{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:48:13Z","timestamp":1785408493054,"version":"3.56.0"},"reference-count":42,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["442948\/2023-9"],"award-info":[{"award-number":["442948\/2023-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"award":["442948\/2023-9"],"award-info":[{"award-number":["442948\/2023-9"]}],"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"National Scientific and Technical Research Council","doi-asserted-by":"crossref","award":["PIP 2020-1243"],"award-info":[{"award-number":["PIP 2020-1243"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"crossref"}]},{"award":["PIP 2020-1243"],"award-info":[{"award-number":["PIP 2020-1243"]}],"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This study investigated the influence of solvent composition on the extraction efficiency and selectivity of phenolic compounds from the Amazonian fruits a\u00e7a\u00ed (Euterpe oleracea) and bacaba (Oenocarpus bacaba). Six choline chloride-based natural deep eutectic solvents (NaDES), combined with different hydrogen bond donors (glycerol, 1,2-propanediol, citric acid, lactic acid, oxalic acid, and urea), were compared with acidified methanol. Extracts were evaluated for total phenolic content (TPC), total flavonoid content (TFC), and antioxidant capacity using FRAP, DPPH, and ORAC assays. In a\u00e7a\u00ed, methanol exhibited the highest TPC and reducing capacity, whereas acid-based NaDESs enhanced phenolic recovery in a matrix-dependent manner. In bacaba, choline chloride\u2013citric acid enhanced total phenolic recovery compared to methanol, highlighting matrix-dependent solvent performance. Differences among FRAP, DPPH, and ORAC responses reflected variations in phenolic composition rather than total concentration alone. HPLC-DAD analysis revealed solvent-selective enrichment of anthocyanins, chlorogenic acid, flavan-3-ols, and rutin, particularly with acid-based NaDES formulations. Molecular docking provided complementary mechanistic insight by indicating favorable interactions between major phenolics and polyphenol oxidase. Overall, the results indicate that choline chloride-based NaDESs can function as tunable extraction systems capable of modulating phenolic profiles in a matrix-dependent manner, representing promising alternatives to conventional organic solvents for phenolic recovery from Amazonian fruits.<\/jats:p>","DOI":"10.3390\/molecules31101762","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:29:58Z","timestamp":1779355798000},"page":"1762","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Matrix-Driven Modulation of Phenolic Profiles from Euterpe oleracea and Oenocarpus bacaba Using Natural Deep Eutectic Solvents"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-2647","authenticated-orcid":false,"given":"Saulo Victor e","family":"Silva","sequence":"first","affiliation":[{"name":"Departamento de Ciencias de los Alimento y Nutrici\u00f3n, Universidad de Antofagasta, Avenida Universidad de Antofagasta, Antofagasta 02800, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0942-7110","authenticated-orcid":false,"given":"Mar\u00eda Celeste","family":"Gallia","sequence":"additional","affiliation":[{"name":"Institute of Research and Development in Process Engineering, Biotechnology and Alternative Energies (PROBIEN), National Council for Scientific and Technical Research (CONICET), Neuqu\u00e9n 8300, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7804-5095","authenticated-orcid":false,"given":"Cristian Sillagana","family":"Verdezoto","sequence":"additional","affiliation":[{"name":"Master\u2019s Program in Innovation in Biosciences and Bioengineering, Faculty of Engineering, Universidad San Sebasti\u00e1n, Concepci\u00f3n 4081339, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8522-9790","authenticated-orcid":false,"given":"Leonardo","family":"Bajda","sequence":"additional","affiliation":[{"name":"Institute of Research and Development in Process Engineering, Biotechnology and Alternative Energies (PROBIEN), National Council for Scientific and Technical Research (CONICET), Neuqu\u00e9n 8300, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3563-3038","authenticated-orcid":false,"given":"Ana","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Institute of Research and Development in Process Engineering, Biotechnology and Alternative Energies (PROBIEN), National Council for Scientific and Technical Research (CONICET), Neuqu\u00e9n 8300, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9073-1995","authenticated-orcid":false,"given":"Gabriel","family":"Araujo-Silva","sequence":"additional","affiliation":[{"name":"Organic Chemistry and Biochemistry Laboratory, Amap\u00e1 State University (UEAP), Av. Presidente Vargas, s\/n, Centro, Macap\u00e1 68900-070, AP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8249-7617","authenticated-orcid":false,"given":"Jefferson Rom\u00e1ryo Duarte da","family":"Luz","sequence":"additional","affiliation":[{"name":"College of Biological Sciences, Federal University of Amap\u00e1 (UNIFAP), Rodovia BR 156, Universidade, Oiapoque 68980-000, AP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5587-0922","authenticated-orcid":false,"given":"Maria das Gra\u00e7as","family":"Almeida","sequence":"additional","affiliation":[{"name":"Multidisciplinary Research Laboratory, Department of Clinical and Toxicological Analyses, Health Sciences Center, Federal University of Rio Grande do Norte, R. Gen. Gustavo Cordeiro de Farias, s\/n, Petr\u00f3polis, Natal 59012-570, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7607-4853","authenticated-orcid":false,"given":"Luisa Quesada","family":"Romero","sequence":"additional","affiliation":[{"name":"School of Nutrition and Dietetics, Facult of Rehabilitation Sciences and Quality of Life, Universidad San Sebasti\u00e1n, Valdivia 5110466, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref_1","first-page":"464","article-title":"Polyphenols from berries and their applications in health promotion and disease prevention","volume":"99","author":"Silva","year":"2020","journal-title":"Trends Food Sci. 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