{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:47:22Z","timestamp":1790952442978,"version":"4.1.0"},"reference-count":133,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["2796234"],"award-info":[{"award-number":["2796234"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2796234"],"award-info":[{"award-number":["2796234"]}],"id":[{"id":"https:\/\/ror.org\/0439y7842","id-type":"ROR","asserted-by":"publisher"}]},{"name":"BioMara Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Fucoidan is a sulfated polysaccharide derived from brown seaweed, reported to possess diverse biological activities that make it a molecule of great interest for nutraceutical and biomedical applications. A significant challenge to its wider implementation is a lack of understanding of the relationship between fucoidan\u2019s structural and chemical characteristics with its biological activity. So far, approaches to identifying these relationships have been limited to qualitative comparisons of chemical and biological datasets or through chemically modified fucoidans. This work aimed to apply a formal methodology to elucidate potential relationships worthy of further exploration. The biological activity of commercial fucoidan extracts was assessed after detailed chemical characterization. The extracts exhibited multiple bioactivities, notably antioxidant activity, antiviral activity against Nipah virus, antifungal activity against Candida dubliensis and prebiotic effects on Lactobacillus casei, with no antifungal activity against Candida albicans, Candida auris and Cryptococcus neoformans, nor antibacterial effects against Klebsiella pneumoniae. Correlation analysis of biological activity and extract chemical characterization data identified several potential key quality attributes. Other than high fucose content, high sulfate content is identified as potentially important for antioxidant, antiviral, antifungal, and prebiotic activities. This work addressed the literature\u2019s debate regarding the optimal molecular weight for bioactivity, suggesting that it depends on the specific microbe to which a fucoidan extract is applied. This study demonstrated that a formalized comparative approach, linking chemical and structural data with biological activity, can effectively identify important characteristics of fucoidan for a specific bioactivity. Future work will focus on expanding this approach by assessing the bioactivity of a wider array of chemically characterized fucoidan extracts. Additionally, extracts possessing identified quality attributes should be produced and employed in mechanistic bioactive studies to further validate the correlations drawn in this work.<\/jats:p>","DOI":"10.3390\/molecules31101618","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:39:32Z","timestamp":1778513972000},"page":"1618","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Structure-Function Correlations of Commercial Fucoidan Extracts: Antioxidant, Antiviral, Antifungal, Antibacterial and Prebiotic Activities"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4581-5457","authenticated-orcid":false,"given":"Matthew","family":"Chadwick","sequence":"first","affiliation":[{"name":"Institute for Bioengineering, The School of Engineering, The University of Edinburgh, Edinburgh EH9 3JL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Sole Regina","family":"Lancerin","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research, Institute of Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Hazelton","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering, The School of Engineering, The University of Edinburgh, Edinburgh EH9 3JL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriakos","family":"Vidalis","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research, Institute of Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1533-6909","authenticated-orcid":false,"given":"Emmanuel","family":"Petit","sequence":"additional","affiliation":[{"name":"UMRT INRAe 1158 BioEcoAgro-BIOPI, IUT-GB, Universit\u00e9 de Picardie Jules Verne, 80025 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2864-4388","authenticated-orcid":false,"given":"Paolina","family":"Lukova","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3605-1929","authenticated-orcid":false,"given":"C\u00e9dric","family":"Delattre","sequence":"additional","affiliation":[{"name":"Institut Pascal, CNRS, Clermont Auvergne INP, Universit\u00e9 Clermont Auvergne, 63000 Clermont-Ferrand, France"},{"name":"Institut Universitaire de France (IUF), 1 Rue Descartes, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3189-2756","authenticated-orcid":false,"given":"Xianfeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering, The School of Engineering, The University of Edinburgh, Edinburgh EH9 3JL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamarai","family":"Schneiders","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research, Institute of Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0668-6157","authenticated-orcid":false,"given":"Vasso","family":"Makrantoni","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research, Institute of Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK"},{"name":"Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining 314400, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sloan","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research, Institute of Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK"},{"name":"Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining 314400, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9695-1278","authenticated-orcid":false,"given":"Simone","family":"Dimartino","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering, The School of Engineering, The University of Edinburgh, Edinburgh EH9 3JL, UK"},{"name":"Planet Crafting Labs, 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Rep."