{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:05:57Z","timestamp":1773745557345,"version":"3.50.1"},"reference-count":89,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Regional Development Funds","award":["GURDTI 2018-1828-0002370"],"award-info":[{"award-number":["GURDTI 2018-1828-0002370"]}]},{"name":"Institute of Ecology and Environment (INEE) of the French National Centre for Scientific Research"},{"name":"R\u00e9gion R\u00e9union","award":["DIRED\/20171403"],"award-info":[{"award-number":["DIRED\/20171403"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The genus Psiadia (Asteraceae), widely distributed in Madagascar and the Mascarene Islands (Mauritius, La R\u00e9union, Rodrigues), is traditionally used to treat bronchitis, asthma, colds, abdominal pain, and other inflammatory disorders. However, few studies have scientifically validated these traditional medicinal uses. To assess P. dentata as a valuable source of bioactive natural products, a combined 1H NMR-based metabolomic, molecular networking, and phytochemical study was conducted. Multivariate analysis (PLS-DA) of crude extracts from Psiadia species collected on Reunion Island enabled rapid discrimination of active extracts from P. dentata and revealed two methoxylated flavonoids and one coumarin as metabolites correlated with its antiplasmodial and anti-inflammatory activities. Additionally, UHPLC-DAD-ESI-QTOF-MS\/MS molecular networking approach enabled detailed chemical profiling of this species, allowing the annotation of 25 compounds (1\u201325) in this species. Subsequent phytochemical investigation of P. dentata leaves led to the isolation and identification of 25 metabolites, including nine new diterpenes (26\u201334), one new coumarin (35), and 15 known compounds (1\u20138, 11, 18, 19 and 36\u201339) from the diterpenoid, flavonoid, and coumarin families. The structures of the new compounds were elucidated using spectroscopic methods, including extensive 1D and 2D NMR and HRESIMS analyses. Biological evaluation of the isolated compounds showed that compounds 1, 7, 26 and 27 showed antiplasmodial activity against Plasmodium falciparum (3D7 strain, IC50 = 7.25\u201313.46 \u03bcM). Compounds 7, 26, 27, 31 and 32 inhibited nitric oxide production (IC50 = 0.87\u201327.71 \u03bcM), indicating potential anti-inflammatory effects. Only compound 1 displayed moderate cytotoxicity against HepG2 and HT29 cancer cell lines (IC50 = 25.67 and 18.35 \u03bcM, respectively).<\/jats:p>","DOI":"10.3390\/molecules31060973","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:06:22Z","timestamp":1773414382000},"page":"973","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolomics, Molecular Networking and Phytochemical Investigation of Psiadia dentata (Cass.) DC., Endemic to Reunion Island: Discovery of Novel Bioactive Molecules"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3044-0966","authenticated-orcid":false,"given":"Lantomalala Elsa","family":"Razafindrabenja","sequence":"first","affiliation":[{"name":"Laboratoire de Chimie et de Biotechnologie des Produits Naturels (ChemBioPro), Universit\u00e9 de La R\u00e9union, 15 Avenue Ren\u00e9 Cassin, CS 92 003, 97744 Saint-Denis Cedex 9, La R\u00e9union, France"},{"name":"SPO, University of Montpellier, INRAE, Institut Agro, 34060 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2753-7409","authenticated-orcid":false,"given":"Keshika","family":"Mahadeo","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie et de Biotechnologie des Produits Naturels (ChemBioPro), Universit\u00e9 de La R\u00e9union, 15 Avenue Ren\u00e9 Cassin, CS 92 003, 97744 Saint-Denis Cedex 9, La R\u00e9union, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3374-2508","authenticated-orcid":false,"given":"Ga\u00ebtan","family":"Herbette","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, CNRS, Centrale M\u00e9diterran\u00e9e, FSCM, Spectropole, Campus de St J\u00e9r\u00f4me-Service 511, 13397 Marseille, France"},{"name":"Universit\u00e9 Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198 Gif-sur-Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia","family":"Mamede","sequence":"additional","affiliation":[{"name":"Pharmacognosy Laboratory, Department of Pharmacy, Centre Interfacultaire de Recherche sur le M\u00e9dicament (CIRM), University of Li\u00e8ge, Campus du Sart-Tilman, Quartier H\u00f4pital, Avenue Hippocrate, 15, B36, 4000 Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0770-9990","authenticated-orcid":false,"given":"Michel","family":"Frederich","sequence":"additional","affiliation":[{"name":"Pharmacognosy Laboratory, Department of Pharmacy, Centre Interfacultaire de Recherche sur le M\u00e9dicament (CIRM), University of Li\u00e8ge, Campus du Sart-Tilman, Quartier H\u00f4pital, Avenue Hippocrate, 15, B36, 4000 Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4962-3191","authenticated-orcid":false,"given":"Carole","family":"Di Giorgio","sequence":"additional","affiliation":[{"name":"IMBE, Aix Marseille Universit\u00e9, Avignon Universit\u00e9, CNRS 7263, IRD 237, 27 Bd Jean Moulin, Service of Environmental Mutagenesis, Faculty of Pharmacy, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8930-338X","authenticated-orcid":false,"given":"B\u00e9atrice","family":"Baghdikian","sequence":"additional","affiliation":[{"name":"IMBE, Aix Marseille Universit\u00e9, Avignon Universit\u00e9, CNRS 7263, IRD 237, 27 Bd Jean Moulin, Service of Pharmacognosy, Faculty of Pharmacy, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Clerc","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie et de Biotechnologie des Produits Naturels (ChemBioPro), Universit\u00e9 de La R\u00e9union, 15 Avenue Ren\u00e9 Cassin, CS 92 003, 97744 Saint-Denis Cedex 9, La R\u00e9union, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7553-8030","authenticated-orcid":false,"given":"Hippolyte","family":"Kodja","sequence":"additional","affiliation":[{"name":"Qualisud, University Montpellier, CIRAD, Institut Agro, Avignon Universit\u00e9, Universit\u00e9 de La R\u00e9union, 34093 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Grondin","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie et de Biotechnologie des Produits Naturels (ChemBioPro), Universit\u00e9 de La R\u00e9union, 15 Avenue Ren\u00e9 Cassin, CS 92 003, 97744 Saint-Denis Cedex 9, La R\u00e9union, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-0704","authenticated-orcid":false,"given":"Anne","family":"Gauvin-Bialecki","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie et de Biotechnologie des Produits Naturels (ChemBioPro), Universit\u00e9 de La R\u00e9union, 15 Avenue Ren\u00e9 Cassin, CS 92 003, 97744 Saint-Denis Cedex 9, La R\u00e9union, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1039\/D1QO01341F","article-title":"A brief overview of classical natural product drug synthesis and bioactivity","volume":"9","author":"Li","year":"2022","journal-title":"Org. 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