{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:37:54Z","timestamp":1787585874299,"version":"build-2736575974"},"reference-count":135,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015999","name":"Lucian Blaga University of Sibiu","doi-asserted-by":"crossref","award":["LBUS-IRG-2024"],"award-info":[{"award-number":["LBUS-IRG-2024"]}],"id":[{"id":"10.13039\/501100015999","id-type":"DOI","asserted-by":"crossref"}]},{"award":["LBUS-IRG-2024"],"award-info":[{"award-number":["LBUS-IRG-2024"]}],"id":[{"id":"https:\/\/ror.org\/026gdz537","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The aim of this study was to analyze the composition and dual beneficial and toxic effects of Achillea millefolium L., Mentha longifolia L., and Thymus serpyllum L. extracts. The phenolic profile, total phenolic content (TPC), antioxidant activity, and drosopterin eye content (DEC) were determined by modern methods. The viability and developmental time of D. melanogaster were assessed by a diet-dependent viability test. The results show that the phenolic profile varied depending on the extract type and plant species. The TPC ranged between 5.32 and 29.32 mg GAE\/g dry weight. All the plant extracts exert antioxidant effect in the applied in vitro tests. In the case of D. melanogaster fed with a normal diet supplement with different concentrations of the plant A. millefolium L. extract, a biphasic effect was observed. A more complex effect was recorded for the M. longifolia L. and T. serpyllum L. extracts. On a high-sugar diet, all the extracts were toxic. All the plant extracts in tested concentrations influenced the DEC, suggesting an impact on gene expression. This study contributes to the expanding knowledge about the beneficial and toxic effects of local medicinal plants, suggesting the need for future studies to elucidate the appropriate use of natural products in therapy.<\/jats:p>","DOI":"10.3390\/molecules31091527","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:57:29Z","timestamp":1777967849000},"page":"1527","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Phytochemical Constituents, Antioxidant Potential, and Toxicological Profile of Selected Medicinal Plants from Romania\u2019s Spontaneous Flora"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9992-9383","authenticated-orcid":false,"given":"Lidia-Ioana","family":"Virchea","sequence":"first","affiliation":[{"name":"Faculty of Medicine, \u201cLucian Blaga\u201d University of Sibiu, Lucian Blaga Str. 2A, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4804-1138","authenticated-orcid":false,"given":"Cecilia","family":"Georgescu","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture Sciences, Food Industry and Environmental Protection, \u201cLucian Blaga\u201d University of Sibiu, Dr. Ion Ra\u021biu Str. 7-9, 550012 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4874-0430","authenticated-orcid":false,"given":"Adina","family":"Frum","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cLucian Blaga\u201d University of Sibiu, Lucian Blaga Str. 2A, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9011-177X","authenticated-orcid":false,"given":"Endre","family":"M\u00e1th\u00e9","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Science, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, B\u00f6sz\u00f6rm\u00e9nyi Str. 128, 4032 Debrecen, Hungary"},{"name":"Department of Life Sciences, Faculty of Medicine, Vasile Goldis Western University of Arad, L. Rebreanu Str. 86, 310414 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5749-8127","authenticated-orcid":false,"given":"Monica","family":"Mironescu","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture Sciences, Food Industry and Environmental Protection, \u201cLucian Blaga\u201d University of Sibiu, Dr. Ion Ra\u021biu Str. 7-9, 550012 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bence","family":"Pecsenye","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Science, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, B\u00f6sz\u00f6rm\u00e9nyi Str. 128, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7574-2178","authenticated-orcid":false,"given":"Robert","family":"Nagy","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Science, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, B\u00f6sz\u00f6rm\u00e9nyi Str. 128, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5721-542X","authenticated-orcid":false,"given":"Oana Viorica","family":"Danci","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, \u201cLucian Blaga\u201d University of Sibiu, Dr. Ion Ra\u021biu Str. 5-7, 550012 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7723-8418","authenticated-orcid":false,"given":"Maria-Lucia","family":"Mure\u0219an","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cLucian Blaga\u201d University of Sibiu, Lucian Blaga Str. 2A, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Totan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cLucian Blaga\u201d University of Sibiu, Lucian Blaga Str. 2A, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3167-9864","authenticated-orcid":false,"given":"Felicia-Gabriela","family":"Gligor","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cLucian Blaga\u201d University of Sibiu, Lucian Blaga Str. 2A, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Medicinal Plants: Past History and Future Perspective","volume":"7","author":"Lorigooini","year":"2018","journal-title":"J. Herbmed Pharmacol."