{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:37:55Z","timestamp":1785411475650,"version":"3.56.0"},"reference-count":62,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016971","name":"Moscow State University","doi-asserted-by":"crossref","award":["AAAA-A21-121012290046-4"],"award-info":[{"award-number":["AAAA-A21-121012290046-4"]}],"id":[{"id":"10.13039\/501100016971","id-type":"DOI","asserted-by":"crossref"}]},{"award":["AAAA-A21-121012290046-4"],"award-info":[{"award-number":["AAAA-A21-121012290046-4"]}],"id":[{"id":"https:\/\/ror.org\/010pmpe69","id-type":"ROR","asserted-by":"publisher"}]},{"name":"the M.V. Lomonosov Moscow State University Program of Development"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A convergent scheme for the preparation of conjugates with the dispiroindolinone-pyrrolidine-thioimidazolone and glutarimide moieties connected via a triazole-containing linker is proposed. Target conjugates were synthesized by azide\u2013alkyne (3+2) cycloaddition reactions between propargylthio-substituted dispiroindolinone-pyrrolidine-imidazolones and an azido-glutarimide derivative. The starting compounds were available isothiocyanates, glycine, substituted benzaldehydes, chloroacetamide, and ethyl acrylate. The key azide\u2013alkyne (3+2) cycloaddition step was carried out using TBTA as a catalyst, achieving &gt;70% product yields. The resulting bifunctional compounds contained a fragment of dispiroindolinone (a p53-MDM2 interaction inhibitor) and glutarimide, a ubiquitin ligase ligand. The obtained dispiroindolinone-glutarimide conjugates were tested for their potential as hetero-PROTAC compounds for p53 reactivation. Individual conjugates showed preferential cytotoxicity against HCT116 colon carcinoma cells (wild-type53) compared to the isogenic HCT116p53\u2212\/\u2212 subline.<\/jats:p>","DOI":"10.3390\/molecules31101602","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:05:22Z","timestamp":1778501122000},"page":"1602","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dispiroindolinone\u2013Glutarimide Conjugates: Synthesis and Evaluation as Potential Hetero-PROTACs for p53 Reactivation"],"prefix":"10.3390","volume":"31","author":[{"given":"Vladislav S.","family":"Polyakov","sequence":"first","affiliation":[{"name":"Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri K.","family":"Grishin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor A.","family":"Tafeenko","sequence":"additional","affiliation":[{"name":"Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina S.","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Institute of Experimental Oncology and Carcinogenesis, Blokhin National Research Center of Oncology, 24 Kashirskoye Shosse, 115522 Moscow, Russia"},{"name":"Institute of Cyber Intelligence, National Research Nuclear University MEPhI, 31 Kashirskoye Shosse, 115409 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofya S.","family":"Pogodaeva","sequence":"additional","affiliation":[{"name":"Center for Molecular and Biological Technologies, ITMO University, 9 Lomonosov Street, 197101 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniil V.","family":"Moldavskii","sequence":"additional","affiliation":[{"name":"Center for Molecular and Biological Technologies, ITMO University, 9 Lomonosov Street, 197101 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A.","family":"Shtil","sequence":"additional","affiliation":[{"name":"Institute of Experimental Oncology and Carcinogenesis, Blokhin National Research Center of Oncology, 24 Kashirskoye Shosse, 115522 Moscow, Russia"},{"name":"Institute of Cyber Intelligence, National Research Nuclear University MEPhI, 31 Kashirskoye Shosse, 115409 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6796-8241","authenticated-orcid":false,"given":"Elena K.","family":"Beloglazkina","sequence":"additional","affiliation":[{"name":"Department of Chemistry, M.V. 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