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Dobrin\u010di\u0107, A., Pedisi\u0107, S., Zori\u0107, Z., Jurin, M., Roje, M., \u010co\u017e-Rakovac, R., and Dragovi\u0107-Uzelac, V. (2021). Microwave Assisted Extraction and Pressurized Liquid Extraction of Sulfated Polysaccharides from Fucus virsoides and Cystoseira barbata. Foods, 10.","DOI":"10.3390\/foods10071481"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jbiosc.2021.06.005","article-title":"Effect of Molecular Mass and Sulfate Content of Fucoidan from Sargassum siliquosum on Antioxidant, Anti-Lipogenesis, and Anti-Inflammatory Activity","volume":"132","author":"Chen","year":"2021","journal-title":"J. Biosci. Bioeng."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"119551","DOI":"10.1016\/j.carbpol.2022.119551","article-title":"A State-of-the-Art Review on Fucoidan as an Antiviral Agent to Combat Viral Infections","volume":"291","author":"Pradhan","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Nosik, M.N., Krylova, N.V., Usoltseva, R.V., Surits, V.V., Kireev, D.E., Shchelkanov, M.Y., Svitich, O.A., and Ermakova, S.P. (2024). In Vitro Anti-HIV-1 Activity of Fucoidans from Brown Algae. Mar. Drugs, 22.","DOI":"10.3390\/md22080355"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.carbpol.2014.08.068","article-title":"Anti-HIV Activity of Fucoidans from Three Brown Seaweed Species","volume":"115","author":"Thuy","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Tabassum, N., Khan, F., Kang, M.-G., Jo, D.-M., Cho, K.-J., and Kim, Y.-M. (2023). Inhibition of Polymicrobial Biofilms of Candida Albicans\u2013Staphylococcus aureus\/Streptococcus mutans by Fucoidan\u2013Gold Nanoparticles. Mar. Drugs, 21.","DOI":"10.3390\/md21020123"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Akl, F.M.A., El-Sheekh, M.M., Makhlof, M.E.M., and Ahmed, S.I. (2025). Antimicrobial, Antidiabetic, Antiviral, and Antioxidant Activities of Fucoidan Extracted from the Brown Seaweed Padina pavonica. BMC Biotechnol., 25.","DOI":"10.1186\/s12896-025-01004-1"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"14452","DOI":"10.1038\/s41598-023-41327-7","article-title":"In Vitro Anticancer Potential of Laminarin and Fucoidan from Brown Seaweeds","volume":"13","author":"Sanniyasi","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"128092","DOI":"10.1016\/j.ijbiomac.2023.128092","article-title":"Orally Administrated Fucoidan and Its Low-Molecular-Weight Derivatives Are Absorbed Differentially to Alleviate Coagulation and Thrombosis","volume":"255","author":"Sun","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Ayrapetyan, O.N., Obluchinskaya, E.D., Zhurishkina, E.V., Skorik, Y.A., Lebedev, D.V., Kulminskaya, A.A., and Lapina, I.M. (2021). Antibacterial Properties of Fucoidans from the Brown Algae Fucus vesiculosus L. of the Barents Sea. Biology, 10.","DOI":"10.3390\/biology10010067"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ijbiomac.2018.11.201","article-title":"Effect of Different Non-Conventional Extraction Methods on the Antibacterial and Antiviral Activity of Fucoidans Extracted from Nizamuddinia zanardinii","volume":"124","author":"Alboofetileh","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Yuan, J., Qin, S., Li, W., Zhang, Y., Wang, Y., Chang, X., and Li, L. (2021). Microbiome-Metabolomics Reveals Prebiotic Benefits of Fucoidan Supplementation in Mice. J. Mar. Sci. Eng., 9.","DOI":"10.3390\/jmse9050505"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chadwick, M., Carvalho, L.G., Vanegas, C., and Dimartino, S. (2025). A Comparative Review of Alternative Fucoidan Extraction Techniques from Seaweed. Mar. Drugs, 23.","DOI":"10.3390\/md23010027"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zayed, A., El-Aasr, M., Ibrahim, A.-R.S., and Ulber, R. (2020). Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties. Mar. Drugs, 18.","DOI":"10.3390\/md18110571"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.ijbiomac.2021.06.182","article-title":"Influence of Molecular Weight Fractionation on the Antimicrobial and Anticancer Properties of a Fucoidan Rich-Extract from the Macroalgae Fucus vesiculosus","volume":"186","author":"Cabral","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Wang, Y., Xing, M., Cao, Q., Ji, A., Liang, H., and Song, S. (2019). Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies. Mar. Drugs, 17.","DOI":"10.3390\/md17030183"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wang, L., Oliveira, C., Li, Q., Ferreira, A.S., Nunes, C., Coimbra, M.A., Reis, R.L., Martins, A., Wang, C., and Silva, T.H. (2023). Fucoidan from Fucus vesiculosus Inhibits Inflammatory Response, Both In Vitro and In Vivo. Mar. Drugs, 21.","DOI":"10.3390\/md21050302"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Mabate, B., Daub, C.D., Malgas, S., Edkins, A.L., and Pletschke, B.I. (2021). Fucoidan Structure and Its Impact on Glucose Metabolism: Implications for Diabetes and Cancer Therapy. Mar. Drugs, 19.","DOI":"10.3390\/md19010030"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.carbpol.2015.04.057","article-title":"Microwave Assisted Extraction of Sulfated Polysaccharides (Fucoidan) from Ascophyllum nodosum and Its Antioxidant Activity","volume":"129","author":"Yuan","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.foodhyd.2018.12.053","article-title":"The Comparative Influence of Novel Extraction Technologies on in Vitro Prebiotic-Inducing Chemical Properties of Fucoidan Extracts from Ascophyllum nodosum","volume":"90","author":"Okolie","year":"2019","journal-title":"Food Hydrocoll."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"McGurrin, A., Suchintita Das, R., Soro, A.B., Maguire, J., Fl\u00f3rez Fern\u00e1ndez, N., Dominguez, H., Torres, M.D., Tiwari, B.K., and Garcia-Vaquero, M. (2025). Antimicrobial Activities of Polysaccharide-Rich Extracts from the Irish Seaweed Alaria esculenta, Generated Using Green and Conventional Extraction Technologies, Against Foodborne Pathogens. Mar. Drugs, 23.","DOI":"10.3390\/md23010046"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"108784","DOI":"10.1016\/j.foodhyd.2023.108784","article-title":"Marine Fucoidans: Structural, Extraction, Biological Activities and Their Applications in the Food Industry","volume":"142","author":"Mensah","year":"2023","journal-title":"Food Hydrocoll."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"20151083","DOI":"10.1098\/rsif.2015.1083","article-title":"Microscopic and Infrared Spectroscopic Comparison of the Underwater Adhesives Produced by Germlings of the Brown Seaweed Species Durvillaea antarctica and Hormosira banksii","volume":"13","author":"Dimartino","year":"2016","journal-title":"J. R. Soc. Interface"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.bbabio.2007.06.004","article-title":"Infrared Spectroscopy of Proteins","volume":"1767","author":"Barth","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.3390\/md11114612","article-title":"Simultaneous Extraction and Depolymerization of Fucoidan from Sargassum muticum in Aqueous Media","volume":"11","author":"Balboa","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"14114","DOI":"10.1002\/slct.201903548","article-title":"Isolation and Bioactive Potential of Fucoidan from Marine Macroalgae Turbinaria conoides","volume":"4","author":"Ganapathy","year":"2019","journal-title":"ChemistrySelect"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Soto-V\u00e1squez, M.R., Alvarado-Garc\u00eda, P.A.A., Youssef, F.S., Ashour, M.L., Bogari, H.A., and Elhady, S.S. (2022). FTIR Characterization of Sulfated Polysaccharides Obtained from Macrocystis integrifolia Algae and Verification of Their Antiangiogenic and Immunomodulatory Potency In Vitro and In Vivo. Mar. Drugs, 21.","DOI":"10.3390\/md21010036"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Lesco, K.C., Williams, S.K.R., and Laurens, L.M.L. (2025). Marine Algae Polysaccharides: An Overview of Characterization Techniques for Structural and Molecular Elucidation. Mar. Drugs, 23.","DOI":"10.3390\/md23030105"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ijbiomac.2022.12.261","article-title":"Extraction of High Purity Fucoidans from Brown Seaweeds Using Cellulases and Alginate Lyases","volume":"229","author":"Horn","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_32","first-page":"100455","article-title":"The Structure of Fucoidan by Linkage Analysis Tailored for Fucose in Four Algae Species: Fucus serratus, Fucus evanescens, Fucus vesiculosus and Laminaria hyperborea","volume":"7","author":"Amin","year":"2024","journal-title":"Carbohydr. Polym. Technol. Appl."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3390\/molecules13081671","article-title":"Fucoidan: Structure and Bioactivity","volume":"13","author":"Li","year":"2008","journal-title":"Molecules"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.procbio.2019.03.026","article-title":"Phenomenological Investigation of the Cytotoxic Activity of Fucoidan Isolated from Fucus vesiculosus","volume":"81","author":"Zayed","year":"2019","journal-title":"Process Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"112655","DOI":"10.1016\/j.foodres.2023.112655","article-title":"Brown Algae and Their Multiple Applications as Functional Ingredient in Food Production","volume":"167","author":"Tagliapietra","year":"2023","journal-title":"Food Res. Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00253-009-2086-5","article-title":"Recent Advances in the Biological Production of Mannitol","volume":"84","author":"Song","year":"2009","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1021\/acs.biomac.0c01485","article-title":"Impact of Alginate Mannuronic-Guluronic Acid Contents and PH on Protein Binding Capacity and Complex Size","volume":"22","author":"Madsen","year":"2021","journal-title":"Biomacromolecules"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"460658","DOI":"10.1016\/j.chroma.2019.460658","article-title":"Size Distribution and Chain Conformation of Six Different Fucoidans Using Size-Exclusion Chromatography with Multiple Detection","volume":"1612","author":"Neupane","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"D\u00f6rschmann, P., Kopplin, G., Thalenhorst, T., Seeba, C., Ullah, S.F., Srivastava, V., Roider, J., and Klettner, A. (2025). Influence of a Very High-Molecular Weight Fucoidan from Laminaria hyperborea on Age-Related Macular Degeneration-Relevant Pathomechanisms in Ocular Cell Models. Mar. Drugs, 23.","DOI":"10.3390\/md23030101"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1021\/acsabm.8b00436","article-title":"Structural Characterization of Fucoidan from Laminaria hyperborea: Assessment of Coagulation and Inflammatory Properties and Their Structure\u2013Function Relationship","volume":"1","author":"Kopplin","year":"2018","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.3390\/md13042327","article-title":"Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential","volume":"13","author":"Atashrazm","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1600340","DOI":"10.1002\/mabi.201600340","article-title":"The Key Role of Sulfation and Branching on Fucoidan Antitumor Activity","volume":"17","author":"Oliveira","year":"2017","journal-title":"Macromol. Biosci."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Cotas, J., Leandro, A., Monteiro, P., Pacheco, D., Figueirinha, A., Gon\u00e7alves, A.M.M., Da Silva, G.J., and Pereira, L. (2020). Seaweed Phenolics: From Extraction to Applications. Mar. Drugs, 18.","DOI":"10.3390\/md18080384"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/pca.1210","article-title":"Phenolic Compounds in the Brown Seaweed Ascophyllum nodosum: Distribution and Radical-Scavenging Activities","volume":"21","author":"Audibert","year":"2010","journal-title":"Phytochem. Anal."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Jayawardena, T.U., Nagahawatta, D.P., Fernando, I.P.S., Kim, Y.-T., Kim, J.-S., Kim, W.-S., Lee, J.S., and Jeon, Y.-J. (2022). A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent. Mar. Drugs, 20.","DOI":"10.3390\/md20120755"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Pozharitskaya, O.N., Obluchinskaya, E.D., and Shikov, A.N. (2020). Mechanisms of Bioactivities of Fucoidan from the Brown Seaweed Fucus vesiculosus L. of the Barents Sea. Mar. Drugs, 18.","DOI":"10.3390\/md18050275"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"143494","DOI":"10.1016\/j.foodchem.2025.143494","article-title":"Study of Phenolic-Polysaccharide Interactions in Brown Seaweed","volume":"477","author":"Lee","year":"2025","journal-title":"Food Chem."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Obluchinskaya, E.D., Pozharitskaya, O.N., and Shikov, A.N. (2022). In Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds. Mar. Drugs, 20.","DOI":"10.3390\/md20100606"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"131654","DOI":"10.1016\/j.ijbiomac.2024.131654","article-title":"Spray-Drying and Rehydration on \u03b2-Carotene Encapsulated Pickering emulsion with Chitosan and Seaweed Polyphenol","volume":"268","author":"Meng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1039\/D0FO02017F","article-title":"Inhibitory Activities of Marine Sulfated Polysaccharides against SARS-CoV-2","volume":"11","author":"Song","year":"2020","journal-title":"Food Funct."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijbiomac.2015.09.078","article-title":"In Vitro Anti-HIV-1 Activity of Fucoidan from Sargassum swartzii","volume":"82","author":"Dinesh","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/1743-422X-9-307","article-title":"In Vitro Characterization of the Antiviral Activity of Fucoidan from Cladosiphon okamuranus against Newcastle Disease Virus","volume":"9","year":"2012","journal-title":"Virol. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s11802-018-3794-1","article-title":"Studies on Antiviral and Immuno-Regulation Activity of Low Molecular Weight Fucoidan from Laminaria japonica","volume":"17","author":"Sun","year":"2018","journal-title":"J. Ocean Univ. China"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2220\/biomedres.29.331","article-title":"Fucoidan Inhibits Parainfluenza Virus Type 2 Infection to LLCMK2 Cells","volume":"29","author":"Taoda","year":"2008","journal-title":"Biomed. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11908-006-0036-2","article-title":"Nipah Virus: Impact, Origins, and Causes of Emergence","volume":"8","author":"Epstein","year":"2006","journal-title":"Curr. Infect. Dis. Rep."},{"key":"ref_56","unstructured":"WHO (2025, April 08). Prioritizing Diseases for Research and Development in Emergency Contexts. Available online: https:\/\/www.who.int\/activities\/prioritizing-diseases-for-research-and-development-in-emergency-contexts."