},{"key":"ref_2","unstructured":"World Health Organization (2025). WHO Global Report on Traditional, Complementary and Integrative Medicine 2024, World Health Organization."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.11648\/j.ijpc.20251103.12","article-title":"Herbal Medicine: Scientific Validation and Future Prospects","volume":"11","author":"Etaware","year":"2025","journal-title":"Int. J. Pharm. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Muscolo, A., Mariateresa, O., Giulio, T., and Mariateresa, R. (2024). Oxidative Stress: The Role of Antioxidant Phytochemicals in the Prevention and Treatment of Diseases. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25063264"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41420-024-02278-8","article-title":"Free Radicals and Their Impact on Health and Antioxidant Defenses: A Review","volume":"11","author":"Chandimali","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/ptr.5840","article-title":"Pharmacognosy, Phytochemistry and Pharmacological Properties of Achillea Millefolium L.: A Review","volume":"31","author":"Ali","year":"2017","journal-title":"Phytother. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0378-8741(00)00381-0","article-title":"Botanical Drugs and Preparations in the Traditional Medicine of West Azerbaijan (Iran)","volume":"75","author":"Miraldi","year":"2001","journal-title":"J. Ethnopharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Perveen, S., and Al-Taweel, A. (2019). Therapeutic Use of Some Romanian Medicinal Plants. Pharmacognosy\u2014Medicinal Plants, IntechOpen.","DOI":"10.5772\/intechopen.78419"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Karpavi\u010dien\u0117, B. (2022). Traditional Uses of Medicinal Plants in South-Western Part of Lithuania. Plants, 11.","DOI":"10.3390\/plants11162093"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kozlowska, W., Wagner, C., Moore, E.M., Matkowski, A., and Komarnytsky, S. (2018). Botanical Provenance of Traditional Medicines From Carpathian Mountains at the Ukrainian-Polish Border. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.00295"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Radu\u0161ien\u0117, J., Karpavi\u010dien\u0117, B., Raudone, L., Vilkickyte, G., \u00c7\u0131rak, C., Seyis, F., Yayla, F., Marksa, M., Rimkien\u0117, L., and Ivanauskas, L. (2023). Trends in Phenolic Profiles of Achillea millefolium from Different Geographical Gradients. Plants, 12.","DOI":"10.3390\/plants12040746"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.25083\/rbl\/26.2\/2499.2510","article-title":"Evaluation of Some Traditional Medicinal Plants: Phytochemical Profile, Antibacterial and Antioxidant Potentials","volume":"26","author":"Turker","year":"2021","journal-title":"Rom. Biotechnol. Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e1800075","DOI":"10.1002\/cbdv.201800075","article-title":"Variation in Polyphenolic Profiles, Antioxidant and Antimicrobial Activity of Different Achillea Species as Natural Sources of Antiglycative Compounds","volume":"15","author":"Afshari","year":"2018","journal-title":"Chem. Biodivers."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Sowa, P., Marcin\u010d\u00e1kov\u00e1, D., Mi\u0142ek, M., Sidor, E., Leg\u00e1th, J., and D\u017cugan, M. (2020). Analysis of Cytotoxicity of Selected Asteraceae Plant Extracts in Real Time, Their Antioxidant Properties and Polyphenolic Profile. Molecules, 25.","DOI":"10.3390\/molecules25235517"},{"key":"ref_15","first-page":"257","article-title":"Comparative HPLC-MS Analysis of Phenolics from Achillea Distans and Achillea millefolium and Their Bioactivity","volume":"60","author":"Benedec","year":"2015","journal-title":"Stud. UBB Chem."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Konarska, A., Weryszko-Chmielewska, E., Materska, M., Sulborska-R\u00f3\u017cycka, A., Dmitruk, M., and Chilczuk, B. (2025). Phenolic Compounds in Flowers and Herb of Achillea millefolium L.: Histochemical and Phytochemical Studies. Molecules, 30.","DOI":"10.3390\/molecules30092084"},{"key":"ref_17","first-page":"1","article-title":"In Vitro Evaluation of Total Phenol and Antioxidant Activity of Achillea millefolium and Stevia Rebaudiana","volume":"13","author":"Devadharshini","year":"2021","journal-title":"J. Chem. Pharm. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Raudone, L., Vilkickyte, G., Marksa, M., and Radusiene, J. (2024). Comparative Phytoprofiling of Achillea millefolium Morphotypes: Assessing Antioxidant Activity, Phenolic and Triterpenic Compounds Variation across Different Plant Parts. Plants, 13.","DOI":"10.3390\/plants13071043"},{"key":"ref_19","first-page":"1347","article-title":"Achillea millefolium L.\u2014Phytochemical Profile and In Vitro Antioxidant Activity","volume":"22","author":"Georgieva","year":"2015","journal-title":"Int. Food Res. J."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Adil, M., Dastagir, G., Quddoos, A., Naseer, M., and Filimban, F.Z. (2024). HPLC Analysis, Genotoxic and Antioxidant Potential of Achillea millefolium L. and Chaerophyllum villosum Wall ex. Dc. BMC Complement. Med. Ther., 24.","DOI":"10.1186\/s12906-024-04344-1"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Bljaji\u0107, K., Brajkovi\u0107, A., \u010ca\u010di\u0107, A., Vuji\u0107, L., Jablan, J., Saraiva De Carvalho, I., and Zovko Kon\u010di\u0107, M. (2021). Chemical Composition, Antioxidant, and \u03b1-Glucosidase-Inhibiting Activity of Aqueous and Hydroethanolic Extracts of Traditional Antidiabetics from Croatian Ethnomedicine. Horticulturae, 7.","DOI":"10.3390\/horticulturae7020015"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3923\/jbs.2018.317.328","article-title":"Evaluation of Antioxidant, Anti-Inflammatory and Anti-Arthritic Activities of Yarrow (Achillea millefolium)","volume":"18","author":"Mohamed","year":"2018","journal-title":"J. Biol. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1134\/S0003683815010044","article-title":"Influence of Phytochemical Profile on Antibacterial Activity of Different Medicinal Plants against Gram-Positive and Gram-Negative Bacteria","volume":"51","author":"Bobis","year":"2015","journal-title":"Appl. Biochem. Microbiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.6001\/chemija.2025.36.2.3","article-title":"Composition of Some Macro and Micro Elements, Polyphenol Content, Antimicrobial and Antioxidant Activity of Achillea millefolium (L.) Grown in Kosovo","volume":"36","author":"Faiku","year":"2025","journal-title":"Chemija"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1080\/10739149.2022.2073369","article-title":"Characterization of the Antioxidant Activity, Total Phenolic Content, Enzyme Inhibition, and Anticancer Properties of Achillea millefolium L. (Yarrow)","volume":"50","author":"Ayhan","year":"2022","journal-title":"Instrum. Sci. Technol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0254-6272(17)30327-8","article-title":"Pharmacological Activity of Mentha longifolia and Its Phytoconstituents","volume":"37","author":"Farzaei","year":"2017","journal-title":"J. Tradit. Chin. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Darwish, R.M., and Aburjai, T.A. (2010). Effect of Ethnomedicinal Plants Used in Folklore Medicine in Jordan as Antibiotic Resistant Inhibitors on Escherichia Coli. BMC Complement. Altern. Med., 10.","DOI":"10.1186\/1472-6882-10-9"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s11101-023-09896-7","article-title":"Traditional Uses and Advances in Recent Research on Wild Aromatic Plant Mentha longifolia and Its Pharmacological Importance","volume":"23","author":"Shahar","year":"2024","journal-title":"Phytochem. Rev."},{"key":"ref_29","first-page":"262","article-title":"LC-MS Analysis and Antioxidantactivity of Phenolic Compounds from Two Indigenous Species of Mentha. Note I","volume":"61","author":"Benedec","year":"2013","journal-title":"Farmacia"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e70634","DOI":"10.1002\/fsn3.70634","article-title":"Exploration of Bioactive Components, Nutritional Properties, Antioxidant, Antimicrobial and Antihemolytic Potential of Different Parts of Mentha longifolia L.","volume":"13","author":"Tourabi","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40643-025-00859-8","article-title":"Optimization of Extraction Process and Solvent Polarities to Enhance the Recovery of Phytochemical Compounds, Nutritional Content, and Biofunctional Properties of Mentha longifolia L. Extracts","volume":"12","author":"Tourabi","year":"2025","journal-title":"Bioresour. Bioprocess."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"103670","DOI":"10.1016\/j.bcab.2025.103670","article-title":"Protective Effects of Hydroethanolic Extract of Mentha longifolia L. Leaves against Hepato-Renal Toxicity Induced by Furan Exposure: In Vivo and In Silico Studies","volume":"67","author":"Tourabi","year":"2025","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Raeisi, H., Azimirad, M., Abdemohamadi, E., Pezzani, R., Zali, M.R., and Yadegar, A. (2023). Pleiotropic Effects of Mentha longifolia L. Extract on the Regulation of Genes Involved in Inflammation and Apoptosis Induced by Clostridioides Difficile Ribotype 001. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1273094"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3906\/tar-1701-61","article-title":"Polyphenols in Northern Hungarian Mentha longifolia (L.) L. Treated with Ultrasonic Extraction for Potential Oenological Uses","volume":"41","author":"Patonay","year":"2017","journal-title":"Turk. J. Agric. For."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"18028","DOI":"10.1038\/s41598-023-45030-5","article-title":"Efficacy of Various Extracting Solvents on Phytochemical Composition, and Biological Properties of Mentha longifolia L. Leaf Extracts","volume":"13","author":"Tourabi","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_36","first-page":"100220","article-title":"Comparison of Extraction Methods for the Assessment of Total Polyphenol Content and in Vitro Antioxidant Capacity of Horsemint (Mentha longifolia (L.) L.)","volume":"15","author":"Patonay","year":"2019","journal-title":"J. Appl. Res. Med. Aromat. Plants"},{"key":"ref_37","first-page":"192","article-title":"Analysis of Phenolic Contents and Biological Activities of Wild Mint, Mentha longifolia (L.) L.","volume":"62","author":"Mohammed","year":"2024","journal-title":"IJEB"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3329\/bjp.v13i1.33243","article-title":"Antithrombotic Activity of Mentha longifolia in Animal Model","volume":"13","author":"Alamgeer","year":"2018","journal-title":"Bangladesh J. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Jalil, B., Pischel, I., Feistel, B., Suarez, C., Blainski, A., Spreemann, R., Roth-Ehrang, R., and Heinrich, M. (2024). Wild Thyme (Thymus serpyllum L.): A Review of the Current Evidence of Nutritional and Preventive Health Benefits. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1380962"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.5897\/AJPP12.871","article-title":"Descriptive Study of Contemporary Status of the Traditional Knowledge on Medicinal Plants in Bulgaria","volume":"7","author":"Kozuharova","year":"2013","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"ref_41","first-page":"10","article-title":"Traditional Tea Uses of Wild and Cultivated Plants in Albania and Kosovo, an Ethnobotanical Review","volume":"8","author":"Icka","year":"2023","journal-title":"Int. Sci. J. Sci. Bus. Soc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"115888","DOI":"10.1016\/j.jep.2022.115888","article-title":"Ethnobotanical Study of Traditionally Used Plants in the Municipality of Zavidovi\u0107i, BiH","volume":"302","author":"Ginko","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_43","first-page":"357","article-title":"Antimicrobial Activity and Chemical Composition of Thyme Essential Oils and the Polyphenolic Content of Different Thymus Extracts","volume":"63","author":"Varga","year":"2015","journal-title":"Farmacia"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Ibragic, S., Djukic, A., Murga, M., Tuka, P., Radoncic, I., Bozur, I., Dizdar, M., Culum, D., and Topcagic, A. (2025). Phenolic Composition, Cholinesterase Inhibition, and in Silico Study of Traditional Medicinal Plants from Bosnia And Herzegovina. Nat. Prod. Res., 1\u201310.","DOI":"10.1080\/14786419.2025.2542309"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"100092","DOI":"10.1016\/j.meafoo.2023.100092","article-title":"Nutritional Composition, Antioxidant Activity and Characterization of Bioactive Compounds from Thymus serpyllum L.: An Underexploited Wild Aromatic Plant","volume":"10","author":"Shahar","year":"2023","journal-title":"Meas. Food"},{"key":"ref_46","first-page":"100328","article-title":"The Influence of Different Extraction Conditions on Polyphenol Content, Antioxidant and Antimicrobial Activities of Wild Thyme","volume":"25","author":"Bugarski","year":"2021","journal-title":"J. Appl. Res. Med. Aromat. Plants"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.31925\/farmacia.2019.2.18","article-title":"Antioxidant Potential of Some Plants Used in Folk Medicine in Romania","volume":"67","author":"Papp","year":"2019","journal-title":"Farmacia"},{"key":"ref_48","first-page":"17","article-title":"Phenolics Content, Antioxidant and Antimicrobial Activities of Some Extracts Obtained from Romanian Summer Savory and Lebanon Wild Thyme","volume":"66","author":"Predescu","year":"2020","journal-title":"Sci. Works Ser. C Vet. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.sajb.2021.06.028","article-title":"Influence of Lyophilized Thymus serpyllum L. Extracts on the Gastrointestinal System: Spasmolytic, Antimicrobial and Antioxidant Properties","volume":"142","author":"Bugarski","year":"2021","journal-title":"S. Afr. J. Bot."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Duda-Chodak, A., and Tarko, T. (2023). Possible Side Effects of Polyphenols and Their Interactions with Medicines. Molecules, 28.","DOI":"10.3390\/molecules28062536"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/ptr.5249","article-title":"Gallic Acid Exhibits Risks of Inducing Muscular Hemorrhagic Liposis and Cerebral Hemorrhage-Its Action Mechanism and Preventive Strategy","volume":"29","author":"Hsieh","year":"2015","journal-title":"Phytother. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"113492","DOI":"10.1016\/j.fct.2022.113492","article-title":"Gallic, Ellagic Acids and Their Oral Combined Administration Induce Kidney, Lung, and Heart Injury after Acute Exposure in Wistar Rats","volume":"170","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.fct.2018.10.040","article-title":"Reproductive and Developmental Toxicity Study of Caffeic Acid in Mice","volume":"123","author":"Liu","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1080\/13510002.2016.1159817","article-title":"Intravenous Rutin in Rat Exacerbates Isoprenaline-Induced Cardiotoxicity Likely Due to Intracellular Oxidative Stress","volume":"22","author":"Palicka","year":"2017","journal-title":"Redox Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/toxsci\/kfh263","article-title":"Resveratrol-Associated Renal Toxicity","volume":"82","author":"Crowell","year":"2004","journal-title":"Toxicol. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Tian, Y., Jiang, X., Guo, J., Lu, H., Xie, J., Zhang, F., Yao, C., and Hao, E. (2025). Pharmacological Potential of Cinnamic Acid and Derivatives: A Comprehensive Review. Pharmaceuticals, 18.","DOI":"10.3390\/ph18081141"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Pang, Y., Jiang, M., Ge, B., Huang, L., Rao, X., Wang, X., Zhou, H., Lyu, J., Wang, Z., and Tan, G. (2026). Safe Dosage and Potential Risks of Chlorogenic Acid: Insights from in Vitro and in Vivo Studies. Front. Pharmacol., 17.","DOI":"10.3389\/fphar.2026.1740609"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"245","DOI":"10.36253\/ahsc-18140","article-title":"Achillea millefolium L.: A Comprehensive Review of Its Phytochemistry and Pharmacological Properties","volume":"39","author":"Prisa","year":"2025","journal-title":"Adv. Hortic. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"189","DOI":"10.31254\/phyto.2023.12307","article-title":"Exploring the Diverse Bioactive Compounds from Medicinal Plants: A Review","volume":"12","author":"Dar","year":"2023","journal-title":"J. Phytopharm."