{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:47:40Z","timestamp":1790102860041,"version":"4.0.1"},"reference-count":225,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"crossref","award":["262102310511"],"award-info":[{"award-number":["262102310511"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Scientific Research Projects of Henan Provincial Higher Education Institutions","award":["26A360022"],"award-info":[{"award-number":["26A360022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Ulcerative colitis (UC) is a multifactorial disease characterized by chronic intestinal inflammation and disrupted oxidative balance, significantly impairing patients\u2019 quality of life. Tannins, a class of polyphenolic compounds widely distributed in plants, have demonstrated notable therapeutic potential against UC due to their inherent antioxidant and anti-inflammatory properties. This study employs a systematic literature review of databases, including PubMed and Web of Science, to investigate the molecular mechanisms by which tannins restore intestinal inflammatory and oxidative homeostasis. The findings indicate that tannins directly scavenge reactive oxygen species (ROS) via their polyphenolic structure, mitigate oxidative damage, upregulate antioxidant enzyme expression, suppress pro-inflammatory cytokine secretion, and preserve intestinal barrier integrity. Despite their significant therapeutic promise, challenges such as low bioavailability and structural complexity remain. Future research should prioritize bioavailability enhancement, clarification of structure-activity relationships, and translational studies to facilitate the clinical application of tannin-based therapies for UC.<\/jats:p>","DOI":"10.3390\/molecules31071116","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T09:57:24Z","timestamp":1774864644000},"page":"1116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tannins as Therapeutic Agents for Ulcerative Colitis: Mechanisms and Prospects in Regulating Gut Inflammatory-Oxidative Homeostasis"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9499-5242","authenticated-orcid":false,"given":"Yanling","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmacy, North Henan Medical University, Xinxiang 453003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Pharmacy, North Henan Medical University, Xinxiang 453003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqi","family":"Hao","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Henan Medical University, Xinxiang 453003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Henan Medical University, Xinxiang 453003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxi","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, North Henan Medical University, Xinxiang 453003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Ming","sequence":"additional","affiliation":[{"name":"College of Pharmacy, North Henan Medical University, Xinxiang 453003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Pharmacy, North Henan Medical University, Xinxiang 453003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, North Henan Medical University, Xinxiang 453003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5298-4505","authenticated-orcid":false,"given":"Huiqin","family":"Qian","sequence":"additional","affiliation":[{"name":"College of Pharmacy, North Henan Medical University, Xinxiang 453003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.gtc.2020.07.005","article-title":"Epidemiology and pathogenesis of ulcerative colitis","volume":"49","author":"Du","year":"2020","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Peng, S., Shen, L., Yu, X., Zhang, L., Xu, K., Xia, Y., Zha, L., Wu, J., and Luo, H. (2023). The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1200111"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/s41590-024-01860-7","article-title":"Stem-like t cells are associated with the pathogenesis of ulcerative colitis in humans","volume":"25","author":"Li","year":"2024","journal-title":"Nat. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/apt.14526","article-title":"Fibrosis in ulcerative colitis is directly linked to severity and chronicity of mucosal inflammation","volume":"47","author":"Gordon","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/den.14526","article-title":"Crystal-storing histiocytosis of the rectum possibly associated with chronic mucosal inflammation by ulcerative colitis","volume":"35","author":"Takedomi","year":"2023","journal-title":"Dig. Endosc."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Aniwan, S., Bruining, D.H., Park, S.H., Al-Bawardy, B., Kane, S.V., Coelho Prabhu, N., Kisiel, J.B., Raffals, L.E., Papadakis, K.A., and Pardi, D.S. (2019). The combination of patient-reported clinical symptoms and an endoscopic score correlates well with health-related quality of life in patients with ulcerative colitis. J. Clin. Med., 8.","DOI":"10.3390\/jcm8081171"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S262","DOI":"10.1111\/j.1440-1746.2008.05413.x","article-title":"Correlations among total colonoscopic findings, clinical symptoms, and laboratory markers in ulcerative colitis","volume":"23","author":"Osada","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_8","first-page":"757","article-title":"Analysis of animal models of ulcerative colitis based on characteristics of clinical symptoms of traditional Chinese and western medicine","volume":"46","author":"Wang","year":"2021","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000530139","article-title":"Medication formulation preference of mild and moderate ulcerative colitis patients: A European survey","volume":"8","author":"Hebuterne","year":"2023","journal-title":"Inflamm. Intest. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MEG.0b013e32830bfb88","article-title":"Ulcerative colitis: Current medical therapy and strategies for improving medication adherence","volume":"21","author":"Zhang","year":"2009","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/00054725-200011000-00003","article-title":"Glomerular and tubular renal functions after long-term medication of sulphasalazine, olsalazine, and mesalazine in patients with ulcerative colitis","volume":"6","author":"Birketvedt","year":"2000","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Szczurek, A. (2021). Perspectives on tannins. Biomolecules, 11.","DOI":"10.3390\/biom11030442"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Falc\u00e3o, L., and Ara\u00fajo, M.E.M. (2018). Vegetable tannins used in the manufacture of historic leathers. Molecules, 23.","DOI":"10.3390\/molecules23051081"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Bar-Ya\u2019Akov, I., Tian, L., Amir, R., and Holland, D. (2019). Primary metabolites, anthocyanins, and hydrolyzable tannins in the pomegranate fruit. Front. Plant Sci., 10.","DOI":"10.3389\/fpls.2019.00620"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1055\/s-2007-967167","article-title":"Antioxidant, antimalarial and antimicrobial activities of tannin-rich fractions, ellagitannins and phenolic acids from Punica granatum L.","volume":"73","author":"Reddy","year":"2007","journal-title":"Planta Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.foodchem.2014.03.027","article-title":"Evaluation of tannins interactions in grape (Vitis vinifera L.) Skins","volume":"159","author":"Rustioni","year":"2014","journal-title":"Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"125120","DOI":"10.1016\/j.ijbiomac.2023.125120","article-title":"Activity and potential mechanisms of action of persimmon tannins according to their structures: A review","volume":"242","author":"Wang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"11044","DOI":"10.1021\/acs.jafc.9b04508","article-title":"Understanding toward the biophysical interaction of polymeric proanthocyanidins (persimmon condensed tannins) with biomembranes: Relevance for biological effects","volume":"67","author":"Zhu","year":"2019","journal-title":"J. Agric. Food. Chem."