{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T08:43:33Z","timestamp":1773218613916,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A new spiral nematode species, Scutellonema curcumae sp. n., was identified from the rhizosphere of turmeric (Curcuma longa L.) in the Western Highlands of Vietnam. Integrative taxonomical analysis, combining detailed morphology and molecular characterization (ITS, 28S D2\u2013D3 rDNA, and COI mtDNA), confirmed its distinctiveness. Scutellonema curcumae sp. n. is characterized by a unique combination of a spiral body, a hemispherical lip region with four annuli, a robust stylet, and a rounded tail with a prominent scutellum, forming a highly divergent lineage within the genus. Beyond its description, this study reveals a significant inverse correlation between nematode population density and the phytochemical quality of the host. High infestation levels were associated with a marked decline in total curcuminoid content. Notably, lower nematode density favored a specific shift in the curcuminoid profile, with bisdemethoxycurcumin levels increasing by up to 250%. These phytochemical alterations directly influenced the therapeutic potential of the rhizomes: lower infestation levels resulted in significantly enhanced antioxidant capacity (lower SC50 values) and cytotoxic activity (lower IC50 against HepG2 and A549 cell lines). This work represents the first report of a Scutellonema species associated with turmeric in Vietnam and underscores its detrimental impact on the medicinal and nutraceutical value of the crop. Our findings suggest that effective nematode management is crucial not only for yield protection but as a strategic intervention in precision agriculture to optimize the secondary metabolite profiles of medicinal plants.<\/jats:p>","DOI":"10.3390\/molecules31060920","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:53:31Z","timestamp":1773140011000},"page":"920","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Scutellonema curcumae sp. n. (Nematoda: Hoplolaimidae) on the Phytochemical Profile and Biological Activities of Turmeric (Curcuma longa L.)"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0172-0061","authenticated-orcid":false,"given":"Tu Thi","family":"Dinh","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Sciences and Technology, 18 Hoang Quoc Viet, Nghia Do, Hanoi 100000, Vietnam"},{"name":"Institute of Chemistry, Vietnam Academy of Sciences and Technology, 18 Hoang Quoc Viet, Nghia Do, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6922-1627","authenticated-orcid":false,"given":"Quan Minh","family":"Pham","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Sciences and Technology, 18 Hoang Quoc Viet, Nghia Do, Hanoi 100000, Vietnam"},{"name":"Institute of Chemistry, Vietnam Academy of Sciences and Technology, 18 Hoang Quoc Viet, Nghia Do, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long Quoc","family":"Pham","sequence":"additional","affiliation":[{"name":"Laboratory of Biophysics, Institute for Advanced Study in Technology, Ton Duc Thang University, Ho Chi Minh 700000, Vietnam"},{"name":"Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh 700000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Kim","family":"Ngo","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Vietnam Academy of Sciences and Technology, 18 Hoang Quoc Viet, Nghia Do, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van Thi Thuy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Forensic Science, People\u2019s Police Academy, Co Nhue 2, Bac Tu Liem, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuong Thi Le","family":"Hoang","sequence":"additional","affiliation":[{"name":"Faculty of Education, Tan Trao University, Tuyen Quang 220000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu Ngoc","family":"Ly","sequence":"additional","affiliation":[{"name":"Graduate Center of Sciences and Technology, Hanoi Metropolitan University, 98 Duong Quang Ham, Nghia Do, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1060-6116","authenticated-orcid":false,"given":"Linh Ngoc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Medicine and Pharmacy, Thanh Do University, Lai Xa, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8451-0812","authenticated-orcid":false,"given":"Thao Thi Phuong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Biological and Food Technology, Hanoi Open University, B101 Nguyen Hien, Bach Mai, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6573-6428","authenticated-orcid":false,"given":"Lam Tien","family":"Do","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Sciences and Technology, 18 Hoang Quoc Viet, Nghia Do, Hanoi 100000, Vietnam"},{"name":"Institute of Chemistry, Vietnam Academy of Sciences and Technology, 18 Hoang Quoc Viet, Nghia Do, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sikora, R.A., Coyne, D., Hallman, J., and Timper, P. 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