{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:36:26Z","timestamp":1785411386351,"version":"3.56.0"},"reference-count":303,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/05dwvd537","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Pharmaceutical, cosmetic, and food industries have contributed to the increasing interest in herbal phytochemicals. Salvia, a multifunctional culinary herb, meets phytotherapeutic requirements in the treatment of heartburn, excessive sweating, flatulence, and mouth, throat, and skin inflammatory conditions. Salviae folium is used in conductive education, i.e., a unique rehabilitation method for individuals with neurological and motor disorders designed to help in learning to perform activities independently. The comparative analysis of bioactive chemical compounds in S. officinalis, S. officinalis subsp. lavandulifolia, and S. sclarea herb showed that S. officinalis had the highest concentration of exogenous amino acids (53 mg\u00b7g\u22121 DW), with a predominance of lecithin and phenylalanine, and endogenous amino acids were dominated by aspartic and glutamic acids. S. officinalis subsp. lavandulifolia was the richest source of omega-3, omega-6, and omega-9 fatty acids, followed by S. officinalis and S. sclarea. The vitamin C content was 4.9 (S. sclarea)\u201314.4 mg\u00b7100 g\u22121 DW (S. officinalis). Phenolic acids were dominated by rosmarinic acid (S. officinalis &gt; S. officinalis sub. lavandulifolia &gt; S. sclarea) and ferulic acid (S. officinalis &gt; S. sclarea &gt; S. officinalis sub. lavandulifolia). Salvia sclarea is a rich source of p-coumaric acid. Among non-phenolic organic acids, the highest content of quinic and malic acids was found in S. sclarea and S. officinalis, respectively. The level of o-dihydroxyphenols was 2140 (S. officinalis)-2222 mg CAE\u00b7100\u00b7g\u22121 DW (S. sclarea). The flavonoid content was 610 (S. officinalis subsp. lavandulifolia)-347 mg RU\u00b7100 g\u22121 DW (S. sclarea). Flavonoids, flavonols, and flavanones were dominated by apigenin, kaempferol, and hesperidin, respectively. These metabolites may be potential components in phytotherapeutic products.<\/jats:p>","DOI":"10.3390\/molecules31091425","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T07:49:36Z","timestamp":1777362576000},"page":"1425","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Selected Pro-Health Biologically Active Chemical Compounds in Salviae herba from Selected Species"],"prefix":"10.3390","volume":"31","author":[{"given":"Miros\u0142awa","family":"Chwil","sequence":"first","affiliation":[{"name":"Department of Botany and Plant Physiology, University of Life Sciences in Lublin, Akademicka 15 Street, 20-950 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarmila","family":"Neugebauerov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Vegetable Growing and Floriculture, Faculty of Horticulture, Mendel University in Brno, Valtick\u00e1 337 Street, 691 44 Lednice, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Matraszek-Gawron","sequence":"additional","affiliation":[{"name":"Department of Botany and Plant Physiology, University of Life Sciences in Lublin, Akademicka 15 Street, 20-950 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2864-2211","authenticated-orcid":false,"given":"Tadeusz","family":"Paszko","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Life Sciences in Lublin, Akademicka 15 Street, 20-950 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,26]]},"reference":[{"key":"ref_1","unstructured":"Tenkate, K., and Larid, S.A. (2019). The botanical medicine industry. The Commercial Use of Biodiversity: Access to Genetic Resources and Benefit-Sharing, Routledge. [2nd ed.]. Chapter 4."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.2174\/1389201020666190819154516","article-title":"Market analysis of medicinal plants in India","volume":"20","author":"Ravi","year":"2019","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101320","DOI":"10.1016\/j.fbio.2021.101320","article-title":"Functional importance of bioactive compounds of foods with potential health benefits: A review on recent trends","volume":"43","author":"Banwo","year":"2021","journal-title":"Food Biosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2174\/1386207323999201110192942","article-title":"Herbal medicine: Clinical perspective and regulatory status","volume":"24","author":"Barkat","year":"2021","journal-title":"Comb. Chem. High Throughput Screen"},{"key":"ref_5","first-page":"18","article-title":"Role of medicinal plants in pharmaceutical sector: An overview","volume":"10","author":"Varshney","year":"2021","journal-title":"Glob. J. Biosci. Biotechnol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.51847\/R0pcRWQc2F","article-title":"The public knowledge, attitude, and practice of using herbal medicines in Makkah province","volume":"13","author":"Haseeb","year":"2022","journal-title":"Arch. Pharm. Pract."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.22159\/ajpcr.2022.v15i12.46134","article-title":"Current status and challenges of herbal drug development and regulatory aspect: A global perspective","volume":"15","author":"Hossain","year":"2022","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Dhara, A.K., and Mandal, S.C. (2024). Market overview of herbal medicines for lifestyle diseases. Role of Herbal Medicines: Management of Lifestyle Diseases, Springer Nature. [1st ed.].","DOI":"10.1007\/978-981-99-7703-1"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.yebeh.2019.06.004","article-title":"Use of complementary and alternative medicine among adults with epilepsy in a University Epilepsy Clinic in Poland","volume":"98","author":"Bosak","year":"2019","journal-title":"Epilepsy Behav."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kasprzycka, K., Kurzawa, M., Kucharz, M., Godawska, M., Oleksa, M., Stawowy, M., S\u0142upinska-Borowka, K., Sznek, W., Gisterek, I., and Boratyn-Nowicka, A. (2022). Complementary and alternative medicine use in hospitalized cancer patients\u2014Study from Silesia, Poland. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19031600"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Melnyk, N., Vlasova, I., Skowro\u0144ska, W., Bazylko, A., Piwowarski, J.P., and Granica, S. (2022). Current knowledge on interactions of plant materials traditionally used in skin diseases in Poland and Ukraine with human skin microbiota. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23179644"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.joim.2023.10.001","article-title":"Promoting whole person health: Exploring the role of traditional Chinese medicine in Polish healthcare","volume":"21","author":"Rybicka","year":"2023","journal-title":"J. Integr. Med."},{"key":"ref_13","first-page":"393","article-title":"Hutsuls\u2019 perceptions of forests and uses of forest resource in Ukrainian and Romanian Bukovina","volume":"24","author":"Mattalia","year":"2022","journal-title":"Int. For. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1002\/ptr.6431","article-title":"Herbal medicine: Who cares? The changing views on medicinal plants and their roles in British lifestyle","volume":"33","author":"Lazarou","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ctim.2019.02.007","article-title":"Use of herbal medicines: Pilot survey of UK users\u2019 views","volume":"44","author":"Zahn","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13002-024-00706-8","article-title":"Knowledge in motion: Temporal dynamics of wild food plant use in the Polish-Lithuanian-Belarusian border region","volume":"20","author":"Prakofjewa","year":"2024","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"172502","DOI":"10.1155\/2015\/172502","article-title":"Knowledge, attitudes, and usage of apitherapy for disease prevention and treatment among undergraduate pharmacy students in Lithuania","volume":"2015","author":"Trumbeckaite","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3940397","DOI":"10.1155\/2019\/3940397","article-title":"Ethnobotanical study of cultivated plants in Kai\u0161iadorys district, Lithuania: Possible trends for new herbal based medicines","volume":"2019","author":"Pranskuniene","year":"2019","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Pranskuniene, Z., Bajoraite, R., Simaitiene, Z., and Bernatoniene, J. (2021). Home gardens as a source of medicinal, herbal and food preparations: Modern and historical approaches in Lithuania. App. Sci., 11.","DOI":"10.3390\/app11219988"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Pranskuniene, Z., Balciunaite, R., Simaitiene, Z., and Bernatoniene, J. (2022). Herbal medicine uses for respiratory system disorders and possible trends in new herbal medicinal recipes during COVID-19 in pasvalys district, Lithuania. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19158905"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"\u00dcnl\u00fcyol, D., G\u00f6k\u00e7eku\u015f, H., Kassem, Y., Tezer, M., Meri\u00e7li, F., and Yavuz, D.\u00d6. (2023). Complementary and alternative medicines in Northern Cyprus: Public awareness, patterns of use, and attitudes. Healthcare, 11.","DOI":"10.3390\/healthcare11070977"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jtcme.2016.05.006","article-title":"Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: Importance, challenges and future","volume":"7","author":"Sen","year":"2017","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_23","first-page":"1245","article-title":"Knowledge and awareness of natural anticarcinogenic herbs among the general population","volume":"14","author":"Niveditha","year":"2020","journal-title":"Drug Invent. Today"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"288","DOI":"10.51470\/PLANTARCHIVES.2022.v22.no1.045","article-title":"Public awareness about the usage of medicinal herbs found in the kitchen and their potential against COVID-19 disease","volume":"22","author":"Singh","year":"2022","journal-title":"Plant Arch."},{"key":"ref_25","first-page":"69","article-title":"Public awareness and bio-management of COVID-19 by four medicinal herbs in district Bhimber, Azad Kashmir, Pakistan: Public awareness and bio-management of COVID-19 by four medicinal herbs","volume":"58","author":"Hussain","year":"2021","journal-title":"Proc. Pak. Acad. Sci. B. Life Environ. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Zaidi, S.F., Saeed, S.A., Khan, M.A., Khan, A., Hazazi, Y., Otayn, M., Rabah, M., and Daniyal, M. (2022). Public knowledge, attitudes, and practices towards herbal medicines; a cross-sectional study in Western Saudi Arabia. BMC Complement. Med. Ther., 22.","DOI":"10.1186\/s12906-022-03783-y"},{"key":"ref_27","first-page":"49624","article-title":"Beliefs about the use of herbs before and after COVID-19: A cross-sectional study in Saudi Arabia","volume":"15","author":"Alhindi","year":"2023","journal-title":"Cureus"},{"key":"ref_28","first-page":"792","article-title":"Herbal food supplements usage awareness of university students: Example of Echinacea and St. John\u2019s Wort","volume":"7","year":"2023","journal-title":"Int. J. Agric. Environ. Food Sci."