{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:26:46Z","timestamp":1777969606261,"version":"3.51.4"},"reference-count":48,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this study, the synthesis of a series of alkaloid analogs\u2014isoxazole and isothiazole esters of 2-substituted 3-oxoindoline-4-carboxylic acid was performed. The target derivatives were obtained by the carbodiimide method. It was established that the studied esters have low cytotoxicity and are able to enhance the effect of the anticancer drug carboplatin, taken in low doses (0.5\u20135 \u03bcM), by up to 30%. Quantum chemical modeling of the obtained compounds and their conjugates with carboplatin was carried out to analyze the relationship between various calculated parameters and the observed biological effects.<\/jats:p>","DOI":"10.3390\/molecules31091528","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:57:29Z","timestamp":1777967849000},"page":"1528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Structure, and Antitumor Activity of Heterocyclic 2-[4-(Dimethylamino)benzyl]-3-oxoisoindoline-4-carboxylates"],"prefix":"10.3390","volume":"31","author":[{"given":"Gulim K.","family":"Mukusheva","sequence":"first","affiliation":[{"name":"Chemistry Faculty, NLC \u201cKaraganda National Research University Named After Academician Ye.A. 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