear transcription factor in hematopoietic cells","volume":"28","author":"Gao","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Li, J., Cai, D.C., Yao, X., Zhang, Y., Chen, L., Jing, P., Wang, L., and Wang, Y. (2016). Protective effect of ginsenoside Rg1 on hematopoietic stem\/progenitor cells through attenuating oxidative stress and the Wnt\/\u03b2-Catenin signaling pathway in a mouse model of d-Galactose-induced aging. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17060849"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"155810","DOI":"10.1016\/j.phymed.2024.155810","article-title":"Unraveling the pathogenesis of myelosuppression and therapeutic potential of natural products","volume":"132","author":"Nian","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"113581","DOI":"10.1016\/j.jep.2020.113581","article-title":"Ameliorative effects of ginsenosides on myelosuppression induced by chemotherapy or radiotherapy","volume":"268","author":"He","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/jrr\/rry093","article-title":"Effect of salidroside on bone marrow haematopoiesis in a mouse model of myelosuppressed anaemia","volume":"60","author":"Chen","year":"2019","journal-title":"J. Radiat. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12984","article-title":"The bone marrow niche for haematopoietic stem cells","volume":"505","author":"Morrison","year":"2014","journal-title":"Nature"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00418-024-02348-z","article-title":"Effect of bone marrow niche on hematopoietic stem cells","volume":"163","author":"Niazi","year":"2024","journal-title":"Histochem. Cell Biol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1186\/s12967-024-05900-6","article-title":"Cellular crosstalk in the bone marrow niche","volume":"22","author":"Huang","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1182\/blood.2021012827","article-title":"The bone marrow niche from the inside out: How megakaryocytes are shaped by and shape hematopoiesis","volume":"139","author":"Stone","year":"2022","journal-title":"Blood"},{"key":"ref_126","first-page":"e352","article-title":"Identification of the natural chalcone glycoside hydroxysafflor yellow A as a suppressor of P53 overactivation-associated hematopoietic defects","volume":"4","author":"Chen","year":"2023","journal-title":"Med. Commun."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jep.2009.08.043","article-title":"Total saponins of Panax ginseng (TSPG) promote erythroid differentiation of human CD34+ cells via EpoR-mediated JAK2\/STAT5 signaling pathway","volume":"126","author":"Chen","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"ref_128","first-page":"5250","article-title":"Target identification and mechanism research on inhibiting thrombocytopenia of icaritin","volume":"52","author":"Wang","year":"2021","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.diff.2015.07.001","article-title":"Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage","volume":"89","author":"Samet","year":"2015","journal-title":"Differentiation"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11655-015-1970-3","article-title":"Effects of panaxadiol saponins component as a new Chinese patent medicine on proliferation, differentiation and corresponding gene expression profile of megakaryocytes","volume":"22","author":"Wen","year":"2015","journal-title":"Chin. J. Integr. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.lfs.2015.01.002","article-title":"Echinacoside improves hematopoietic function in 5-FU-induced myelosuppression mice","volume":"123","author":"Wang","year":"2015","journal-title":"Life Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"5448","DOI":"10.3390\/molecules19045448","article-title":"Two ellagic acids isolated from roots of Sanguisorba officinalis L. promote hematopoietic progenitor cell proliferation and megakaryocyte differentiation","volume":"19","author":"Gao","year":"2014","journal-title":"Molecules"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4103\/ijh.ijh_9_25","article-title":"Immune thrombocytopenia: Modern management, knowledge gaps, and future perspectives","volume":"14","author":"Ghanima","year":"2025","journal-title":"Iraqi J. Hematol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"101222","DOI":"10.1016\/j.blre.2024.101222","article-title":"Immune thrombocytopenia: Pathophysiology and impacts of romiplostim treatment","volume":"67","author":"Semple","year":"2024","journal-title":"Blood Rev."},{"key":"ref_135","first-page":"1132","article-title":"Research progress of immunomodulatory mechanisms in immune thrombocytopenia","volume":"21","author":"Xu","year":"2024","journal-title":"Clin. Lab. