{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:13:05Z","timestamp":1790698385815,"version":"4.1.0"},"reference-count":157,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Polyphenols, abundant compounds found in natural sources, exhibit various biological activities, including immunomodulatory properties that can either stimulate or suppress immune responses, making them promising for therapeutic applications. However, their poor solubility, low bioavailability, rapid metabolism, and non-specific distribution require advanced drug delivery strategies to overcome limitations in clinical translations. Therefore, nano-drug delivery systems have been intensively studied to explore the full therapeutic potential of polyphenols. Distinct from conventional paradigms where polyphenols serve solely as active compounds, this review advances the concept of polyphenol-based nanomedicine as dual-functional platforms: bioactive structural components and intrinsic immune modulators. Recent strategies to improve the loading efficacy of polyphenols, enhance their cellular uptake, prolong circulation, and enhance specific delivery based on those nanocarriers are emphasized. In addition, polyphenol-based nanoparticles, in which polyphenols serve as structural components, were also studied as self-therapeutics or multifunctional nanocarriers for drug delivery. We intensively focus on their immunomodulatory applications and highlight their potential in preclinical as well as clinical settings for the treatment of various diseases and therapeutic purposes, including autoimmune diseases, cancer immunotherapy, vaccination, inflammation, and infectious diseases. Although polyphenol nanoparticle development has made significant advances, there remain challenges in formulation stability, unclear in vivo toxicity profiles, and clinical translation. Further studies on optimizing nanoparticle design and assessing long-term toxicity are necessary to materialize their application. A combination of polyphenol nanoparticles with other immunotherapies may promise a pronounced efficacy and safety profile.<\/jats:p>","DOI":"10.3390\/molecules31061051","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:47:42Z","timestamp":1774255662000},"page":"1051","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Polyphenol-Based Nanomedicine: Versatile Platforms for Immune Modulation and Therapeutic Delivery"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0062-2243","authenticated-orcid":false,"given":"Quoc-Viet","family":"Le","sequence":"first","affiliation":[{"name":"Research Group in Pharmaceutical and Biomedical Sciences, Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City 72912, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0911-9946","authenticated-orcid":false,"given":"Trinh K. T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 70000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc-Nhi","family":"Phuong","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City 72912, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai-Phuc Phan","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City 72912, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-1804","authenticated-orcid":false,"given":"Van-An","family":"Duong","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-4944","authenticated-orcid":false,"given":"Hien V.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Van Lang University, Ho Chi Minh City 70000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuoc-Quyen","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Ajou University, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy Truong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Research Group in Pharmaceutical and Biomedical Sciences, Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City 72912, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4571-7246","authenticated-orcid":false,"given":"Minh-Quan","family":"Le","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 70000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Liu, Y., Wang, J., Sun, Z., Liu, Y., Wang, J., and Sun, Z. (2024). Aromatic Biobased Polymeric Materials Using Plant Polyphenols as Sustainable Alternative Raw Materials: A Review. Polymers, 16.","DOI":"10.3390\/polym16192752"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e08924","DOI":"10.1002\/advs.202508924","article-title":"Polyphenol-Based Functional Materials: Structural Insights, Composite Strategies, and Biomedical Applications","volume":"12","author":"Xue","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"30671","DOI":"10.34172\/bi.30671","article-title":"Overview of Dendritic Cells Subsets and Their Involvement in Immune-Related Pathological Disease","volume":"15","author":"Abbaszadeh","year":"2025","journal-title":"Bioimpacts"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"150907","DOI":"10.1016\/j.bbrc.2024.150907","article-title":"Epigallocatechin-3-Gallate Induces Immunogenic Cell Death and Enhances Cancer Immunotherapy in Colorectal Cancer","volume":"736","author":"Lei","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Pagano, M.T., Fecchi, K., Pierdominici, M., Ortona, E., Peruzzu, D., Pagano, M.T., Fecchi, K., Pierdominici, M., Ortona, E., and Peruzzu, D. (2022). Human Monocyte-Derived Dendritic Cells Are the Pharmacological Target of the Immunosuppressant Flavonoid Silibinin. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810417"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.2174\/0929867327666200515101228","article-title":"Curcumin: A Dietary Phytochemical for Targeting the Phenotype and Function of Dendritic Cells","volume":"28","author":"Rahimi","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"152131","DOI":"10.1016\/j.cej.2024.152131","article-title":"Programming of Macrophage Polarization in Different Stages for Accelerating Wound Healing","volume":"491","author":"Zhu","year":"2024","journal-title":"Chem. Eng. J."