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Lopez-Ortiz, C., Gracia-Rodriguez, C., Belcher, S., Flores-Iga, G., Das, A., Nimmakayala, P., Balagurusamy, N., and Reddy, U.K. (2023). Drosophila melanogaster as a Translational Model System to Explore the Impact of Phytochemicals on Human Health. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202308.0667.v1"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S1369-7021(11)70113-4","article-title":"Drosophila\u2014A Versatile Model in Biology & Medicine","volume":"14","author":"Jennings","year":"2011","journal-title":"Mater. Today"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.biopha.2017.03.001","article-title":"Drosophila melanogaster \u201ca Potential Model Organism\u201d for Identification of Pharmacological Properties of Plants\/Plant-Derived Components","volume":"89","author":"Panchal","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11130-018-0699-5","article-title":"Total Phenolic Contents and Antioxidant Potential of Herbs Used for Medical and Culinary Purposes","volume":"74","author":"Wesolowski","year":"2019","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.sjbs.2016.01.036","article-title":"Comparative Analysis of Bioactive Phenolic Compounds Composition from 26 Medicinal Plants","volume":"25","author":"Sytar","year":"2018","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0305-1978(01)00033-3","article-title":"Flavonoids as Chemotaxonomic Markers for Asteraceae","volume":"29","author":"Emerenciano","year":"2001","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1002\/fsn3.855","article-title":"Resveratrol: A Miraculous Natural Compound for Diseases Treatment","volume":"6","author":"Koushki","year":"2018","journal-title":"Food Sci. Nutr."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Vojvodi\u0107, S., Bo\u017eovi\u0107, D., A\u0107imovi\u0107, M., Ga\u0161i\u0107, U., Zekovi\u0107, Z., Bebek Markovinovi\u0107, A., Bursa\u0107 Kova\u010devi\u0107, D., Zlatkovi\u0107, B., and Pavli\u0107, B. (2025). A Preliminary Insight into Under-Researched Plants from the Asteraceae Family in the Balkan Peninsula: Bioactive Compound Diversity and Antioxidant Potential. Plants, 14.","DOI":"10.3390\/plants14182904"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Ulewicz-Magulska, B., and Wesolowski, M. (2023). Antioxidant Activity of Medicinal Herbs and Spices from Plants of the Lamiaceae, Apiaceae and Asteraceae Families: Chemometric Interpretation of the Data. Antioxidants, 12.","DOI":"10.3390\/antiox12122039"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"928","DOI":"10.31925\/farmacia.2021.5.15","article-title":"Comparative Phytochemical Evaluation in Several Achillea Species from Romania","volume":"69","author":"Popovici","year":"2021","journal-title":"Farmacia"},{"key":"ref_70","first-page":"45","article-title":"Identification and Quantification of Phenolic Compounds from Red Grape Pomace","volume":"19","author":"Frum","year":"2018","journal-title":"Sci. Study Res. Chem. Chem. Eng. Biotechnol. Food Ind."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Georgescu, C., Frum, A., Virchea, L.-I., Sumacheva, A., Shamtsyan, M., Gligor, F.-G., Olah, N.K., Mathe, E., and Mironescu, M. (2022). Geographic Variability of Berry Phytochemicals with Antioxidant and Antimicrobial Properties. Molecules, 27.","DOI":"10.3390\/molecules27154986"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.hermed.2015.04.002","article-title":"Phytochemical Variation: How to Resolve the Quality Controversies of Herbal Medicinal Products?","volume":"5","author":"Dhami","year":"2015","journal-title":"J. Herb. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"218","DOI":"10.5530\/pres.13.4.14","article-title":"Seasonal Variation of Phytochemicals in Four Selected Medicinal Plants","volume":"13","author":"Mwamatope","year":"2021","journal-title":"Pharmacogn. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"604","DOI":"10.5897\/AJB2013.13432","article-title":"Seasonal Variation in Phytochemicals and Antioxidant Activities in Different Tissues of Various Broccoli Cultivars","volume":"13","author":"Bhandari","year":"2014","journal-title":"Afr. J. Biotechnol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Rizzuti, B., Grande, F., Conforti, F., Jimenez-Alesanco, A., Ceballos-Laita, L., Ortega-Alarcon, D., Vega, S., Reyburn, H.T., Abian, O., and Velazquez-Campoy, A. (2021). Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs. Biomedicines, 9.","DOI":"10.3390\/biomedicines9040375"},{"key":"ref_76","first-page":"1","article-title":"Rutin: A Potential Antiviral for Repurposing as a SARS-CoV-2 Main Protease (Mpro ) Inhibitor","volume":"16","author":"Agrawal","year":"2021","journal-title":"Nat. Prod. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"184241","DOI":"10.1155\/2015\/184241","article-title":"Antiviral Activity of Resveratrol against Human and Animal Viruses","volume":"2015","author":"Abba","year":"2015","journal-title":"Adv. Virol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Leonardi, R., Lo Bianco, M., Spinello, S., Betta, P., Gagliano, C., Calabrese, V., Polizzi, A., and Malaguarnera, G. (2025). Resveratrol as an Adjunct Antiviral Agent in Pediatric Viral Infections: A Review on Mechanistic Insights and Gut Microbiota Modulation. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262311341"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"112767","DOI":"10.1016\/j.biopha.2022.112767","article-title":"The Potential Role of Resveratrol as Supportive Antiviral in Treating Conditions Such as COVID-19\u2014A Formulator\u2019s Perspective","volume":"148","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"138756","DOI":"10.1155\/2022\/7138756","article-title":"Insights into the Anti-Inflammatory and Antiviral Mechanisms of Resveratrol","volume":"2022","author":"Chen","year":"2022","journal-title":"Mediat. Inflamm."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/BF02977330","article-title":"Anti-Asthmatic Action of Quercetin and Rutin in Conscious Guinea-Pigs Challenged with Aerosolized Ovalbumin","volume":"30","author":"Jung","year":"2007","journal-title":"Arch. Pharmacal Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"433","DOI":"10.5114\/ada.2022.117543","article-title":"Resveratrol in the Treatment of Asthma Based on an Animal Model","volume":"39","author":"Leis","year":"2022","journal-title":"Post\u0119py Dermatol. Alergol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"106163","DOI":"10.1016\/j.phrs.2022.106163","article-title":"Rutin Ameliorates Inflammation and Improves Metabolic Function: A Comprehensive Analysis of Scientific Literature","volume":"178","author":"Muvhulawa","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"8431","DOI":"10.1007\/s12010-024-05003-4","article-title":"Anti-Inflammatory Effects of Quercetin, Rutin, and Troxerutin Result From the Inhibition of NO Production and the Reduction of COX-2 Levels in RAW 264.7 Cells Treated with LPS","volume":"196","author":"Lee","year":"2024","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_85","first-page":"32394","article-title":"Rutin Promotes Wound Healing by Inhibiting Oxidative Stress and Inflammation in Metformin-Controlled Diabetes in Rats","volume":"9","author":"Naseeb","year":"2024","journal-title":"ACS Omega"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/iwj.13601","article-title":"The Impact of Resveratrol on Skin Wound Healing, Scarring, and Aging","volume":"19","author":"Hecker","year":"2022","journal-title":"Int. Wound J."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Zou, Z., Zhang, F., Pan, Z., Xu, J., Li, X., Sun, X., Wang, X., Qin, F., Abulizi, A., and Chen, Q. (2025). Assessing the Therapeutic Potential of Rutin in Alleviating Symptoms of Inflammatory Bowel Disease: A Meta-Analysis. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1539469"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"25162","DOI":"10.1038\/s41598-025-08450-z","article-title":"Resveratrol Attenuates Hepatic Oxidative Stress and Preserves Gut Mucosal Integrity in High-Fat Diet-Fed Rats by Modulating Antioxidant and Anti-Inflammatory Pathways","volume":"15","author":"Yasmin","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_89","first-page":"100320","article-title":"Extraction of Rutin from Tagetes Erecta (Marigold) and Preparation of Peroral Nano-Suspension for Effective Antitussive\/Expectorant Therapy","volume":"5","author":"Moravkar","year":"2023","journal-title":"Carbohydr. Polym. Technol. Appl."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.2147\/DDDT.S148868","article-title":"Resveratrol as a Potential Therapeutic Drug for Respiratory System Diseases","volume":"11","author":"Zhu","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"107613","DOI":"10.1016\/j.pharmthera.2020.107613","article-title":"Therapeutic Potential of Resveratrol against Emerging Respiratory Viral Infections","volume":"214","author":"Filardo","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.antiviral.2012.03.005","article-title":"Quercetin Inhibits Rhinovirus Replication In Vitro and In Vivo","volume":"94","author":"Ganesan","year":"2012","journal-title":"Antivir. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/13880209.2018.1474932","article-title":"Quercetin Promotes Gastrointestinal Motility and Mucin Secretion in Loperamide-Induced Constipation of SD Rats through Regulation of the mAChRs Downstream Signal","volume":"56","author":"Kim","year":"2018","journal-title":"Pharm. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"114852","DOI":"10.1016\/j.intimp.2025.114852","article-title":"Promotion of Sleep by Cinnamic Acid in Parachlorophenylalanine-Induced Insomnia in Rats","volume":"158","author":"Ye","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"109864","DOI":"10.1155\/2013\/109864","article-title":"Cinnamic Acid Is Partially Involved in Propolis Immunomodulatory Action on Human Monocytes","volume":"2013","author":"Conti","year":"2013","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Ivani\u0161ov\u00e1, E., Hor\u0148\u00e1k, M., \u010cech, M., Harangozo, \u013d., Ka\u010d\u00e1niov\u00e1, M., Grygorieva, O., and Kowalczewski, P.\u0141. (2023). Polyphenol Content, Mineral Compounds Composition, Antimicrobial and Antioxidant Activities of Selected Medicinal Herbs from Slovak Republic. Appl. Sci., 13.","DOI":"10.3390\/app13031918"},{"key":"ref_97","first-page":"10626","article-title":"In Vitro Antioxidant and Antifungal Properties of Achillea millefolium L.","volume":"20","author":"Fierascu","year":"2015","journal-title":"Rom. Biotechnol. Lett."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Gavan, A., Colobatiu, L., Hanganu, D., Bogdan, C., Olah, N.K., Achim, M., and Mirel, S. (2022). Development and Evaluation of Hydrogel Wound Dressings Loaded with Herbal Extracts. Processes, 10.","DOI":"10.3390\/pr10020242"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1134\/S1021443724610553","article-title":"Phytochemicals and Antioxidant Activity of Mentha longifolia Ecotypes","volume":"72","author":"Tabar","year":"2025","journal-title":"Russ. J. Plant Physiol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Horablaga, N.M., Cozma, A., Alexa, E., Obistioiu, D., Cocan, I., Poiana, M.