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1177\/15353702211009787","article-title":"Regulation of Th1\/Th2 and Th17\/Treg by pDC\/mDC imbalance in primary immune thrombocytopenia","volume":"246","author":"Li","year":"2021","journal-title":"Exp. Biol. Med."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Gao, J., Gao, J.H., Zhang, Y.F., Gao, D., and Zhang, Y.P. (2026). The multifaceted regulatory effect of icariin on macrophages: A mini-review. Front. Immunol., 17.","DOI":"10.3389\/fimmu.2026.1765533"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"108861","DOI":"10.1016\/j.intimp.2022.108861","article-title":"Impact of icariin and its derivatives on inflammatory diseases and relevant signaling pathways","volume":"108","author":"Luo","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s10787-023-01388-6","article-title":"Icariin ameliorates the cuprizone-induced demyelination associated with antioxidation and anti-inflammation","volume":"32","author":"Song","year":"2024","journal-title":"Inflammopharmacology"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"38","DOI":"10.21037\/atm-21-4800","article-title":"Panaxdiol saponins component promotes hematopoiesis by regulating GATA transcription factors of intracellular signaling pathway in mouse bone marrow","volume":"10","author":"Dai","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_141","first-page":"2751","article-title":"Effects of Tripterygium wilfordii polyglycoside tablets on expression of CD4+\/CD8+ and CD4+ CD25+ Treg in elderly patients with relapsing refractory immune thrombocytopenic purpura","volume":"24","author":"Jiang","year":"2017","journal-title":"Chin. J. Prim. Med. Pharm."},{"key":"ref_142","first-page":"1400","article-title":"Therapeutic efficacy of multigly-cosidorum tripterygium combined with rhIL-11 for immune thrombocytopenia","volume":"23","author":"Yu","year":"2015","journal-title":"J. Exp. Hematol."},{"key":"ref_143","first-page":"482","article-title":"Efficacy of Tripterygium wilfordii polyglycosides combined with different doses of rituximab in refractory primary immune thrombocytopenia in adults","volume":"9","author":"Yang","year":"2016","journal-title":"Glob. Tradit. Chin. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"5789381","DOI":"10.1155\/2016\/5789381","article-title":"Hematopoietic effects of paeoniflorin and albiflorin on radiotherapy-induced myelosuppression mice","volume":"2016","author":"Zhu","year":"2016","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_145","first-page":"599","article-title":"Protective effects of paeoniflorin and albiflorin on chemotherapy-induced myelosuppression in mice","volume":"14","author":"Zhu","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jep.2018.10.025","article-title":"Comparisons of antithrombosis, hematopoietic effects and chemical profiles of dried and rice wine-processed rehmanniae radix extracts","volume":"231","author":"Gong","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"12742","DOI":"10.1038\/s41598-021-91471-1","article-title":"Ginsenoside Rg1 can restore hematopoietic function by inhibiting Bax translocation-mediated mitochondrial apoptosis in aplastic anemia","volume":"11","author":"Cao","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"591","DOI":"10.4252\/wjsc.v16.i5.591","article-title":"Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway","volume":"16","author":"Wang","year":"2024","journal-title":"World J. Stem Cells"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"900","DOI":"10.4252\/wjsc.v16.i11.900","article-title":"Potential of ginsenoside Rg1 to treat aplastic anemia via mitogen activated protein kinase pathway in cyclophosphamide-induced myelosuppression mouse model","volume":"16","author":"Park","year":"2024","journal-title":"World J. Stem Cells"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/pbc.25434","article-title":"Oxidant\/antioxidant status in children and adolescents with immune thrombocytopenia (ITP) and the role of an adjuvant antioxidant therapy","volume":"62","author":"Elalfy","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1053\/j.seminhematol.2013.06.011","article-title":"Oxidative stress and immune thrombocytopenia","volume":"50","author":"Zhang","year":"2013","journal-title":"Semin. Hematol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/med.21876","article-title":"Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets","volume":"42","author":"Zhong","year":"2022","journal-title":"Med. Res. Rev."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1055\/s-0043-1772683","article-title":"Variations of redox balance in different stages of childhood immune thrombocytopenic purpura","volume":"123","author":"Medovic","year":"2023","journal-title":"Thromb. Haemost."