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e463","DOI":"10.1016\/S2542-5196(24)00119-0","article-title":"Mapping the Distribution of Nipah Virus Infections: A Geospatial Modelling Analysis","volume":"8","author":"Sun","year":"2024","journal-title":"Lancet Planet. Health"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/20477724.2024.2380131","article-title":"Global and Regional Mortality Statistics of Nipah Virus from 1994 to 2023: A Comprehensive Systematic Review and Meta-Analysis","volume":"118","author":"Vasudevan","year":"2024","journal-title":"Pathog. Glob. Health"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1128\/JVI.80.10.4878-4889.2006","article-title":"N-Glycans on Nipah Virus Fusion Protein Protect against Neutralization but Reduce Membrane Fusion and Viral Entry","volume":"80","author":"Aguilar","year":"2006","journal-title":"J. Virol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Cagno, V., Tseligka, E.D., Jones, S.T., and Tapparel, C. (2019). Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?. Viruses, 11.","DOI":"10.3390\/v11070596"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1007\/s11224-023-02148-6","article-title":"Are We Ready to Fight the Nipah Virus Pandemic? An Overview of Drug Targets, Current Medications, and Potential Leads","volume":"34","author":"Yang","year":"2023","journal-title":"Struct. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Mak, N.S.C., Liu, J., Zhang, D., Taylor, J., Li, X., Rahman, K., Chen, F., Datta, S.A.K., Lai, K.K., and Shi, Z. (2024). Alternative Splicing Expands the Antiviral IFITM Repertoire in Chinese Rufous Horseshoe Bats. PLoS Pathog., 20.","DOI":"10.1371\/journal.ppat.1012763"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Cantoni, D., Wilkie, C., Bentley, E.M., Mayora-Neto, M., Wright, E., Scott, S., Ray, S., Castillo-Olivares, J., Heeney, J.L., and Mattiuzzo, G. (2023). Correlation between Pseudotyped Virus and Authentic Virus Neutralisation Assays, a Systematic Review and Meta-Analysis of the Literature. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1184362"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Rizatdinova, S.N., Ershova, A.E., and Astrakhantseva, I.V. (2025). Pseudotyped Viruses: A Useful Platform for Pre-Clinical Studies Conducted in a BSL-2 Laboratory Setting. Biomolecules, 15.","DOI":"10.3390\/biom15010135"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1016\/j.vaccine.2015.04.071","article-title":"The Use of Pseudotypes to Study Viruses, Virus Sero-Epidemiology and Vaccination","volume":"33","author":"Bentley","year":"2015","journal-title":"Vaccine"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Andreu, S., von Kobbe, C., Delgado, P., Ripa, I., Buz\u00f3n, M.J., Genesc\u00e0, M., Giron\u00e8s, N., del Moral-Salmoral, J., Ram\u00edrez, G.A., and Z\u00fa\u00f1iga, S. (2023). Dextran Sulfate from Leuconostoc mesenteroides B512F Exerts Potent Antiviral Activity against SARS-CoV-2 In Vitro and In Vivo. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1185504"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"115688","DOI":"10.1016\/j.bcp.2023.115688","article-title":"Natural Fucoidans Inhibit Coronaviruses by Targeting Viral Spike Protein and Host Cell Furin","volume":"215","author":"Yang","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e0012822","DOI":"10.1128\/jvi.00128-22","article-title":"Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity","volume":"96","author":"Essalmani","year":"2022","journal-title":"J. Virol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41421-020-00192-8","article-title":"Sulfated Polysaccharides Effectively Inhibit SARS-CoV-2 in Vitro","volume":"6","author":"Kwon","year":"2020","journal-title":"Cell Discov."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"8110","DOI":"10.1128\/JVI.00815-13","article-title":"Productive Entry of HIV-1 during Cell-to-Cell Transmission via Dynamin-Dependent Endocytosis","volume":"87","author":"Sloan","year":"2013","journal-title":"J. Virol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e428","DOI":"10.1016\/S1473-3099(23)00692-8","article-title":"Global Incidence and Mortality of Severe Fungal Disease","volume":"24","author":"Denning","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41579-022-00720-1","article-title":"Tackling the Emerging Threat of Antifungal Resistance to Human Health","volume":"20","author":"Fisher","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Jackson, K.M., Ding, M., and Nielsen, K. (2023). Importance of Clinical Isolates in Cryptococcus neoformans Research. J. Fungi, 9.","DOI":"10.3390\/jof9030364"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1473-3099(17)30243-8","article-title":"Global Burden of Disease of HIV-Associated Cryptococcal Meningitis: An Updated Analysis","volume":"17","author":"Rajasingham","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"a019778","DOI":"10.1101\/cshperspect.a019778","article-title":"The Candida Pathogenic Species Complex","volume":"4","author":"Turner","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/jac\/dkad139","article-title":"Invasive Candidiasis: Current Clinical Challenges and Unmet Needs in Adult Populations","volume":"78","author":"Soriano","year":"2023","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s10266-019-00437-3","article-title":"Properties of Fucoidans Beneficial to Oral Healthcare","volume":"108","author":"Oka","year":"2020","journal-title":"Odontology"},{"key":"ref_78","first-page":"277","article-title":"The Antibiotic Resistance Crisis","volume":"40","author":"Ventola","year":"2015","journal-title":"Pharm. Ther."