{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:31:59Z","timestamp":1785439919914,"version":"3.56.0"},"reference-count":33,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Serbian Ministry of Science, Technological Development, and Innovations","award":["451-03-34\/2026-03\/200111"],"award-info":[{"award-number":["451-03-34\/2026-03\/200111"]}]},{"name":"Serbian Ministry of Science, Technological Development, and Innovations","award":["451-03-33\/2026-03\/200111"],"award-info":[{"award-number":["451-03-33\/2026-03\/200111"]}]},{"award":["451-03-34\/2026-03\/200111"],"award-info":[{"award-number":["451-03-34\/2026-03\/200111"]}],"id":[{"id":"https:\/\/ror.org\/01znas443","id-type":"ROR","asserted-by":"publisher"}]},{"award":["451-03-33\/2026-03\/200111"],"award-info":[{"award-number":["451-03-33\/2026-03\/200111"]}],"id":[{"id":"https:\/\/ror.org\/01znas443","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010301","name":"Faculty of Medical Sciences, University of Kragujevac","doi-asserted-by":"crossref","award":["14\/24"],"award-info":[{"award-number":["14\/24"]}],"id":[{"id":"10.13039\/501100010301","id-type":"DOI","asserted-by":"crossref"}]},{"award":["14\/24"],"award-info":[{"award-number":["14\/24"]}],"id":[{"id":"https:\/\/ror.org\/04f7vj627","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Psoriasis is a chronic inflammatory skin disease linked to immune dysregulation and oxidative stress. Due to the limitations and side effects of conventional therapies, natural compounds are gaining increasing attention. The aim of this study was to evaluate the therapeutic potential of Melissa officinalis extract in psoriasis. HPLC analysis was used to characterize the extract, while its antioxidant activity was assessed by DPPH, ABTS, and FRAP assays. An in vivo study was conducted on 18 male Wistar albino rats divided into control (CTRL), psoriasis (PSORI), and psoriasis treated with M. officinalis (PSORI+MO) groups. Psoriasis was induced by daily topical application of 5% imiquimod cream on the shaved back skin of rats for seven constitutive days. The PSORI+MO group received M. officinalis extract orally at a dose of 200 mg\/kg during seven days. Redox and inflammatory cytokine analysis were performed. Isolated skin was fixed and stained with H\/E and immunohistochemical staining. Morphometric and histological analyses revealed reduced inflammation, keratinocyte proliferation, and epidermal thickness. Systemic and tissue redox status showed decreased oxidative stress biomarkers and enhanced antioxidant defense. Inflammatory cytokines (IL-17A, IL-22, IL-23, IL-1\u03b2, and IL-6) were significantly reduced. Our findings suggest that Melissa officinalis extract exerts anti-psoriatic effects through antioxidant, anti-inflammatory, and antiproliferative mechanisms.<\/jats:p>","DOI":"10.3390\/molecules31091471","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:46:11Z","timestamp":1777455971000},"page":"1471","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multi-Target Anti-Psoriatic Effects of Melissa officinalis: Phytochemical, Redox, Immunological, and Histological Evidence from an In Vivo Study"],"prefix":"10.3390","volume":"31","author":[{"given":"Branislava","family":"Daskalovic","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0071-8376","authenticated-orcid":false,"given":"Vladimir","family":"Jakovljevic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia"},{"name":"Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, 34000 Kragujevac, Serbia"},{"name":"Department of Human Pathology, 1st Moscow State Medical University IM Sechenov, Trubetskaya Str. 2, 119992 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergej","family":"Bolevic","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, 1st Moscow State Medical University IM Sechenov, Trubetskaya Str. 2, 119992 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijana","family":"Andjic","sequence":"additional","affiliation":[{"name":"Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, 34000 Kragujevac, Serbia"},{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5388-6085","authenticated-orcid":false,"given":"Jovana","family":"Bradic","sequence":"additional","affiliation":[{"name":"Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, 34000 Kragujevac, Serbia"},{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9906-436X","authenticated-orcid":false,"given":"Aleksadar","family":"Kocovic","sequence":"additional","affiliation":[{"name":"Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, 34000 Kragujevac, Serbia"},{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5386-8116","authenticated-orcid":false,"given":"Nevena","family":"Lazarevic","sequence":"additional","affiliation":[{"name":"Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, 34000 Kragujevac, Serbia"},{"name":"Department of Human Pathology, 1st Moscow State Medical University IM Sechenov, Trubetskaya Str. 2, 119992 Moscow, Russia"},{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1761-604X","authenticated-orcid":false,"given":"Vanja","family":"Tadic","sequence":"additional","affiliation":[{"name":"Institute for Medicinal Plant Research \u201cDr. Josif Pancic\u201d, Tadeusa Koscuska 1, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7722-6169","authenticated-orcid":false,"given":"Ana","family":"Zugic","sequence":"additional","affiliation":[{"name":"Institute for Medicinal Plant Research \u201cDr. Josif Pancic\u201d, Tadeusa Koscuska 1, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos","family":"Krivokapic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Montenegro, Kru\u0161evac bb, 81000 Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9734-9135","authenticated-orcid":false,"given":"Nenad","family":"Stankovic","sequence":"additional","affiliation":[{"name":"Independent Researcher, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Trifunovic","sequence":"additional","affiliation":[{"name":"Department of Cytology, Institute for Biological Research \u201cSinisa Stankovic\u201d\u2014National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5849-1998","authenticated-orcid":false,"given":"Jasmina","family":"Sretenovic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia"},{"name":"Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Deng, J., Tan, S., Liu, R., Yu, W., Chen, H., Tang, N., Han, L., and Lu, C. 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