{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:26:13Z","timestamp":1792718773983,"version":"4.5.0"},"reference-count":105,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Metabolic disorders such as obesity, type 2 diabetes, and lipid disorders are major health challenges worldwide. There is increasing interest in the role of food-derived antioxidants in the context of metabolic disorders due to their documented antioxidant activity. Antioxidants such as flavonoids and polyphenols neutralize reactive oxygen species and reduce oxidative stress, which can affect cell function and metabolic processes. Anthocyanins, curcumin, and resveratrol exhibit physiological and pharmacological properties such as antioxidant, anti-inflammatory, anti-cancer, anti-obesity, and anti-diabetic effects. The main aim of this systematic review is to comprehensively evaluate and synthesize the current scientific evidence on the role of anthocyanins, curcumin, and resveratrol in the prevention and management of metabolic disorders, with a focus on obesity, type 2 diabetes, and dyslipidemia. Databases such as PubMed and Embase were searched, and the final selection included 105 studies that met the inclusion criteria. The analyzed studies demonstrated that anthocyanin supplementation (up to 320 mg\/day) was associated with reductions in inflammatory markers such as IL-6 and TNF-\u03b1, improvements in HDL cholesterol, and modest reductions in HbA1c (~0.3\u20130.5%). Curcumin supplementation was associated with decreases in body weight (up to 0.82 kg), BMI (up to 0.30 kg\/m2), triglycerides, total cholesterol, and fasting glucose levels. Resveratrol showed mixed but potentially beneficial effects on insulin sensitivity, oxidative stress markers, and lipid metabolism, although the clinical outcomes remained inconsistent across studies. These findings suggest that the antioxidant effects of anthocyanins, curcumin, and resveratrol may be related to their ability to suppress oxidative stress and inflammatory processes, thereby contributing to improvements in glucose and lipid metabolism. The conclusions from this analysis may contribute to a better understanding of the role of antioxidants in the management of metabolic health and indicate directions for future research in this area.<\/jats:p>","DOI":"10.3390\/molecules31111837","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:17:58Z","timestamp":1779812278000},"page":"1837","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Role of Anthocyanins, Curcumin, and Resveratrol in the Prevention and Management of Metabolic Disorders: A Systematic Review"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0768-6271","authenticated-orcid":false,"given":"Patrycja","family":"Gazda","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Microbiology and Human Nutrition, Faculty of Food Sciences and Biotechnology, University of Life Sciences in Lublin, 20-950 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1774-6899","authenticated-orcid":false,"given":"Pawe\u0142","family":"Glibowski","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Microbiology and Human Nutrition, Faculty of Food Sciences and Biotechnology, University of Life Sciences in Lublin, 20-950 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Khutami, C., Sumiwi, S.A., KhairulIkram, N.K., and Muchtaridi, M. (2022). Effect of antioxidants from natural products on obesity, dyslipidemia, diabetes and their molecular signaling mechanism. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042056"},{"key":"ref_2","unstructured":"Ostrowska, O.L., Bogda\u0144ski, P., and Mamcarz, A. (2021). Obesity and Its Complications: Practical Diagnostic and Therapeutic Recommendations, PZWL Medical Publishing."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1089\/ars.2016.6756","article-title":"Metabolic Syndrome as a Multifaceted Risk Factor for Oxidative Stress","volume":"26","author":"Spahis","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00394-018-1790-2","article-title":"Adipose tissue inflammation and metabolic syndrome. The proactive role of probiotics","volume":"58","author":"Torres","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1016\/j.jacc.2024.09.016","article-title":"Sudden Death in Obesity: Mechanisms and Management","volume":"84","author":"Holmstrom","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4103\/ijmr.IJMR_1768_17","article-title":"Obesity Subtypes, Related Biomarkers & Heterogeneity","volume":"151","author":"Mayoral","year":"2020","journal-title":"Indian J. Med. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s13668-023-00513-9","article-title":"Dietary and Lifestyle Risk Factors of Obesity Among Young Adults: A Scoping Review of Observational Studies","volume":"12","author":"Lee","year":"2023","journal-title":"Curr. Nutr. Rep."},{"key":"ref_8","first-page":"176","article-title":"Obesity: Definition, comorbidities, causes, and burden","volume":"22","author":"Apovian","year":"2016","journal-title":"Am. J. Manag. Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its effect on metabolic syndrome","volume":"114","author":"Furukawa","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2174\/1573406419666221130162512","article-title":"Prevention of Oxidative Stress and Diseases by Antioxidant Supplementation","volume":"19","author":"Martemucci","year":"2023","journal-title":"Med. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1017\/S0007114521000064","article-title":"Abdominal obesity and risk of CVD: A dose-response meta-analysis of thirty-one prospective studies","volume":"126","author":"Xue","year":"2021","journal-title":"Br. J. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s11883-023-01167-2","article-title":"Obesity and Dyslipidemia","volume":"25","author":"Nussbaumerova","year":"2023","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.metabol.2018.11.005","article-title":"Obesity and dyslipidemia","volume":"92","author":"Vekic","year":"2019","journal-title":"Metabolism"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Senoner, T., and Dichtl, W. (2019). Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?. Nutrients, 11.","DOI":"10.3390\/nu11092090"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1159\/000485089","article-title":"Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species","volume":"44","author":"He","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4493817","DOI":"10.1155\/2021\/4493817","article-title":"The Critical Role of Oxidative Stress in Sarcopenic Obesity","volume":"2021","author":"Gonzalez","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Torres, I., Castrej\u00f3n-T\u00e9llez, V., Soto, M.E., Rubio-Ruiz, M.E., Manzano-Pech, L., and Guarner-Lans, V. (2021). Oxidative Stress, Plant Natural Antioxidants, and Obesity. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041786"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Zielinska-Blizniewska, H., Sitarek, P., Merecz-Sadowska, A., Malinowska, K., Zajdel, K., Jablonska, M., Sliwinski, T., and Zajdel, R. (2019). Plant extracts and reactive forms of oxygen as two counteracting agents with anti-obesity and anti-obesity properties. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184556"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"122019","DOI":"10.1016\/j.lfs.2023.122019","article-title":"Oxidative stress in animal models of obesity caused by hypercaloric diets: A systematic review","volume":"331","year":"2023","journal-title":"Life Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.lfs.2017.11.019","article-title":"Mitochondrial dysfunction in obesity","volume":"192","author":"Costa","year":"2018","journal-title":"Life Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","article-title":"Mitochondrial dysfunction and oxidative stress in metabolic disorders\u2014A step towards mitochondria based therapeutic strategies","volume":"1863","author":"Bhatti","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_24","first-page":"809","article-title":"Oxidative stress and inflammatory markers in prediabetes and diabetes","volume":"70","author":"Luc","year":"2019","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4082\/kjfm.18.0086","article-title":"Relationship between abdominal obesity and oxidative stress in Korean adults","volume":"40","author":"Na","year":"2019","journal-title":"Korean J. Fam. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.23736\/S0026-4806.18.05897-4","article-title":"Treating prediabetes: Why and how should we do it?","volume":"110","author":"Braga","year":"2019","journal-title":"Minerva Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Khan, R.M.M., Chua, Z.J.Y., Tan, J.C., Yang, Y., Liao, Z., and Zhao, Y. (2019). From Pre-Diabetes to Diabetes: Diagnosis, Treatments and Translational Research. Medicina, 55.","DOI":"10.3390\/medicina55090546"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2337\/db16-0806","article-title":"Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis","volume":"66","author":"Skyler","year":"2017","journal-title":"Diabetes"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4093\/dmj.2021.0280","article-title":"Insulin Resistance: From Mechanisms to Therapeutic Strategies","volume":"46","author":"Lee","year":"2022","journal-title":"Diabetes Metab. J."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez, P., Lozano, P., Ros, G., and Solano, F. (2023). Hyperglycemia and Oxidative Stress: An Integral, Updated and Critical Overview of Their Metabolic Interconnections. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119352"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"C420","DOI":"10.1152\/ajpcell.00141.2019","article-title":"Oxidative stress pathways in pancreatic \u03b2-cells and insulin-sensitive cells and tissues: Importance to cell metabolism, function, and dysfunction","volume":"317","author":"Newsholme","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1016\/j.dsx.2016.03.009","article-title":"Assessment of oxidative stress and inflammation in prediabetes-A hospital based cross-sectional study","volume":"10","author":"Agarwal","year":"2016","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5555149","DOI":"10.1155\/2021\/5555149","article-title":"The Problem of Abnormal Body Weight and Dyslipidemia as Risk Factors for Cardiovascular Diseases in Children and Adolescents with Type 1 Diabetes","volume":"2021","author":"Noras","year":"2021","journal-title":"J. Diabetes Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.numecd.2020.08.017","article-title":"Effect of coffee consumption on dyslipidemia: A meta-analysis of randomized controlled trials","volume":"30","author":"Du","year":"2020","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/j.ihj.2023.12.005","article-title":"Dietary management of dyslipidemia","volume":"76","author":"Chopra","year":"2024","journal-title":"Indian Heart J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.recesp.2018.01.003","article-title":"Valor predictivo de la alb\u00faminaplasm\u00e1tica, la vitamina D y las apolipoprote\u00ednas A y B comobiomarcadores de riesgocoronarioenelestudio REGICOR","volume":"71","author":"Zamora","year":"2018","journal-title":"Rev. Espa\u00f1ola Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cca.2020.01.015","article-title":"The exchangeable apolipoproteins in lipid metabolism and obesity","volume":"503","author":"Su","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-3-030-33330-0_8","article-title":"Oxidative Stress, Frailty and Cardiovascular Diseases: Current Evidence","volume":"1216","author":"Uchmanowicz","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"El Hadri, K., Smith, R., Duplus, E., and El Amri, C. (2021). Inflammation, Oxidative Stress, Senescence in Atherosclerosis: Thioredoxine-1 as an Emerging Therapeutic Target. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010077"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2017.05.005","article-title":"Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases","volume":"100","author":"Incalza","year":"2018","journal-title":"Vasc. Pharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11130-019-00747-5","article-title":"Natural Sources of Antioxidants\u2014A Review","volume":"74","author":"Dziedzic","year":"2019","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Sarkate, A.P., Jambhorkar, V.S., and Sakhale, B.K. (2020). Natural Food Antioxidants BT\u2014Plant Antioxidants and Health, Springer International Publishing.","DOI":"10.1007\/978-3-030-45299-5_32-1"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1515\/pac-2020-0902","article-title":"Methods to evaluate the scavenging activity of antioxidants toward reactive oxygen and nitrogen species (IUPAC Technical Report)","volume":"94","author":"Apak","year":"2022","journal-title":"Pure Appl. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cofs.2020.02.003","article-title":"Bioactive compounds produced by probiotics in food products","volume":"32","author":"Chugh","year":"2020","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"100334","DOI":"10.1016\/j.fochx.2022.100334","article-title":"Effect of food processing on antioxidants, their bioavailability and potential relevance to human health","volume":"14","author":"Toydemir","year":"2022","journal-title":"Food Chem. X"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Nani, A., Murtaza, B., Khan, A.S., Khan, N.A., and Hichami, A. (2021). Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms. Molecules, 26.","DOI":"10.3390\/molecules26040985"},{"key":"ref_47","first-page":"2024","article-title":"Anthocyanins in Thai rice varieties: Distribution and pharmacological significance","volume":"25","author":"Sivamaruthi","year":"2018","journal-title":"Int. Food Res. J."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Brooks, M.S.-L., and Celli, G.B. (2019). Natural sources of anthocyanins. Anthocyanins from Natural Sources: Exploiting Targeted Delivery for Improved Health, The Royal Society of Chemistry. [1st ed.].","DOI":"10.1039\/9781788012614"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.1080\/10408398.2023.2187212","article-title":"Anthocyanins-gut microbiota-health axis: A review","volume":"64","author":"Liang","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1361779","DOI":"10.1080\/16546628.2017.1361779","article-title":"Anthocyanidins and anthocyanins: Colored pigments as food, pharmaceutical ingredients, and the potential health benefits","volume":"61","author":"Khoo","year":"2017","journal-title":"Food Nutr. Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Sivamaruthi, B.S., Kesika, P., and Chaiyasut, C. (2020). The Influence of Supplementation of Anthocyanins on Obesity-Associated Comorbidities: A Concise Review. Foods, 9.","DOI":"10.3390\/foods9060687"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"10147","DOI":"10.1016\/j.redox.2020.101474","article-title":"Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-response manner in subjects with dyslipidemia","volume":"32","author":"Zhang","year":"2020","journal-title":"Redox Biol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Xu, L., Tian, Z., Chen, H., Zhao, Y., and Yang, Y. (2021). Anthocyanins, Anthocyanin-Rich Berries, and Cardiovascular Risks: Systematic Review and Meta-Analysis of 44 Randomized Controlled Trials and 15 Prospective Cohort Studies. Front. Nutr., 15.","DOI":"10.3389\/fnut.2021.747884"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1039\/D5FO02803E","article-title":"Effects of anthocyanins on human health: An umbrella review of systematic reviews and meta-analyses","volume":"16","author":"Liu","year":"2025","journal-title":"Food Funct."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"109379","DOI":"10.1016\/j.foodres.2020.109379","article-title":"Effect of dietary anthocyanins on biomarkers of glycemic control and glucose metabolism: A systematic review and meta-analysis of randomized clinical trials","volume":"137","author":"Fallah","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"De Oliveira, M.S., Pellenz, F.M., de Souza, B.M., and Crispim, D. (2022). Blueberry Consumption and Changes in Obesity and Diabetes Mellitus Outcomes: A Systematic Review. Metabolites, 13.","DOI":"10.3390\/metabo13010019"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"114076","DOI":"10.1016\/j.biopha.2022.114076","article-title":"Plasma anthocyanins and their metabolites reduce in vitro migration of pancreatic cancer cells, PANC-1, in a FAK- and NF-kB dependent manner: Results from the ATTACH-study a randomized, controlled, crossover trial in healthy subjects","volume":"158","author":"Mostafa","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nutres.2022.06.004","article-title":"Consumption of oils and anthocyanins may positively modulate PPAR-\u03b3 expression in chronic noncommunicable diseases: A systematic review","volume":"105","author":"Brum","year":"2022","journal-title":"Nutr. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"i17","DOI":"10.1136\/bmj.i17","article-title":"Dietary flavonoid intake and weight maintenance: Three prospective cohorts of 124 086 US men and women followed for up to 24 years","volume":"352","author":"Bertoia","year":"2016","journal-title":"BMJ"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Park, S., Choi, M., and Lee, M. (2021). Effects of Anthocyanin Supplementation on Reduction of Obesity Criteria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 13.","DOI":"10.3390\/nu13062121"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"102273","DOI":"10.1016\/j.redox.2022.102273","article-title":"A randomized placebo-controlled cross-over study on the effects of anthocyanins on inflammatory and metabolic responses to a high-fat meal in healthy subjects","volume":"51","author":"Cremonini","year":"2022","journal-title":"Redox Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/ajcn\/nqy380","article-title":"Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial","volume":"109","author":"Curtis","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/ejcn.2016.142","article-title":"Associations of dietary intakes of anthocyanins and berry fruits with risk of type 2 diabetes mellitus: A systematic review and meta-analysis of prospective cohort studies","volume":"70","author":"Guo","year":"2016","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"110922","DOI":"10.1016\/j.fct.2019.110922","article-title":"Impact of dietary anthocyanins on systemic and vascular inflammation: Systematic review and meta-analysis on randomised clinical trials","volume":"135","author":"Fallah","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Yang, L., Ling, W., Yang, Y., Chen, Y., Tian, Z., Du, Z., Chen, J., Xie, Y., Liu, Z., and Yang, L. (2017). Role of Purified Anthocyanins in Improving Cardiometabolic Risk Factors in Chinese Men and Women with Prediabetes or Early Untreated Diabetes-A Randomized Controlled Trial. Nutrients, 9.","DOI":"10.3390\/nu9101104"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Est\u00e9vez-Santiago, R., Silv\u00e1n, J.M., Can-Cauich, C.A., Veses, A.M., Alvarez-Acero, I., Martinez-Bartolome, M.A., San-Rom\u00e1n, R., C\u00e1mara, M., Olmedilla-Alonso, B., and De Pascual-Teresa, S. (2019). Lack of a synergistic effect on cardiometabolic and redox markers in a dietary supplementation with anthocyanins and xanthophylls in postmenopausal women. Nutrients, 11.","DOI":"10.3390\/nu11071533"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","article-title":"The Essential Medicinal Chemistry of Curcumin","volume":"60","author":"Nelson","year":"2017","journal-title":"J. Med. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1002\/ptr.7737","article-title":"Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies","volume":"37","author":"Heidari","year":"2023","journal-title":"Phytother. Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Kotha, R.R., and Luthria, D.L. (2019). Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects. Molecules, 24.","DOI":"10.3390\/molecules24162930"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Mohammadian, K., Fakhar, F., Keramat, S., and Stanek, A. (2024). The Role of Antioxidants in the Treatment of Metabolic Dysfunction-Associated Fatty Liver Disease: A Systematic Review. Antioxidants, 13.","DOI":"10.3390\/antiox13070797"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41401-023-01176-6","article-title":"Protective effects of curcumin on desipramine-induced islet beta-cell damage via AKAP150\/PKA\/PP2B complex","volume":"45","author":"Hu","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1007\/s12011-024-04314-1","article-title":"Curcumin treatment ameliorates hepatic insulin resistance induced by sub-chronic oral exposure to cadmium LOAEL dose via NF-\u03baB and Nrf2 pathways","volume":"203","author":"Diaz","year":"2025","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s11011-017-0017-1","article-title":"Curcumin reverses the depressive-like behavior and insulin resistance induced by chronic mild stress","volume":"32","author":"Shen","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jad.2021.03.023","article-title":"Antidepressants use and the risk of type 2 diabetes mellitus: A systematic review and meta-analysis","volume":"287","author":"Wang","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nutres.2018.08.003","article-title":"Meta-analysis of randomized controlled trials of 4 weeks or longer suggest that curcumin may afford some protection against oxidative stress","volume":"60","author":"Qin","year":"2018","journal-title":"Nutr. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-3-030-73234-9_6","article-title":"The Multifaceted Actions of Curcumin in Obesity","volume":"1328","author":"Bianconi","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1002\/ptr.7800","article-title":"Effects of curcumin\/turmeric supplementation on obesity indices and adipokines in adults: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials","volume":"37","author":"Dehzad","year":"2023","journal-title":"Phytother. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.ajcnut.2023.03.006","article-title":"The effect of curcumin supplementation on weight loss and anthropometric indices: An umbrella review and updated meta-analyses of randomized controlled trials","volume":"117","author":"Unhapipatpong","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12937-022-00816-7","article-title":"Effects of curcumin and\/or coenzyme Q10 supplementation on metabolic control in subjects with metabolic syndrome: A randomized clinical trial","volume":"21","author":"Sangouni","year":"2022","journal-title":"Nutr. J."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1111\/dom.14804","article-title":"The effect of curcumin on hepatic fat content in individuals with obesity","volume":"24","author":"Hellmann","year":"2022","journal-title":"Diabetes Obes. Metab."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12937-024-01022-3","article-title":"Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: A randomized controlled trial","volume":"23","author":"Yaikwawong","year":"2024","journal-title":"Nutr. J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1002\/ptr.7136","article-title":"The effect of curcumin and zinc co-supplementation on glycemic parameters in overweight or obese prediabetic subjects: A phase 2 randomized, placebo-controlled trial with a multi-arm, parallel-group design","volume":"35","author":"Karandish","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.2337\/dc21-1507","article-title":"Adherence to the American Diabetes Association\u2019s Glycemic Goals in the Treatment of Diabetes Among Older Americans, 2001\u20132018","volume":"45","author":"Le","year":"2022","journal-title":"Diabetes Care"},{"key":"ref_84","first-page":"13","article-title":"Health benefits of resveratrol administration","volume":"66","author":"Galiniak","year":"2019","journal-title":"Acta Biochim. Pol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Inchingolo, A.D., Inchingolo, A.M., Malcangi, G., Avantario, P., Azzollini, D., Buongiorno, S., Viapiano, F., Campanelli, M., Ciocia, A.M., and De Leonardis, N. (2022). Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism-A Systematic Review. Nutrients, 14.","DOI":"10.3390\/nu14173519"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"9932218","DOI":"10.1155\/2021\/9932218","article-title":"Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases","volume":"2021","author":"Zhou","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Breuss, J.M., Atanasov, A.G., and Uhrin, P. (2019). Resveratrol and Its Effects on the Vascular System. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071523"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"109767","DOI":"10.1016\/j.biopha.2019.109767","article-title":"A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications","volume":"125","author":"Huang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Barber, T.M., Kabisch, S., Randeva, H.S., Pfeiffer, A.F.H., and Weickert, M.O. (2022). Implications of Resveratrol in Obesity and Insulin Resistance: A State-of-the-Art Review. Nutrients, 14.","DOI":"10.3390\/nu14142870"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/10408363.2017.1343274","article-title":"Role of resveratrol in the management of insulin resistance and related conditions: Mechanism of action","volume":"54","author":"Goodarzi","year":"2017","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00592-017-1098-3","article-title":"The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial","volume":"55","author":"Seyyedebrahimi","year":"2018","journal-title":"Acta Diabetol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1053\/j.jrn.2016.06.005","article-title":"Effects of Resveratrol Supplementation in Nrf2 and NF-\u03baB Expressions in Nondialyzed Chronic Kidney Disease Patients: A Randomized, Double-Blind, Placebo-Controlled, Crossover Clinical Trial","volume":"26","author":"Saldanha","year":"2016","journal-title":"J. Ren. Nutr."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e13186","DOI":"10.1111\/aji.13186","article-title":"Resveratrol treatment in patients with polycystic ovary syndrome decreased pro-inflammatory and endoplasmic reticulum stress markers","volume":"83","author":"Brenjian","year":"2020","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_94","first-page":"55","article-title":"Systematic review and meta-analysis of the protective effect of resveratrol on multiple organ injury induced by sepsis in animal models","volume":"10","author":"Zhou","year":"2019","journal-title":"Biomed. Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"102224","DOI":"10.1016\/j.dsx.2021.102224","article-title":"A comprehensive insight into the potential effects of resveratrol supplementation on SIRT-1: A systematic review","volume":"15","author":"Najafi","year":"2021","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/obr.12775","article-title":"Resveratrol supplementation significantly influences obesity measures: A systematic review and dose-response meta-analysis of randomized controlled trials","volume":"20","author":"Mousavi","year":"2019","journal-title":"Obes. Rev."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/10408398.2018.1529654","article-title":"The effects of resveratrol intake on weight loss: A systematic review and meta-analysis of randomized controlled trials","volume":"60","author":"Tabrizi","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/21623945.2021.1965315","article-title":"Resveratrol supplementation reduces ACE2 expression in human adipose tissue","volume":"10","author":"Hesselink","year":"2021","journal-title":"Adipocyte"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"117962","DOI":"10.1016\/j.lfs.2020.117962","article-title":"Oral resveratrol supplementation improves Metabolic Syndrome features in obese patients submitted to a lifestyle-changing program","volume":"256","author":"Silveira","year":"2020","journal-title":"Life Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3109\/00365521.2015.1107620","article-title":"Placebo-controlled, randomised clinical trial: High-dose resveratrol treatment for non-alcoholic fatty liver disease","volume":"51","author":"Kreuzfeldt","year":"2016","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.nut.2018.06.015","article-title":"Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial","volume":"58","year":"2019","journal-title":"Nutrition"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Zeng, Y., Pan, Z., Jin, Y., Li, Q., Pang, J., Wang, X., Chen, Y., Yang, Y., and Ling, W. (2023). A Randomized Trial on Resveratrol Supplement Affecting Lipid Profile and Other Metabolic Markers in Subjects with Dyslipidemia. Nutrients, 15.","DOI":"10.3390\/nu15030492"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"106903","DOI":"10.1016\/j.prostaglandins.2024.106903","article-title":"Efficacy of resveratrol supplementation on lipid profile parameters: An umbrella of meta-analysis","volume":"175","author":"Li","year":"2024","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"102819","DOI":"10.1016\/j.ctim.2022.102819","article-title":"Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial","volume":"66","author":"Mahjabeen","year":"2022","journal-title":"Complement. Ther. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"9734738","DOI":"10.1155\/2022\/9734738","article-title":"Effects of Resveratrol on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis","volume":"2022","author":"Gu","year":"2022","journal-title":"Int. J. Clin. Pract."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/11\/1837\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:18:39Z","timestamp":1779812319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/11\/1837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":105,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["molecules31111837"],"URL":"https:\/\/doi.org\/10.3390\/molecules31111837","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]}}}