},{"key":"ref_19","first-page":"232","article-title":"Tannin-classification, analysis and applications","volume":"13","author":"Ramakrishnan","year":"1994","journal-title":"Anc. Sci. Life"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.2174\/1389557522666211229112223","article-title":"Dietary intake of hydrolyzable tannins and condensed tannins to regulate lipid metabolism","volume":"22","author":"He","year":"2022","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.anaerobe.2015.05.010","article-title":"Hydrolyzable and condensed tannins resistance in clostridium perfringens","volume":"34","author":"Redondo","year":"2015","journal-title":"Anaerobe"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7286","DOI":"10.1038\/s41598-021-86608-1","article-title":"Persimmon-derived tannin ameliorates the pathogenesis of ulcerative colitis in a murine model through inhibition of the inflammatory response and alteration of microbiota","volume":"11","author":"Kitabatake","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_23","unstructured":"He, Y.L. (2023). Therapeutic Effect of Tannic Acid on Dss-Induced Ulcerative Colitis In Mice and Its Effect on Intestinal Flora. [Master\u2019s Thesis, Wuhan University of Science and Technology]."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.apjtm.2016.03.014","article-title":"Antioxidant potential, tannin and polyphenol contents of seed and pericarp of three coffea species","volume":"9","author":"Patay","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Qin, J., Yu, L., Peng, F., Ye, X., Li, G., Sun, C., Cheng, F., Peng, C., and Xie, X. (2023). Tannin extracted from Penthorum chinense pursh, a potential drug with antimicrobial and antibiofilm effects against methicillin-sensitive staphylococcus aureus and methicillin-resistant staphylococcus aureus. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1134207"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Maisetta, G., Batoni, G., Caboni, P., Esin, S., Rinaldi, A.C., and Zucca, P. (2019). Tannin profile, antioxidant properties, and antimicrobial activity of extracts from two mediterranean species of parasitic plant Cytinus. BMC Complement. Altern. Med., 19.","DOI":"10.1186\/s12906-019-2487-7"},{"key":"ref_27","first-page":"787","article-title":"Experimental study on tannic acid inhibiting proliferation, migration and invasion of bladder cancer cells","volume":"30","author":"Wang","year":"2024","journal-title":"Chin. J. Surg. Integr. Tradit. West. Med."},{"key":"ref_28","first-page":"1471","article-title":"Agrimoniin, an antitumor tannin of agrimonia pilosa ledeb., Induces interleukin-1","volume":"12","author":"Murayama","year":"1992","journal-title":"Anticancer Res."},{"key":"ref_29","first-page":"e6163","article-title":"Safety and efficacy of DSP\u00ae (Na2EDTA, tannin-rich extract of castanea sativa, thyme oil and origanum oil) for pigs for fattening","volume":"18","author":"Bampidis","year":"2020","journal-title":"EFSA J."},{"key":"ref_30","first-page":"337","article-title":"Therapeutic experiences with a synthetic tannin preparation","volume":"30","author":"Koch","year":"1961","journal-title":"Z. Haut Geschlechtskrankh."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/20.4.295","article-title":"A histochemical reaction from 1807: Iron tannin","volume":"20","author":"Lillie","year":"1972","journal-title":"J. Histochem. Cytochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e70813","DOI":"10.1002\/cam4.70813","article-title":"Uncovering the effects and molecular mechanisms of shaoyao decoction against colorectal cancer using network pharmacology analysis coupled with experimental validation and gut microbiota analysis","volume":"14","author":"Rong","year":"2025","journal-title":"Cancer Med."},{"key":"ref_33","first-page":"181","article-title":"Chinese herbal medicines for treating ulcerative colitis via regulating gut microbiota-intestinal immunity axis","volume":"15","author":"Yang","year":"2023","journal-title":"Chin. Herb. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: A narrative review","volume":"19","author":"Del","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Liu, R., Luo, Y., Ma, J., Zhang, Q., Sheng, Y., Li, J., Li, H., and Zhao, T. (2024). Traditional Chinese medicine for functional gastrointestinal disorders and inflammatory bowel disease: Narrative review of the evidence and potential mechanisms involving the brain-gut axis. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1444922"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.2147\/IJGM.S532534","article-title":"Mechanism of morbidity based on ulcerative colitis: A review of traditional Chinese medicine treatment of ulcerative colitis","volume":"18","author":"Huang","year":"2025","journal-title":"Int. J. Gen. Med."},{"key":"ref_37","first-page":"1","article-title":"Immune response and inflammatory pathway of ulcerative colitis","volume":"30","author":"Chatuphonprasert","year":"2018","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"112217","DOI":"10.1016\/j.intimp.2024.112217","article-title":"mTOR promotes an inflammatory response through the hif1 signaling pathway in ulcerative colitis","volume":"134","author":"Wang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jep.2017.01.042","article-title":"Anti-inflammatory effects of Brucea javanica oil emulsion by suppressing NF-\u03baB activation on dextran sulfate sodium-induced ulcerative colitis in mice","volume":"198","author":"Huang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.3748\/wjg.v16.i33.4145","article-title":"Effect of probiotics on pro-inflammatory cytokines and NF-\u03baB activation in ulcerative colitis","volume":"16","author":"Hegazy","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"119483","DOI":"10.1016\/j.jep.2025.119483","article-title":"Fuzi lizhong pill inhibited inflammatory response and promoted colon mucosal healing in dextran sulfate sodium-induced ulcerative colitis mice by down-regulating PI3K\/AKT\/NF-\u03baB signaling pathway","volume":"343","author":"Li","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1002\/ptr.7429","article-title":"Anti-inflammatory effect of rhein on ulcerative colitis via inhibiting PI3K\/Akt\/mTOR signaling pathway and regulating gut microbiota","volume":"36","author":"Dong","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"109551","DOI":"10.1016\/j.cbpc.2023.109551","article-title":"Tannin alleviates glyphosate exposure-induced apoptosis, necrosis and immune dysfunction in hepatic l8824 cell line by inhibiting ROS\/PTEN\/PI3K\/AKT pathway","volume":"266","author":"Zhang","year":"2023","journal-title":"Comp. Biochem. Physiol. C-Toxicol. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"9754","DOI":"10.1039\/D2FO01286C","article-title":"Intake of an enological oak tannin powder alters hepatic gene express patterns indicative of a reduction of inflammation in male mice fed an obesogenic diet","volume":"13","author":"Egea","year":"2022","journal-title":"Food Funct."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.cbi.2019.01.037","article-title":"Penta-o-galloyl-\u03b2-d-glucose, a hydrolysable tannin from radix paeoniae alba, inhibits adipogenesis and TNF-\u03b1-mediated inflammation in 3T3-L1 cells","volume":"302","author":"Peng","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1093\/jpp\/rgab178","article-title":"Modulation of NF-\u039aB and MAPK signalling pathways by hydrolysable tannin fraction from Terminalia chebula fruits contributes to its anti-inflammatory action in raw 264.7 cells","volume":"74","author":"Ekambaram","year":"2022","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1039\/C3FO60635J","article-title":"Persimmon tannin accounts for hypolipidemic effects of persimmon through activating of AMPK and suppressing NF-\u03baB activation and inflammatory responses in high-fat diet rats","volume":"5","author":"Zou","year":"2014","journal-title":"Food Funct."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"135874","DOI":"10.1016\/j.ijbiomac.2024.135874","article-title":"Condensed tannin improves growth and alleviates intestinal inflammation of juvenile largemouth bass (Micropterus salmoides) fed with high cottonseed protein concentrate diet","volume":"280","author":"Yang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Molino, S., De Lellis, L.F., Morone, M.V., Cordara, M., Larsen, D.S., Piccinocchi, R., Piccinocchi, G., Baldi, A., Di Minno, A., and El-Seedi, H.R. (2025). Improving irritable bowel syndrome (IBS) symptoms and quality of life with quebracho and chestnut tannin-based supplementation: A single-centre, randomised, double-blind, placebo-controlled clinical trial. Nutrients, 17.","DOI":"10.3390\/nu17030552"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.4049\/jimmunol.163.7.3963","article-title":"Inflammatory cytokines IL-1\u03b1, IL-1\u03b2, IL-6, and TNF-\u03b1 impart neuroprotection to an excitotoxin through distinct pathways","volume":"163","author":"Carlson","year":"1999","journal-title":"J. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S1063-4584(03)00156-0","article-title":"Influence of pro-inflammatory (IL-1\u03b1, IL-6, TNF-\u03b1, IFN-\u03b3) and anti-inflammatory (IL-4) cytokines on chondrocyte function","volume":"11","author":"Schuerwegh","year":"2003","journal-title":"Osteoarthr. Cartil."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1139\/cjpp-2011-0488","article-title":"Inflammatory cytokine TNF-\u03b1 inhibits Na+-glutamine cotransport in intestinal epithelial cells","volume":"91","author":"Talukder","year":"2013","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1097\/MIB.0000000000000192","article-title":"Opposite effects of interferon regulatory factor 1 and osteopontin on the apoptosis of epithelial cells induced by TNF-\u03b1 in inflammatory bowel disease","volume":"20","author":"Tang","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"113735","DOI":"10.1016\/j.jep.2020.113735","article-title":"Dilodendron bipinnatum radlk. Extract alleviates ulcerative colitis induced by TNBS in rats by reducing inflammatory cell infiltration, TNF-\u03b1 and IL-1\u03b2 concentrations, IL-17 and COX-2 expressions, supporting mucus production and promotes an antioxidant effect","volume":"269","author":"Oliveira","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"101397","DOI":"10.1016\/j.gendis.2024.101397","article-title":"Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3\/IL-1\u03b2 pro-inflammatory signaling","volume":"12","author":"He","year":"2025","journal-title":"Genes Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e35020","DOI":"10.1097\/MD.0000000000035020","article-title":"Pathological mechanism and targeted drugs of ulcerative colitis: A review","volume":"102","author":"Guo","year":"2023","journal-title":"Medicine"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Piazza, S., Fumagalli, M., Martinelli, G., Pozzoli, C., Maranta, N., Angarano, M., Sangiovanni, E., and Dell\u2019Agli, M. (2022). Hydrolyzable tannins in the management of Th1, Th2 and Th17 inflammatory-related diseases. Molecules, 27.","DOI":"10.3390\/molecules27217593"},{"key":"ref_58","unstructured":"Li, Z. (2023). Preparation of Anti-Inflammatory Nanodrugs for Suppressing Cytokine Storm. [Master\u2019s Thesis, University of Science and Technology of China]."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"105356","DOI":"10.1016\/j.jff.2022.105356","article-title":"Randomized placebo-controlled trial of oral tannin supplementation on COVID-19 symptoms, gut dysbiosis and cytokine response","volume":"99","author":"Molino","year":"2022","journal-title":"J. Funct. Foods"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00232-015-9858-x","article-title":"Biomolecular interactions of tannin isolated from oenothera gigas with liposomes","volume":"249","author":"Sekowski","year":"2016","journal-title":"J. Membr. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.bbamem.2019.03.017","article-title":"Action of tannin on cellular membranes: Novel insights from concerted studies on lipid bilayers and native cells","volume":"1861","author":"Borisova","year":"2019","journal-title":"Biochim. Biophys. Acta-Biomembr."},{"key":"ref_62","first-page":"384","article-title":"Preliminary study of stored red blood cell metabolites persistently affecting macrophage function","volume":"37","author":"Hou","year":"2024","journal-title":"J. Clin. Hematol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1136\/gut.43.6.856","article-title":"Role of NF-\u03baB in immune and inflammatory responses in the gut","volume":"43","author":"Neurath","year":"1998","journal-title":"Gut"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1159\/000354525","article-title":"IL-17a induces pro-inflammatory cytokines production in macrophages via mapkinases, NF-\u03baB and AP-1","volume":"32","author":"Chen","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.diabres.2010.06.016","article-title":"NF-\u03baB binding activity and pro-inflammatory cytokines expression correlate with body mass index but not glycosylated hemoglobin in Chinese population","volume":"90","author":"He","year":"2010","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jnutbio.2005.01.006","article-title":"In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice","volume":"16","author":"Seeram","year":"2005","journal-title":"J. Nutr. Biochem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"102411","DOI":"10.1016\/j.clinre.2024.102411","article-title":"Sinomenine hydrochloride improves DSS-induced colitis in mice through inhibition of the TLR2\/NF-\u03baB signaling pathway","volume":"48","author":"Zhang","year":"2024","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_68","first-page":"104","article-title":"Digestive stability of tannin-enriched fraction of rubus chingii hu fruits and its regulatory effect on the intestinal microflora","volume":"44","author":"Jia","year":"2023","journal-title":"Food Sci."},{"key":"ref_69","unstructured":"Guo, H. (2020). Biological Evaluations of Antioxidative, Anti-Glycation, and Antiinflammatory Effects of Pomegranate Extract in Keratinocytes, and the Study of Paget\u2019s Disease. [Ph.D. Thesis, China Pharmaceutical University]."},{"key":"ref_70","unstructured":"Zhao, R.Q. (2020). Study on the Effects of Pomegranate Peel Polyphenols on Colonic Tissue Damage and Gut Microbiota Dysbiosis Induced by a High-Fat Diet in Rats. [Master\u2019s Thesis, Shaanxi Normal University]."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"skac039","DOI":"10.1093\/jas\/skac039","article-title":"Grape seed tannin extract and polyunsaturated fatty acids affect in vitro ruminal fermentation and methane production","volume":"100","author":"Thanh","year":"2022","journal-title":"J. Anim. Sci."},{"key":"ref_72","first-page":"184","article-title":"Study on antioxidation of tannin from grape seeds","volume":"34","author":"Wang","year":"2009","journal-title":"Food Sci. Technol."},{"key":"ref_73","unstructured":"Qiu, J.Q. (2024). Research on the Antioxidant and Immune Effects of Grape Seed Condensed Tannins and Their Monomers In Vitro and Their Feeding Effects on Litopenaeus vannamei. [Master\u2019s Thesis, Huazhong Agricultural University]."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"10196","DOI":"10.1038\/s41598-025-94731-6","article-title":"Antilisterial activity of tannin rich preparations isolated from raspberry (Rubus idaeus L.) And strawberry (Fragaria \u00d7 ananassa Duch.) Fruit","volume":"15","author":"Sojka","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_75","unstructured":"Wang, Z.Q. (2015). Studies on Antitumor and Antioxidant Activities of Phenolic Constituents in Strawberry. [Master\u2019s Thesis, Jilin University]."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1248\/bpb.b13-00619","article-title":"Topical application of Rosa multiflora root extract improves atopic dermatitis-like skin lesions induced by mite antigen in NC\/Nga mice","volume":"37","author":"Park","year":"2014","journal-title":"Biol. Pharm. Bull."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1002\/ptr.3578","article-title":"Topical application of two condensed tannins from the root of Rosa multiflora thunberg for the treatment of atopic dermatitis (AD) in NC\/Nga mice","volume":"25","author":"Park","year":"2011","journal-title":"Phytother. Res."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Mannelli, F., Daghio, M., Alves, S.P., Bessa, R., Minieri, S., Giovannetti, L., Conte, G., Mele, M., Messini, A., and Rapaccini, S. (2019). Effects of chestnut tannin extract, vescalagin and gallic acid on the dimethyl acetals profile and microbial community composition in rumen liquor: An in vitro study. Microorganisms, 7.","DOI":"10.3390\/microorganisms7070202"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/1082013214525429","article-title":"Functional properties and in vitro antioxidant and antibacterial effectiveness of pigskin gelatin films incorporated with hydrolysable chestnut tannin","volume":"21","author":"Martucci","year":"2015","journal-title":"Food Sci. Technol. Int."