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/sji.12048","article-title":"Antioxidant status and oxidative stress in patients with chronic ITP","volume":"77","author":"Jin","year":"2013","journal-title":"Scand. J. Immunol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"103489","DOI":"10.1016\/j.redox.2025.103489","article-title":"Reactive oxygen species: Orchestrating the delicate dance of platelet life and death","volume":"80","author":"Liao","year":"2025","journal-title":"Redox Biol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.thromres.2020.12.008","article-title":"Reduced intracellular antioxidant capacity in platelets contributes to primary immune thrombocytopenia via ROS-NLRP3-caspase-1 pathway","volume":"199","author":"Wang","year":"2021","journal-title":"Thromb. Res."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Kui, L., Wang, G., Huang, J., Yang, X., Yu, J., Li, X., Peng, H., Leng, B., Jiao, Y., and Zhang, Z. (2025). Therapeutic efficacy and mechanisms of gentiopicroside in various diseases. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1634722"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13020-024-00921-1","article-title":"Total iridoid glycoside extract of Lamiophlomis rotata (Benth) Kudo accelerates diabetic wound healing by the NRF2\/COX2 axis","volume":"19","author":"Geng","year":"2024","journal-title":"Chin. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.taap.2014.03.011","article-title":"\u03b1-Dihydroxychalcone-glycoside (\u03b1-DHC) isolated from the heartwood of pterocarpus marsupium inhibits LPS induced MAPK activation and up regulates HO-1 expression in murine RAW 264.7 macrophage","volume":"277","author":"Chakraborty","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.fct.2016.09.010","article-title":"2,3,4\u2032,5-tetrahydroxystilbene-2-O-\u03b2-d-glucoside exerts anti-inflammatory effects on lipopolysaccharide-stimulated microglia by inhibiting NF-\u03baB and activating AMPK\/Nrf2 pathways","volume":"97","author":"Park","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1002\/mnfr.201300102","article-title":"Cyanidin-3-O-glucoside counters the response to TNF-alpha of endothelial cells by activating Nrf2 pathway","volume":"57","author":"Speciale","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1007\/s10787-025-01893-w","article-title":"Deciphering the iridoids\u2019 boundaries: From soil ecology to anti-inflammatory medicines","volume":"33","author":"Chaitanya","year":"2025","journal-title":"Inflammopharmacology"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Tang, L., Zhu, M., Che, X., Yang, X., Xu, Y., Ma, Q., Zhang, M., Ni, Z., Shao, X., and Mou, S. (2022). Astragaloside IV targets macrophages to alleviate renal ischemia-reperfusion injury via the crosstalk between Hif-1\u03b1 and NF-\u03baB (p65)\/Smad7 pathways. J. Pers. Med., 13.","DOI":"10.3390\/jpm13010059"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2147\/DDDT.S399423","article-title":"The molecular basis of the anti-inflammatory property of Astragaloside IV for the treatment of diabetes and its complications","volume":"17","author":"Li","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_165","first-page":"1470","article-title":"Exploration of active ingredients and mechanism of Lithospermum erythrorhizon in preventing and treating blood-heat syndrome","volume":"39","author":"Qiong","year":"2023","journal-title":"Chin. Pharmacol. Bull."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1055\/s-0040-1722621","article-title":"Protocatechuic acid protects platelets from apoptosis via inhibiting oxidative stress-mediated PI3K\/Akt\/GSK3\u03b2 signaling","volume":"121","author":"Ya","year":"2021","journal-title":"Thromb. Haemost."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s11655-017-2754-8","article-title":"Ginseng-derived panaxadiol saponins promote hematopoiesis recovery in cyclophosphamide-induced myelosuppressive mice: Potential novel treatment of chemotherapy-induced cytopenias","volume":"24","author":"Sun","year":"2017","journal-title":"Chin. J. Integr. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s11655-012-1292-4","article-title":"Research and development of the effective components of panaxdiol saponin as new chinese patent medicine for treating hemocytopenia","volume":"18","author":"Gao","year":"2012","journal-title":"Chin. J. Integr. Med."