{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:39:00Z","timestamp":1787855940224,"version":"build-2784847793"},"reference-count":85,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["2022J01172"],"award-info":[{"award-number":["2022J01172"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["2024J01458"],"award-info":[{"award-number":["2024J01458"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"crossref"}]},{"award":["2022J01172"],"award-info":[{"award-number":["2022J01172"]}],"id":[{"id":"https:\/\/ror.org\/04aqat463","id-type":"ROR","asserted-by":"publisher"}]},{"award":["2024J01458"],"award-info":[{"award-number":["2024J01458"]}],"id":[{"id":"https:\/\/ror.org\/04aqat463","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Key Projects of Scientific and Technological Innovation in Fujian Province","award":["2022G028"],"award-info":[{"award-number":["2022G028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Fatty acid amide hydrolase (FAAH) is a critical metabolic enzyme in the endocannabinoid system. Through regulating the metabolism of lipid signaling molecules, FAAH is involved in a variety of physiological and pathological processes, including cell proliferation, inflammatory responses, and metabolic homeostasis. Polycystic ovary syndrome (PCOS), one of the most common endocrine and metabolic disorders affecting women of reproductive age, is closely associated with abnormal follicular development, dysregulated hormone secretion, insulin resistance, dyslipidemia, and inflammatory imbalance. Emerging evidence suggests that FAAH-mediated dysregulation of endocannabinoid metabolism is associated with the pathogenesis of PCOS through the modulation of inflammatory pathways, insulin sensitivity, and hormone secretion. This review systematically summarizes the structure, biological functions, and regulatory mechanisms of FAAH, with particular emphasis on its roles in PCOS-associated pathological processes, including reproductive dysfunction, hormonal dysregulation, metabolic imbalance, and inflammatory responses. This review aims to provide a theoretical foundation for elucidating the molecular mechanisms underlying PCOS and for the development of novel therapeutic strategies.<\/jats:p>","DOI":"10.3390\/molecules31121996","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T02:32:46Z","timestamp":1780885966000},"page":"1996","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["FAAH as a Molecular Regulator of Endocannabinoid Signaling: Mechanistic Insights into Reproductive, Metabolic, and Inflammatory Dysfunctions in Polycystic Ovary Syndrome"],"prefix":"10.3390","volume":"31","author":[{"given":"Qinghe","family":"Lin","sequence":"first","affiliation":[{"name":"Provincial Key Laboratory for Developmental Biology and Neurosciences, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defan","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingting","family":"Guo","sequence":"additional","affiliation":[{"name":"Provincial Key Laboratory for Developmental Biology and Neurosciences, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China"},{"name":"College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4309-0221","authenticated-orcid":false,"given":"Zhenghong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Provincial Key Laboratory for Developmental Biology and Neurosciences, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7439-9630","authenticated-orcid":false,"given":"Zhengchao","family":"Wang","sequence":"additional","affiliation":[{"name":"Provincial Key Laboratory for Developmental Biology and Neurosciences, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,7]]},"reference":[{"key":"ref_1","first-page":"607","article-title":"Review of the Endocannabinoid System","volume":"6","author":"Lu","year":"2021","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0009-3084(00)00190-0","article-title":"The fatty acid amide hydrolase (FAAH)","volume":"108","author":"Ueda","year":"2000","journal-title":"Chem. Phys. Lipids"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/s41401-020-0385-7","article-title":"Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases-focusing on FAAH\/MAGL inhibitors","volume":"41","author":"Ren","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Gleicher, N., Darmon, S., Patrizio, P., and Barad, D.H. (2022). Reconsidering the Polycystic Ovary Syndrome (PCOS). Biomedicines, 10.","DOI":"10.3390\/biomedicines10071505"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"7327","DOI":"10.1021\/jm800311k","article-title":"Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors","volume":"51","author":"Seierstad","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/13543776.2026.2619515","article-title":"Novel