},{"key":"ref_29","first-page":"366","article-title":"Public awareness and attitude towards herbal medicine campaigns for the prevention and treatment of sexually transmitted diseases in South-East Nigeria","volume":"8","author":"Chidimma","year":"2018","journal-title":"Int. J. Sci. Res. Publ."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/ijar.ijar_4_22","article-title":"Traditional and complementary medicine in Australia: Clinical practice, research, education, and regulation","volume":"3","author":"Bhuyan","year":"2022","journal-title":"Int. J. Ayurveda Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1080\/17512433.2016.1238762","article-title":"Herbal medicines: Challenges in the modern world. Part 4. Canada and United States","volume":"9","author":"Job","year":"2016","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1177\/2374373517706612","article-title":"Prevalence and predictors of herbal mdicine use among adults in the United States","volume":"4","author":"Rashrash","year":"2017","journal-title":"J. Patient Exp."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jtcme.2016.12.014","article-title":"Pharmacological properties of Salvia officinalis and its components","volume":"7","author":"Ghorbani","year":"2017","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"330","DOI":"10.2174\/0113894501255093240117092328","article-title":"Deciphering neuroprotective effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through preclinical and clinical studies","volume":"25","author":"Oresanya","year":"2024","journal-title":"Curr. Drug Targets"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biopha.2016.11.113","article-title":"Antiproliferative effects of extracts from Salvia officinalis L. and Saliva miltiorrhiza Bunge on hepatocellular carcinoma cells","volume":"85","author":"Jiang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1515\/znc-2006-5-609","article-title":"Establishment of Salvia officinalis L. hairy root cultures for the production of rosmarinic acid","volume":"61","author":"Grzegorczyk","year":"2006","journal-title":"Z. Naturforsch C. J. Biosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1002\/ptr.3506","article-title":"Antihyperlipidemic effects of Salvia officinalis L. leaf extract in patients with hyperlipidemia: A randomized double-blind placebo-controlled clinical trial","volume":"25","author":"Kianbakht","year":"2011","journal-title":"Phytother. Res."},{"key":"ref_38","first-page":"509","article-title":"Assessment of Salvia officinalis (L.) hydroalcoholic extract for possible use in cosmetic formulation as inhibitor of pathogens in the skin","volume":"33","author":"Garcia","year":"2012","journal-title":"Rev. Ci\u00eanc. Farm. B\u00e1sica Apl."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8516153","DOI":"10.1155\/2020\/8516153","article-title":"Phytocomplex consisting of Tropaeolum majus L. and Salvia officinalis L. extracts alleviates the inflammatory response of dermal fibroblasts to bacterial lipopolysaccharides","volume":"2020","author":"Jurca","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_40","first-page":"4997","article-title":"Mouth rinse based on a tea solution of Salvia officinalis for oral discomfort in palliative cancer care: A randomized controlled trial","volume":"29","author":"Monsen","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Mot, M.D., Gavrila\u0219, S., Lupitu, A.I., Moisa, C., Chambre, D., Tit, D.M., Bogdan, M.A., Bodescu, A.M., Copolovici, L., and Copolovici, D.M. (2022). Salvia officinalis L. essential oil: Characterization, antioxidant properties, and the effects of aromatherapy in adult patients. Antioxidants, 11.","DOI":"10.3390\/antiox11050808"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Alomar, H.A., Elkady, W.M., Abdel-Aziz, M.M., Ibrahim, T.A., and Fathallah, N. (2023). Anti-Heliobacter pylori and anti-inflammatory potential of Salvia officinalis metabolites: In vitro and in silico studies. Metabolites, 13.","DOI":"10.3390\/metabo13010136"},{"key":"ref_43","first-page":"1","article-title":"Evaluation of the chemical composition and biological activities of Salvia officinalis subsp. lavandulifolia (Vahl) Gams essential oil","volume":"5","author":"Demirci","year":"2018","journal-title":"Nat. Volatiles Essent. Oils"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"420","DOI":"10.5513\/JCEA01\/22.2.3104","article-title":"Antifungal activity of Salvia officinalis subsp. lavandulifolia and Salvia officinalis subsp. major aqueous extracts against Botrytis cinerea","volume":"22","author":"Rabilu","year":"2021","journal-title":"J. Cent. Eur. Agric."},{"key":"ref_45","first-page":"1934578X221139402","article-title":"Volatile composition and enantiomeric distribution of spanish sage (Salvia officinalis subsp. lavandulifolia [Vahl] Gams) from Spain","volume":"17","author":"Dosoky","year":"2022","journal-title":"Nat. Prod. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/ptr.1911","article-title":"In vitro antiproliferative effect of six Salvia species on human tumor cell lines","volume":"20","author":"Fiore","year":"2006","journal-title":"Phytother. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1515\/znc-2006-7-804","article-title":"Cytotoxic and proapoptotic activity of diterpenoids from in vitro cultivated Salvia sclarea roots. Studies on the leukemia cell lines","volume":"61","author":"Krajewska","year":"2006","journal-title":"Z. Naturforsch. C. J. Biosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.phymed.2005.10.008","article-title":"Antimicrobial activity of diterpenoids from hairy roots of Salvia sclarea L.: Salvipisone as a potential anti-biofilm agent active against antibiotic resistant Staphylococci","volume":"14","author":"Walencka","year":"2007","journal-title":"Phytomedicine"},{"key":"ref_49","first-page":"621","article-title":"Diterpenoid production in hairy root culture of Salvia sclarea L. Z. Naturforsch","volume":"63","author":"Bruchajzer","year":"2008","journal-title":"C J. Biosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40529-015-0096-4","article-title":"Antimicrobial activity and mechanisms of Salvia sclarea essential oil","volume":"56","author":"Cui","year":"2015","journal-title":"Bot. Stud."},{"key":"ref_51","first-page":"18","article-title":"Salvia sclarea: Chemical composition and biological activity","volume":"1","author":"Kiprovski","year":"2018","journal-title":"J. Agron. Technol. Eng. Manag."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.5650\/jos.ess17187","article-title":"Phytochemical compositions and antidiabetic potentials of Salvia sclarea L. Essential Oils","volume":"67","author":"Raafat","year":"2018","journal-title":"J. Oleo Sci."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Wong, J., Chiang, Y.F., Shih, Y.H., Chiu, C.H., Chen, H.Y., Shieh, T.M., Wang, K.L., Huang, T.C., Hong, Y.H., and Hsia, S.M. (2020). Salvia sclarea L. essential oil extract and its antioxidative phytochemical sclareol inhibit oxytocin-induced uterine hypercontraction dysmenorrhea model by inhibiting the Ca2+-MLCK-MLC20 signaling cascade: An ex vivo and in vivo study. Antioxidants, 9.","DOI":"10.3390\/antiox9100991"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Zhussupova, A., Zhumaliyeva, G., Ogay, V., Issabekova, A., Ross, S.A., and Zhusupova, G.E. (2022). Immunomodulatory effects of plant extracts from Salvia deserta Schang. and Salvia sclarea L. Plants, 11.","DOI":"10.3390\/plants11202690"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ka\u010d\u00e1niov\u00e1, M., Vukovic, N.L., \u010cmikov\u00e1, N., Galovi\u010dov\u00e1, L., Schwarzov\u00e1, M., \u0160imora, V., Kowalczewski, P.\u0141., Kluz, M.I., Puchalski, C., and Bakay, L. (2023). Salvia sclarea essential oil chemical composition and biological activities. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065179"},{"key":"ref_56","first-page":"263","article-title":"Applications of Salvia in treating cognitive disorders and Alzheimer\u2019s disease","volume":"4","author":"Zdrojewicz","year":"2015","journal-title":"Post. Fitot."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.26477\/idj.v39i1.111","article-title":"Anti-inflammatory effect of sage (Salvia officinalis) extracts on oral health","volume":"39","author":"Fawzi","year":"2017","journal-title":"Iraqi Dent. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1159\/000530017","article-title":"Reduction of viral load in patients with acute sore throats: Results from an observational clinical trial with Echinacea\/Salvia Lozenges","volume":"30","author":"Weishaupt","year":"2023","journal-title":"Complement. Med. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/mutage\/geab001","article-title":"Manool, a diterpene from Salvia officinalis, exerts preventive effects on chromosomal damage and preneoplastic lesions","volume":"36","author":"Nicolella","year":"2021","journal-title":"Mutagenesis"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"102245","DOI":"10.1016\/j.ctim.2019.102245","article-title":"Efficacy of Salvia officinalis extract on the prevention of insulin resistance in euglycemic patients with polycystic ovary syndrome: A double-blinded placebo-controlled clinical trial","volume":"48","author":"Amini","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11011-022-01063-9","article-title":"Natural remedies for Alzheimer\u2019s disease: A systematic review of randomized controlled trials","volume":"38","author":"Ahmad","year":"2023","journal-title":"Metab. Brain Dis."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ertas, A., Yigitkan, S., and Orhan, I.E. (2023). A focused review on cognitive improvement by the genus Salvia L. (Sage)-from ethnopharmacology to clinical evidence. Pharmaceuticals, 16.","DOI":"10.3390\/ph16020171"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Franc\u00e9s, V., Hahn, E., R\u00edos, S., Rivera, D., Reich, E., Vila, R., and Ca\u00f1igueral, S. (2017). Ethnopharmacological and chemical characterization of Salvia species used in valencian traditional herbal preparations. Front. Pharmacol., 8.","DOI":"10.3389\/fphar.2017.00467"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jep.2017.01.020","article-title":"Anti-inflammatory effect of the Salvia sclarea L. ethanolic extract on lipopolysaccharide-induced periodontitis in rats","volume":"199","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1016\/j.sjbs.2021.06.068","article-title":"Chromatographic profiles and antimicrobial activity of the essential oils obtained from some species and cultivars of the mentheae tribe (Lamiaceae)","volume":"28","author":"Shanaida","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_66","first-page":"5757","article-title":"Minerals, proximate composition and their correlations of medicinal plants from Jordan","volume":"6","author":"Khalil","year":"2012","journal-title":"J. Med. Plant Res."