{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:44:22Z","timestamp":1785437062265,"version":"3.56.0"},"reference-count":54,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bowling Green State University for Startup Funding"},{"id":[{"id":"https:\/\/ror.org\/00ay7va13","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute of the US National Institute of Health","doi-asserted-by":"publisher","award":["1R15HL168693-01"],"award-info":[{"award-number":["1R15HL168693-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"award":["1R15HL168693-01"],"award-info":[{"award-number":["1R15HL168693-01"]}],"id":[{"id":"https:\/\/ror.org\/012pb6c26","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Nitric oxide (NO) is a gaseous biocompatible radical molecule with demonstrated biomedical and antimicrobial benefits. Developing adaptable, long-lasting delivery systems for NO has become an essential goal for both combating resistant bacterial growth and providing sustained medical benefits. Silsesquioxane (SQ)-based organogels were chosen and synthesized as robust, tunable NO-release platforms. These highly stable SQ gel frameworks, composed of silicon\u2013oxygen backbones with variable R groups, exhibited high porosity and surface area and offered chemical versatility, enabling control over NO loading and release. 3-Mercaptopropyl groups were utilized as sulfur-based NO-releasing substituents (-RSNOs), with additional R groups capable of altering accessibility to RSNO sites through hydrophobicity and steric hindrance. The NO release profile, rate, and duration of the functionalized gels were also tailored by adjusting the number of RSNO sites in the elastomeric system, thereby enabling a customizable release profile. This combination of NO-releasing silsesquioxanes with silicone elastomers yields composite materials that are integratable into biomedical applications, offering NO release up to 40 days within modeled physiological conditions in PBS buffer.<\/jats:p>","DOI":"10.3390\/molecules31081343","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:15:08Z","timestamp":1776669308000},"page":"1343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Network Silsesquioxane-Based Organogel\/Silicone Composites for the Long-Lasting Delivery of Nitric Oxide"],"prefix":"10.3390","volume":"31","author":[{"given":"Kyle D.","family":"Hallowell","sequence":"first","affiliation":[{"name":"Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0688-3238","authenticated-orcid":false,"given":"Fatima","family":"Naser Aldine","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope N. Vonder","family":"Vonder Brink","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley K.","family":"Mockensturm","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-7374","authenticated-orcid":false,"given":"Hitesh","family":"Handa","sequence":"additional","affiliation":[{"name":"School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA 30602, USA"},{"name":"Pharmaceutical and Biomedical Sciences Department, College of Pharmacy, University of Georgia, Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9283-5448","authenticated-orcid":false,"given":"Elizabeth J.","family":"Brisbois","sequence":"additional","affiliation":[{"name":"School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3207-1845","authenticated-orcid":false,"given":"Alexis D.","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7040-0793","authenticated-orcid":false,"given":"Joseph C.","family":"Furgal","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/jbm.820270909","article-title":"In vitro platelet interactions in whole human blood exposed to biomaterial surfaces: Insights on blood compatibility","volume":"27","author":"Haycox","year":"1993","journal-title":"J. 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