{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:54:15Z","timestamp":1774360455789,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The development of sustainable and environmentally benign N-methylation methodologies is essential for enhancing sustainable synthetic practice in pharmaceutical manufacturing. In this study, we demonstrate that microwave heating (MWH) markedly enhanced the efficiency of cobalt-catalyzed N-methylation using methanol or methanol-d4 as green C1 sources. Compared with conventional heating (CH), MWH enabled highly efficient syntheses of key pharmaceutical intermediates\u2014including 6-dimethylamino-1-hexanol, imipramine hydrochloride, and butenafine hydrochloride\u2014under milder conditions and shorter reaction times and without generating hazardous halogen-containing waste. UV\u2013vis spectroscopic analysis revealed that MWH accelerated the transformation of Co(acac)2 into catalytically active Co species by approximately four-fold, providing a mechanistic basis for the enhanced reactivity. We hypothesized that this effect was caused by the selective microwave heating of the catalyst, which in turn promoted the rapid generation of catalytically active species. Notably, MWH also significantly improved the N-trideuteromethylation of amines using methanol-d4, achieving a 95% yield for imipramine-d3 hydrochloride versus 32% under CH. Molecular dynamics simulations indicated that methanol-d4 exhibited slower dipole relaxation and enhanced cluster fragmentation under microwave fields, improving catalyst\u2013substrate contact, while kinetic isotope effects stabilized reactive intermediates. These synergistic effects account for the pronounced microwave promotion observed in deuterated systems. Overall, the combination of MWH and cobalt catalysis offers an energy-efficient, waste-minimizing, and environmentally benign strategy for the scalable synthesis of both methylated and deuterated amines.<\/jats:p>","DOI":"10.3390\/molecules31071068","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:58:59Z","timestamp":1774357139000},"page":"1068","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Accelerated Cobalt-Catalyzed N-Methylation via Microwave-Induced Rapid Formation of Active Species Using Methanol and Methanol-d4"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0878-6038","authenticated-orcid":false,"given":"Miki","family":"Takizawa","sequence":"first","affiliation":[{"name":"Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku 102-8554, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yamane","sequence":"additional","affiliation":[{"name":"Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku 102-8554, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinobu","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Wisdom Pool Research Institute G.K., 32F Tokyo Midtown Yaesu Yaesu Central Tower, 2-1-1, Yaesu, Chuo-ku 104-0082, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Wisdom Pool Research Institute G.K., 32F Tokyo Midtown Yaesu Yaesu Central Tower, 2-1-1, Yaesu, Chuo-ku 104-0082, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6588-5821","authenticated-orcid":false,"given":"Satoshi","family":"Horikoshi","sequence":"additional","affiliation":[{"name":"Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku 102-8554, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"ref_1","unstructured":"The IQVIA Institute for Human Data Science (2025). 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