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global Burden of Bacterial Antimicrobial Resistance in 2019: A Systematic Analysis","volume":"399","author":"Murray","year":"2022","journal-title":"Lancet"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1038\/s41467-021-24448-3","article-title":"A Genomic Surveillance Framework and Genotyping Tool for Klebsiella Pneumoniae and Its Related Species Complex","volume":"12","author":"Lam","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_81","unstructured":"WHO (2025, April 15). Joint FAO\/WHO Expert Consultation on Evaluation of Health and Nutritional Properties of Probiotics in Food Including Powder Milk with Live Lactic Acid Bacteria. Available online: https:\/\/openknowledge.fao.org\/items\/db384295-64d9-47e2-b65b-3c918efc5140."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"481651","DOI":"10.5402\/2013\/481651","article-title":"Health Benefits of Probiotics: A Review","volume":"2013","author":"Kechagia","year":"2013","journal-title":"ISRN Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.1002\/jcph.1121","article-title":"Probiotics in Disease Prevention and Treatment","volume":"58","author":"Liu","year":"2018","journal-title":"J. Clin. Pharmacol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Cristofori, F., Dargenio, V.N., Dargenio, C., Miniello, V.L., Barone, M., and Francavilla, R. (2021). Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.578386"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S.J., Berenjian, A., and Ghasemi, Y. (2019). Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications. Foods, 8.","DOI":"10.3390\/foods8030092"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"131776","DOI":"10.1016\/j.ijbiomac.2024.131776","article-title":"Potential Prebiotic and Antibacterial Activities of Fucoidan from Laminaria japonica","volume":"268","author":"Habibi","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Ric\u00f3s-Mu\u00f1oz, N., Maicas, S., and Pina-P\u00e9rez, M.C. (2021). Probiotic Lactobacillus reuteri Growth Improved under Fucoidan Exposure. Proceedings, 70.","DOI":"10.3390\/foods_2020-07724"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"141998","DOI":"10.1016\/j.foodchem.2024.141998","article-title":"In Vitro Fermentation Characteristics of Fucoidan and Its Regulatory Effects on Human Gut Microbiota and Metabolites","volume":"465","author":"Zhou","year":"2025","journal-title":"Food Chem."},{"key":"ref_89","unstructured":"Floch, M.H., Ringel, Y., and Allan Walker, W. (2017). The Use of Lactobacillus casei and Lactobacillus paracasei in Clinical Trials for the Improvement of Human Health. The Microbiota in Gastrointestinal Pathophysiology, Academic Press."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/ajcn\/67.1.111","article-title":"Milk Fermented with Yogurt Cultures and Lactobacillus casei Compared with Yogurt and Gelled Milk: Influence on Intestinal Microflora in Healthy Infants","volume":"67","author":"Chabanet","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Aktas, B., Wolfe, T.J.D., Safdar, N., Darien, B.J., and Steele, J.L. (2016). The Impact of Lactobacillus casei on the Composition of the Cecal Microbiota and Innate Immune System Is Strain Specific. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0156374"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1017\/S000711451100420X","article-title":"Evaluation of the Immune Benefits of Two Probiotic Strains Bifidobacterium animalis ssp. Lactis, BB-12\u00ae and Lactobacillus paracasei ssp. paracasei, L. Casei 431\u00ae in an Influenza Vaccination Model: A Randomised, Double-Blind, Placebo-Controlled Study","volume":"107","author":"Rizzardini","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1093\/jn\/135.6.1462","article-title":"Lactobacillus casei Improves Resistance to Pneumococcal Respiratory Infection in Malnourished Mice","volume":"135","author":"Villena","year":"2005","journal-title":"J. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Yang, C., Dwan, C., Wimmer, B.C., Wilson, R., Johnson, L., and Caruso, V. (2024). Fucoidan from Undaria pinnatifida Enhances Exercise Performance and Increases the Abundance of Beneficial Gut Bacteria in Mice. Mar. Drugs, 22.","DOI":"10.20944\/preprints202409.1494.v1"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.cmet.2018.03.019","article-title":"Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection","volume":"27","author":"Tucey","year":"2018","journal-title":"Cell Metab."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Kondybayev, A., Konuspayeva, G., Strub, C., Loiseau, G., Mestres, C., Grabulos, J., Manzano, M., Akhmetsadykova, S., and Achir, N. (2022). Growth and Metabolism of Lacticaseibacillus casei and Lactobacillus kefiri Isolated from Qymyz, a Traditional Fermented Central Asian Beverage. Fermentation, 8.","DOI":"10.2139\/ssrn.4048751"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"132591","DOI":"10.1016\/j.foodchem.2022.132591","article-title":"Antioxidant Potential of Low Molecular Weight Fucoidans from Sargassum autumnale against H2O2-Induced Oxidative Stress in Vitro and in Zebrafish Models Based on Molecular Weight Changes","volume":"384","author":"Jayawardena","year":"2022","journal-title":"Food Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"145309","DOI":"10.1016\/j.ijbiomac.2025.145309","article-title":"Low