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/15384101.2018.1426413","article-title":"Icariin improves fanconi anemia hematopoietic stem cell function through SIRT6-mediated NF-kappa B inhibition","volume":"17","author":"Li","year":"2018","journal-title":"Cell Cycle"},{"key":"ref_170","first-page":"1437","article-title":"Effects of quercetin-3-O-\u03b2-D-glucuronide on platelet apoptosis and activation in mice with immune-mediated bone marrow failure via PI3K\/AKT pathway","volume":"31","author":"Xia","year":"2023","journal-title":"J. Exp. Hematol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"116533","DOI":"10.1016\/j.jep.2023.116533","article-title":"Systems pharmacology reveals the mechanism of Astragaloside IV in improving immune activity on cyclophosphamide-induced immunosuppressed mice","volume":"313","author":"Yao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"e14198","DOI":"10.1111\/eci.14198","article-title":"Echinacoside promotes osteogenesis and angiogenesis and inhibits osteoclast formation","volume":"54","author":"Yi","year":"2024","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Lin, S., Meng, Z., Wang, M., Ye, Z., Long, M., Zhang, Y., Liu, F., Chen, H., Li, M., and Qin, J. (2025). Icariin modulates osteogenic and adipogenic differentiation in ADSCs via the Hippo-YAP\/TAZ pathway: A novel therapeutic strategy for osteoporosis. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1510561"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"152888","DOI":"10.1016\/j.bbrc.2025.152888","article-title":"Icariin regulates the Hippo\/TAZ signaling pathway to promote osteogenic differentiation and bone remodeling in osteoporosis","volume":"792","author":"Zhao","year":"2025","journal-title":"Biophys. Res. Commun."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.bbrc.2018.11.201","article-title":"Icariin inhibits RANKL-induced osteoclastogenesis via modulation of the NF-\u03baB and MAPK signaling pathways","volume":"508","author":"Xu","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_176","first-page":"240","article-title":"Experimental study on rehmaionoside D in the action of nourishing yin, enriching the blood and reducing the blood sugar","volume":"28","author":"Zhen","year":"2001","journal-title":"Liaoning J. Tradit. Chin. Med."},{"key":"ref_177","first-page":"137","article-title":"The clinical study of patients with immune thrombocytopenia treated by Sheng-xue-ling capsule (Total Ginseng Saponins)","volume":"36","author":"Ma","year":"2012","journal-title":"J. Zhejiang Chin. Med. Univ."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11655-021-3283-z","article-title":"Treatment of chronic aplastic anemia with Chinese patent medicine Pai-Neng-Da capsule for replacing androgen partially: A clinical multi-center study","volume":"28","author":"Jiang","year":"2022","journal-title":"Chin. J. Integr. Med."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"95513","DOI":"10.12998\/wjcc.v13.i6.95513","article-title":"Efficacy and safety of Tripterygium wilfordii glycosides tablets combined with western medicine for patients with rheumatic immune diseases","volume":"13","author":"Shu","year":"2025","journal-title":"World J. Clin. Cases"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Mititelu, A., Onisai, M.C., Rosca, A., and Vladareanu, A.M. (2024). Current understanding of immune thrombocytopenia: A review of pathogenesis and treatment options. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25042163"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1182\/bloodadvances.2021006438","article-title":"Dissecting platelet proteomics to understand the pathophysiology of immune thrombocytopenia: Studies in mouse models","volume":"6","author":"Meinders","year":"2022","journal-title":"Blood Adv."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Ma, Y., Zhao, Y., Luo, M., Jiang, Q., Liu, S., Jia, Q., Bai, Z., Wu, F., and Xie, J. (2024). Advancements and challenges in pharmacokinetic and pharmacodynamic research on the traditional Chinese medicine saponins: A comprehensive review. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1393409"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"21561","DOI":"10.1021\/acsomega.0c02180","article-title":"Caco-2 cell permeability of flavonoids and saponins from Gynostemma pentaphyllum: The immortal Herb","volume":"5","author":"Ahmed","year":"2020","journal-title":"ACS Omega"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1021\/acs.jafc.2c06312","article-title":"Pharmacokinetics and oral bioavailability of panax notoginseng saponins administered to rats using a validated UPLC-MS\/MS method","volume":"71","author":"Fu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Wang, C., Dai, S., Gong, L., Fu, K., Ma, C., Liu, Y., Zhou, H., and Li, Y. (2021). A review of pharmacology, toxicity and pharmacokinetics of 2,3,5,4\u2032-tetrahydroxystilbene-2-O-beta-D-glucoside. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.791214"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/5\/894\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:51:24Z","timestamp":1773071484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/5\/894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,8]]},"references-count":185,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["molecules31050894"],"URL":"https:\/\/doi.org\/10.3390\/molecules31050894","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,8]]}}}