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Kim, Y., Cho, A.Y., Kim, H.C., Ryu, D., Jo, S.A., Jung, Y.-S., Kim, Y., Cho, A.Y., Kim, H.C., and Ryu, D. (2022). Effects of Natural Polyphenols on Oxidative Stress-Mediated Blood-Brain Barrier Dysfunction. Antioxidants, 11.","DOI":"10.3390\/antiox11020197"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Chen, S., Liang, H., Ji, Y., Kou, H., Zhang, C., Shang, G., Shang, C., Song, Z., Yang, L., and Liu, L. (2021). Curcumin Modulates the Crosstalk Between Macrophages and Bone Mesenchymal Stem Cells to Ameliorate Osteogenesis. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.634650"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Gao, Y.Y., Zhuang, Z., Lu, Y., Tao, T., Zhou, Y., Liu, G.J., Wang, H., Zhang, D.D., Wu, L.Y., and Dai, H.B. (2019). Curcumin Mitigates Neuro-Inflammation by Modulating Microglia Polarization Through Inhibiting TLR4 Axis Signaling Pathway Following Experimental Subarachnoid Hemorrhage. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.01223"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"106237","DOI":"10.1016\/j.archoralbio.2025.106237","article-title":"Gallic Acid Promotes M2 Macrophage Polarization through Mitochondrial Oxidative Phosphorylation in Periodontitis","volume":"174","author":"Zhang","year":"2025","journal-title":"Arch. Oral Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1080\/13880209.2022.2149821","article-title":"Resveratrol Accelerates Wound Healing by Inducing M2 Macrophage Polarisation in Diabetic Mice","volume":"60","author":"Ding","year":"2022","journal-title":"Pharm. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"151739","DOI":"10.1016\/j.acthis.2021.151739","article-title":"Resveratrol Activates PI3K\/AKT to Reduce Myocardial Cell Apoptosis and Mitochondrial Oxidative Damage Caused by Myocardial Ischemia\/Reperfusion Injury","volume":"123","author":"Yu","year":"2021","journal-title":"Acta Histochem."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Li, W., Qi, Y., Li, Y., Liu, L., Dong, X., and Li, B. (2025). Resveratrol Suppresses OSCC Invasion and Migration by Regulating Macrophage Polarization via Syk Signaling Pathway. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1660851"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Or\u0161oli\u0107, N., Kun\u0161ti\u0107, M., Jembrek, M.J., Or\u0161oli\u0107, N., Kun\u0161ti\u0107, M., and Jembrek, M.J. (2025). Antitumor and Antiangiogenic Effect of Tannic Acid in the Advanced Stage of Ehrlich Ascites Tumor in Mice. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26189070"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2035117","DOI":"10.1080\/21645515.2022.2035117","article-title":"Regulatory T Cells (Tregs) and Their Therapeutic Potential against Autoimmune Disorders\u2014Advances and Challenges","volume":"18","author":"Goswami","year":"2022","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.intimp.2009.01.025","article-title":"Amelioration of Experimental Autoimmune Encephalomyelitis by Curcumin Treatment through Inhibition of IL-17 Production","volume":"9","author":"Xie","year":"2009","journal-title":"Int. Immunopharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"109946","DOI":"10.1016\/j.biopha.2020.109946","article-title":"Curcumin Regulates the Differentiation of Na\u00efve CD4+T Cells and Activates IL-10 Immune Modulation against Acute Lung Injury in Mice","volume":"125","author":"Chai","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s10753-020-01265-2","article-title":"Curcumin Promotes the Expression of IL-35 by Regulating Regulatory T Cell Differentiation and Restrains Uncontrolled Inflammation and Lung Injury in Mice","volume":"43","author":"Chen","year":"2020","journal-title":"Inflammation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"109617","DOI":"10.1016\/j.intimp.2022.109617","article-title":"Procyanidin B2 3,3\u2033-Di-O-Gallate Suppresses IFN-\u03b3 Production in Murine CD4+ T Cells through the Regulation of Glutamine Influx via Direct Interaction with ASCT2","volume":"115","author":"Endo","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"111346","DOI":"10.1016\/j.biopha.2021.111346","article-title":"The Suppression of IL-17 Production from T Cells by Gallate-Type Procyanidin Is Mediated by Selectively Inhibiting Cytokine Production from Dendritic Cells","volume":"137","author":"Endo","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1089\/jmf.2018.4259","article-title":"Quercetin, a Plant Polyphenol, Has Potential for the Prevention of Bone Destruction in Rheumatoid Arthritis","volume":"22","author":"Kim","year":"2019","journal-title":"J. Med. Food"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Roy, T., Banang-Mbeumi, S., Boateng, S.T., Ruiz, E.M., Chamcheu, R.C.N., Kang, L., King, J.A., Walker, A.L., Nagalo, B.M., and Kousoulas, K.G. (2023). Dual Targeting of MTOR\/IL-17A and Autophagy by Fisetin Alleviates Psoriasis-like Skin Inflammation. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1075804"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"03946320221086084","DOI":"10.1177\/03946320221086084","article-title":"Dose-Dependent Effects of Oleuropein Administration on Regulatory T-Cells in Patients with Rheumatoid Arthritis: An in Vitro Approach","volume":"36","author":"Yousefi","year":"2022","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1829346","DOI":"10.1080\/2162402X.2020.1829346","article-title":"Resveratrol Exerts Antitumor Effects by Downregulating CD8+CD122+ Tregs in Murine Hepatocellular Carcinoma","volume":"9","author":"Zhang","year":"2020","journal-title":"Oncoimmunology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"107895","DOI":"10.1016\/j.intimp.2021.107895","article-title":"Resveratrol for Targeting the Tumor Microenvironment and Its Interactions with Cancer Cells","volume":"98","author":"Mu","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Neamah, W.H., Rutkovsky, A., Abdullah, O., Wilson, K., Bloomquist, R., Nagarkatti, P., Nagarkatti, M., Neamah, W.H., Rutkovsky, A., and