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jenvrad.2016.05.034","article-title":"Extraction, purification and anti-radiation activity of persimmon tannin from Diospyros kaki L.f","volume":"162\u2013163","author":"Zhou","year":"2016","journal-title":"J. Environ. Radioact."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jphs.2025.02.001","article-title":"Intraoral treatment of persimmon tannin, a polyphenol extracted from persimmon, significantly ameliorates gingivitis, plaque and halitosis via directly influence the periodontal bacteria Porphyromonas gulae","volume":"157","author":"Toyooka","year":"2025","journal-title":"J. Pharmacol. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1039\/C7FO00995J","article-title":"Reshaped fecal gut microbiota composition by the intake of high molecular weight persimmon tannin in normal and high-cholesterol diet-fed rats","volume":"9","author":"Zhu","year":"2018","journal-title":"Food Funct."},{"key":"ref_83","first-page":"198","article-title":"Enzymatic degradation process of hawthorn tannin","volume":"37","author":"Li","year":"2019","journal-title":"Henan Sci."},{"key":"ref_84","first-page":"101","article-title":"Hawthorn polyphenols relieve benzo(a)pyrene-induced inflammatory injury in respiratory epithelial cells","volume":"44","author":"Yan","year":"2023","journal-title":"Food Sci."},{"key":"ref_85","unstructured":"Kong, Q. (2024). The Effects of Gallic Acid and Tannic Acid on the Growth, Immunity, Intestinal Tissue, and Microbiota of Micropterus salmoides. [Master\u2019s Thesis, Guizhou University]."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"245103","DOI":"10.1063\/1.3156020","article-title":"Rigidity, conformation, and solvation of native and oxidized tannin macromolecules in water-ethanol solution","volume":"130","author":"Zanchi","year":"2009","journal-title":"J. Chem. Phys."},{"key":"ref_87","unstructured":"Xu, Y.H. (2024). Preparation and Anti-Inflammatory Activity of Polyphenol Agent from Apple. [Master\u2019s Thesis, Shandong Agricultural University]."},{"key":"ref_88","unstructured":"Liu, F. (2021). Study of the Preventive Effects and the Mechanisms of Apple Polyphenol Extract on Acute Ulcerative Colitis. [Master\u2019s Thesis, Soochow University]."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Le Bourvellec, C., Bagano, V.B.P., Lepercq, P., Comtet-Marre, S., Auffret, P., Ruiz, P., Bott, R., Renard, C., Dufour, C., and Chatel, J.M. (2019). Procyanidin-cell wall interactions within apple matrices decrease the metabolization of procyanidins by the human gut microbiota and the anti-inflammatory effect of the resulting microbial metabolome in vitro. Nutrients, 11.","DOI":"10.3390\/nu11030664"},{"key":"ref_90","unstructured":"Luo, Q. (2017). Polyphenol Components and Functional Evaluation of Quercus variabilis Acorn Nutlet. [Master\u2019s Thesis, Northwest A&F University]."},{"key":"ref_91","unstructured":"Huang, B.J. (2022). Effect and Study on the Intervention Mechanismof Peanut Skin Procyanidins on Ulcerative Colitis. [Master\u2019s Thesis, Huazhong Agricultural University]."},{"key":"ref_92","unstructured":"Wang, N. (2022). Study on the Preparation of Peanut Skin Proanthocyanidins and Its Anti-Intestinal Inflammation Mechan. [Ph.D. Thesis, Henan Agricultural University]."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"127970","DOI":"10.1016\/j.foodchem.2020.127970","article-title":"Contents of tannins of cultivars of sorghum cultivated in brazil, as determined by four quantification methods","volume":"337","author":"Palacios","year":"2021","journal-title":"Food Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.3390\/cimb44090273","article-title":"Prophylactic effects of purple shoot green tea on cytokine immunomodulation through scavenging free radicals and no in LPS-stimulated macrophages","volume":"44","author":"Lin","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.archoralbio.2015.02.021","article-title":"Green tea polyphenol epigallocatechin-3-gallate and cranberry proanthocyanidins act in synergy with cathelicidin (LL-37) to reduce the LPS-induced inflammatory response in a three-dimensional co-culture model of gingival epithelial cells and fibroblasts","volume":"60","author":"Lombardo","year":"2015","journal-title":"Arch. Oral Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.fitote.2007.11.019","article-title":"Antibacterial activity of tannin constituents from Phaseolus vulgaris, Fagoypyrum esculentum, Corylus avellana and Juglans nigra","volume":"79","author":"Amarowicz","year":"2008","journal-title":"Fitoterapia"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jnutbio.2005.09.004","article-title":"The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma caco-2 cells by using the mitochondrial pathway","volume":"17","author":"Larrosa","year":"2006","journal-title":"J. Nutr. Biochem."},{"key":"ref_98","first-page":"1541","article-title":"Studies on hydrolysable tannin constituents in seed of Juglans regia(i)","volume":"32","author":"Jin","year":"2007","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_99","first-page":"174","article-title":"Optimization of extraction process of tannins from almond skin and its dpph radical scavenging activity","volume":"40","author":"Du","year":"2019","journal-title":"Sci. Technol. Food Ind."},{"key":"ref_100","first-page":"1183","article-title":"Study on purification of almond skin tannins by macroporous resins","volume":"49","author":"Du","year":"2020","journal-title":"Appl. Chem. Ind."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1007\/BF02975114","article-title":"Determination of flavonoids, tannins and ellagic acid in leaves from Rubus L. Species","volume":"27","author":"Gudej","year":"2004","journal-title":"Arch. Pharm. Res."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Wang, X.J., Zhang, D., Yang, Y.T., Li, X.Y., Li, H.N., Zhang, X.P., Long, J.Y., Lu, Y.Q., Liu, L., and Yang, G. (2023). Suppression of microRNA-222-3p ameliorates ulcerative colitis and colitis-associated colorectal cancer to protect against oxidative stress via targeting brg1 to activate Nrf2\/Ho-1 signaling pathway. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1089809"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/carcin\/24.3.353","article-title":"Oxidative stress and ulcerative colitis-associated carcinogenesis: Studies in humans and animal models","volume":"24","author":"Seril","year":"2003","journal-title":"Carcinogenesis"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/MEG.0000000000002370","article-title":"Upregulated NORAD is implicated in apoptosis, inflammation, and oxidative stress in ulcerative colitis through the nuclear factor-\u03baappaB signaling","volume":"34","author":"Lei","year":"2022","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.crohns.2014.01.007","article-title":"Relationship of cytokines, oxidative stress and GI motility with bacterial overgrowth in ulcerative colitis patients","volume":"8","author":"Rana","year":"2014","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e202200834","DOI":"10.1002\/cbdv.202200834","article-title":"Antioxidant activity, total phenolic, tannin, and flavonoid content of five plants used in traditional medicine in penjamo, guanajuato","volume":"20","year":"2023","journal-title":"Chem. Biodivers."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/0973-1296.177913","article-title":"The attenuation of scutellariae radix extract on oxidative stress for colon injury in lipopolysaccharide-induced raw264.7 cell and 2,4,6-trinitrobenzene sulfonic acid-induced ulcerative colitis rats","volume":"12","author":"Jin","year":"2016","journal-title":"Pharmacogn. Mag."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1111\/1750-3841.14853","article-title":"Liposomal encapsulated ethanolic coconut husk extract: Antioxidant and antibacterial properties","volume":"84","author":"Olatunde","year":"2019","journal-title":"J. Food Sci."},{"key":"ref_109","first-page":"54","article-title":"In vitro and in vivo antioxidant activity of persimmon tannin fractions of different degrees of polymerization","volume":"34","author":"Tian","year":"2013","journal-title":"Food Sci."