-A., Lalescu, D., Pop, G., Imbrea, I.M., and Buzna, C. (2023). Influence of Sample Preparation\/Extraction Method on the Phytochemical Profile and Antimicrobial Activities of 12 Commonly Consumed Medicinal Plants in Romania. Appl. Sci., 13.","DOI":"10.3390\/app13042530"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Yang, R., Dong, Y., Gao, F., Li, J., Stevanovic, Z.D., Li, H., and Shi, L. (2023). Comprehensive Analysis of Secondary Metabolites of Four Medicinal Thyme Species Used in Folk Medicine and Their Antioxidant Activities In Vitro. Molecules, 28.","DOI":"10.3390\/molecules28062582"},{"key":"ref_102","first-page":"23","article-title":"Ethanol Thymus serpyllum Extracts: Evaluation of Extraction Conditions via Total Polyphenol Content and Radical Scavenging Activity","volume":"39","author":"Skrt","year":"2019","journal-title":"Lek. Sirov."},{"key":"ref_103","first-page":"3467","article-title":"Studies on the Antioxidant Activity, Phenol and Flavonoid Contents of Some Selected Romanian Medicinal Plants Used for Wound Healing","volume":"12","author":"Alexandru","year":"2007","journal-title":"Rom. Biotechnol. Lett."},{"key":"ref_104","first-page":"1459","article-title":"Total Phenol\/Flavonoid Content, Antibacterial and DPPH Free Radical Scavenging Activities of Medicinal Plants","volume":"21","author":"Fahmideh","year":"2019","journal-title":"J. Agric. Sci. Technol."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Sepahpour, S., Selamat, J., Abdul Manap, M., Khatib, A., and Abdull Razis, A. (2018). Comparative Analysis of Chemical Composition, Antioxidant Activity and Quantitative Characterization of Some Phenolic Compounds in Selected Herbs and Spices in Different Solvent Extraction Systems. Molecules, 23.","DOI":"10.3390\/molecules23020402"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Saini, R.K., Ranjit, A., Sharma, K., Prasad, P., Shang, X., Gowda, K.G.M., and Keum, Y.-S. (2022). Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes. Antioxidants, 11.","DOI":"10.3390\/antiox11020239"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.foodchem.2011.04.045","article-title":"Comparative Antioxidant Activities of Carotenoids Measured by Ferric Reducing Antioxidant Power (FRAP), ABTS Bleaching Assay (\u03b1TEAC), DPPH Assay and Peroxyl Radical Scavenging Assay","volume":"129","year":"2011","journal-title":"Food Chem."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Virchea, L.-I., Georgescu, C., M\u00e1th\u00e9, E., Frum, A., Mironescu, M., Pecsenye, B., Nagy, R., Danci, O., Mure\u0219an, M.-L., and Totan, M. (2025). Assessment of Purple Loosestrife (Lythrum salicaria L.) Extracts from Wild Flora of Transylvania: Phenolic Profile, Antioxidant Activity, In Vivo Toxicity, and Gene Expression Variegation Studies. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17091097"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2007.08.007","article-title":"Hormesis Defined","volume":"7","author":"Mattson","year":"2008","journal-title":"Ageing Res. Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10522-017-9700-1","article-title":"Hormetic Efficacy of Rutin to Promote Longevity in Drosophila melanogaster","volume":"18","author":"Chattopadhyay","year":"2017","journal-title":"Biogerontology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/gerona\/glr103","article-title":"Aloe Vera or Resveratrol Supplementation in Larval Diet Delays Adult Aging in the Fruit Fly, Drosophila melanogaster","volume":"66A","author":"Chandrashekara","year":"2011","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.bbrc.2018.06.114","article-title":"Resveratrol Prolongs Lifespan and Improves 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Oxidative Damage and Behavioural Deficits in Drosophila melanogaster","volume":"503","author":"Abolaji","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11357-011-9332-3","article-title":"The Effect of Resveratrol on Lifespan Depends on Both Gender and Dietary Nutrient Composition in Drosophila melanogaster","volume":"35","author":"Wang","year":"2013","journal-title":"Age"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s13596-019-00393-x","article-title":"Gallic Acid Protects against Neurochemical Alterations in Transgenic Drosophila Model of Alzheimer\u2019s Disease","volume":"20","author":"Ogunsuyi","year":"2020","journal-title":"Adv. Tradit. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4314\/jaaps.v11i1.5","article-title":"Modulatory Role of Dose-Dependent Quercetin Supplemented Diet on Behavioral and Anti-Oxidant System in Drosophila melanogaster Model","volume":"11","author":"Olanrewaju","year":"2023","journal-title":"J. Afr. Assoc. Physiol. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.3923\/pjbs.2007.1708.1712","article-title":"Recovering Effects of Aqueous Extracts of Some Selected Medical Plants on the Teratogenic Effects During the Development of D. Melanogaster","volume":"10","author":"Uysal","year":"2007","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"803","DOI":"10.63369\/ijat.2025.21.3.803-816","article-title":"Nutritional Evaluation of Santol (Sandoricum Koetjape) and the Effects of Santol Flesh Extract on Drosophila melanogaster","volume":"21","author":"Aphichartphankawee","year":"2025","journal-title":"Int. J. Agric. Tech."