{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:02:45Z","timestamp":1780376565300,"version":"3.54.1"},"reference-count":45,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005621","name":"Kasetsart University Research and Development Institute","doi-asserted-by":"crossref","award":["R-M 23.62"],"award-info":[{"award-number":["R-M 23.62"]}],"id":[{"id":"10.13039\/501100005621","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Division of Innovative Botany, Department of Science and Bioinnovation, Faculty of Liberal Arts and Science, Kasetsart University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Phyllanthus emblica L. is a nutraceutically important medicinal plant; however, the relationship between genetic variation and bioactive potential remains poorly understood. This study integrates genome-wide SNP analysis, phytochemical profiling, and functional bioassays to investigate cross-scale differentiation among fourteen cultivars. Genotyping-by-sequencing (GBS) identified 5644 high-quality SNPs from an initial dataset of 9018 SNPs, revealing moderate but structured genomic divergence (0.0275\u20130.0845). Phytochemical analysis of five commercial cultivars demonstrated significant variation (p &lt; 0.05) in total phenolic content (6.58\u201315.53 mg GAE\/gDW) and tannin content (284.52\u2013333.81 mg TAE\/gDW). Functional assays revealed strong anti-obesity potential, with crude extracts exhibiting superior \u03b1-glucosidase inhibition (up to 98.75%), while tannin-enriched extracts showed enhanced pancreatic lipase inhibition (up to 46.26%). Importantly, enzyme inhibition did not correlate directly with total phenolic or tannin content, indicating compound-specific bioactivity. LC-MS\/QTOF analysis identified flavonoids (e.g., quercetin and kaempferol), phenolic acids, and other candidate metabolites potentially associated with enzyme inhibitory activity. These findings demonstrate a non-proportional association among genomic variation, metabolite composition, and functional bioactivity, suggesting that bioactivity may be influenced more strongly by compound-specific metabolite composition than by genome-wide similarity alone.<\/jats:p>","DOI":"10.3390\/molecules31111786","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T12:14:52Z","timestamp":1779452092000},"page":"1786","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating GBS-Derived SNP Markers with Phytochemical Profiling and Anti-Obesity Enzyme Inhibition in Phyllanthus emblica"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1627-8653","authenticated-orcid":false,"given":"Pimchanok","family":"Satapoomin","sequence":"first","affiliation":[{"name":"Department of Science and Bioinnovation, Faculty of Liberal Arts and Science, Kamphaeng Saen Campus, Kasetsart University, Nakhon Pathom 73140, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiplada","family":"Juntranon","sequence":"additional","affiliation":[{"name":"Plant Science Program, Department of Science and Bioinnovation, Faculty of Liberal Arts and Science, Kamphaeng Saen Campus, Kasetsart University, Nakhon Pathom 73140, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9076-3145","authenticated-orcid":false,"given":"Siriporn","family":"Sripinyowanich","sequence":"additional","affiliation":[{"name":"Department of Science and Bioinnovation, Faculty of Liberal Arts and Science, Kamphaeng Saen Campus, Kasetsart University, Nakhon Pathom 73140, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s13205-020-02615-5","article-title":"Advances in biotechnology of Emblica officinalis Gaertn. syn. 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