Molecular Weight Fucoidan: Production Methods and Their Therapeutic Applications","volume":"318","author":"Gunarathne","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Krylova, N.V., Silchenko, A.S., Pott, A.B., Ermakova, S.P., Iunikhina, O.V., Rasin, A.B., Kompanets, G.G., Likhatskaya, G.N., and Shchelkanov, M.Y. (2021). In Vitro Anti-Orthohantavirus Activity of the High-and Low-Molecular-Weight Fractions of Fucoidan from the Brown Alga Fucus evanescens. Mar. Drugs, 19.","DOI":"10.3390\/md19100577"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ijbiomac.2022.12.307","article-title":"Inhibitory Effects of Fucoidan from Laminaria Japonica against Some Pathogenic Bacteria and SARS-CoV-2 Depend on Its Large Molecular Weight","volume":"229","author":"Sun","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Xu, Z., Xia, Q., Li, L., Shi, Y., Gao, Y., Ma, Y., Liu, S., He, Y., Wang, Q., and Ren, D. (2025). Absorption Patterns of Fucoidan Oligosaccharides from Kjellmaniella crassifolia in the Caco-2 Monolayer Cell Model and Their Pharmacokinetics in Mice. Foods, 14.","DOI":"10.3390\/foods14091486"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1007\/s00343-022-2225-8","article-title":"Pharmacokinetics of Fucoidan and Low Molecular Weight Fucoidan from Saccharina Japonica after Oral Administration to Mice","volume":"41","author":"Tan","year":"2023","journal-title":"J. Ocean. Limnol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"105287","DOI":"10.1016\/j.fbio.2024.105287","article-title":"Degradation of Low-Molecular-Weight Fucoidans by Human Intestinal Microbiota and Their Regulation Effect on Intestinal Microbiota and Metabolites during In Vitro Fermentation","volume":"62","author":"Sun","year":"2024","journal-title":"Food Biosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/095632020701800305","article-title":"Structural Features and Antiviral Activity of Sulphated Fucans from the Brown Seaweed Cystoseira Indica","volume":"18","author":"Mandal","year":"2007","journal-title":"Antivir. Chem. Chemother."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"40760","DOI":"10.1038\/srep40760","article-title":"Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Wang, L., Oh, J.-Y., Yang, H.-W., Hyun, J., Ahn, G., Fu, X., Xu, J., Gao, X., Cha, S.-H., and Jeon, Y.-J. (2023). Protective Effect of Sargassum Fusiforme fucoidan against Ethanol-Induced Oxidative Damage in In Vitro and In Vivo Models. Polymers, 15.","DOI":"10.3390\/polym15081912"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/med.21405","article-title":"Mechanistic Studies of Viral Entry: An Overview of Dendrimer-Based Microbicides As Entry Inhibitors Against Both HIV and HSV-2 Overlapped Infections","volume":"37","year":"2017","journal-title":"Med. Res. Rev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nchembio.2007.17","article-title":"High-Throughput Screening Assays for the Identification of Chemical Probes","volume":"3","author":"Inglese","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/glycob\/cwaa064","article-title":"Ion-Exchange Purification and Structural Characterization of Five Sulfated Fucoidans from Brown Algae","volume":"31","author":"Sichert","year":"2021","journal-title":"Glycobiology"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Saravana, P.S., Karuppusamy, S., Rai, D.K., Wanigasekara, J., Curtin, J., and Tiwari, B.K. (2024). Elimination of Ethanol for the Production of Fucoidans from Brown Seaweeds: Characterization and Bioactivities. Mar. Drugs, 22.","DOI":"10.3390\/md22110493"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Marinval, N., Saboural, P., Haddad, O., Maire, M., Bassand, K., Geinguenaud, F., Djaker, N., Ben Akrout, K., Lamy de la Chapelle, M., and Robert, R. (2016). Identification of a Pro-Angiogenic Potential and Cellular Uptake Mechanism of a LMW Highly Sulfated Fraction of Fucoidan from Ascophyllum nodosum. Mar. Drugs, 14.","DOI":"10.3390\/md14100185"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Colorado-R\u00edos, J., Restrepo-Espinosa, D.C., Restrepo-Mon\u00e1, Y., Monsalve, J.D., M\u00e1rquez-Fern\u00e1ndez, D.M., Castellanos, L., and Mart\u00ednez-Mart\u00ednez, A. (2025). Chemical Exploration of Polysaccharides, Fatty Acids, and Antioxidants as Functional Ingredients from Colombian Macroalgae Acanthophora spicifera, Sargassum ramifolium, and Sargassum fluitans. Molecules, 30.","DOI":"10.3390\/molecules30163333"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.jtha.2022.12.030","article-title":"Dual Roles of Fucoidan-GPIb\u03b1 Interaction in Thrombosis and Hemostasis: Implications for Drug Development Targeting GPIb\u03b1","volume":"21","author":"Shen","year":"2023","journal-title":"J. Thromb. Haemost."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e15790","DOI":"10.7717\/peerj.15790","article-title":"Review of Knockout Technology Approaches in Bacterial Drug Resistance Research","volume":"11","author":"Tong","year":"2023","journal-title":"PeerJ"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Ponce, N.M.A., and Stortz, C.A. (2020). A Comprehensive and Comparative Analysis of the Fucoidan Compositional Data Across the Phaeophyceae. Front. Plant Sci., 11.","DOI":"10.3389\/fpls.2020.556312"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.1111\/are.15485","article-title":"The Effect of Seasonality and Geographic Location on Sulphated Polysaccharides from Brown Algae","volume":"52","author":"Ptak","year":"2021","journal-title":"Aquac. Res."