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Aimaier, S., Tao, Y., Lei, F., Yupeng, Z., Wenhui, S., Aikemu, A., and Maimaitiyiming, D. (2023). Protective effects of the terminalia bellirica tannin-induced nrf2\/ho-1 signaling pathway in rats with high-altitude pulmonary hypertension. BMC Complement. Med. Ther., 23.","DOI":"10.1186\/s12906-023-03981-2"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Kim, J.E., Choi, Y.J., Lee, S.J., Gong, J.E., Lee, Y.J., Sung, J.E., Jung, Y.S., Lee, H.S., Hong, J.T., and Hwang, D.Y. (2021). Antioxidant activity and laxative effects of tannin-enriched extract of Ecklonia cava in loperamide-induced constipation of SD rats. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0246363"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"117549","DOI":"10.1016\/j.biopha.2024.117549","article-title":"Agmatine attenuates the severity of immunometabolic disorders by suppressing macrophage polarization: An in vivo study using an ulcerative colitis mouse model","volume":"180","author":"Zhang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Liu, H., Hu, J., Mahfuz, S., and Piao, X. (2020). Effects of hydrolysable tannins as zinc oxide substitutes on antioxidant status, immune function, intestinal morphology, and digestive enzyme activities in weaned piglets. Animals, 10.","DOI":"10.3390\/ani10050757"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Tong, Z., Lei, F., Liu, L., Wang, F., and Guo, A. (2021). Effects of Plotytarya strohilacea sieb. Et zuce tannin on the growth performance, oxidation resistance, intestinal morphology and cecal microbial composition of broilers. Front. Vet. Sci., 8.","DOI":"10.3389\/fvets.2021.806105"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Niu, X., Qu, W., Chen, Z., Li, H., Liu, P., Sun, M., Yang, J., Xing, Y., and Li, D. (2025). Condensed tannin from Caragana korshinskii extraction and protection effects on intestinal barrier function in mice. Front. Vet. Sci., 12.","DOI":"10.3389\/fvets.2025.1513371"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Wang, Z., Liu, Z., Wu, C., Liu, S., Wang, D., Hu, C., Chen, T., Ran, Z., Gan, W., and Li, G. (2022). Computational analysis on antioxidant activity of four characteristic structural units from persimmon tannin. Materials, 16.","DOI":"10.3390\/ma16010320"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1007\/s11356-016-7532-1","article-title":"Hydroxyl radical production by a heterogeneous fenton reaction supported in insoluble tannin from bark of pinus radiata","volume":"24","author":"Romero","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_118","first-page":"3752","article-title":"Effects of tannin extract of valonia on growth performance, serum biochemical indices, intestinal health and antioxidant function of broilers","volume":"37","author":"Liu","year":"2025","journal-title":"Chin. J. Anim. Nutr."},{"key":"ref_119","unstructured":"Xue, W.Y. (2018). Influencing Factors on Content and Antioxidant Activity of Tannin in Quercus acutissima. [Master\u2019s Thesis, Northwest A&F University]."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"115039","DOI":"10.1016\/j.jep.2022.115039","article-title":"Quercus acutissima carruth. Root extract triggers apoptosis, autophagy and inhibits cell viability in breast cancer cells","volume":"289","author":"Ding","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.fct.2011.04.018","article-title":"High molecular weight persimmon tannin ameliorates cognition deficits and attenuates oxidative damage in senescent mice induced by d-galactose","volume":"49","author":"Tian","year":"2011","journal-title":"Food. Chem. Toxicol."},{"key":"ref_122","unstructured":"Lu, Y.H. (2024). Study on Protective Effect of A-Ecg Dimer of Persimmon Tannin on Oxidative Damage of Retinal Pigment Epithelial Cell. [Master\u2019s Thesis, Huazhong Agricultural University]."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"7973","DOI":"10.1039\/D0FO01652G","article-title":"Preparation, characterization and in vitro hypoglycemic activity of banana condensed tannin-inulin conjugate","volume":"11","author":"Zeng","year":"2020","journal-title":"Food Funct."},{"key":"ref_124","first-page":"153","article-title":"Antioxidant activity and \u03b1-glucosidase inhibitory activity of five banana pulp polyphenols","volume":"39","author":"Ran","year":"2023","journal-title":"Food Mach."},{"key":"ref_125","first-page":"93","article-title":"Study on extraction and antioxidation activity of tannin from Heritiera littoralis shell","volume":"31","author":"Hu","year":"2018","journal-title":"Cereals Oils"},{"key":"ref_126","unstructured":"Yao, K., Lv, Y., He, Q., and Shi, B. (2002). Antioxidant activity of different fractions of black wattle bark tannin. China Oils Fats, 24\u201325."},{"key":"ref_127","first-page":"185","article-title":"The effect of tannin on the antioxidant capacity and immune performance of sheep","volume":"58","author":"Xie","year":"2022","journal-title":"Chin. J. Anim. Sci."},{"key":"ref_128","unstructured":"Li, Q. (2013). Studies on Isolation, Identification and Antioxidant Activity of Oligomeric Proanthocyanidins from Lotus Seed Peel. [Master\u2019s Thesis, Hunan Agricultural University]."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Gao, C., Qi, M., and Zhou, Y. (2024). Chestnut tannin extract modulates growth performance and fatty acid composition in finishing tan lambs by regulating blood antioxidant capacity, rumen fermentation, and biohydrogenation. BMC Vet. Res., 20.","DOI":"10.1186\/s12917-023-03870-3"},{"key":"ref_130","first-page":"6468","article-title":"Effects of dietary quebracho tannin supplementation on growth performance, nutrient digestion and metabolism, and antioxidant capacity of liaoning cashmere goats","volume":"36","author":"Chen","year":"2024","journal-title":"Chin. J. Anim. Nutr."},{"key":"ref_131","first-page":"84","article-title":"Chemical structure of tannins in cercis chinensis and cercis glabra and their antioxidant activity","volume":"42","author":"Wang","year":"2022","journal-title":"Chem. Ind. For. Prod."},{"key":"ref_132","first-page":"74","article-title":"Study on ultrasonic extraction of tannin from orange peel and lts antioxidant activity","volume":"47","author":"Chen","year":"2022","journal-title":"China Condiment"},{"key":"ref_133","first-page":"6802","article-title":"Effects of dietary Plotytarya strohilacea sieb. Et zuce tannin on immune organ indexes, plasma antioxidant and biochemical indexes and cecal microflora of broilers","volume":"33","author":"Cong","year":"2021","journal-title":"Chin. J. Anim. Nutr."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.foodchem.2010.05.058","article-title":"The influence of roasting, pasteurisation, and storage on the polyphenol content and antioxidant capacity of california almond skins","volume":"123","author":"Bolling","year":"2010","journal-title":"Food Chem."},{"key":"ref_135","unstructured":"Chen, Y. (2024). Extraction of Tannins from Total Bract of Chestnut and Study on Their Antioxidant and Antibacterial Activities. [Master\u2019s Thesis, Central South University of Forestry and Technology]."},{"key":"ref_136","first-page":"142","article-title":"Study on isolation, purification and antioxidant activities of tannins of potentilla anserina","volume":"51","author":"Qu","year":"2023","journal-title":"J. Anhui Agric. Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/15287394.2025.2470845","article-title":"Protective effect of polyphenols from potentilla anserina l. Against in rat myocardial ischemia-reperfusion on injury by wnt\/\u03b2-catenin pathway","volume":"88","author":"Li","year":"2025","journal-title":"J. Toxicol. Env. Health Part A"},{"key":"ref_138","first-page":"60","article-title":"Isolation and antioxidant activity analysis of condensed tannin polymers in walnut pellicle","volume":"50","author":"Cui","year":"2025","journal-title":"China Oils Fats"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"136451","DOI":"10.1016\/j.chemosphere.2022.136451","article-title":"Mechanistic study of the solid-liquid extraction of phenolics from walnut pellicle fibers enhanced by ultrasound, microwave and mechanical agitation forces","volume":"309","author":"Xu","year":"2022","journal-title":"Chemosphere"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Magangana, T.P., Makunga, N.P., Fawole, O.A., Stander, M.A., and Opara, U.L. (2022). Antioxidant, antimicrobial, and metabolomic characterization of blanched pomegranate peel extracts: Effect of cultivar. Molecules, 27.","DOI":"10.3390\/molecules27092979"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Feng, Y., Lin, J., He, G., Liang, L., Liu, Q., Yan, J., and Yao, Q. (2022). Compositions and biological activities of pomegranate peel polyphenols extracted by different solvents. Molecules, 27.","DOI":"10.3390\/molecules27154796"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e20200153","DOI":"10.1590\/0001-3765202320200153","article-title":"Obtaining polyphenolic extracts from pomegranate peel (Punica granatum) to evaluate the bactericide and antioxidant activity","volume":"95","year":"2023","journal-title":"An. Acad. Bras. Cienc."