Abdullah, O. (2023). Resveratrol Attenuates 2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Mediated Induction of Myeloid-Derived Suppressor Cells (MDSC) and Their Functions. Nutrients, 15.","DOI":"10.3390\/nu15214667"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e40281","DOI":"10.1016\/j.heliyon.2024.e40281","article-title":"Differential Neutrophil Responses in Murine Following Intraperitoneal Injections of Escherichia Coli and Staphylococcus Aureus","volume":"10","author":"Zhu","year":"2024","journal-title":"Heliyon"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1182\/blood.2020005505","article-title":"Neutrophils Promote Clearance of Nuclear Debris Following Acid-Induced Lung Injury","volume":"137","author":"Oved","year":"2021","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s11010-020-03905-5","article-title":"Gallic Acid Ameliorates COPD-Associated Exacerbation in Mice","volume":"476","author":"Singla","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"114358","DOI":"10.1016\/j.biopha.2023.114358","article-title":"Resveratrol Improves Hepatic Ischemia-Reperfusion Injury by Inhibiting Neutrophils via the ERK Signaling Pathway","volume":"160","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.molimm.2017.06.025","article-title":"IL-18\/IL-15\/IL-12 Synergy Induces Elevated and Prolonged IFN-\u03b3 Production by Ex Vivo Expanded NK Cells Which Is Not Due to Enhanced STAT4 Activation","volume":"88","author":"Lusty","year":"2017","journal-title":"Mol. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Lee, Y.-J., Kim, J., Lee, Y.-J., and Kim, J. (2020). Resveratrol Activates Natural Killer Cells through Akt- and MTORC2-Mediated c-Myb Upregulation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249575"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"276","DOI":"10.4149\/av_2020_309","article-title":"Potential Therapeutic Effects of Resveratrol against SARS-CoV-2","volume":"64","author":"Ramdani","year":"2020","journal-title":"Acta Virol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Liu, Y.S., Song, J.W., Zhong, W.X., Yuan, M.H., Guo, Y.R., Peng, C., Guo, L., and Guo, Y.P. (2023). Dual Drug-Loaded Nanoliposomes Encapsulating Curcumin and 5-Fluorouracil with Advanced Medicinal Applications: Self-Monitoring and Antitumor Therapy. Molecules, 28.","DOI":"10.3390\/molecules28114353"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1186\/s12951-021-01175-x","article-title":"Remodeling Immune Microenvironment in Periodontitis Using Resveratrol Liposomes as an Antibiotic-Free Therapeutic Strategy","volume":"19","author":"Shi","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s13346-024-01565-2","article-title":"High Mobility Group Box 1 Cytokine Targeted Topical Delivery of Resveratrol Embedded Nanoemulgel for the Management of Atopic Dermatitis","volume":"15","author":"Nene","year":"2025","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"132835","DOI":"10.1016\/j.ijbiomac.2024.132835","article-title":"Hyaluronic Acid-Poly(Glyceryl)10-Stearate Nanoemulsion for Co-Delivery of Fish Oil and Resveratrol: Enhancing Bioaccessibility and Antioxidant Potency","volume":"273","author":"Ao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Wang, W., Zhou, M., Xu, Y., Peng, W., Zhang, S., Li, R., Zhang, H., Zhang, H., Cheng, S., and Wang, Y. (2021). Resveratrol-Loaded TPGS-Resveratrol-Solid Lipid Nanoparticles for Multidrug-Resistant Therapy of Breast Cancer: In Vivo and In Vitro Study. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.762489"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"De Gaetano, F., Cristiano, M.C., Venuti, V., Crupi, V., Majolino, D., Paladini, G., Acri, G., Testagrossa, B., Irrera, A., and Paolino, D. (2021). Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation. Molecules, 26.","DOI":"10.3390\/molecules26041039"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13000-024-01468-3","article-title":"Evaluating the Effects of Curcumin Nano-Chitosan on MiR-221 and MiR-222 Expression and Wnt\/\u03b2-Catenin Pathways in MCF-7, MDA-MB-231 and SKBR3 Cell Lines","volume":"19","author":"Eslaminejad","year":"2024","journal-title":"Diagn. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Lin, Z., Zhan, L., Qin, K., Li, Y., Qin, Y., Yang, L., Sun, Q., Ji, N., Xie, F., and Lin, Z. (2024). Design and Characterization of a Novel Core\u2013Shell Nano Delivery System Based on Zein and Carboxymethylated Short-Chain Amylose for Encapsulation of Curcumin. Foods, 13.","DOI":"10.2139\/ssrn.4690736"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1080\/02652048.2023.2198026","article-title":"The Anti-Cancer Effect of Resveratrol Nano-Encapsulated Supplements against Breast Cancer via the Regulation of Oxidative Stress","volume":"40","author":"Sajadimajd","year":"2023","journal-title":"J. Microencapsul."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11033-023-09112-x","article-title":"The Urolithin B Nanomicellar Delivery System as an Efficient Selective Anticancer Compound","volume":"51","author":"Albuthyab","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.ijbiomac.2016.06.001","article-title":"Rutin-Encapsulated Chitosan Nanoparticles Targeted to the Brain in the Treatment of Cerebral Ischemia","volume":"91","author":"Ahmad","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"111538","DOI":"10.1016\/j.msec.2020.111538","article-title":"Zein- vs PLGA-Based Nanoparticles Containing Rutin: A Comparative Investigation","volume":"118","author":"Gagliardi","year":"2021","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"125247","DOI":"10.1016\/j.ijpharm.2025.125247","article-title":"Tannic Acid-Modified FK506-Loaded Nanoparticles Targeting Lymph Nodes for Acute Heart Transplant Rejection Treatment","volume":"671","author":"Qiu","year":"2025","journal-title":"Int. J. Pharm."