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Dziadek, K., Kope\u0107, A., Dziadek, M., Sadowska, U., and Cholewa-Kowalska, K. (2022). The changes in bioactive compounds and antioxidant activity of chia (Salvia hispanica L.) herb under storage and different drying conditions: A comparison with other species of sage. Molecules, 27.","DOI":"10.3390\/molecules27051569"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/IJBCRR\/2018\/43273","article-title":"Nutrients and constituents relevant to antioxidant, antimicrobial and anti-breast cancer properties of Salvia officinalis L","volume":"23","author":"Darwish","year":"2018","journal-title":"Int. J. Biochem. Res. Rev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"143","DOI":"10.15414\/afz.2024.27.02.143-150","article-title":"Effects of sage (Salvia officinalis L.) supplementation in hen diets on laying productivity, egg quality, and biochemical parameters","volume":"27","author":"Todorova","year":"2024","journal-title":"Acta Fytotech. Zootech."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11","DOI":"10.21608\/mjab.2021.169121","article-title":"A comparative study between green tea (Camellia sinensis) and common sage (Salvia officinalis) (chemical composition and active compounds)","volume":"6","author":"Draz","year":"2021","journal-title":"Menoufia J. Agric. Biotech."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.anifeedsci.2008.04.006","article-title":"Fatty acid and nutritive quality of chia (Salvia hispanica L.) seeds and plant during growth","volume":"148","author":"Peiretti","year":"2009","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"20230115","DOI":"10.1515\/chem-2023-0115","article-title":"Impact of climatic disturbances on the chemical compositions and metabolites of Salvia officinalis","volume":"21","author":"Laftouhi","year":"2023","journal-title":"Open Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e1900021","DOI":"10.1002\/mnfr.201900021","article-title":"Chia (Salvia hispanica L.) seed total protein and protein fractions digests reduce biomarkers of inflammation and atherosclerosis in macrophages in vitro","volume":"63","author":"Grancieri","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.lwt.2015.05.033","article-title":"Inhibitory activity of chia (Salvia hispanica L.) protein fractions against angiotensin I-converting enzyme and antioxidant capacity","volume":"64","author":"Valverde","year":"2015","journal-title":"LWT\u2014Food Sci. Technol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1046\/j.1432-1327.2000.01141.x","article-title":"Biochemical and functional characterization of the Tn-specific lectin from Salvia sclarea seeds","volume":"267","author":"Medeiros","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"ref_76","first-page":"560","article-title":"Growth characteristics and changes in the active ingredients of Salvia mirzayanii essential oil under foliar application of humic acid and amino acid","volume":"13","author":"Bahadour","year":"2023","journal-title":"J. Med. Plants By-Prod."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Farruggia, D., Di Miceli, G., Licata, M., Leto, C., Salamone, F., and Novak, J. (2024). Foliar application of various biostimulants produces contrasting response on yield, essential oil and chemical properties of organically grown sage (Salvia officinalis L.). Front. Plant Sci., 15.","DOI":"10.3389\/fpls.2024.1397489"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1007\/s42729-021-00608-8","article-title":"Nutritive composition, growth, biochemical traits, essential oil content and compositions of Salvia officinalis L. grown in different nitrogen levels in soilless culture","volume":"21","author":"Khammar","year":"2021","journal-title":"J. Soil. Sci. Plant Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s10600-011-9976-3","article-title":"Amino-acid and monosaccharide compositions of Salvia officinalis leaves","volume":"47","author":"Koshevoi","year":"2011","journal-title":"Chem. Nat. Compd."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"33","DOI":"10.24959\/nphj.16.2071","article-title":"The amino-acid and monosaccharide composition of a dry extract from Salvia officinalis leaves obtained by complex processing","volume":"1","author":"Vovk","year":"2016","journal-title":"News Pharm."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Oh, G.S., Lee, J.H., Byun, K., Kim, D.I., and Park, K.D. (2022). Effect of intake of leucine-rich protein supplement in parallel with resistance exercise on the body composition and function of healthy adults. Nutrients, 14.","DOI":"10.3390\/nu14214501"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/jn\/nxaa006","article-title":"Leucine supplementation increases muscle strength and volume, reduces inflammation, and affects wellbeing in adults and adolescents with cerebral palsy","volume":"151","author":"Theis","year":"2021","journal-title":"J. Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Kang, Y., Kim, N., Choi, Y.J., Lee, Y., Yun, J., Park, S.J., and Park, Y.K. (2020). Supplementation increases lean body mass in healthy Korean adults aged 50 years and older: A randomized, double-blind, placebo-controlled trial. Nutrients, 12.","DOI":"10.3390\/nu12061816"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/jcsm.12208","article-title":"Beta-hydroxy-beta-methylbutyrate supplementation and skeletal muscle in healthy and muscle-wasting conditions","volume":"8","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle (JCSM)"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2478\/hukin-2019-0070","article-title":"Mechanism of action and the effect of Beta-Hydroxy-Beta-Methylbutyrate (HMB) supplementation on different types of physical performance\u2014A systematic review","volume":"68","author":"Kaczka","year":"2019","journal-title":"J. Hum. Kinet."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"00346","DOI":"10.1042\/BSR20160096","article-title":"Leucine alleviates dexamethasone-induced suppression of muscle protein synthesis via synergy involvement of mTOR and AMPK pathways","volume":"36","author":"Wang","year":"2016","journal-title":"Biosci. Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/J.ENG.2017.03.008","article-title":"Leucine supplementation in a chronically protein-restricted diet enhances muscle weight and postprandial protein synthesis of skeletal muscle by promoting the mTOR pathway in adult rats","volume":"3","author":"Zhang","year":"2017","journal-title":"Engineering"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Cholewa, J., Shang, H., Yang, Y., Ding, X., Liu, S., Xia, Z., Zanchi, N.E., and Wang, Q. (2021). Exercise may promote skeletal muscle hypertrophy via enhancing leucine-sensing: Preliminary evidence. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.741038"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"33076","DOI":"10.1074\/jbc.M507201200","article-title":"hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase","volume":"280","author":"Byfield","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_90","first-page":"222","article-title":"Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis","volume":"11","author":"Drummond","year":"2008","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Cholewa, J., Shang, H., Yang, Y., Ding, X., Wang, Q., Su, Q., Zanchi, N.E., and Xia, Z. (2021). Advances in the role of leucine-sensing in the regulation of protein synthesis in aging skeletal muscle. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.646482"},{"key":"ref_92","first-page":"71","article-title":"Importance of aromatic amino acids phenylalanine and tyrosine in fish nutrition","volume":"29","author":"Rodrigues","year":"2019","journal-title":"Ci\u00eanc. Anim."},{"key":"ref_93","unstructured":"Surguchov, A. (2020). Role of phenylalanine and its metabolites in health and neurological disorders. Synucleins\u2014Biochemisty and Role in Diseases, IntechOpen. Chapter 5."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3934\/Neuroscience.2020002","article-title":"The many faces of thyroxine","volume":"7","author":"Dratman","year":"2020","journal-title":"AIMS Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1093\/schbul\/sbz138","article-title":"Assessing the causal effects of human serum metabolites on 5 major psychiatric disorders","volume":"46","author":"Yang","year":"2020","journal-title":"Schizophr. Bull."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"15165","DOI":"10.1111\/exd.15165","article-title":"The amino acid transporter SLC16A10 promotes melanogenesis by facilitating the transportation of phenylalanine","volume":"33","author":"Luo","year":"2024","journal-title":"Exp. Dermatol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/1523-1747.ep12519975","article-title":"Phenylalanine lowers melanin synthesis in mammalian melanocytes by reducing tyrosinase uptake: Implications for pigment reduction in phenylketonuria","volume":"74","author":"Farishian","year":"1980","journal-title":"J. Investig. Dermatol."},{"key":"ref_98","first-page":"423","article-title":"Serum tyrosine-to-phenylalanine ratio is low in Parkinson\u2019s disease","volume":"6","author":"Hirayama","year":"2016","journal-title":"J. Park. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jpsychires.2018.01.019","article-title":"13C-phenylalanine breath test and serum biopterin in schizophrenia, bipolar disorder and major depressive disorder","volume":"99","author":"Teraishi","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"219","DOI":"10.20471\/dec.2023.59.02.05","article-title":"Comparative effect between antidepressants and D-phenylalanine, a phenethylamine precursor, in an animal model of depression","volume":"59","author":"Guevara","year":"2023","journal-title":"Arch. Psychiatry Res."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Li, S., Song, H., and Yu, C. (2024). Causal association between phenylalanine and Parkinson\u2019s disease: A two-sample bidirectional mendelian randomization study. Front. Genet., 15.","DOI":"10.3389\/fgene.2024.1322551"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Shebl, N., El-Jaafary, S., Saeed, A.A., Elkafrawy, P., El-Sayed, A., Shamma, S., Elnemr, R., Mekky, J., Mohamed, L.A., and Kittaneh, O. (2024). Metabolomic profiling reveals altered phenylalanine metabolism in Parkinson\u2019s disease in an Egyptian cohort. Front. Mol. Biosci., 11.","DOI":"10.3389\/fmolb.2024.1341950"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuint.2004.08.002","article-title":"Allosteric modulation of GABA(B) receptor function in human frontal cortex","volume":"46","author":"Olianas","year":"2005","journal-title":"Neurochem. Int."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.2174\/1381612821666150914121624","article-title":"GABA receptors: Pharmacological potential and pitfalls","volume":"21","author":"Jembrek","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13023-023-02770-x","article-title":"Aspartame and Phenylketonuria: An analysis of the daily phenylalanine intake of aspartame-containing drugs marketed in France","volume":"18","author":"Maler","year":"2023","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1210\/clinem\/dgad268","article-title":"Low circulating valine associate with high risk of hip fractures","volume":"108","author":"Grahnemo","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s40995-020-01031-x","article-title":"In vitro antidiabetic activity of free amino acids and protein amino acid extracts from four Iranian medicinal plants","volume":"45","author":"Siahbalaei","year":"2021","journal-title":"Iran. J. Sci. Technol. Trans. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/bbb\/zbad169","article-title":"Valine improves mitochondrial function and protects against oxidative stress","volume":"88","author":"Sharma","year":"2024","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41586-021-04244-1","article-title":"Valine tRNA levels and availability regulate complex I assembly in leukaemia","volume":"601","author":"Thandapani","year":"2022","journal-title":"Nature"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"23","DOI":"10.15587\/2519-4852.2020.197299","article-title":"Phytochemical study of Salvia grandiflora and Salvia officinalis leaves for establishing prospects for use in medical and pharmaceutical practice","volume":"1","author":"Myha","year":"2020","journal-title":"ScienceRise Pharm. Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"14069","DOI":"10.1016\/S0021-9258(18)66982-0","article-title":"Isolation and characterization of an N-acetylgalactosamine specific lectin from Salvia sclarea seeds","volume":"261","author":"Piller","year":"1986","journal-title":"J. Biol. Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s10600-010-9688-0","article-title":"A comparative study of the fatty acid composition and lipid content of Salvia sclarea","volume":"46","author":"Kara","year":"2010","journal-title":"Chem. Nat. Compd."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"239539","DOI":"10.1590\/1519-6984.239539","article-title":"Biochemical parameters and antioxidant property of three Salvia L. taxa endemic in Turkey","volume":"82","author":"Emre","year":"2021","journal-title":"Braz. J. Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1515\/znc-2004-5-601","article-title":"Fatty acid and tocochromanol patterns of some Salvia L. species","volume":"59","author":"Bagci","year":"2004","journal-title":"Z. Naturforsch. C J. Biosci. C"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Carta, G., Murru, E., Banni, S., and Manca, C. (2017). Palmitic acid: Physiological role, metabolism, and nutritional implications. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00902"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1740-8709.2011.00300.x","article-title":"Dietary lipids from an evolutionary perspective: Sources, structures and functions","volume":"7","author":"German","year":"2011","journal-title":"Matern. Child Nutr."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1080\/10408398.2015.1018045","article-title":"Palmitic acid in early human development","volume":"56","author":"Innis","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00011-019-01273-5","article-title":"The effect of palmitic acid on inflammatory response in macrophages: An overview of molecular mechanisms","volume":"68","author":"Korbecki","year":"2019","journal-title":"Inflamm. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cellsig.2015.10.001","article-title":"Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression","volume":"28","author":"Rueda","year":"2016","journal-title":"Cell. Signal."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1210\/endo.142.8.8293","article-title":"Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells","volume":"142","author":"Mu","year":"2001","journal-title":"Endocrinology"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0006-291X(03)00449-2","article-title":"Saturated free fatty acids, palmitic acid and stearic acid, induce apoptosis by stimulation of ceramide generation in rat testicular Leydig cell","volume":"303","author":"Lu","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.clnu.2024.12.012","article-title":"Stearic acid metabolism in human health and disease","volume":"44","author":"Shen","year":"2024","journal-title":"Clin. Nutr."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1473-2165.2010.00510.x","article-title":"Original Contribution: Stearic acid delivery to corneum from a mild and moisturizing cleanser","volume":"9","author":"Mukherjee","year":"2010","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/ics.12042","article-title":"Stratum corneum fatty acids: Their critical role in preserving barrier integrity during cleansing","volume":"35","author":"Ananthapadmanabhan","year":"2013","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Pereira-Leite, C., Bom, M., Ribeiro, A., Almeida, C., and Rosado, C. (2023). Exploring stearic-acid-based nanoparticles for skin applications\u2014Focusing on stability and cosmetic benefits. Cosmetics, 10.","DOI":"10.3390\/cosmetics10040099"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1021\/acs.molpharmaceut.3c00126","article-title":"Natural ingredients of transdermal drug delivery systems as permeation enhancers of active substances through the stratum corneum","volume":"20","author":"Schafer","year":"2023","journal-title":"Mol. Pharm."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/ajcn\/73.4.715","article-title":"Influence of a stearic acid\u2013rich structured triacylglycerol on postprandial lipemia, factor VII concentrations, and fibrinolytic activity in healthy subjects","volume":"73","author":"Sanders","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1007\/s11745-005-1489-7","article-title":"Influence of stearic acid on postprandial lipemia and hemostatic function","volume":"40","author":"Sanders","year":"2005","journal-title":"Lipids"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1745-7254.2007.00512.x","article-title":"Stearic acid protects primary cultured cortical neurons against oxidative stress","volume":"28","author":"Wang","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s11745-005-1486-x","article-title":"Effects of stearic acid on plasma lipid and lipoproteins in humans","volume":"40","author":"Mensink","year":"2005","journal-title":"Lipids"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1080\/01635580902825597","article-title":"Stearate preferentially induces apoptosis in human breast cancer cells","volume":"61","author":"Evans","year":"2009","journal-title":"Nutr. Cancer"},{"key":"ref_132","first-page":"14013","article-title":"Myristic acid reduces skin inflammation and nociception","volume":"46","year":"2022","journal-title":"J. Food Biochem."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Tanjung, C., Harris, C.P., Demmelmair, H., Dwitya, S., Munasir, Z., Sudoyo, H., Standl, M., Sjarif, D.R., and Koletzko, B. (2022). Novel interactions of myristic acid and FADS3 variants predict atopic dermatitis among Indonesian infants. Nutrients, 14.","DOI":"10.3390\/nu14214676"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.earlhumdev.2017.08.009","article-title":"Myristic acid in amniotic fluid produces appetitive responses in human newborns","volume":"115","author":"Contreras","year":"2017","journal-title":"Early Hum. Dev."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"19473","DOI":"10.1021\/acsami.8b05235","article-title":"Myristic acid-modified DA7R peptide for whole-process glioma-targeted drug delivery","volume":"10","author":"Ying","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1093\/jn\/nxaa202","article-title":"The positive association between plasma myristic acid and ApoCIII concentrations in cardiovascular disease patients is supported by the effects of myristic acid in HepG2 cells","volume":"150","author":"Olivieri","year":"2020","journal-title":"J. Nutr."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Yuan, S., Li, X., Morange, P.E., Bruzelius, M., Larsson, S.C., and Invent Consortium (2022). Plasma phospholipid fatty acids and risk of venous thromboembolism: Mendelian randomization investigation. Nutrients, 14.","DOI":"10.3390\/nu14163354"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"104676","DOI":"10.1016\/j.tifs.2024.104676","article-title":"Advances of \u03b1-linolenic acid: Sources, extraction, biological activity and its carrier","volume":"152","author":"Zhu","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1089\/jmf.2012.0137","article-title":"Chronic food administration of Salvia sclarea oil reduces animals\u2019 anxious and dominant behavior","volume":"16","author":"Gross","year":"2013","journal-title":"J. Med. Food."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Saini, R.K., Prasad, P., Sreedhar, R.V., Naidu, K.A., Shang, X., and Keum, Y.S. (2021). Omega-3 polyunsaturated fatty acids (PUFAs): Emerging plant and microbial sources, oxidative stability, bioavailability, and health benefits-a review. Antioxidants, 10.","DOI":"10.3390\/antiox10101627"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1021\/acs.jproteome.1c00208","article-title":"Targeted metabolic profiling and PRM analysis of proteins revealed impaired polyunsaturated fatty acid metabolism and GTP metabolism in the brainstem of spontaneously hypertensive rats","volume":"20","author":"Zhou","year":"2021","journal-title":"J. Proteome Res."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Iino, T., Toh, R., Nagao, M., Shinohara, M., Harada, A., Murakami, K., Irino, Y., Nishimori, M., Yoshikawa, S., and Seto, Y. (2021). Effects of elaidic acid on HDL cholesterol uptake capacity. Nutrients, 13.","DOI":"10.3390\/nu13093112"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000449205","article-title":"Elaidic acid, a trans-fatty acid, enhances the metastasis of colorectal cancer cells","volume":"84","author":"Ohmori","year":"2017","journal-title":"Pathobiology"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1017\/S0007114510004885","article-title":"Distinct effects of oleic acid and its trans-isomer elaidic acid on the expression of myokines and adipokines in cell models","volume":"105","author":"Granados","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"286","DOI":"10.18006\/2020.8(Spl-2-AABAS).S286.S291","article-title":"Phenolics and ascorbic contents in two sage (Salvia sps. L) species","volume":"8","author":"Bimenyindavyi","year":"2020","journal-title":"J. Exp. Biol. Agric. Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1093\/jxb\/erad505","article-title":"The ascorbate biosynthesis pathway in plants is known, but there is a way to go with understanding control and functions","volume":"75","author":"Smirnoff","year":"2024","journal-title":"J. Exp. Bot."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Afonso, A.F., Pereira, O.R., and Cardoso, S.M. (2021). Salvia species as nutraceuticals: Focus on antioxidant, antidiabetic and anti-obesity properties. Appl. Sci., 11.","DOI":"10.3390\/app11209365"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1089\/ars.2013.5205","article-title":"Role of vitamin C in the function of the vascular endothelium","volume":"19","author":"May","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Orywal, K., Socha, K., Iwaniuk, P., Kaczy\u0144ski, P., Farhan, J.A., Zo\u0144, W., \u0141ozowicka, B., Perkowski, M., and Mroczko, B. (2025). Vitamins in the prevention and support therapy of neurodegenerative diseases. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26031333"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Kocot, J., Luchowska-Kocot, D., Kie\u0142czykowska, M., Musik, I., and Kurzepa, J. (2017). Does Vitamin C influence neurodegenerative diseases and psychiatric disorders?. Nutrients, 9.","DOI":"10.3390\/nu9070659"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Rai, S.N., Singh, P., Steinbusch, H.W.M., Vamanu, E., Ashraf, G., and Singh, M.P. (2021). The role of vitamins in neurodegenerative disease: An update. Biomedicines, 9.","DOI":"10.3390\/biomedicines9101284"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"766","DOI":"10.2174\/1871527320666211119122150","article-title":"Role of vitamins in neurodegenerative diseases: A review","volume":"21","author":"Kumar","year":"2022","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12967-017-1179-7","article-title":"The role of vitamin C in the treatment of pain: New insights","volume":"15","author":"Carr","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Mahmoudi, M., and Rezaei, N. (2019). Vitamin C and the immune system. Nutrition and Immunity, Springer. [1st ed.]. Chapter 4.","DOI":"10.1007\/978-3-030-16073-9"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"110231","DOI":"10.1016\/j.vetimm.2021.110231","article-title":"Rutin, \u03b1-tocopherol, and l-ascorbic acid up-regulate type I interferon-regulated gene and type I and II interferon expressions and reduce inflammatory cytokine expressions in monocyte-derived macrophages infected with highly pathogenic porcine reproductive and respiratory syndrome virus","volume":"235","author":"Suebsaard","year":"2021","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"10467","DOI":"10.1016\/j.heliyon.2022.e10467","article-title":"Structure-antiradical activity relationships of 25 natural antioxidant phenolic compounds from different classes","volume":"8","author":"Moazzen","year":"2022","journal-title":"Heliyon"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jpba.2015.01.043","article-title":"Metabolic profile of miltirone in rats by high performance liquid chromatography\/quadrupole time-of-flight mass spectrometry","volume":"107","author":"Guo","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_158","first-page":"299","article-title":"A review study of therapeutic effects of Salvia officinalis L","volume":"8","author":"Miraj","year":"2016","journal-title":"Pharm. Lett."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1055\/a-1087-8276","article-title":"Current state of the art on the antioxidant activity of sage (Salvia spp.) and its bioactive components","volume":"86","author":"Poulios","year":"2020","journal-title":"Planta Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1021\/acschemneuro.2c00227","article-title":"Anticonvulsive and neuroprotective effects of eupafolin in rats are associated with the inhibition of glutamate overexcitation and upregulation of the Wnt\/\u03b2-Catenin signaling pathway","volume":"13","author":"Jean","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1021\/jf011314o","article-title":"Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method","volume":"50","author":"Miura","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Mervi\u0107, M., Bival \u0160tefan, M., Kindl, M., Bla\u017eekovi\u0107, B., Marijan, M., and Vladimir-Kne\u017eevi\u0107, S. (2022). Comparative antioxidant; anti-acetylcholinesterase and anti-\u03b1-glucosidase activities of Mediterranean Salvia species. Plants, 11.","DOI":"10.3390\/plants11050625"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0168-9452(02)00052-3","article-title":"Phenolic antioxidant compounds produced by in vitro shoots of sage (Salvia officinalis L.)","volume":"162","author":"Seabra","year":"2002","journal-title":"Plant Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1365\/s10337-007-0278-7","article-title":"Development and validation of a LC method for the analysis of phenolic acids in Turkish Salvia species","volume":"66","author":"Kan","year":"2007","journal-title":"Chromatographia"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.indcrop.2013.06.047","article-title":"Characterization and quantification of phenolic compounds and antioxidant properties of Salvia species growing in different habitats","volume":"49","author":"Farhat","year":"2013","journal-title":"Ind. Crop. Prod."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"305","DOI":"10.5513\/JCEA01\/20.1.2144","article-title":"Rosmarinic acid content in selected varieties of sage (Salvia officinalis L.)","volume":"20","year":"2019","journal-title":"J. Cent. Eur. Agric."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4103\/0973-1296.93316","article-title":"Comparative study of rosmarinic acid content in some plants of Labiatae family","volume":"8","author":"Shekarchi","year":"2012","journal-title":"Pharmacogn. Mag."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.sajb.2022.07.030","article-title":"The characterization of phenolic compounds via LC-ESI-MS\/MS, antioxidant, enzyme inhibitory activities of Salvia absconditiflora, Salvia sclarea, and Salvia palaestina: A comparative analysis","volume":"150","author":"Onder","year":"2022","journal-title":"S. Afr. J. Bot."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Luo, C., Zou, L., Sun, H., Peng, J., Gao, C., Bao, L., Ji, R., Jin, Y., and Sun, S. (2020). A review of the anti-inflammatory effects of rosmarinic acid on inflammatory diseases. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00153"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"106421","DOI":"10.1016\/j.phrs.2022.106421","article-title":"Anxiolytic and antidepressive potentials of rosmarinic acid: A review with a focus on antioxidant and anti-inflammatory effects","volume":"184","author":"Dahchour","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12272-022-01378-2","article-title":"Biomedical features and therapeutic potential of rosmarinic acid","volume":"45","author":"Noor","year":"2022","journal-title":"Arch. Pharm. Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tifs.2022.07.001","article-title":"Beyond aroma: A review on advanced extraction processes from rosemary (Rosmarinus officinalis) and sage (Salvia officinalis) to produce phenolic acids and diterpenes","volume":"127","author":"Pizani","year":"2022","journal-title":"Trends Food Sci. Technol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.47495\/okufbed.1385154","article-title":"In vitro callus culture of Salvia officinalis L. and the effect of some amino acids on rosmarinic acid accumulation","volume":"7","author":"Duran","year":"2024","journal-title":"Osman. Korkut Ata \u00dcniv. Fen Biliml. Enstit\u00fcs\u00fc Derg."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s43088-024-00498-6","article-title":"Chemical composition, antioxidant, cytotoxic, antiviral, and lung-protective activities of Salvia officinalis L. ethanol extract herb growing in Sinai, Egypt","volume":"13","author":"Amer","year":"2024","journal-title":"Beni-Suef Univ. J. Basic. Appl. Sci."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Pavi\u0107, V., Jakovljevi\u0107, M., Molnar, M., and Joki\u0107, S. (2019). Extraction of carnosic acid and carnosol from sage (Salvia officinalis L.) leaves by supercritical fluid extraction and their antioxidant and antibacterial activity. Plants, 8.","DOI":"10.3390\/plants8010016"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2602454","DOI":"10.1155\/2023\/2602454","article-title":"Antioxidant, antimicrobial activities, and characterization of phenolic compounds of thyme (Thymus vulgaris L.), sage (Salvia officinalis L.), and thyme\u2013sage mixture extracts","volume":"2023","author":"Mokhtari","year":"2023","journal-title":"J. Food Qual."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"506","DOI":"10.5530\/pj.2021.13.64","article-title":"Chemical composition, antioxidant and anti-inflammatory properties of Salvia officinalis extract from Algeria","volume":"13","author":"Boufadi","year":"2021","journal-title":"Pharmacogn. J."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Margetts, G., Kleidonas, S., Zaibi, N.S., Zaibi, M.S., and Edwards, K.D. (2022). Evidence for anti-inflammatory effects and modulation of neurotransmitter metabolism by Salvia officinalis L. BMC Complement. Med. Ther., 22.","DOI":"10.1186\/s12906-022-03605-1"},{"key":"ref_179","first-page":"4512","article-title":"Study the molecular mechanism of Salvia species in prevention of diabetes","volume":"9","author":"Mahdizadeh","year":"2018","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"112763","DOI":"10.1016\/j.jpba.2019.07.011","article-title":"Rosmarinic and carnosic acid contents and correlated antioxidant and antidiabetic activities of 14 Salvia species from Anatolia","volume":"175","author":"Dirmenci","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Rashed, A.A., and Rathi, D.N.G. (2021). Bioactive components of Salvia and their potential antidiabetic properties: A review. Molecules, 26.","DOI":"10.3390\/molecules26103042"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Bahri, S., Mies, F., Ben Ali, R., Mlika, M., Jameleddine, S., Mc Entee, K., and Shlyonsky, V. (2017). Rosmarinic acid potentiates carnosic acid induced apoptosis in lung fibroblasts. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184368"},{"key":"ref_183","first-page":"14226","article-title":"Investigation of cytotoxic and apoptotic effects of 63 compounds obtained from Salvia species: Promising anticancer agents","volume":"46","author":"Fidan","year":"2022","journal-title":"J. Food Biochem."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Brindisi, M., Bouzidi, C., Frattaruolo, L., Loizzo, M.R., Tundis, R., Dugay, A., Deguin, B., Cappello, A.R., and Cappello, M.S. (2020). Chemical profile, antioxidant, anti-inflammatory, and anti-cancer effects of Italian Salvia rosmarinus Spenn. methanol leaves extracts. Antioxidants, 9.","DOI":"10.3390\/antiox9090826"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s43450-023-00489-1","article-title":"Chemical constituents and anti-inflammatory, antinociceptive, and antioxidant activities of Salvia melissiflora aerial parts","volume":"34","author":"Oliveira","year":"2024","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"108600","DOI":"10.1016\/j.biopha.2019.108600","article-title":"Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action","volume":"112","author":"Elufioye","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1039\/D1FO02988F","article-title":"Insights into the neuroprotective effects of Salvia officinalis L. and Salvia microphylla Kunth in the memory impairment rat model","volume":"13","author":"Ayoub","year":"2022","journal-title":"Food Funct."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Faridzadeh, A., Salimi, Y., Ghasemirad, H., Kargar, M., Rashtchian, A., Mahmoudvand, G., Karimi, M.A., Zerangian, N., Jahani, N., and Masoudi, A. (2022). Neuroprotective potential of aromatic herbs: Rosemary, sage, and lavender. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.909833"},{"key":"ref_189","first-page":"108","article-title":"Evaluation of Salvia rosmarinus and Coriandrum sativum as chemopreventive agents in induced oral squamous cell carcinoma (an experimental study)","volume":"50","author":"Abdelmoez","year":"2025","journal-title":"Alex. Dental J."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.fct.2012.12.036","article-title":"Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions","volume":"55","author":"Russo","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Zhao, J., Xu, L., Jin, D., Xin, Y., Tian, L., Wang, T., Zhao, D., Wang, Z., and Wang, J. (2022). Rosmarinic acid and related dietary supplements: Potential applications in the prevention and treatment of cancer. Biomolecules, 12.","DOI":"10.3390\/biom12101410"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Musolino, V., Macr\u00ec, R., Cardamone, A., Tucci, L., Serra, M., Lupia, C., Maurotti, S., Mare, R., Nucera, S., and Guarnieri, L. (2023). Salvia rosmarinus spenn. (Lamiaceae) hydroalcoholic extract: Phytochemical analysis, antioxidant activity and in vitro evaluation of fatty acid accumulation. Plants, 12.","DOI":"10.3390\/plants12183306"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Baptista, A., Menicucci, F., Brunetti, C., dos Santos Nascimento, L.B., Pasquini, D., Alderotti, F., Detti, C., Ferrini, F., and Gori, A. (2024). Unlocking the hidden potential of rosemary (Salvia rosmarinus Schleid): New insights into phenolics, terpenes, and antioxidants of Mediterranean cultivars. Plants, 13.","DOI":"10.3390\/plants13233395"},{"key":"ref_194","first-page":"1118","article-title":"Screening of Salvia L. species from Iran for antioxidant activity and evaluation of rosmarinic acid content to meet highly active extract","volume":"13","author":"Hashempour","year":"2024","journal-title":"J. Med. Plants By-Prod."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"110003","DOI":"10.1016\/j.intimp.2023.110003","article-title":"Rosmarinic acid ameliorates skin inflammation and pruritus in allergic contact dermatitis by inhibiting mast cell-mediated MRGPRX2\/PLC\u03b31 signaling pathway","volume":"117","author":"Ding","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1346-8138.2008.00565.x","article-title":"Effect of rosmarinic acid on atopic dermatitis","volume":"35","author":"Lee","year":"2008","journal-title":"J. Dermatol."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Shim, K.S., Kim, H.J., Ji, K.Y., Jung, D.H., Park, S.H., Song, H.K., Kim, T., and Kim, K.M. (2024). Rosmarinic acid ameliorates dermatophagoides farinae extract-induced atopic dermatitis-like skin inflammation by activating the Nrf2\/HO-1 signaling pathway. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252312737"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Kowalczyk, A., Tuberoso, C.I.G., and Jerkovi\u0107, I. (2024). The role of rosmarinic acid in cancer prevention and therapy: Mechanisms of antioxidant and anticancer activity. Antioxidants, 13.","DOI":"10.3390\/antiox13111313"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.compbiolchem.2018.05.005","article-title":"New insights into the in vitro biological effects, in silico docking and chemical profile of clary sage\u2014Salvia sclarea L","volume":"75","author":"Zengin","year":"2018","journal-title":"Comput. Biol. Chem."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"801","DOI":"10.31925\/farmacia.2019.5.8","article-title":"Evaluation of polyphenolic profile and antioxidant activity for some Salvia species","volume":"67","author":"Hanganu","year":"2019","journal-title":"Farmacia"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Mao, J.L., Wang, L., Chen, S.J., Yan, B., Xun, L.Y., Li, R.C., Wang, P.C., and Zhao, Q.T. (2023). Design, synthesis, antiviral activities of ferulic acid derivatives. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1133655"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1007\/s00044-023-03134-7","article-title":"Synthesis of indole-based ferulic acid derivatives and in vitro evaluation of antiviral activity against SARS-CoV-2","volume":"32","author":"Verzola","year":"2023","journal-title":"Med. Chem. Res."},{"key":"ref_203","first-page":"247","article-title":"Antimicrobial activity of ferulic acid in Indonesian purple rice through toll-like receptor signaling","volume":"25","author":"Wijayanti","year":"2021","journal-title":"Makara J. Sci."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"3598000","DOI":"10.1155\/2021\/3598000","article-title":"Cytotoxic and antifungal amides derived from ferulic acid: Molecular docking and mechanism of action","volume":"2021","author":"Silva","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jphotobiol.2018.05.026","article-title":"Ferulic acid photoprotective properties in association with UV filters: Multifunctional sunscreen with improved SPF and UVA-PF","volume":"185","author":"Peres","year":"2018","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1016\/j.matpr.2020.02.625","article-title":"Ferulic acid surface modified silica polymer nanocomposites (SMS\/FA) for antioxidant and antifungal activities","volume":"26","author":"Dubey","year":"2020","journal-title":"Mater. Today Proc."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1134\/S1070427222120096","article-title":"A UV spectroscopic study of the photoprotective properties of troxerutin, ferulic acid, and aqueous extracts of Melissa officinalis and Mentha piperita","volume":"95","author":"Larionov","year":"2022","journal-title":"Russ. J. Appl. Chem."},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Alam, M.A. (2019). Anti-hypertensive effect of cereal antioxidant ferulic acid and its mechanism of action. Front. Nutr., 6.","DOI":"10.3389\/fnut.2019.00121"},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Mancuso, A., Cristiano, M.C., Pandolfo, R., Greco, M., Fresta, M., and Paolino, D. (2021). Improvement of ferulic acid antioxidant activity by multiple emulsions: In vitro and in vivo evaluation. Nanomaterials, 11.","DOI":"10.3390\/nano11020425"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1080\/08923973.2020.1733012","article-title":"Ferulic acid alleviates atopic dermatitis-like symptoms in mice via its potent anti-inflammatory effect","volume":"42","author":"Zhou","year":"2020","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s13273-021-00219-5","article-title":"Ferulic acid exhibits anti-inflammatory effects by inducing autophagy and blocking NLRP3 inflammasome activation","volume":"18","author":"Liu","year":"2022","journal-title":"Mol. Cell. Toxicol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.2174\/1381612826666201020163331","article-title":"Activity in topical formulations: Technological and scientific prospecting","volume":"27","author":"Cavalcanti","year":"2021","journal-title":"Curr. Pharm. Des."},{"key":"ref_213","first-page":"388","article-title":"Ferulic acid: Potential therapeutic applications","volume":"122","author":"Dragan","year":"2018","journal-title":"Rev. Med. Chir. Soc. Med. Nat. Ia\u015fi."},{"key":"ref_214","first-page":"100063","article-title":"A critical appraisal on ferulic acid: Biological profile, biopharmaceutical challenges and nano formulations","volume":"5","author":"Raj","year":"2022","journal-title":"Health Sci. Rev."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"001801","DOI":"10.1136\/openhrt-2021-001801","article-title":"Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity","volume":"9","author":"DiNicolantonio","year":"2022","journal-title":"Open Heart"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"11321","DOI":"10.1021\/acsomega.3c07289","article-title":"Preparation, characterization, antioxidant activities, and determination of anti-Alzheimer effects of PLGA-based DDSs containing ferulic acid","volume":"9","author":"Ozturk","year":"2024","journal-title":"ACS Omega"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"111291","DOI":"10.1016\/j.cellsig.2024.111291","article-title":"Potential utilization of ferulic acid and its derivatives in the management of metabolic diseases and disorders: An insight into mechanisms","volume":"121","author":"Khatun","year":"2024","journal-title":"Cell. Signal."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1021\/acschemneuro.4c00130","article-title":"Design, synthesis, and biological evaluation of ferulic acid-piperazine derivatives targeting pathological hallmarks of Alzheimer\u2019s disease","volume":"15","author":"Singh","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s41110-023-00247-2","article-title":"Beneficial effects of ferulic acid in streptozotocin-induced diabetic neuropathy in male Wistar rats","volume":"49","author":"Ahmad","year":"2024","journal-title":"Nutrire"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1002\/jsfa.13931","article-title":"Ferulic acid: Extraction, estimation, bioactivity and applications for human health and food","volume":"105","author":"Kumar","year":"2024","journal-title":"J. Sci. Food Agric."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"159511","DOI":"10.1016\/j.bbalip.2024.159511","article-title":"SIRT1\/AMPK-mediated pathway: Ferulic acid from sugar beet pulp mitigating obesity-induced diabetes-linked complications and improving metabolic health","volume":"1869","author":"Singh","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Cell. Biol. Lipids"},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Gu, Y., Zhang, Y., Li, M., Huang, Z., Jiang, J., Chen, Y., Chen, J., Jia, Y., Zhang, L., and Zhou, F. (2021). Ferulic acid ameliorates atherosclerotic injury by modulating gut microbiota and lipid metabolism. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.621339"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1039\/D4FO02955K","article-title":"Ferulic acid and protocatechuic acid alleviate atherosclerosis by promoting UCP1 expression to inhibit the NLRP3-IL-1\u03b2 signaling pathway","volume":"16","author":"Hong","year":"2025","journal-title":"Food Funct."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"2045894020903953","DOI":"10.1177\/2045894020903953","article-title":"Renal protective effect of sodium ferulate on pulmonary hypertension patients undergoing computed tomography pulmonary angiography","volume":"10","author":"Zhao","year":"2020","journal-title":"Pulm. Circ."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s43440-023-00494-0","article-title":"Molecular mechanism of ferulic acid and its derivatives in tumor progression","volume":"75","author":"Bao","year":"2023","journal-title":"Pharmacol. Rep."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Chen, S., Zhao, D., Luan, C., Zheng, J., Liu, W., Feng, Z., Luo, R., Han, X., and Wang, D. (2023). Ferulic acid induces autophagy and apoptosis in colon cancer CT26 cells via the MAPK pathway. Molecules, 28.","DOI":"10.3390\/molecules28166014"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1177\/10815589241270489","article-title":"Ferulic acid inhibits tumor proliferation and attenuates inflammation of hepatic tissues in experimentally induced HCC in rats","volume":"72","author":"Abdulal","year":"2024","journal-title":"J. Investig. Med."