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1007\/s13197-016-2222-z","article-title":"Standardization of the conditions for extraction of polyphenols from pomegranate peel","volume":"53","author":"Venkataramanamma","year":"2016","journal-title":"J. Food Sci. Technol.-Mysore"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"skac099","DOI":"10.1093\/jas\/skac099","article-title":"Effects of Chinese gallnut tannic acid on growth performance, blood parameters, antioxidative status, intestinal histomorphology, and cecal microbial shedding in broilers challenged with aflatoxin B1","volume":"100","author":"Zhang","year":"2022","journal-title":"J. Anim. Sci."},{"key":"ref_145","unstructured":"Qin, Q.Q. (2022). Change of Tannin Content in the Leaves and Branches of Gallnut Plants, Effect of Tannin on Antioxidant Capacity and Intestinal Development of Apis mellifera L.. [Master\u2019s Thesis, Huazhong Agricultural University]."},{"key":"ref_146","first-page":"3830","article-title":"Study on gallic acid from galla chinensis by ultrasonic-assisted tannin enzymatic method and its antioxygenation","volume":"31","author":"Li","year":"2019","journal-title":"Chin. J. Anim. Nutr."},{"key":"ref_147","unstructured":"Zhang, M.F. (2024). Study on the Degradation of Box Myrtle Tannin and the Activity of its Products. [Master\u2019s Thesis, Fujian Agriculture and Forestry University]."},{"key":"ref_148","first-page":"40","article-title":"Optimization in extraction process of tannin from myrtle fruit and its antioxidant activity","volume":"38","author":"Xu","year":"2021","journal-title":"Chem. Bioeng."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"9105847","DOI":"10.1155\/2020\/9105847","article-title":"Optimization of bioactive compound extraction from rose myrtle fruit (Rhodomyrtus tomentosa, (W.Ait), Myrtaceae) as the antioxidant source","volume":"2020","author":"Ismandari","year":"2020","journal-title":"Sci. World J."},{"key":"ref_150","unstructured":"Liu, X. (2020). Efficient Extraction of Tannin from Sorghum Grains and Its Roles in Chilled Pork Preservation. [Master\u2019s Thesis, Shandong Agricultural University]."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Jacimovic, S., Kiprovski, B., Ristivojevic, P., Dimic, D., Nakarada, D., Dojcinovic, B., Sikora, V., Teslic, N., and Pantelic, N.D. (2023). Chemical composition, antioxidant potential, and nutritional evaluation of cultivated sorghum grains: A combined experimental, theoretical, and multivariate analysis. Antioxidants, 12.","DOI":"10.3390\/antiox12081485"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"6813","DOI":"10.1021\/jf050419e","article-title":"Phenolic compounds and antioxidant activity of sorghum grains of varying genotypes","volume":"53","author":"Dykes","year":"2005","journal-title":"J. Agric. Food. Chem."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-1-4939-9039-9_8","article-title":"Tannin analysis in sorghum grains","volume":"1931","author":"Dykes","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1021\/acs.jafc.4c08975","article-title":"Dynamic metabolomic changes in the phenolic compound profile and antioxidant activity in developmental sorghum grains","volume":"73","author":"Morel","year":"2025","journal-title":"J. Agric. Food. Chem."},{"key":"ref_155","unstructured":"Liu, J. (2021). Condensed Tannin from Ficus altissima Fruit: Structure and Biological Activity. [Master\u2019s Thesis, Xiamen University]."},{"key":"ref_156","first-page":"62","article-title":"Study on extraction, purification and antioxidant activity of tannins of eucalyptus citriodora bark","volume":"39","author":"Shang","year":"2018","journal-title":"Sci. Technol. Food Ind."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.phymed.2014.10.002","article-title":"Protective role of ellagitannins from eucalyptus citriodora against ethanol-induced gastric ulcer in rats: Impact on oxidative stress, inflammation and calcitonin-gene related peptide","volume":"22","year":"2015","journal-title":"Phytomedicine"},{"key":"ref_158","first-page":"12","article-title":"Optimization of extraction technology and antioxidation of tannin from Kalopanax septemlobus by response surface method","volume":"40","author":"Xu","year":"2019","journal-title":"Food Ind."},{"key":"ref_159","unstructured":"Peng, K. (2017). Effects of Conservation Methods on Chemical Structure and Biological Activity of Condensed Tannins in Purple Prairie Clover. [Ph.D. Thesis, China Agricultural University]."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Peng, K., Huang, Q., Xu, Z., Mcallister, T.A., Acharya, S., Mueller-Harvey, I., Drake, C., Cao, J., Huang, Y., and Sun, Y. (2018). Characterization of condensed tannins from purple prairie clover (Dalea purpurea vent.) Conserved as either freeze-dried forage, sun-cured hay or silage. Molecules, 23.","DOI":"10.3390\/molecules23030586"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Li, X., Sun, R., Liu, Q., Gong, Y., Ou, Y., Qi, Q., Xie, Y., Wang, X., Hu, C., and Jiang, S. (2022). Effects of dietary supplementation with dandelion tannins or soybean isoflavones on growth performance, antioxidant function, intestinal morphology, and microbiota composition in Wenchang chickens. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.1073659"},{"key":"ref_162","unstructured":"Qu, B. (2024). Study on the In Vitro Digestive Stability and Biological Activity of Dandelion Polyphenols. [Master\u2019s Thesis, Liaoning University]."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Molino, S., Lerma-Aguilera, A., Jimenez-Hernandez, N., Gosalbes, M.J., Rufian-Henares, J.A., and Francino, M.P. (2021). Enrichment of food with tannin extracts promotes healthy changes in the human gut microbiota. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.625782"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"13988","DOI":"10.1021\/acs.jafc.3c02949","article-title":"Evaluation of tannin-delivery approaches for gut microbiota modulation: Comparison of pectin-based microcapsules and unencapsulated extracts","volume":"71","author":"Molino","year":"2023","journal-title":"J. Agric. Food. Chem."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Fabbrini, M., D\u2019Amico, F., Barone, M., Conti, G., Mengoli, M., Brigidi, P., and Turroni, S. (2022). Polyphenol and tannin nutraceuticals and their metabolites: How the human gut microbiota influences their properties. Biomolecules, 12.","DOI":"10.3390\/biom12070875"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"8893","DOI":"10.1039\/D4FO02236J","article-title":"Tannin-based supplementation influences gut microbiota composition and activity in IBS-d patients with a potential impact on symptoms: A pilot study","volume":"15","author":"Molino","year":"2024","journal-title":"Food Funct."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"125692","DOI":"10.1016\/j.foodchem.2019.125692","article-title":"Transcriptomic and metabolomic analyses reveal antibacterial mechanism of astringent persimmon tannin against methicillin-resistant staphylococcus aureus isolated from pork","volume":"309","author":"Liu","year":"2020","journal-title":"Food Chem."