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"849","DOI":"10.2217\/nnm-2017-0306","article-title":"Implication of Nano-Antioxidant Therapy for Treatment of Hepatocellular Carcinoma Using PLGA Nanoparticles of Rutin","volume":"13","author":"Pandey","year":"2018","journal-title":"Nanomed."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jare.2017.10.003","article-title":"Formulation and Evaluation of PH-Sensitive Rutin Nanospheres against Colon Carcinoma Using HCT-116 Cell Line","volume":"9","author":"Asfour","year":"2018","journal-title":"J. Adv. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"7777","DOI":"10.1021\/acsami.2c20334","article-title":"Zinc\u2013Epigallocatechin-3-Gallate Network-Coated Nanocomposites against the Pathogenesis of Amyloid-Beta","volume":"15","author":"Andrikopoulos","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8038","DOI":"10.1039\/D5TB00815H","article-title":"Immunomodulatory Green Nanomedicine Production, Tumor Cellular Targeting, in Vivo Biodistributions and Preclinical Therapeutic Efficacy Investigations of Resveratrol-Functionalized Gold and Theranostic 198gold Nanoparticles","volume":"13","author":"Sakr","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"126854","DOI":"10.1016\/j.ijbiomac.2023.126854","article-title":"PMN-Incorporated Multifunctional Chitosan Hydrogel for Postoperative Synergistic Photothermal Melanoma Therapy and Skin Regeneration","volume":"253","author":"Chang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s40824-023-00473-9","article-title":"Development of a Composite Hydrogel Incorporating Anti-Inflammatory and Osteoinductive Nanoparticles for Effective Bone Regeneration","volume":"27","author":"Byun","year":"2023","journal-title":"Biomater. Res."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Wu, H., Su, M., Jin, H., Li, X., Wang, P., Chen, J., and Chen, J. (2020). Rutin-Loaded Silver Nanoparticles with Antithrombotic Function. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.598977"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"127893","DOI":"10.1016\/j.ijbiomac.2023.127893","article-title":"Polyphenol Modified CuO Nanorods Capped by Kappa-Carrageenan for Controlled Paclitaxel Release in Furnishing Targeted Chemotherapy in Breast Carcinoma Cells","volume":"255","author":"Singh","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"125635","DOI":"10.1016\/j.jcrysgro.2020.125635","article-title":"A Facile Preparation of Rutin Nanoparticles and Its Effects on Controlled Growth and Morphology of Calcium Oxalate Crystals","volume":"540","author":"Saha","year":"2020","journal-title":"J. Cryst. Growth"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"130744","DOI":"10.1016\/j.ijbiomac.2024.130744","article-title":"3D-Printing of Alginate\/Gelatin Scaffold Loading Tannic Acid@ZIF-8 for Wound Healing: In Vitro and in Vivo Studies","volume":"265","author":"Maghsoudi","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"128950","DOI":"10.1016\/j.ijbiomac.2023.128950","article-title":"Fabrication of Resveratrol-Loaded Soy Protein Isolate-Glycyrrhizin Nanocomplex for Improving Bioavailability via PH-Responsive Hydrogel Properties","volume":"258","author":"Cui","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1021\/acsmaterialsau.3c00032","article-title":"Lipid-Based Nanoparticles for Drug\/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development","volume":"3","author":"Mehta","year":"2023","journal-title":"ACS Mater. Au"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"952","DOI":"10.3390\/encyclopedia2020063","article-title":"Solid Lipid Nanoparticles","volume":"2","author":"Nguyen","year":"2022","journal-title":"Encyclopedia"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s40265-021-01480-7","article-title":"BNT162b2 MRNA COVID-19 Vaccine: First Approval","volume":"81","author":"Lamb","year":"2021","journal-title":"Drugs"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Dhiman, N., Awasthi, R., Sharma, B., Kharkwal, H., and Kulkarni, G.T. (2021). Lipid Nanoparticles as Carriers for Bioactive Delivery. Front. Chem., 9.","DOI":"10.3389\/fchem.2021.580118"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s40199-023-00455-1","article-title":"Lipid Nanoparticles for Gene Therapy in Ocular Diseases","volume":"31","year":"2023","journal-title":"Daru"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"123105","DOI":"10.1016\/j.ijpharm.2023.123105","article-title":"Liposome Encapsulated Anticancer Drugs on Autophagy in Cancer Cells\u2014Current and Future Perspective","volume":"642","author":"Bhagya","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/08982104.2023.2226216","article-title":"Liposome Bilayer Stability: Emphasis on Cholesterol and Its Alternatives","volume":"34","author":"Nsairat","year":"2024","journal-title":"J. Liposome Res."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Duong, V.A., Nguyen, T.T.L., and Maeng, H.J. (2023). Recent Advances in Intranasal Liposomes for Drug, Gene, and Vaccine Delivery. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15010207"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jconrel.2022.09.035","article-title":"Nanoemulsion Applications in Photodynamic Therapy","volume":"351","author":"Moghassemi","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Nguyen, T.T.L., Duong, V.A., and Maeng, H.J. (2021). Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13071103"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jconrel.2017.03.008","article-title":"Nanoemulsion: Concepts, Development and Applications in Drug Delivery","volume":"252","author":"Singh","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1007\/s13346-021-01071-9","article-title":"Lipid-Based Emulsion Drug Delivery Systems\u2014A Comprehensive Review","volume":"12","author":"Dhaval","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Duong, V.-A., Nguyen, T.-T.-L., Maeng, H.-J., Duong, V.-A., Nguyen, T.-T.-L., and Maeng, H.-J. (2020). Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method. Molecules, 25.","DOI":"10.3390\/molecules25204781"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/17425247.2020.1727883","article-title":"SLN and NLC for Topical, Dermal, and Transdermal Drug Delivery","volume":"17","author":"Souto","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2174\/2211738511666221026163303","article-title":"Solid Lipid Nanoparticles (SLNs): Advancements in Modification Strategies Toward Drug Delivery Vehicle","volume":"11","author":"Verma","year":"2023","journal-title":"Pharm. Nanotechnol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s11095-019-2672-x","article-title":"Preparation of Ondansetron Hydrochloride-Loaded Nanostructured Lipid Carriers Using Solvent Injection Method for Enhancement of Pharmacokinetic Properties","volume":"36","author":"Duong","year":"2019","journal-title":"Pharm. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1080\/17425247.2024.2410951","article-title":"Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) for the Delivery of Bioactives Sourced from Plants: Part I\u2013Composition and Production Methods","volume":"21","author":"Fathi","year":"2024","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Avramovi\u0107, N., Mandi\u0107, B., Savi\u0107-Radojevi\u0107, A., Simi\u0107, T., Avramovi\u0107, N., Mandi\u0107, B., Savi\u0107-Radojevi\u0107, A., and Simi\u0107, T. (2020). Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12040298"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3390\/pharmaceutics3040793","article-title":"Encapsulation of Natural Polyphenolic Compounds; a Review","volume":"3","author":"Munin","year":"2011","journal-title":"Pharmaceutics"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Zhao, D., Yu, S., Sun, B., Gao, S., Guo, S., and Zhao, K. (2018). Biomedical Applications of Chitosan and Its Derivative Nanoparticles. Polymers, 10.","DOI":"10.3390\/polym10040462"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.molliq.2017.08.024","article-title":"Probing the Binding of Resveratrol, Genistein and Curcumin with Chitosan Nanoparticles","volume":"243","author":"Chanphai","year":"2017","journal-title":"J. Mol. Liq."},{"key":"ref_80","first-page":"765","article-title":"Recent Advances of Chitosan Nanoparticles as Drug Carriers","volume":"6","author":"Wang","year":"2011","journal-title":"Int. J. Nanomed."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.ijbiomac.2018.09.185","article-title":"Evaluation of the Mucoadhesive Properties of Chitosan Nanoparticles Prepared Using Different Chitosan to Tripolyphosphate (CS:TPP) Ratios","volume":"120","author":"Hejjaji","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"10274","DOI":"10.1038\/s41598-023-37152-7","article-title":"Synthesis, Characterization and Evaluation of Anti-Arthritic and Anti-Inflammatory Potential of Curcumin Loaded Chitosan Nanoparticles","volume":"13","author":"Asif","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"100116","DOI":"10.1016\/j.prmcm.2022.100116","article-title":"In Vitro Anticancer Activity of Curcumin Loaded Chitosan Nanoparticles (CLCNPs) against Vero Cells","volume":"3","author":"Deepika","year":"2022","journal-title":"Pharmacol. Res. Mod. Chin. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ijbiomac.2022.01.123","article-title":"Preparation, Characterization and Releasing Property of Antibacterial Nano-Capsules Composed of \u03b5-PL-EGCG and Sodium Alginate-Chitosan","volume":"204","author":"Li","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1021\/nn900451a","article-title":"Layer-by-Layer-Coated Gelatin Nanoparticles as a Vehicle for Delivery of Natural Polyphenols","volume":"3","author":"Shutava","year":"2009","journal-title":"ACS Nano"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"5581177","DOI":"10.1155\/2021\/5581177","article-title":"Preparation and Assessment of Some Characteristics of Nanoparticles Based on Sodium Alginate, Chitosan, and Camellia chrysantha Polyphenols","volume":"2021","author":"Luong","year":"2021","journal-title":"Int. J. Polym. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"114222","DOI":"10.1016\/j.foodres.2024.114222","article-title":"Polyphenol Nanoparticles Based on Bioresponse for the Delivery of Anthocyanins","volume":"184","author":"Zang","year":"2024","journal-title":"Food Res. Int."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Mostafa, M.M., Amin, M.M., Zakaria, M.Y., Hussein, M.A., Shamaa, M.M., and Abd El-Halim, S.M. (2023). Chitosan Surface-Modified PLGA Nanoparticles Loaded with Cranberry Powder Extract as a Potential Oral Delivery Platform for Targeting Colon Cancer Cells. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15020606"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.2174\/0929867325666171229141156","article-title":"Inorganic Nanoparticles for Cancer Therapy: A Transition from Lab to Clinic","volume":"25","author":"Bayda","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1039\/D3NA00043E","article-title":"Organic and Inorganic Nanomedicine for Combination Cancer Therapies","volume":"5","author":"Lee","year":"2023","journal-title":"Nanoscale Adv."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Wang, B., Xu, Y., Shao, D., Li, L., Ma, Y., Li, Y., Zhu, J., Shi, X., and Li, W. (2022). Inorganic Nanomaterials for Intelligent Photothermal Antibacterial Applications. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.1047598"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.2147\/IJN.S512509","article-title":"Adjuvanticity of Tannic Acid-Modified Nanoparticles Improves Effectiveness of the Antiviral Response","volume":"20","author":"Janicka","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"110782","DOI":"10.1016\/j.jinorgbio.2019.110782","article-title":"Formation of Gallic Acid Layer on \u03b3-AlOOH Nanoparticles Surface and Their Antioxidant and Membrane-Protective Activity","volume":"199","author":"Martakov","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"114366","DOI":"10.1016\/j.biopha.2023.114366","article-title":"Epigallocatechin-3-Gallate (EGCG) Based Metal-Polyphenol Nanoformulations Alleviates Chondrocytes Inflammation by Modulating Synovial Macrophages Polarization","volume":"161","author":"Wei","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"124088","DOI":"10.1016\/j.ijbiomac.2023.124088","article-title":"Polydopamine Nanoparticles Coated with a Metal-Polyphenol Network for Enhanced Photothermal\/Chemodynamic Cancer Combination Therapy","volume":"238","author":"Su","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/jphp.13322","article-title":"Synthesis, Characterization, Antidiabetic and Antioxidative Evaluation of a Novel Zn(II)-Gallic Acid Complex with Multi-Facet Activity","volume":"72","author":"Motloung","year":"2020","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"119196","DOI":"10.1016\/j.molliq.2022.119196","article-title":"Synthesis, Spectroscopic Characterizations, Conductometric Titration and Investigation of Potent Antioxidant Activities of Gallic Acid Complexes with Ca (II), Cu (II), Zn(III), Cr(III) and Se (IV) Metal Ions","volume":"358","author":"Hamza","year":"2022","journal-title":"J. Mol. Liq."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2302578","DOI":"10.1002\/smll.202302578","article-title":"Facile Synthesis of Self-Targeted Zn2+-Gallic Acid Nanoflowers for Specific Adhesion and Elimination of Gram-Positive Bacteria","volume":"19","author":"Huang","year":"2023","journal-title":"Small"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"15927","DOI":"10.1021\/acsami.1c24576","article-title":"Tannic Acid\u2013Iron Complex-Based Nanoparticles as a Novel Tool against Oxidative Stress","volume":"14","author":"Pucci","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"14316","DOI":"10.1021\/acsomega.3c10214","article-title":"Curcumin@Fe\/Tannic Acid Complex Nanoparticles for Inflammatory Bowel Disease Treatment","volume":"9","author":"Jin","year":"2024","journal-title":"ACS Omega"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2302551","DOI":"10.1002\/adma.202302551","article-title":"Inhalable Capsular Polysaccharide-Camouflaged Gallium-Polyphenol Nanoparticles Enhance Lung Cancer Chemotherapy by Depleting Local Lung Microbiota","volume":"35","author":"Han","year":"2023","journal-title":"Adv. Mater."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2307680","DOI":"10.1002\/adma.202307680","article-title":"Engineering Antimicrobial Metal\u2013Phenolic Network Nanoparticles with High Biocompatibility for Wound Healing","volume":"36","author":"Yu","year":"2024","journal-title":"Adv. Mater."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2303706","DOI":"10.1002\/advs.202303706","article-title":"Transcutaneous Immunotherapy for RNAi: A Cascade-Responsive Decomposable Nanocomplex Based on Polyphenol-Mediated Framework Nucleic Acid in Psoriasis","volume":"10","author":"Zhang","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2208571","DOI":"10.1002\/adma.202208571","article-title":"Mitochondrial-Targeted Delivery of Polyphenol-Mediated Antioxidases Complexes against Pyroptosis and Inflammatory Diseases","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv. Mater."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"eadf3887","DOI":"10.1126\/sciadv.adf3887","article-title":"Oral Polyphenol-Armored Nanomedicine for Targeted Modulation of Gut Microbiota-Brain Interactions in Colitis","volume":"9","author":"He","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"122132","DOI":"10.1016\/j.biomaterials.2023.122132","article-title":"Repair of Degenerative Nucleus Pulposus by Polyphenol Nanosphere-Encapsulated Hydrogel Gene Delivery System","volume":"298","author":"Wang","year":"2023","journal-title":"Biomaterials"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"120846","DOI":"10.1016\/j.biomaterials.2021.120846","article-title":"Controllable Assembly\/Disassembly of Polyphenol-DNA Nanocomplex for Cascade-Responsive Drug Release in Cancer Cells","volume":"273","author":"Han","year":"2021","journal-title":"Biomaterials"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.actbio.2023.05.042","article-title":"A Smart Metal-Polyphenol-DNAzyme Nanoplatform for Gene-Chemodynamic Synergistic Tumor Therapy","volume":"167","author":"Xing","year":"2023","journal-title":"Acta Biomater."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.jcis.2023.03.204","article-title":"Bimetallic Infinite Coordination Nanopolymers via Phototherapy and STING Activation for Eliciting Robust Antitumor Immunity","volume":"642","author":"Sun","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.actbio.2023.11.006","article-title":"A Multivalent Polyphenol\u2013Metal-Nanoplatform for Cascade Amplified Chemo-Chemodynamic Therapy","volume":"173","author":"Li","year":"2024","journal-title":"Acta Biomater."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Qin, J., Guo, N., Yang, J., Chen, Y., Qin, J., Guo, N., Yang, J., and Chen, Y. (2023). Recent Advances of Metal\u2013Polyphenol Coordination Polymers for Biomedical Applications. Biosensors, 13.","DOI":"10.3390\/bios13080776"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1186\/s12951-024-02756-2","article-title":"Tea Polyphenol Nanoparticles Enable Targeted SiRNA Delivery and Multi-Bioactive Therapy for Abdominal Aortic Aneurysms","volume":"22","author":"Wu","year":"2024","journal-title":"J. Nanobiotechnology"},{"key":"ref_113","unstructured":"Tafti, D., Ehsan, M., and Xixis, K.L. (2024). Multiple Sclerosis, StatPearls."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1007\/s13311-023-01378-0","article-title":"Nanoparticles Enhance Solubility and Neuroprotective Effects of Resveratrol in Demyelinating Disease","volume":"20","author":"Shamsher","year":"2023","journal-title":"Neurotherapeutics"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2202670","DOI":"10.1002\/adma.202202670","article-title":"Tolerogenic Nanovaccine for Prevention and Treatment of Autoimmune Encephalomyelitis","volume":"35","author":"Park","year":"2023","journal-title":"Adv. Mater."