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1667\/RR3228","article-title":"The Linear No-Threshold Model Does Not Hold for Low-Dose Ionizing Radiation","volume":"162","author":"Hooker","year":"2004","journal-title":"Radiat. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1177\/0960327112455069","article-title":"Hormesis: Its Impact on Medicine and Health","volume":"32","author":"Calabrese","year":"2012","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e13318","DOI":"10.1111\/jfbc.13318","article-title":"Modulatory Effects of Moringa ( Moringa oleifera L.) Leaves Infested with African Mistletoe ( Tapinanthus bangwensis L.) on the Antioxidant, Antidiabetic, and Neurochemical Indices in High Sucrose Diet-induced Diabetic-like Phenotype in Fruit Flies (Drosophila melanogaster M.)","volume":"45","author":"Oyeniran","year":"2021","journal-title":"J. Food Biochem."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.biopha.2017.02.076","article-title":"High-Sucrose Diet Induces Diabetic-like Phenotypes and Oxidative Stress in Drosophila melanogaster: Protective Role of Syzygium Cumini and Bauhinia Forficata","volume":"89","author":"Ecker","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Wang, M., Mao, H., Chen, J., Qi, L., and Wang, J. (2022). Ameliorative Effect of Bayberry Leaves Proanthocyanidins on High Sugar Diet Induced Drosophila melanogaster. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1008580"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1242\/dmm.007948","article-title":"A High-Sugar Diet Produces Obesity and Insulin Resistance in Wild-Type Drosophila","volume":"4","author":"Fink","year":"2011","journal-title":"Dis. Models Mech."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e1712","DOI":"10.52225\/narra.v5i1.1712","article-title":"Exploring the Antidiabetic Potential of Sulawesi Ethnomedicines: A Study of Cordia Myxa and Syzygium Malaccense in a Drosophila Model of Hyperglycemia","volume":"5","author":"Nainu","year":"2025","journal-title":"Narra J."},{"key":"ref_125","first-page":"2564","article-title":"Flos Chrysanthemi Indici Extract Improves a High-Sucrose Diet-Induced Metabolic Disorder in Drosophila","volume":"16","author":"Bai","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"a017780","DOI":"10.1101\/cshperspect.a017780","article-title":"Position-Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila","volume":"5","author":"Elgin","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Hoyer-Fender, S. (2020). Transgenerational Effect of Drug-Mediated Inhibition of LSD1 on Eye Pigment Expression in Drosophila. BMC Ecol., 20.","DOI":"10.1186\/s12898-020-00330-6"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e11148","DOI":"10.15252\/msb.202211148","article-title":"Stress-sensitive Dynamics of miRNAs and Elba1 in Drosophila Embryogenesis","volume":"19","author":"Skog","year":"2023","journal-title":"Mol. Syst. Biol."},{"key":"ref_129","unstructured":"S\u00e2rbu, I., \u015etefan, N., and Oprea, A. (2013). Plante Vasculare din Romania: Determinator Ilustrat de Teren, Editura Victor B Victor."},{"key":"ref_130","first-page":"612","article-title":"The Simultaneous Determination of Candesartan, Amlodipine and Hydrochlorothiazide Byhigh-Performance Liquid Chromatography, from A Mixture and Pharmaceutical Formulations","volume":"64","author":"Moisei","year":"2016","journal-title":"Farmacia"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Frum, A., Dobrea, C.M., Rus, L.L., Virchea, L.-I., Morgovan, C., Chis, A.A., Arseniu, A.M., Butuca, A., Gligor, F.G., and Vicas, L.G. (2022). Valorization of Grape Pomace and Berries as a New and Sustainable Dietary Supplement: Development, Characterization, and Antioxidant Activity Testing. Nutrients, 14.","DOI":"10.3390\/nu14153065"},{"key":"ref_132","first-page":"267","article-title":"Assessment of Antioxidant Capacity of Some Extracts for Further Use in Therapy","volume":"63","author":"Marian","year":"2015","journal-title":"Farmacia"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Aleya, A., Mihok, E., Pecsenye, B., Jolji, M., Kert\u00e9sz, A., B\u00e1rsony, P., V\u00edgh, S., Cziaky, Z., M\u00e1th\u00e9, A.-B., and Burtescu, R.F. (2023). Phytoconstituent Profiles Associated with Relevant Antioxidant Potential and Variable Nutritive Effects of the Olive, Sweet Almond, and Black Mulberry Gemmotherapy Extracts. Antioxidants, 12.","DOI":"10.3390\/antiox12091717"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF00484381","article-title":"Control of Drosopterin Synthesis in Drosophila melanogaster: Mutants Showing an Altered Pattern of GTP Cyclohydrolase Activity During Development","volume":"16","author":"Evans","year":"1978","journal-title":"Biochem. Genet."},{"key":"ref_135","first-page":"41","article-title":"Phenolic Content, Antioxidant Activity and Effect on Collagen Synthesis of a Traditional Wound Healing Polyherbal Formula","volume":"25","author":"Alexandru","year":"2015","journal-title":"Stud. Univ. Vasile Goldi\u015f Ser. \u015etiin\u0163. Vie\u0163ii"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/9\/1527\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:06:37Z","timestamp":1778162797000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/9\/1527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":135,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["molecules31091527"],"URL":"https:\/\/doi.org\/10.3390\/molecules31091527","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]}}}