},{"key":"ref_117","unstructured":"APExBIO Technology LLC (2025, April 22). Fucoidan. Available online: https:\/\/www.apexbt.com\/fucoidan.html."},{"key":"ref_118","unstructured":"Shandong Jiejing Group (2025, April 22). Fucoidan_Seafood_Product_Shandong Jiejing Group. Available online: http:\/\/en.china-jiejing.com\/index.php?c=show&id=23."},{"key":"ref_119","unstructured":"(2025, April 22). Marine Sulfated Polysaccharide Fucoidan: Nutraceutical & Cosmeceutical Powerhouse. Available online: https:\/\/www.marknature.com\/products\/fucoidan-sulfated-polysaccharide."},{"key":"ref_120","unstructured":"Marinova Pty Ltd (2025, April 22). Maritech\u00ae Undaria Pinnatifida Extract | Product Portfolio. Available online: https:\/\/maritechfucoidan.com.au\/maritech-undaria-pinnatifida-extract\/."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Rajauria, G., Ravindran, R., Garcia-Vaquero, M., Rai, D.K., Sweeney, T., and O\u2019Doherty, J. (2023). Purification and Molecular Characterization of Fucoidan Isolated from Ascophyllum nodosum Brown Seaweed Grown in Ireland. Mar. Drugs, 21.","DOI":"10.3390\/md21050315"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Vandanjon, L., Burlot, A.-S., Zamanileha, E.F., Douzenel, P., Ravelonandro, P.H., Bourgougnon, N., and Bedoux, G. (2023). The Use of FTIR Spectroscopy as a Tool for the Seasonal Variation Analysis and for the Quality Control of Polysaccharides from Seaweeds. Mar. Drugs, 21.","DOI":"10.3390\/md21090482"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13007-021-00830-6","article-title":"Complementarity of Raman and Infrared Spectroscopy for Rapid Characterization of Fucoidan Extracts","volume":"17","author":"Ptak","year":"2021","journal-title":"Plant Methods"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Apostolova, E., Lukova, P., Baldzhieva, A., Delattre, C., Molini\u00e9, R., Petit, E., Elboutachfaiti, R., Nikolova, M., Iliev, I., and Murdjeva, M. (2022). Structural Characterization and In Vivo Anti-Inflammatory Activity of Fucoidan from Cystoseira crinita (Desf.) Borry. Mar. Drugs, 20.","DOI":"10.3390\/md20110714"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.indcrop.2017.12.030","article-title":"Metabolomic Analysis by UAE-GC MS and Antioxidant Activity of Salvia hispanica (L.) Seeds Grown under Different Irrigation Regimes","volume":"112","author":"Fiore","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jconrel.2023.09.001","article-title":"Polyethylenimine (PEI) in Gene Therapy: Current Status and Clinical Applications","volume":"362","author":"Casper","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Kuete, V., Karaosmano\u011flu, O., and Sivas, H. (2017). Anticancer Activities of African Medicinal Spices and Vegetables. Medicinal Spices and Vegetables from Africa, Elsevier.","DOI":"10.1016\/B978-0-12-809286-6.00010-8"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e01563-18","DOI":"10.1128\/JCM.01563-18","article-title":"A Resazurin Reduction-Based Assay for Rapid Detection of Polymyxin Resistance in Acinetobacter baumannii and Pseudomonas aeruginosa","volume":"57","author":"Lescat","year":"2019","journal-title":"J. Clin. Microbiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"e00027-12","DOI":"10.1128\/genomeA.00027-12","article-title":"Genome Sequence of Klebsiella Pneumoniae Ecl8, a Reference Strain for Targeted Genetic Manipulation","volume":"1","author":"Fookes","year":"2013","journal-title":"Genome Announc."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Majumdar, S.D., Yu, J., Fookes, M., McAteer, S.P., Llobet, E., Finn, S., Spence, S., Monaghan, A., Kissenpfennig, A., and Ingram, R.J. (2015). Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004627"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00328721","article-title":"Isolation of the Candida Albicans Gene for Orotidine-5\u2019-Phosphate Decarboxylase by Complementation of S. Cerevisiae Ura3 and E. coli PyrF Mutations","volume":"198","author":"Gillum","year":"1984","journal-title":"Mol. Gen. Genet."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1128\/JB.181.6.1868-1874.1999","article-title":"Rapid Hypothesis Testing with Candida albicans through Gene Disruption with Short Homology Regions","volume":"181","author":"Wilson","year":"1999","journal-title":"J. Bacteriol."},{"key":"ref_133","unstructured":"Janbon, G., Ormerod, K.L., Paulet, D., Byrnes, E.J., Yadav, V., Chatterjee, G., Mullapudi, N., Hon, C.-C., Billmyre, R.B., and Brunel, F. (2014). Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation. PLoS Genet, 10."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/10\/1618\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:50:38Z","timestamp":1778835038000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/10\/1618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":133,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["molecules31101618"],"URL":"https:\/\/doi.org\/10.3390\/molecules31101618","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]}}}