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2305563","DOI":"10.1002\/adfm.202305563","article-title":"Tannic Acid-Based Nanomaterials for Tolerogenic Immunotherapy of Rheumatoid Arthritis","volume":"33","author":"Wu","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.7150\/thno.81650","article-title":"Fe(III)-Shikonin Supramolecular Nanomedicines as Immunogenic Cell Death Stimulants and Multifunctional Immunoadjuvants for Tumor Vaccination","volume":"13","author":"Feng","year":"2023","journal-title":"Theranostics"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2147\/IJN.S438359","article-title":"Enhancing Dendritic Cell Activation Through Manganese-Coated Nanovaccine Targeting the CGAS-STING Pathway","volume":"19","author":"Wang","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1039\/D4BM00490F","article-title":"Acidity-Responsive Polyphenol-Coordinated Nanovaccines for Improving Tumor Immunotherapy via Bidirectional Reshaping of the Immunosuppressive Microenvironment and Controllable Release of Antigens","volume":"12","author":"Qiu","year":"2024","journal-title":"Biomater. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"35080","DOI":"10.1021\/acsami.5c03008","article-title":"Precision Drug Delivery for Multifunctional Treatment of Abdominal Aortic Aneurysm Using Bioactive Tea Polyphenol Nanoparticles","volume":"17","author":"Xu","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Qiu, P., Ishimoto, T., Fu, L., Zhang, J., Zhang, Z., and Liu, Y. (2022). The Gut Microbiota in Inflammatory Bowel Disease. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.733992"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"12917","DOI":"10.1021\/acsnano.4c00830","article-title":"Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease","volume":"18","author":"Hu","year":"2024","journal-title":"ACS Nano"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.actbio.2023.08.020","article-title":"An Oral Polyphenol Host-Guest Nanoparticle for Targeted Therapy of Inflammatory Bowel Disease","volume":"169","author":"Zhang","year":"2023","journal-title":"Acta Biomater."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Yunus, M.H.M., Nordin, A., Kamal, H., Yunus, M.H.M., Nordin, A., and Kamal, H. (2020). Pathophysiological Perspective of Osteoarthritis. Medicina, 56.","DOI":"10.3390\/medicina56110614"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Zhang, S., Xu, J., Si, H., Wu, Y., Zhou, S., Shen, B., Zhang, S., Xu, J., Si, H., and Wu, Y. (2022). The Role Played by Ferroptosis in Osteoarthritis: Evidence Based on Iron Dyshomeostasis and Lipid Peroxidation. Antioxidants, 11.","DOI":"10.3390\/antiox11091668"},{"key":"ref_126","first-page":"164","article-title":"Supramolecular Self-Assembly of EGCG-Selenomethionine Nanodrug for Treating Osteoarthritis","volume":"32","author":"Yu","year":"2024","journal-title":"Bioact. Mater."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jdsr.2022.10.002","article-title":"Macrophages in Periodontitis: A Dynamic Shift between Tissue Destruction and Repair","volume":"58","author":"Yin","year":"2022","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"101907","DOI":"10.1016\/j.mtbio.2025.101907","article-title":"Multifunctional Injectable Hydrogel Incorporating EGCG-Cu Complexes for Synergistic Antibacterial, Immunomodulatory, and Osteogenic Therapy in Periodontitis","volume":"32","author":"Hu","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"100633","DOI":"10.1016\/j.mtadv.2025.100633","article-title":"Quaternized Chitosan Nanoparticles Encapsulating EGCG-Zn Complex: A Novel Approach to Accelerate Diabetic Wound Healing in Mice","volume":"28","author":"Han","year":"2025","journal-title":"Mater. Today Adv."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"123607","DOI":"10.1016\/j.ijpharm.2023.123607","article-title":"A Polyglutamic Acid\/Tannic Acid-Based Nano Drug Delivery System: Antibacterial, Immunoregulation and Sustained Therapeutic Strategies for Oral Ulcers","volume":"648","author":"He","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Ceccarelli, M.C., Lai, L., Carmignani, A., Battaglini, M., and Ciofani, G. (2025). Polydopamine Nanoparticles as Immunomodulators: Inhibition of M1 Microglial Polarization. Front. Bioeng. Biotechnol., 13.","DOI":"10.3389\/fbioe.2025.1672520"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"18562","DOI":"10.1021\/acsnano.3c06991","article-title":"Robust and Multifunctional Nanoparticles Assembled from Natural Polyphenols and Metformin for Efficient Spinal Cord Regeneration","volume":"17","author":"Yuan","year":"2023","journal-title":"ACS Nano"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1097\/MS9.0000000000003528","article-title":"From Flat Bones to Functional Healing: Redefining Rodent Calvarial Defect Models for Translational Bone Regeneration Research","volume":"87","author":"Banu","year":"2025","journal-title":"Ann. Med. Surg."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2308477","DOI":"10.1002\/adma.202308477","article-title":"A Cardiac-Targeted Nanozyme Interrupts the Inflammation-Free Radical Cycle in Myocardial Infarction","volume":"36","author":"Liu","year":"2024","journal-title":"Adv. Mater."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Wang, Y.-Q., Li, Q.-S., Zheng, X.-Q., Lu, J.-L., Liang, Y.-R., Wang, Y.-Q., Li, Q.-S., Zheng, X.-Q., Lu, J.-L., and Liang, Y.-R. (2021). Antiviral Effects of Green Tea EGCG and Its Potential Application against COVID-19. Molecules, 26.","DOI":"10.3390\/molecules26133962"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1039\/D3FO05131E","article-title":"Resveratrol Inhibits Respiratory Syncytial Virus Replication by Targeting Heparan Sulfate Proteoglycans","volume":"15","author":"Xiong","year":"2024","journal-title":"Food Funct."