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/fpd.2013.1675","article-title":"Tannin-rich fraction from pomegranate rind damages membrane of listeria monocytogenes","volume":"11","author":"Li","year":"2014","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/bab.2461","article-title":"Reconnoitring the antioxidant and antibacterial potential of different fruits after tannin acyl hydrolase mediated biotransformation","volume":"70","author":"Sharma","year":"2023","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_170","first-page":"93","article-title":"Anti-oxidant anti-inflammatory and antibacterial tannin-crosslinked citrate-based mussel-inspired bioadhesives facilitate scarless wound healing","volume":"20","author":"Wu","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"133784","DOI":"10.1016\/j.ijbiomac.2024.133784","article-title":"Chitosan-casein blended with condensed tannin and carnauba wax for the fabrication of antibacterial and antioxidant food packing films","volume":"277","author":"Xu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_172","first-page":"34","article-title":"Antibacterial effect of fourty-five Chinese herb extractions to vibrio isolates from mud crab, Scylla serrata (forskal)","volume":"29","author":"Qiu","year":"2010","journal-title":"J. Zhejiang Ocean Univ. (Nat. Sci.)"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"107815","DOI":"10.1016\/j.micpath.2025.107815","article-title":"Characterization and toxicity assessment of metabiotic produced through natural tannin fermentation by newly isolated probiotic lactiplantibacillus plantarum pki15 and study of its effect on gut microbiome through metagenomics approach","volume":"206","author":"Biswas","year":"2025","journal-title":"Microb. Pathog."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"134162","DOI":"10.1016\/j.ijbiomac.2024.134162","article-title":"Eco-friendly versatile shielding revolution: Tannin tailored bamboo waste composite with wave-absorbing, flame retardancy, and antibacterial abilities","volume":"277","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"e202100558","DOI":"10.1002\/cbdv.202100558","article-title":"Antioxidant and antibacterial activities of dodecyl tannin derivative linked with 1,2,3-triazole","volume":"19","author":"Yuan","year":"2022","journal-title":"Chem. Biodivers."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"5539701","DOI":"10.1155\/2024\/5539701","article-title":"Effects of tannin supplementation in diet on the resistance to ammonia stress of pacific white shrimp Litopenaeus vannamei","volume":"2024","author":"Zhang","year":"2024","journal-title":"Aquac. Nutr."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"8266189","DOI":"10.1155\/2024\/8266189","article-title":"Effects of diet supplemented with hydrolyzable tannin on the growth performance, antioxidant capacity, and muscle nutritional quality of juvenile Mastacembelus armatus","volume":"2024","author":"Xue","year":"2024","journal-title":"Aquac. Nutr."},{"key":"ref_178","first-page":"1165","article-title":"Effects of dietary condensed tannins on growth performance body composition, serum biochemical and antioxidant indexes of Litopenaeus vannamei","volume":"34","author":"Peng","year":"2022","journal-title":"Chin. J. Anim. Nutr."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"132232","DOI":"10.1016\/j.ijbiomac.2024.132232","article-title":"The effects of inulin on solubilizing and improving anti-obesity activity of high polymerization persimmon tannin","volume":"270","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"e1800512","DOI":"10.1002\/mnfr.201800512","article-title":"Body mass index as a determinant of systemic exposure to gallotannin metabolites during 6-week consumption of mango (Mangifera indica L.) And modulation of intestinal microbiota in lean and obese individuals","volume":"63","author":"Barnes","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Kim, H., Castellon-Chicas, M.J., Arbizu, S., Talcott, S.T., Drury, N.L., Smith, S., and Mertens-Talcott, S.U. (2021). Mango (Mangifera indica L.) Polyphenols: Anti-inflammatory intestinal microbial health benefits, and associated mechanisms of actions. Molecules, 26.","DOI":"10.3390\/molecules26092732"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.foodres.2019.03.014","article-title":"Grinding levels of raspberry pomace affect intestinal microbial activity, lipid and glucose metabolism in wistar rats","volume":"120","author":"Fotschki","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"22848","DOI":"10.3390\/molecules201219878","article-title":"Ellagitannins and flavan-3-ols from raspberry pomace modulate caecal fermentation processes and plasma lipid parameters in rats","volume":"20","author":"Fotschki","year":"2015","journal-title":"Molecules"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s00726-021-03082-9","article-title":"A mix of functional amino acids and grape polyphenols promotes the growth of piglets, modulates the gut microbiota in vivo and regulates epithelial homeostasis in intestinal organoids","volume":"54","author":"Beaumont","year":"2022","journal-title":"Amino Acids"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1039\/D1FO03396D","article-title":"Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a d-galactose-induced aging mouse model by modulating the gut microbiota","volume":"13","author":"Sheng","year":"2022","journal-title":"Food Funct."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"80313","DOI":"10.18632\/oncotarget.13450","article-title":"Dietary grape seed proanthocyanidins (GSPs) improve weaned intestinal microbiota and mucosal barrier using a piglet model","volume":"7","author":"Han","year":"2016","journal-title":"Oncotarget"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"129439","DOI":"10.1016\/j.foodchem.2021.129439","article-title":"Effects of bioactive components of pu-erh tea on gut microbiomes and health: A review","volume":"353","author":"Liu","year":"2021","journal-title":"Food Chem."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.1021\/acs.jafc.8b05010","article-title":"Tea is a significant dietary source of ellagitannins and ellagic acid","volume":"67","author":"Yang","year":"2019","journal-title":"J. Agric. Food. Chem."},{"key":"ref_189","unstructured":"Zeng, H., Zhou, F., Liu, C., and Chen, J. (2022). Research progress on the regulatory effect of tea and its functional components on intestinal flora. China Tea Process., 5\u201310."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1080\/00498254.2022.2073291","article-title":"Pomegranate peel polyphenols interaction with intestinal flora and its metabolic transformation","volume":"52","author":"Shi","year":"2022","journal-title":"Xenobiotica"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"8273","DOI":"10.1039\/C9FO02077B","article-title":"Pomegranate peel polyphenols reduce chronic low-grade inflammatory responses by modulating gut microbiota and decreasing colonic tissue damage in rats fed a high-fat diet","volume":"10","author":"Zhao","year":"2019","journal-title":"Food Funct."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"6829","DOI":"10.1021\/acs.jafc.1c02532","article-title":"Apple polyphenol extract improves high-fat diet-induced hepatic steatosis by regulating bile acid synthesis and gut microbiota in c57bl\/6 male mice","volume":"69","author":"Li","year":"2021","journal-title":"J. Agric. Food. Chem."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1039\/D1FO04116A","article-title":"Apple polyphenol extract modulates bile acid metabolism and gut microbiota by regulating the circadian rhythms in daytime-restricted high fat diet feeding c57bl\/6 male mice","volume":"13","author":"Cui","year":"2022","journal-title":"Food Funct."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/ptr.6910","article-title":"Apple polyphenols extract alleviated dextran sulfate sodium-induced ulcerative colitis in c57bl\/6 male mice by restoring bile acid metabolism disorder and gut microbiota dysbiosis","volume":"35","author":"Liu","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3945\/jn.113.182659","article-title":"Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice","volume":"144","author":"Espley","year":"2014","journal-title":"J. Nutr."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"116418","DOI":"10.1016\/j.foodres.2025.116418","article-title":"Unripe apple polyphenols extract improves intestinal inflammation and restructures gut microbiota in spontaneously hypertensive rats","volume":"212","author":"Li","year":"2025","journal-title":"Food Res. Int."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"14649","DOI":"10.1021\/acs.jafc.3c04606","article-title":"Blueberry and blackberry anthocyanins ameliorate metabolic syndrome by modulating gut microbiota and short-chain fatty acids metabolism in high-fat diet-fed c57bl\/6j mice","volume":"71","author":"Du","year":"2023","journal-title":"J. Agric. Food. Chem."