{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:53:42Z","timestamp":1785405222549,"version":"3.56.0"},"reference-count":355,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074122"],"award-info":[{"award-number":["82074122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174078"],"award-info":[{"award-number":["82174078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82074122"],"award-info":[{"award-number":["82074122"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"award":["82174078"],"award-info":[{"award-number":["82174078"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ8128"],"award-info":[{"award-number":["2024JJ8128"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Research Foundation of the Education Bureau of Hunan Province","award":["23A0280"],"award-info":[{"award-number":["23A0280"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The genus Alchornea Sw. belongs to the Euphorbiaceae family. Alchornea species are commonly used in traditional medicine to treat inflammation; infectious, gastrointestinal, respiratory, musculoskeletal, and dermatological disorders; as well as other diseases. This comprehensive review provides an overview of recent scientific findings on the taxonomy, ethnomedicinal uses, phytochemistry, pharmacological potential, and toxicology of the Alchornea species. The literature was searched using SciFindern, Google Scholar, and PubMed. The taxonomy of all reported plants was authenticated using \u201cPlants of the World Online\u201d. Studies were examined and categorized according to the genus\u2019s taxonomic classification, traditional uses, phytochemistry, pharmacological potential, and toxicity. Phytochemical studies have identified 396 bioactive compounds, primarily triterpenoids, alkaloids, flavonoids, and phenolics. Pharmacological studies have reported significant antimicrobial, anti-inflammatory, antioxidant, anti-plasmodial, and cytotoxic effects. Nevertheless, toxicological statistics are limited and vary among species and extracts. The genus Alchornea exhibits significant pharmacological potential, as evidenced by its traditional uses. In comparison, the genus remains underexplored in terms of detailed mechanistic pharmacological evaluation. Studies of chemical constituents and biological activities have been conducted for only approximately 17 species. To translate the pharmacological potential of the genus Alchornea into clinical practice, a strategic focus on modern plant valorization is required. Future research should focus on the valorization of Alchornea species by developing standardized oral formulations and topical preparations that harness their validated anti-inflammatory and antimicrobial effects beyond traditional uses. However, these findings suggest that further research is needed to assess the efficacy and safety of the largely unexplored genus Alchornea.<\/jats:p>","DOI":"10.3390\/molecules31101726","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:53:10Z","timestamp":1779191590000},"page":"1726","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Genus Alchornea (Euphorbiaceae): A Comprehensive Review of Its Taxonomy, Traditional Uses, Phytochemistry, Pharmacological Potential, and Toxicology"],"prefix":"10.3390","volume":"31","author":[{"given":"Muhammad","family":"Aamer","sequence":"first","affiliation":[{"name":"TCM and Ethnomedicine Innovation and Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feibing","family":"Huang","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation and Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Long","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation and Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-5428","authenticated-orcid":false,"given":"Xudong","family":"Zhou","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation and Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Jian","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation and Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Iqbal","family":"Choudhary","sequence":"additional","affiliation":[{"name":"H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan"},{"name":"Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation and Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0876-2205","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation and Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.2307\/2989706","article-title":"Architecture and growth of tropical trees exemplified by the Euphorbiaceae","volume":"3","author":"Halle","year":"1971","journal-title":"Biotropica"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kubitzki, K. 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