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"50442","DOI":"10.1021\/acsami.4c11525","article-title":"Sonication-Assisted Self-Assembled Resveratrol Nanoparticles with Enhanced Antiviral and Anti-Inflammatory Activity against Respiratory Syncytial Virus-Induced Pneumonia","volume":"16","author":"Chang","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Ebrahimi, S., Sadeghizadeh, M., Aghasadeghi, M.R., Ardestani, M.S., Amini, S.A., and Vahabpour, R. (2024). Inhibition of HIV-1 Infection with Curcumin Conjugated PEG-Citrate Dendrimer; a New Nano Formulation. BMC Complement. Med. Ther., 24.","DOI":"10.1186\/s12906-024-04634-8"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1021\/acsbiomaterials.4c00091","article-title":"A Supramolecular Assembly of EGCG for Long-Term Treatment of Allergic Rhinitis","volume":"10","author":"Zhang","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_140","unstructured":"(2026, March 06). Biological Effects of Quercetin in Chronic Obstructive Pulmonary Disease. ClinicalTrials.gov Identifier: NCT03989271, Available online: https:\/\/clinicaltrials.gov\/study\/NCT03989271."},{"key":"ref_141","unstructured":"(2026, March 06). Oxygen Atomizing Inhalation of EGCG in the Treatment of Interstitial Pneumonia in Cancer Patients. ClinicalTrials.gov Identifier: NCT05758571, Available online: https:\/\/clinicaltrials.gov\/study\/NCT05758571."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.2147\/DDDT.S327238","article-title":"Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review","volume":"15","author":"Alotaibi","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"110505","DOI":"10.1016\/j.colsurfb.2019.110505","article-title":"Effect of Tannic Acid on Blood Components and Functions","volume":"184","author":"Deng","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1039\/D2LC00799A","article-title":"Nanoparticle Protein Corona: From Structure and Function to Therapeutic Targeting","volume":"23","author":"Bashiri","year":"2023","journal-title":"Lab Chip"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1007\/s00289-019-02924-7","article-title":"Nanoparticle Opsonization: Forces Involved and Protection by Long Chain Polymers","volume":"77","author":"Wani","year":"2019","journal-title":"Polym. Bull."},{"key":"ref_146","first-page":"1032","article-title":"Cardiopulmonary and Hemodynamic Changes in Complement Activation-Related Pseudoallergy","volume":"5","author":"Urbanics","year":"2013","journal-title":"Health N. Hav."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"14482","DOI":"10.1039\/D2NR02995B","article-title":"Tailored Polyethylene Glycol Grafting on Porous Nanoparticles for Enhanced Targeting and Intracellular SiRNA Delivery","volume":"14","author":"Yoo","year":"2022","journal-title":"Nanoscale"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12951-025-03210-7","article-title":"Nanomedicine\u2019s Shining Armor: Understanding and Leveraging the Metal-Phenolic Networks","volume":"23","author":"Tang","year":"2025","journal-title":"J. Nanobiotechnology"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Zhou, X., Iqbal, A., Li, J., Liu, C., Murtaza, A., Xu, X., Pan, S., Hu, W., Zhou, X., and Iqbal, A. (2021). Changes in Browning Degree and Reducibility of Polyphenols during Autoxidation and Enzymatic Oxidation. Antioxidants, 10.","DOI":"10.3390\/antiox10111809"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"142208","DOI":"10.1016\/j.foodchem.2024.142208","article-title":"Polyphenol Autoxidation and Prooxidative Activity Induce Protein Oxidation and Protein-Polyphenol Adduct Formation in Model Systems","volume":"466","author":"Bayati","year":"2025","journal-title":"Food Chem."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1039\/D4TB00462K","article-title":"Dual Drug-Loaded Metal\u2013Phenolic Networks for Targeted Magnetic Resonance Imaging and Synergistic Chemo\u2013Chemodynamic Therapy of Breast Cancer","volume":"12","author":"Xia","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Kang, D.Y., Sp, N., Jo, E.S., Rugamba, A., Hong, D.Y., Lee, H.G., Yoo, J.-S., Liu, Q., Jang, K.-J., and Yang, Y.M. (2020). The Inhibitory Mechanisms of Tumor PD-L1 Expression by Natural Bioactive Gallic Acid in Non-Small-Cell Lung Cancer (NSCLC) Cells. Cancers, 12.","DOI":"10.3390\/cancers12030727"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Limsakul, P., Srifa, P., Huang, Z., Zhu, L., Wu, Y., and Charupanit, K. (2025). Immunomodulatory Effects of Curcumin on CAR T-Cell Therapy. Antioxidants, 14.","DOI":"10.3390\/antiox14040454"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"171784","DOI":"10.1016\/j.cej.2025.171784","article-title":"Therapeutic Cell Backpacks in Adoptive Cell Transfer Therapy: Strategies for Immunomodulation, Targeted Delivery, and Synergistic Therapy","volume":"527","author":"Yi","year":"2026","journal-title":"Chem. Eng. J."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s43556-023-00122-6","article-title":"Gallic Acid Enhances Anti-Lymphoma Function of Anti-CD19 CAR-T Cells in Vitro and in Vivo","volume":"4","author":"Luo","year":"2023","journal-title":"Mol. Biomed."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"e2106612118","DOI":"10.1073\/pnas.2106612118","article-title":"Engineering Genetic Devices for in Vivo Control of Therapeutic T Cell Activity Triggered by the Dietary Molecule Resveratrol","volume":"118","author":"Yang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"6092","DOI":"10.1021\/acs.nanolett.4c01235","article-title":"Polyphenolic Nanoparticle Platforms (PARCELs) for In Vitro and In Vivo MRNA Delivery","volume":"24","author":"Ma","year":"2024","journal-title":"Nano Lett."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/6\/1051\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:48:38Z","timestamp":1774255718000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/6\/1051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,22]]},"references-count":157,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["molecules31061051"],"URL":"https:\/\/doi.org\/10.3390\/molecules31061051","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,22]]}}}