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.foodres.2018.11.001","article-title":"Antioxidant potential and phenolic profile of blackberry anthocyanin extract followed by human gut microbiota fermentation","volume":"120","author":"Gowd","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.foodchem.2018.07.020","article-title":"Antioxidant and antidiabetic activity of blackberry after gastrointestinal digestion and human gut microbiota fermentation","volume":"269","author":"Gowd","year":"2018","journal-title":"Food Chem."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1021\/acsami.2c18441","article-title":"Chestnut-tannin-crosslinked, antibacterial, antifreezing, conductive organohydrogel as a strain sensor for motion monitoring, flexible keyboards, and velocity monitoring","volume":"15","author":"Song","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Orso, G., Solovyev, M.M., Facchiano, S., Tyrikova, E., Sateriale, D., Kashinskaya, E., Pagliarulo, C., Hoseinifar, H.S., Simonov, E., and Varricchio, E. (2021). Chestnut shell tannins: Effects on intestinal inflammation and dysbiosis in zebrafish. Animals, 11.","DOI":"10.3390\/ani11061538"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.rvsc.2019.03.012","article-title":"Dietary supplementation of chestnut and quebracho tannins mix: Effect on caecal microbial communities and live performance of growing rabbits","volume":"124","author":"Turchi","year":"2019","journal-title":"Res. Vet. Sci."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Dai, K., Agarwal, N., Rodriguez-Palacios, A., and Basson, A.R. (2024). Regulation of intestinal inflammation by walnut-derived bioactive compounds. Nutrients, 16.","DOI":"10.3390\/nu16162643"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.clnu.2017.03.012","article-title":"The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome","volume":"37","author":"Selma","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"E965","DOI":"10.1152\/ajpendo.00560.2019","article-title":"Blueberry proanthocyanidins and anthocyanins improve metabolic health through a gut microbiota-dependent mechanism in diet-induced obese mice","volume":"318","author":"Morissette","year":"2020","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1038\/s41598-020-58863-1","article-title":"Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice","volume":"10","author":"Daoust","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Jing, N., Wang, L., Zhuang, H., Jiang, G., and Liu, Z. (2023). Enhancing therapeutic effects of murine cancer vaccine by reshaping gut microbiota with Lactobacillus rhamnosus gg and jujube powder. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1195075"},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Li, Z., Wu, M., Wei, W., An, Y., Li, Y., Wen, Q., Zhang, D., Zhang, J., Yao, C., and Bi, Q. (2023). Fingerprinting evaluation and gut microbiota regulation of polysaccharides from jujube (Ziziphus jujuba mill.) Fruit. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087239"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"110616","DOI":"10.1016\/j.ecoenv.2020.110616","article-title":"Changes in the gut microbiota of honey bees associated with jujube flower disease","volume":"198","author":"Ma","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Fotschki, B., Juskiewicz, J., Kolodziejczyk, K., Jurgonski, A., Kosmala, M., Milala, J., Ognik, K., and Zdunczyk, Z. (2018). Protective effects of ellagitannin-rich strawberry extracts on biochemical and metabolic disturbances in rats fed a diet high in fructose. Nutrients, 10.","DOI":"10.3390\/nu10040445"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Weyns, A.S., Ahannach, S., Van Rillaer, T., De Bruyne, T., Lebeer, S., and Hermans, N. (2024). Enhancing pediatric attention-deficit hyperactivity disorder treatment: Exploring the gut microbiota effects of french maritime pine bark extract and methylphenidate intervention. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1422253"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.foodchem.2014.01.126","article-title":"Influence of in vitro gastrointestinal digestion of fruit juices enriched with pine bark extract on intestinal microflora","volume":"157","year":"2014","journal-title":"Food Chem."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Yang, K., Jian, S., Wen, C., Guo, D., Liao, P., Wen, J., Kuang, T., Han, S., Liu, Q., and Deng, B. (2022). Gallnut tannic acid exerts anti-stress effects on stress-induced inflammatory response, dysbiotic gut microbiota, and alterations of serum metabolic profile in beagle dogs. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.847966"},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Capaldo, C.T. (2023). Claudin barriers on the brink: How conflicting tissue and cellular priorities drive IBD pathogenesis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24108562"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nrgastro.2017.110","article-title":"The IBD interactome: An integrated view of aetiology, pathogenesis and therapy","volume":"14","author":"Fiocchi","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"142932","DOI":"10.1016\/j.foodchem.2025.142932","article-title":"Advances in dietary polyphenols: Regulation of inflammatory bowel disease (IBD) via bile acid metabolism and the gut-brain axis","volume":"472","author":"Jiang","year":"2025","journal-title":"Food Chem."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"118393","DOI":"10.1016\/j.jep.2024.118393","article-title":"Casearia sylvestris var. lingua (c\u00e0mbess.) Eichler leaves aqueous extract improves colon inflammation through mucogenic, antioxidant and anti-inflammatory actions in TNBS- induced IBD rats","volume":"332","author":"Arunachalam","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Cicio, A., Serio, R., and Zizzo, M.G. (2022). Anti-inflammatory potential of brassicaceae-derived phytochemicals: In vitro and in vivo evidence for a putative role in the prevention and treatment of IBD. Nutrients, 15.","DOI":"10.3390\/nu15010031"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"125705","DOI":"10.1016\/j.ijpharm.2025.125705","article-title":"A novel pH-responsive berberine-loaded attapulgite microsphere for IBD therapy via the regulation of gut immunity and flora","volume":"679","author":"Gong","year":"2025","journal-title":"Int. J. Pharm."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"127987","DOI":"10.1016\/j.ijbiomac.2023.127987","article-title":"Cationic fructan-based ph and intestinal flora dual stimulation nanoparticle with berberine for targeted therapy of IBD","volume":"256","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s10620-009-0843-z","article-title":"Oral administration of curcumin emulsified in carboxymethyl cellulose has a potent anti-inflammatory effect in the il-10 gene-deficient mouse model of IBD","volume":"55","author":"Ung","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"109991","DOI":"10.1016\/j.vetimm.2019.109991","article-title":"Different doses of tannin reflect a double-edged impact on broiler chicken immunity","volume":"220","author":"Ramah","year":"2020","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"106948","DOI":"10.1016\/j.phrs.2023.106948","article-title":"C4BP(\u03b2-)-mediated immunomodulation attenuates inflammation in DSS-induced murine colitis and in myeloid cells from IBD patients","volume":"197","author":"Serrano","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Kim, J.J., Shajib, M.S., Manocha, M.M., and Khan, W.I. (2012). Investigating intestinal inflammation in DSS-induced model of IBD. J. Vis. Exp., 3678.","DOI":"10.3791\/3678-v"},{"key":"ref_225","unstructured":"He, Q.Y. (2023). The Study of Tannins and Its Metabolite Gallic Acid in the Progression of Inflammatory Bowel Disease. [Master\u2019s Thesis, Army Medical University]."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/7\/1116\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:12:57Z","timestamp":1774930377000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/7\/1116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,28]]},"references-count":225,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["molecules31071116"],"URL":"https:\/\/doi.org\/10.3390\/molecules31071116","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,28]]}}}