},{"key":"ref_228","first-page":"27","article-title":"Synergistic antimicrobial activity of apigenin against oral pathogens","volume":"2","author":"Cha","year":"2016","journal-title":"Int. J. Eng. Res. Sci."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"22290","DOI":"10.1016\/j.heliyon.2023.e22290","article-title":"Research progress on antisepsis effect of apigenin and its mechanism of action","volume":"9","author":"Zhu","year":"2023","journal-title":"Heliyon"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"2236828","DOI":"10.1080\/23311932.2023.2236828","article-title":"Antiviral activities of olive oil apigenin and taxifolin against SARS-CoV-2 RNA-dependent RNA polymerase (RdRP): In silico, pharmacokinetic, ADMET, and in-vitro approaches","volume":"9","author":"Selim","year":"2023","journal-title":"Cogent. Food Agric."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s13237-023-00431-9","article-title":"In silico screening of flavonoids unearthed apigenin and epigallocatechin gallate, possessing antiviral potentiality against Delta and Omicron variants of SARS-CoV-2","volume":"67","author":"Chatterjee","year":"2024","journal-title":"Nucleus"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"37","DOI":"10.14715\/cmb\/2023.69.9.6","article-title":"Effects of apigenin and shell nano-additives on antifungal behaviour and roughness of the soft prosthesis lining","volume":"69","author":"Jaffer","year":"2023","journal-title":"Cell. Mol. Biol."},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Alghamdi, A., Almuqbil, M., Alrofaidi, M.A., Burzangi, A.S., Alshamrani, A.A., Alzahrani, A.R., Kamal, M., Imran, M., Alshehri, S., and Mannasaheb, B.A. (2022). Potential antioxidant activity of apigenin in the obviating stress-mediated depressive symptoms of experimental mice. Molecules, 27.","DOI":"10.3390\/molecules27249055"},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Zafar, A., Alruwaili, N.K., Imam, S.S., Alsaidan, O.A., Ahmed, M.M., Yasir, M., Warsi, M.H., Alquraini, A., Ghoneim, M.M., and Alshehri, S. (2022). Development and optimization of hybrid polymeric nanoparticles of apigenin: Physicochemical characterization, antioxidant activity and cytotoxicity evaluation. Sensors, 22.","DOI":"10.3390\/s22041364"},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Yoon, J.H., Kim, M.Y., and Cho, J.Y. (2023). Apigenin: A therapeutic agent for treatment of skin inflammatory diseases and cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021498"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"8803","DOI":"10.1007\/s00210-024-03200-w","article-title":"Apigenin attenuates indomethacin-induced gastric ulcer in rats: Emphasis on antioxidant, anti-inflammatory, anti-apoptotic, and TGF-\u03b21 enhancing activities","volume":"397","author":"Alamri","year":"2024","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1007\/s10787-024-01538-4","article-title":"Apigenin and inflammation in the brain: Can apigenin inhibit neuroinflammation in preclinical models?","volume":"32","author":"Olasehinde","year":"2024","journal-title":"Inflammopharmacology"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Marzo, N., P\u00e9rez-S\u00e1nchez, A., Ruiz-Torres, V., Mart\u00ednez-T\u00e9bar, A., Castillo, J., Herranz-L\u00f3pez, M., and Barraj\u00f3n-Catal\u00e1n, E. (2019). Antioxidant and photoprotective activity of apigenin and its potassium salt derivative in human keratinocytes and absorption in Caco-2 cell monolayers. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092148"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1002\/biof.2113","article-title":"The influence of apigenin on cellular responses to radiation: From protection to sensitization","volume":"51","author":"Monadi","year":"2025","journal-title":"BioFactors"},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Lorusso, F., Scarano, A., Fulle, S., Valbonetti, L., Mancinelli, R., and Di Filippo, E.S. (2023). Effectiveness of apigenin, resveratrol, and curcumin as adjuvant nutraceuticals for calvarial bone defect healing: An in vitro and histological study on rats. Nutrients, 15.","DOI":"10.3390\/nu15051235"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1007\/s11010-023-04885-y","article-title":"Apigenin accelerates wound healing in diabetic mice by promoting macrophage M2-type polarization via increasing miR-21 expression","volume":"479","author":"Li","year":"2024","journal-title":"Mol. Cell. Biochem."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1021\/acsabm.3c00609","article-title":"Apigenin self-assembled collagen biomatrix for reprogramming the obese wound microenvironment for its management and repair","volume":"7","author":"Sreekumar","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1010428317728480","DOI":"10.1177\/1010428317728480","article-title":"Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice","volume":"39","author":"Medhat","year":"2017","journal-title":"Tumor Biol."},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Oh, H.M., Cho, C.K., Lee, N.H., and Son, C.G. (2024). Experimental evidence for anti-metastatic actions of apigenin: A mini review. Front. Oncol., 14.","DOI":"10.3389\/fonc.2024.1380194"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1258\/ebm.2012.012148","article-title":"Apigenin-induced apoptosis in A375 and A549 cells through selective action and dysfunction of mitochondria","volume":"237","author":"Das","year":"2012","journal-title":"Exp. Biol. Med."},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Ghi\u021bu, A., Schwiebs, A., Radeke, H.H., Avram, S., Zupko, I., Bor, A., Pavel, I.Z., Dehelean, C.A., Oprean, C., and Bojin, F. (2019). A comprehensive assessment of apigenin as an antiproliferative, proapoptotic, antiangiogenic and immunomodulatory phytocompound. Nutrients, 11.","DOI":"10.3390\/nu11040858"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1080\/14786419.2022.2069765","article-title":"Effects of doxorubicin and apigenin on chronic myeloid leukemia cells (K562) in vitro: Anti-proliferative and apoptosis induction assessments","volume":"37","author":"Noorian","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.5650\/jos.ess24056","article-title":"Eco-friendly nanoparticles synthesized from Salvia sclarea ethanol extract protect against STZ-induced diabetic nephropathy in rats via antioxidant, anti-inflammatory, and apoptosis mechanisms","volume":"73","author":"Ma","year":"2024","journal-title":"J. Oleo. Sci."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"109966","DOI":"10.1016\/j.cbi.2022.109966","article-title":"Apigenin inhibits angiogenesis and tumor growth by suppressing HIF-1\u03b1 expression in non-small cell lung cancer","volume":"361","author":"Fu","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"ref_250","first-page":"5552664","article-title":"An in vitro-in vivo evaluation of the antiproliferative and antiangiogenic effect of flavone apigenin against SK-MEL-24 human melanoma cell line","volume":"2021","author":"Pavel","year":"2021","journal-title":"Anal. Cell. Pathol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"216961","DOI":"10.1016\/j.canlet.2024.216961","article-title":"Apigenin inhibits tumor angiogenesis by hindering microvesicle biogenesis via ARHGEF1","volume":"596","author":"Zhang","year":"2024","journal-title":"Cancer Lett."},{"key":"ref_252","doi-asserted-by":"crossref","unstructured":"Liu, X., Zhao, T., Shi, Z., Hu, C., Li, Q., and Sun, C. (2023). Synergism antiproliferative effects of apigenin and naringenin in NSCLC cells. Molecules, 28.","DOI":"10.3390\/molecules28134947"},{"key":"ref_253","first-page":"307","article-title":"comparative analysis of apigenin-3 acetate versus apigenin and methyl-prednisolone in inhibiting proliferation and gene expression of Th1 cells in multiple sclerosis","volume":"25","author":"Kasiri","year":"2023","journal-title":"Cell J."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"101008","DOI":"10.1016\/j.esmoop.2023.101008","article-title":"42P Apigenin: An immunomodulatory nutraceutical overriding PD-L1 inhibitors by halting AKT\/mTOR pathway in triple-negative breast cancer (TNBC)","volume":"8","author":"Samir","year":"2023","journal-title":"ESMO Open"},{"key":"ref_255","unstructured":"de Oliveira, M.R. (2024). Neuroprotection induced by apigenin. Natural Molecules in Neuroprotection and Neurotoxicity, Academic Press. [1st ed.]."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/WNF.0000000000000608","article-title":"Molecular docking analysis reveals the promising role of apigenin as a potential treatment for neurological disorders","volume":"47","author":"Wasim","year":"2024","journal-title":"Clin. Neuropharmacol."},{"key":"ref_257","first-page":"32","article-title":"The potential role of apigenin in diabetes mellitus","volume":"3","author":"Barky","year":"2020","journal-title":"Int. J. Clin. Case Rep. Rev."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/j.fshw.2023.03.021","article-title":"Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K\/Akt\/Glut-4 signaling pathways in insulin-resistant HepG2 cells","volume":"12","author":"Miao","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_259","first-page":"40943","article-title":"Exploring the therapeutic potential of apigenin in obesity-associated fibrinolytic dysfunction: Insights from an animal study","volume":"15","author":"Qadi","year":"2023","journal-title":"Cureus"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.7150\/ijbs.91695","article-title":"Apigenin targets fetuin-A to ameliorate obesity-induced insulin resistance","volume":"20","author":"Hsu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"ref_261","doi-asserted-by":"crossref","unstructured":"Thomas, S.D., Jha, N.K., Jha, S.K., Sadek, B., and Ojha, S. (2023). Pharmacological and molecular insight on the cardioprotective role of apigenin. Nutrients, 15.","DOI":"10.3390\/nu15020385"},{"key":"ref_262","doi-asserted-by":"crossref","unstructured":"Tomou, E.M., Papakyriakopoulou, P., Skaltsa, H., Valsami, G., and Kadoglou, N.P. (2023). Bio-actives from natural products with potential cardioprotective properties: Isolation, identification, and pharmacological actions of apigenin, quercetin, and silibinin. Molecules, 28.","DOI":"10.3390\/molecules28052387"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"14024","DOI":"10.1016\/j.heliyon.2023.e14024","article-title":"Apigenin-coated gold nanoparticles as a cardioprotective strategy against doxorubicin-induced cardiotoxicity in male rats via reducing apoptosis","volume":"9","author":"Sharifiaghdam","year":"2023","journal-title":"Heliyon"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.sjbs.2021.11.008","article-title":"The role of serotonergic and catecholaminergic systems for possible antidepressant activity of apigenin","volume":"29","author":"Asdaq","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_265","doi-asserted-by":"crossref","unstructured":"Amin, F., Ibrahim, M.A.A., Rizwan-ul-Hasan, S., Khaliq, S., Gabr, G.A., Muhammad Khan, A., Sidhom, P.A., Tikmani, P., Shawky, A.M., and Ahmad, S. (2022). Interactions of apigenin and safranal with the 5HT1A and 5HT2A receptors and behavioral effects in depression and anxiety: A molecular docking, lipid-mediated molecular dynamics, and in vivo analysis. Molecules, 27.","DOI":"10.3390\/molecules27248658"},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Alizadeh, A., Pourfallah-Taft, Y., Khoshnazar, M., Safdari, A., Komari, S.V., Zanganeh, M., Sami, N., Valizadeh, M., Faridzadeh, A., and Alijanzadeh, D. (2024). Flavonoids against depression: A comprehensive review of literature. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1411168"},{"key":"ref_267","doi-asserted-by":"crossref","unstructured":"Kramer, D.J., and Johnson, A.A. (2024). Apigenin: A natural molecule at the intersection of sleep and aging. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1359176"},{"key":"ref_268","first-page":"2573","article-title":"Effect of apigenin on learning and memory ability of senile dementia mice","volume":"30","author":"Qi","year":"2020","journal-title":"Rev. Cient. Fac. Cienc. Vet."},{"key":"ref_269","doi-asserted-by":"crossref","unstructured":"Allemailem, K.S., Almatroudi, A., Alharbi, H.O.A., AlSuhaymi, N., Alsugoor, M.H., Aldakheel, F.M., Khan, A.A., and Rahmani, A.H. (2024). Apigenin: A bioflavonoid with a promising role in disease prevention and treatment. Biomedicines, 12.","DOI":"10.3390\/biomedicines12061353"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"468","DOI":"10.2174\/1871527322666230406082625","article-title":"Effect of apigenin on neurodegenerative diseases","volume":"23","author":"Gaur","year":"2024","journal-title":"CNS Neurol. Disord. Drug. Targets"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/cbdv.201100219","article-title":"Seasonal variations of phenolic compounds and biological properties in sage (Salvia officinalis L.)","volume":"9","author":"Skroza","year":"2012","journal-title":"Chem. Biodivers."},{"key":"ref_272","first-page":"81","article-title":"Identification of flavonoids in leaves of seven wild growing Salvia L. (Lamiaceae) species from Iran","volume":"3","author":"Kharazian","year":"2013","journal-title":"Prog. Biol. Sci."},{"key":"ref_273","doi-asserted-by":"crossref","unstructured":"Sharma, N., Biswas, S., Al-Dayan, N., Alhegaili, A.S., and Sarwat, M. (2021). Antioxidant role of kaempferol in prevention of hepatocellular carcinoma. Antioxidants, 10.","DOI":"10.3390\/antiox10091419"},{"key":"ref_274","doi-asserted-by":"crossref","unstructured":"Alrumaihi, F., Almatroodi, S.A., Alharbi, H.O.A., Alwanian, W.M., Alharbi, F.A., Almatroudi, A., and Rahmani, A.H. (2024). Pharmacological potential of kaempferol, a flavonoid in the management of pathogenesis via modulation of inflammation and other biological activities. Molecules, 29.","DOI":"10.3390\/molecules29092007"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s00217-016-2650-z","article-title":"Antibacterial effect of kaempferol and (\u2212)-epicatechin on Helicobacter pylori","volume":"242","author":"Toledo","year":"2016","journal-title":"Eur. Food Res. Technol."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"ftab048","DOI":"10.1093\/femspd\/ftab048","article-title":"Combination of kaempferol and azithromycin attenuates Staphylococcus aureus-induced osteomyelitis via anti-biofilm effects and by inhibiting the phosphorylation of ERK1\/2 and SAPK","volume":"79","author":"Gao","year":"2021","journal-title":"Pathog. Dis."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"984","DOI":"10.3109\/13880209.2015.1091483","article-title":"The roles of CDR1, CDR2, and MDR1 in kaempferol-induced suppression with fluconazole-resistant Candida albicans","volume":"54","author":"Shao","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"200127","DOI":"10.1590\/0074-02760200127","article-title":"Ultrastructural and proapoptotic-like effects of kaempferol in Giardia duodenalis trophozoites and bioinformatics prediction of its potential protein target","volume":"115","author":"Calzada","year":"2020","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1080\/10942912.2023.2205040","article-title":"Anticancer, antioxidant, ameliorative and therapeutic properties of kaempferol","volume":"26","author":"Shahbaz","year":"2023","journal-title":"Int. J. Food Prop."},{"key":"ref_280","doi-asserted-by":"crossref","unstructured":"Alam, W., Khan, H., Shah, M.A., Cauli, O., and Saso, L. (2020). Kaempferol as a dietary anti-inflammatory agent: Current therapeutic standing. Molecules, 25.","DOI":"10.3390\/molecules25184073"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/09168451.2018.1528140","article-title":"Anti-inflammatory effects of kaempferol on Helicobacter pylori\u2014Induced inflammation","volume":"83","author":"Yeon","year":"2019","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/cei.13363","article-title":"Kaempferol attenuates imiquimod-induced psoriatic skin inflammation in a mouse model","volume":"198","author":"Liu","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.indcrop.2012.08.029","article-title":"Evaluation of antioxidant activity, total phenols and phenolic compounds in thyme (Thymus vulgaris L.), sage (Salvia officinalis L.), and marjoram (Origanum majorana L.) extracts","volume":"43","author":"Roby","year":"2013","journal-title":"Ind. Crops Prod."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ptr.2628","article-title":"Antioxidant metabolism induced by quinic acid. Increased urinary excretion of tryptophan and nicotinamide","volume":"23","author":"Pero","year":"2009","journal-title":"Phytother. Res."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.17798\/bitlisfen.1167047","article-title":"Antioxidant and antimicrobial capacity of quinic acid","volume":"11","author":"Ercan","year":"2022","journal-title":"Bitlis Eren \u00dcniversitesi Fen Bilim. Derg."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1080\/02648725.2022.2122303","article-title":"Pharmacological insights into the multifaceted biological properties of quinic acid","volume":"40","author":"Benali","year":"2024","journal-title":"Biotechnol. Genet. Eng. Rev."},{"key":"ref_287","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wang, Y., Zhao, T., Li, M., Wang, Y., Cao, J., Liu, Y., Wang, Z., and Cheng, G. (2024). Protective effect of que zui tea on d-galactose-induced oxidative stress damage in mice via regulating SIRT1\/Nrf2 signaling pathway. Molecules, 29.","DOI":"10.3390\/molecules29061384"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4062\/biomolther.2023.184","article-title":"Quinic acid alleviates behavior impairment by reducing neuroinflammation and MAPK activation in LPS-treated mice","volume":"32","author":"Park","year":"2024","journal-title":"Biomol. Therap."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"2374608","DOI":"10.1080\/19490976.2024.2374608","article-title":"Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3\/IKK\/NF-\u03baB signaling via gut microbial tryptophan metabolites","volume":"16","author":"Li","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"14","DOI":"10.4103\/pm.pm_36_18","article-title":"Quinic acid attenuates oral cancer cell proliferation by downregulating cyclin D1 Expression and Akt signaling","volume":"14","author":"Singh","year":"2018","journal-title":"Pharmacogn. Mag."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12985-015-0443-9","article-title":"Quinic acid derivatives inhibit dengue virus replication in vitro","volume":"12","author":"Zanello","year":"2015","journal-title":"Virol. J."},{"key":"ref_292","doi-asserted-by":"crossref","unstructured":"Cal\u00edn-S\u00e1nchez, \u00c1., Lipan, L., Cano-Lamadrid, M., Kharaghani, A., Masztalerz, K., Carbonell-Barrachina, \u00c1.A., and Figiel, A. (2020). Comparison of traditional and novel drying techniques and its effect on quality of fruits, vegetables and aromatic herbs. Foods, 9.","DOI":"10.3390\/foods9091261"},{"key":"ref_293","doi-asserted-by":"crossref","unstructured":"Hii, C.L., and Shirkole, S.S. (2023). Guideline and selection of dryers for herbs, spices, and medicinal plants. Drying of Herbs, Spices, and Medicinal Plants, CRC Press. [1st ed.]. Chapter 2.","DOI":"10.1201\/9781003269250"},{"key":"ref_294","doi-asserted-by":"crossref","unstructured":"Nielsen, S.S. (2010). Determination of moisture content. Food Analysis Laboratory Manual, Springer. [2nd ed.]. Chapter 3.","DOI":"10.1007\/978-1-4419-1463-7_3"},{"key":"ref_295","unstructured":"Nielsen, S.S. (2017). Ash analysis. Food Analysis, Springer International Publishing."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/10408347.2012.751786","article-title":"An overview of the Kjeldahl method of nitrogen determination. Part I. Early history, chemistry of the procedure, and titrimetric finish","volume":"43","author":"Navas","year":"2013","journal-title":"Crit. Rev. Anal. Chem."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/00218839.1983.11100572","article-title":"The nitrogen content of pollen protein","volume":"22","author":"Rabie","year":"1983","journal-title":"J. Apic. Res."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/jsfa.2740241208","article-title":"An investigation of hydrolytic techniques for the amino acid analysis of foodstuffs","volume":"24","author":"Davies","year":"1973","journal-title":"J. Sci. Food Agric."},{"key":"ref_299","doi-asserted-by":"crossref","unstructured":"Andreson, S. (2019). Soxtec: Its principles and applications. Oil Extraction and Analysis, Imprint AOCS Publishing. [1st ed.]. Chapter 2.","DOI":"10.1201\/9780429104527-2"},{"key":"ref_300","unstructured":"(2014). Animal and Vegetable Fats and Oils: Gas Chromatography of Fatty Acids Methyl Esters. Part 1. Guidelines on Modern Gas Chromatography of Fatty Acid Methyl Esters (Standard No. ISO 12966-1:2014)."},{"key":"ref_301","unstructured":"(2004). Foodstuffs\u2014Determination of Vitamin C by HPLC (Standard No. PN-EN 14130:2004)."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5344\/ajev.1965.16.3.144","article-title":"Colorimetry of total phenolics with phosphomolybilic-phosphotungstic acid reagents","volume":"16","author":"Singelton","year":"1965","journal-title":"Am. J. Enol. Vitic."},{"key":"ref_303","first-page":"315","article-title":"Teneurs en principaux flavonoids des fleurs de Crataegeus monogyna Jacq et de Crataegeus laevigata (Poiret D.C) en function de la vegetation","volume":"65","author":"Lamaison","year":"1990","journal-title":"Pharm. Acta Helv."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/9\/1425\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:20:31Z","timestamp":1778559631000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/9\/1425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,26]]},"references-count":303,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["molecules31091425"],"URL":"https:\/\/doi.org\/10.3390\/molecules31091425","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,26]]}}}