{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:16:14Z","timestamp":1785417374106,"version":"3.56.0"},"reference-count":45,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007771","name":"Medical University of Silesia","doi-asserted-by":"publisher","award":["BNW-1-055\/K\/4\/O"],"award-info":[{"award-number":["BNW-1-055\/K\/4\/O"]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"publisher"}]},{"award":["BNW-1-055\/K\/4\/O"],"award-info":[{"award-number":["BNW-1-055\/K\/4\/O"]}],"id":[{"id":"https:\/\/ror.org\/005k7hp45","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Glycation is a type of post-translational protein modification that affects antigen self-recognition, cell signaling, the proteasomal degradation of proteins, protein solubility, and the mechanical properties of tissues. Some glycation products are able to cross-link proteins. Serum concentrations of the cross-linking GOLD (glyoxal lysine dimer) and MOLD (methylglyoxal lysine dimer), and the non-cross-linking MG-H1 (methylglyoxal-derived hydroimidazolone isomer 1) in patients with psoriasis (n = 63) and in healthy controls (n = 35) were examined using the LC-Orbitrap-MS\/MS (liquid chromatography\u2013Orbitrap tandem mass spectrometry) technique. The following indices were assessed in the patients: BSA (body surface area), PASI (psoriasis area and severity index), and DLQI (Dermatology Life Quality Index). Serum concentrations of GOLD, MOLD, and MG-H1 were found to be significantly lower in psoriasis patients compared with healthy individuals. The concentrations of GOLD, MOLD, and MG-H1 did not correlate with the indices of disease activity and severity. These results may reflect the complexity of metabolic dysregulation accompanying immune-mediated inflammatory diseases such as psoriasis.<\/jats:p>","DOI":"10.3390\/molecules31091481","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:31:56Z","timestamp":1777465916000},"page":"1481","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psoriasis Is Accompanied by Low Serum Levels of MG-H1, GOLD and MOLD: LC-Orbitrap-MS\/MS Analysis of Chosen Glycation Products"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4400-1502","authenticated-orcid":false,"given":"Aleksandra","family":"Damasiewicz-Bodzek","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1947-9299","authenticated-orcid":false,"given":"Agnieszka","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0037-3232","authenticated-orcid":false,"given":"Maciej","family":"Maciejczyk","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0916-9972","authenticated-orcid":false,"given":"Magdalena","family":"Szumska","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"},{"name":"Research and Implementation Center Silesia LabMed, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomir","family":"Walig\u00f3ra","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8963-3549","authenticated-orcid":false,"given":"Beata","family":"Pastuszka","sequence":"additional","affiliation":[{"name":"Research and Implementation Center Silesia LabMed, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3017-0740","authenticated-orcid":false,"given":"Beata","family":"Janoszka","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"},{"name":"Research and Implementation Center Silesia LabMed, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(07)61128-3","article-title":"Pathogenesis and Clinical Features of Psoriasis","volume":"370","author":"Griffiths","year":"2007","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3892\/etm.2022.11124","article-title":"Update on the Etiopathogenesis of Psoriasis (Review)","volume":"23","author":"Branisteanu","year":"2022","journal-title":"Exp. 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