{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:27:33Z","timestamp":1785421653507,"version":"3.56.0"},"reference-count":76,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research of Nanchang Institute of Science and Technology","award":["NGRCZX 22\u201303"],"award-info":[{"award-number":["NGRCZX 22\u201303"]}]},{"award":["NGRCZX 22\u201303"],"award-info":[{"award-number":["NGRCZX 22\u201303"]}],"id":[{"id":"https:\/\/ror.org\/02q5y6156","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Tofu wastewater (TWW), characterized as a high-strength organic effluent with elevated chemical oxygen demand (COD) and low pH, presents significant environmental challenges, including eutrophication, soil degradation, and greenhouse gas emissions. Conventional disposal methods have proven inadequate in mitigating these risks; however, thermophilic anaerobic digestion (TAD) has emerged as a viable technology for bioenergy recovery. Nonetheless, TAD is impeded by rapid acidification, ammonia and hydrogen sulfide inhibition, and the accumulation of volatile fatty acids (VFAs). This review introduces nano-calcium-peroxide-modified biochar (nano-CaO2\/BC) as a multifunctional additive designed to establish an integrated framework for intervention, risk mitigation, and resource recovery. The proposed amendment synergistically combines the adsorptive and microbial-supportive properties of biochar with the controlled oxidative and alkaline characteristics of nano-CaO2. Under thermophilic conditions, the slow hydrolysis of nano-CaO2 generates transient microaerobic zones that enhance polymer hydrolysis, suppress ammonia (NH3) and hydrogen sulfide (H2S) formation, and facilitate the oxidation of inhibitory VFAs, concurrently releasing calcium hydroxide (Ca(OH)2) for sustained pH buffering. Utilizing failure mode and effects analysis (FMEA) as a semi-quantitative assessment tool, the results indicate that the composite significantly reduces risk priority numbers associated with acidification, ammonia toxicity, and sulfide inhibition when compared with conventional TAD methods. The resultant digestates, which are enriched in nutrients and recalcitrant carbon, possess the potential to serve as valuable soil amendments, thereby contributing to a circular bioeconomy. A techno-economic assessment grounded in unit cost analysis suggests that positive net benefits may be realized through enhanced biogas recovery and the mitigation of environmental penalties. However, empirical validation at the pilot scale is essential to substantiate the projected performance. This review underscores critical knowledge gaps and proposes a systematic experimental framework aimed at translating the conceptual risk mitigation strategy into practical applications.<\/jats:p>","DOI":"10.3390\/molecules31111882","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:19:42Z","timestamp":1780316382000},"page":"1882","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nano-CaO2-Modified Biochar for Enhancing Thermophilic Anaerobic Digestion of Tofu Wastewater: A Review of Risk Mitigation and Resource Recovery Strategies"],"prefix":"10.3390","volume":"31","author":[{"given":"Xingzhong","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Economics and Management, China University of Geosciences, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2205-8084","authenticated-orcid":false,"given":"Ndungutse Jean","family":"Maurice","sequence":"additional","affiliation":[{"name":"College of Resources and Environment, Southwest University, Chongqing 400716, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halima Niyilolawa","family":"Giwa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Natural and Applied Sciences, Oduduwa University Ipetumodu, Ile Ife P.M.B. 5533, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9905-0312","authenticated-orcid":false,"given":"Abdulmoseen Segun","family":"Giwa","sequence":"additional","affiliation":[{"name":"School of Civil and Environmental Engineering, Nanchang Institute of Science and Technology, Nanchang 330108, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"122550","DOI":"10.1016\/j.jenvman.2024.122550","article-title":"Tofu wastewater as a carbon source flowing into municipal wastewater treatment plants for reductions of costs and greenhouse gas emissions","volume":"370","author":"Feng","year":"2024","journal-title":"J. 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