{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:48:04Z","timestamp":1776055684744,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>An environmentally friendly synthesis of polysubstituted pyrroles in ionic liquid was achieved via a gold-catalyzed propargylic substitution\/hydration\/amination\/cycloisomerization sequence. Treatment of propargylic alcohols, 1,3-dicarbonyl compounds, and arylamines in the presence of AuBr3 (5 mol%) and AgOTf (15 mol%) in [EMIM][NTf2] afforded polysubstituted pyrroles in good to high yield. This reaction involves reacting arylamine with the hydrated propargylic substitution product formed as an intermediate to yield polysubstituted pyrroles.<\/jats:p>","DOI":"10.3390\/molecules31071203","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:19:32Z","timestamp":1775434772000},"page":"1203","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Environmentally Friendly Synthesis of Polysubstituted Pyrroles in Ionic Liquid via Gold-Catalyzed Propargylic Substitution\/Hydration\/Amination\/Cycloisomerization Sequence"],"prefix":"10.3390","volume":"31","author":[{"given":"Hitomi","family":"Chiaki","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Showa Pharmaceutical University, Machida 194-8543, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukinori","family":"Umezawa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Showa Pharmaceutical University, Machida 194-8543, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2868-901X","authenticated-orcid":false,"given":"Yoshimitsu","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Showa Pharmaceutical University, Machida 194-8543, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyoshi","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Showa Pharmaceutical University, Machida 194-8543, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1039\/b209440c","article-title":"Tandem Reactions, Cascade Sequences, and Biomimetic Strategies in Total Synthesis","volume":"34","author":"Nicolaou","year":"2003","journal-title":"Chem. 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