fatty acid amide hydrolase (FAAH) inhibitors: A patent review from 2015 to 2025","volume":"36","author":"Landolfi","year":"2026","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e1071","DOI":"10.1210\/clinem\/dgaa839","article-title":"Update on PCOS: Consequences, Challenges, and Guiding Treatment","volume":"106","author":"Hoeger","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Qian, H., Tao, J., Shi, L., Sun, H., Yang, L., Cui, L.J., Xu, W., and Wang, L. (2026). Bile acids and gut microbiota: Interactions and impacts on polycystic ovary syndrome. Front. Microbiomes, 4.","DOI":"10.3389\/frmbi.2025.1702198"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41390-019-0615-1","article-title":"Curtailing PCOS","volume":"87","author":"Witchel","year":"2020","journal-title":"Pediatr. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Lin, Y., Xiong, X., Chen, X., Liu, X., and Huang, H. (2026). Network toxicology and single-cell analysis reveal key gene-mediated bisphenol a interference with granulosa cell function in polycystic ovary syndrome. Front. Pharmacol., 17.","DOI":"10.3389\/fphar.2026.1754568"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1365-2265.2010.03956.x","article-title":"PCOS Forum: Research in polycystic ovary syndrome today and tomorrow","volume":"74","author":"Pasquali","year":"2011","journal-title":"Clin. Endocrinol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1210\/jcem.84.6.5803","article-title":"Polycystic ovary syndrome (PCOS): Arguably the most common endocrinopathy is associated with significant morbidity in women","volume":"84","author":"Carmina","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2260500","DOI":"10.1080\/09513590.2023.2260500","article-title":"Effect of Bushen Huoxue recipe on serum metabolomics in polycystic ovary syndrome rats","volume":"39","author":"Li","year":"2023","journal-title":"Gynecol. Endocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s13668-023-00479-8","article-title":"Pathophysiology and Nutritional Approaches in Polycystic Ovary Syndrome (PCOS): A Comprehensive Review","volume":"12","author":"Cacciapuoti","year":"2023","journal-title":"Curr. Nutr. Rep."},{"key":"ref_16","first-page":"e103619","article-title":"Beyond Metformin: A Review of Non-pharmacological Treatments for Polycystic Ovary Syndrome","volume":"18","author":"Lakshmi","year":"2026","journal-title":"Cureus"},{"key":"ref_17","first-page":"512","article-title":"Endometrial Cell-Type Specific Regulation of the Endocannabinoids System and the Impact of Menstrual Cycle and Endometriosis","volume":"10","author":"Tanaka","year":"2025","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1080\/09513590.2016.1269742","article-title":"Decreased expression of fatty acid amide hydrolase in women with polycystic ovary syndrome","volume":"33","author":"Cui","year":"2017","journal-title":"Gynecol. Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Lin, Q., Zhang, Z., Wang, D., Wang, F., and Wang, Z. (2026). Fatty Acid Amide Hydrolase Signaling and Ovarian Disorders: From Molecular Mechanism to Clinical Significance. Molecules, 31.","DOI":"10.3390\/molecules31030556"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Nicoara, C., Fezza, F., and Maccarrone, M. (2025). FAAH Modulators from Natural Sources: A Collection of New Potential Drugs. Cells, 14.","DOI":"10.3390\/cells14070551"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Soundararajan, S., Kazmi, N., Brooks, A.T., Krumlauf, M., Schwandt, M.L., George, D.T., Hodgkinson, C.A., Wallen, G.R., and Ramchandani, V.A. (2021). FAAH and CNR1 Polymorphisms in the Endocannabinoid System and Alcohol-Related Sleep Quality. Front. Psychiatry, 12.","DOI":"10.3389\/fpsyt.2021.712178"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/schbul\/sbae212","article-title":"The Role of Fatty Acid Amide Hydrolase, a Key Regulatory Endocannabinoid Enzyme, in Domain-Specific Cognitive Performance in Psychosis","volume":"51","author":"Weidenauer","year":"2025","journal-title":"Schizophr. Bull."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Della Pietra, A., Giniatullin, R., and Savinainen, J.R. (2021). Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031204"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"jeb242635","DOI":"10.1242\/jeb.242635","article-title":"Early suppression of the endocannabinoid degrading enzymes FAAH and MAGL alters locomotor development in zebrafish","volume":"224","author":"Sufian","year":"2021","journal-title":"J. Exp. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e81919","DOI":"10.7554\/eLife.81919","article-title":"A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice","volume":"12","author":"Balsevich","year":"2023","journal-title":"eLife"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Genovese, T., Duranti, A., D\u2019Amico, R., Fusco, R., Impellizzeri, D., Peritore, A.F., Crupi, R., Gugliandolo, E., Cuzzocrea, S., and Di Paola, R. (2022). Fatty Acid Amide Hydrolase (FAAH) Inhibition Plays a Key Role in Counteracting Acute Lung Injury. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052781"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13048-018-0478-9","article-title":"The role of the endocannabinoid system in female reproductive tissues","volume":"12","author":"Walker","year":"2019","journal-title":"J. Ovarian Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1172\/JCI28621","article-title":"Fatty acid amide hydrolase deficiency limits early pregnancy events","volume":"116","author":"Wang","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"910","DOI":"10.18632\/oncotarget.28534","article-title":"FAAH inhibition ameliorates breast cancer in a murine model","volume":"14","author":"Tripathy","year":"2023","journal-title":"Oncotarget"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41418-022-01054-4","article-title":"FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system","volume":"30","author":"Zhu","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e48005","DOI":"10.1097\/MD.0000000000048005","article-title":"Mediating role of the systemic immune-inflammation index in obesity-induced glycolipid dysmetabolism and compromised IVF\/ICSI outcomes in polycystic ovary syndrome: A retrospective cohort study","volume":"105","author":"Zhang","year":"2026","journal-title":"Medicine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12958-016-0173-x","article-title":"Genetic, hormonal and metabolic aspects of PCOS: An update","volume":"14","author":"Musacchio","year":"2016","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Karampela, A.I., and Druce, M. (2026). The Relationship Between Polycystic Ovary Syndrome (PCOS) and Depression. Clin. Endocrinol., Online ahead of print.","DOI":"10.1111\/cen.70124"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e70255","DOI":"10.1111\/jog.70255","article-title":"Anthropometric Measurements to Predict Metabolic Syndrome in Thai Women With Polycystic Ovary Syndrome: A Retrospective Study","volume":"52","author":"Yokyongsakul","year":"2026","journal-title":"J. Obs. Gynaecol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"113207","DOI":"10.1016\/j.diabres.2026.113207","article-title":"Gestational diabetes mellitus in low- and middle-income countries: A systematic review and meta-analysis of associated factors","volume":"235","author":"Sadore","year":"2026","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_36","first-page":"100060","article-title":"Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article","volume":"3","author":"Ajmal","year":"2019","journal-title":"Eur. J. Obs. Gynecol. Reprod. Biol. X"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Jiao, Y., Yuan, M., Chen, L., Qiu, S., Chen, J., and Wang, D. (2026). Edible bird\u2019s nest ameliorates hyperandrogenism and gonadotropin imbalance in a rat model of polycystic ovary syndrome. Front. Nutr., 13.","DOI":"10.3389\/fnut.2026.1779908"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lu, Y., Li, L., Fang, J., Ju, W., Yan, Y., and Wu, F. (2026). Gui Shen Wan ameliorates PCOS-like cellular phenotypes by suppressing TNF-\u03b1-mediated inflammation and restoring the PI3K\/Akt signaling pathway. Front. Immunol., 17.","DOI":"10.3389\/fimmu.2026.1739230"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.29063\/ajrh2026\/v30i5.9","article-title":"Effects of acupuncture on improving hormonal and metabolic biochemical characteristics in polycystic ovary syndrome","volume":"30","author":"Shao","year":"2026","journal-title":"Afr. J. Reprod. Health"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1002\/ar.21181","article-title":"Temporal and spatial distribution of the cannabinoid receptors (CB1.; CB2) and fatty acid amide hydroxylase in the rat ovary","volume":"293","author":"Bagavandoss","year":"2010","journal-title":"Anat. Rec."},{"key":"ref_41","first-page":"1171","article-title":"The role of cannabinoid agonists and antagonists on folliculogenesis and evolutionary events in the mouse ovary","volume":"28","author":"Mirzaie","year":"2025","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.fertnstert.2015.03.027","article-title":"Endocannabinoid system activation may be associated with insulin resistance in women with polycystic ovary syndrome","volume":"104","author":"Juan","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Peng, Q., Chen, X., Liang, X., Ouyang, J., Wang, Q., Ren, S., Xie, H., Wang, C., Sun, Y., and Wu, X. (2023). Metformin improves polycystic ovary syndrome in mice by inhibiting ovarian ferroptosis. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1070264"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.clinthera.2017.02.007","article-title":"Restored Plasma Anandamide and Endometrial Expression of Fatty Acid Amide Hydrolase in Women with Polycystic Ovary Syndrome by the Combination Use of Diane-35 and Metformin","volume":"39","author":"Cui","year":"2017","journal-title":"Clin. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/mrd.23537","article-title":"Metformin improves epigenetic modification involved in oocyte growth and embryo development in polycystic ovary syndrome mice model","volume":"88","author":"Safdarian","year":"2021","journal-title":"Mol. Reprod. Dev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e2411679","DOI":"10.1002\/advs.202411679","article-title":"Multiomics and Systematic Analyses Reveal the Roles of Hemoglobin and the HIF-1 Pathway in Polycystic Ovary Syndrome","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Lotfishokouh, M., and Foroutan, T. (2026). L-carnitine improves polycystic ovary syndrome by increasing CYP11A1, estrogen receptor, and decreasing XNIP and VEGF expression. Naunyn Schmiedeberg\u2019s Arch. Pharmacol., Online ahead of print.","DOI":"10.1007\/s00210-026-05110-5"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13048-025-01637-y","article-title":"SRC involves in lysosomal function and regulates ferroptosis in polycystic ovary syndrome","volume":"18","author":"Wang","year":"2025","journal-title":"J. Ovarian Res."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Wang, Z., Li, X., Moura, A.K., Hu, J.Z., Wang, Y.T., and Zhang, Y. (2025). Lysosome Functions in Atherosclerosis: A Potential Therapeutic Target. Cells, 14.","DOI":"10.3390\/cells14030183"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e005","DOI":"10.48130\/animadv-0025-0003","article-title":"Animal models and lysosomal pathogenesis of atherosclerosis","volume":"2","author":"Wang","year":"2025","journal-title":"Anim. Adv."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e014","DOI":"10.48130\/animadv-0025-0014","article-title":"HIF-1\u03b1 regulates mitochondria function for oxidative stress and autophagy during oocyte maturation","volume":"2","author":"Pan","year":"2025","journal-title":"Anim. Adv."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Shi, C., and Wang, Z. (2023). Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha. Nutrients, 15.","DOI":"10.3390\/nu15132833"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Shi, C., and Wang, Z. (2023). The physiological functions and therapeutic potential of exosomes during the development and treatment of polycystic ovary syndrome. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1279469"},{"key":"ref_54","first-page":"574044","article-title":"Exosomes for Polycystic Ovary Syndrome Treatment: Mechanisms and Therapeutic Potential","volume":"21","author":"Liu","year":"2026","journal-title":"Int. J. Nanomed."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1089\/can.2021.0183","article-title":"Analysis of 2-Arachidonoylglycerol Levels in Polycystic Ovary Syndrome in the Context of Hormonal and Metabolic Alterations and Across the Classical Phenotypes","volume":"8","author":"Kabakchieva","year":"2023","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Liao, B., Qiao, J., and Pang, Y. (2021). Central Regulation of PCOS: Abnormal neuronal-reproductive-metabolic circuits in PCOS pathophysiology. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.667422"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s13679-023-00531-2","article-title":"Hypothalamic-ovarian axis and adiposity relationship in polycystic ovary syndrome: Physiopathology and therapeutic options for the management of metabolic and inflammatory aspects","volume":"13","author":"Lonardo","year":"2024","journal-title":"Curr. Obes. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: Definition, aetiology, diagnosis and treatment","volume":"14","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41574-024-01057-w","article-title":"Polycystic ovary syndrome as a metabolic disease","volume":"21","author":"Helvaci","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00441-020-03253-2","article-title":"The physiology of regulated BDNF release","volume":"382","author":"Brigadski","year":"2020","journal-title":"Cell Tissue Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1021\/acschemneuro.5c00574","article-title":"BDNF-dysregulation as a neurobiological bridge between polycystic ovarian syndrome and autism spectrum disorder","volume":"17","author":"Nautiyal","year":"2026","journal-title":"ACS Chem. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Mizgier, M., Formanowicz, D., Sansoni, V., Jarz\u0105bek-Bielecka, G., Lombardi, G., K\u0119dzia, W., and Opydo-Szymaczek, J. (2026). Serum BDNF as an integrative neuro-immunometabolic marker in adolescent polycystic ovary syndrome: Divergent dietary and inflammatory associations across weight phenotypes. Front. Nutr., 13.","DOI":"10.3389\/fnut.2026.1830074"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nrn.2016.24","article-title":"Neurotrophic factor control of satiety and body weight","volume":"17","author":"Xu","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Dilbaz, B., and Ate\u015f, \u00c7. (2026). The effects of glucagon-like peptide-1 receptor agonists on fertility, contraception, and pregnancy: Clinical perspectives. Eur. J. Contracept. Reprod. Health Care, Online ahead of print.","DOI":"10.1080\/13625187.2026.2644895"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Przybycie\u0144, P., G\u0105sior-Perczak, D., and Placha, W. (2022). Cannabinoids and PPAR Ligands: The Future in Treatment of Polycystic Ovary Syndrome Women with Obesity and Reduced Fertility. Cells, 11.","DOI":"10.3390\/cells11162569"},{"key":"ref_66","first-page":"e103615","article-title":"Effects of Ketogenic Diet (KD) on Metabolic, Endocrine, and Reproductive Outcomes in Overweight\/Obese Women with Polycystic Ovary Syndrome (PCOS): A Systematic Review","volume":"18","author":"Diha","year":"2026","journal-title":"Cureus"},{"key":"ref_67","first-page":"73","article-title":"PCOS and obesity: Insulin resistance might be a common etiology for the development of type I endometrial carcinoma","volume":"4","author":"Li","year":"2014","journal-title":"Am. J. Cancer Res."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Xu, R., and Wang, Z. (2021). Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.649295"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Du, Z., Yerebake, M., Shi, A., Zhao, S., Li, S., Wan, Y., Wang, J., and Yan, C. (2026). Efficacy and safety of acupuncture-related therapies in improving insulin resistance, reproductive endocrine outcomes, and ovarian morphology in polycystic ovary syndrome: A systematic review and network meta-analysis. Front. Endocrinol., 17.","DOI":"10.3389\/fendo.2026.1748814"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Cowan, S., Lim, S., Alycia, C., Pirotta, S., Thomson, R., Gibson-Helm, M., Blackmore, R., Naderpoor, N., Bennett, C., and Ee, C. (2023). Lifestyle management in polycystic ovary syndrome\u2014Beyond diet and physical activity. BMC Endocr. Disord., 23.","DOI":"10.1186\/s12902-022-01208-y"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Parker, J. (2023). Pathophysiological Effects of Contemporary lifestyle on evolutionary-conserved survival mechanisms in polycystic ovary syndrome. Life, 13.","DOI":"10.20944\/preprints202303.0521.v1"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1089\/can.2021.0237","article-title":"Fatty acid amide hydrolase: An integrative clinical perspective","volume":"8","author":"Santoso","year":"2023","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s13668-024-00601-4","article-title":"The role of diet, glycaemic index and glucose control in polycystic ovary syndrome (PCOS) management and mechanisms of progression","volume":"14","author":"Johnson","year":"2025","journal-title":"Curr. Nutr. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Ee, C., Pirotta, S., Mousa, A., Moran, L., and Lim, S. (2021). Providing lifestyle advice to women with PCOS: An overview of practical issues affecting success. BMC Endocr. Disord., 21.","DOI":"10.1186\/s12902-021-00890-8"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Herbert, S., and Woolf, K. (2023). Moving beyond weight: A narrative review of the dietary and lifestyle management for reducing cardiometabolic risk in polycystic ovary syndrome (PCOS). Nutrients, 15.","DOI":"10.3390\/nu15245069"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/advances\/nmaa092","article-title":"Effects of dietary glycemic index and glycemic load on cardiometabolic and reproductive profiles in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials","volume":"12","author":"Kazemi","year":"2021","journal-title":"Adv. Nutr."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Mizgier, M., Jarz\u0105bek-Bielecka, G., Formanowicz, D., Jod\u0142owska-Siewert, E., Mruczyk, K., Cisek-Wo\u017aniak, A., K\u0119dzia, W., and Opydo-Szymaczek, J. (2021). Dietary and physical activity habits in adolescent girls with polycystic ovary syndrome (PCOS)-HAstudy. J. Clin. Med., 10.","DOI":"10.3390\/jcm10163469"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Mizgier, M., Jarz\u0105bek-Bielecka, G., Wendland, N., Jod\u0142owska-Siewert, E., Nowicki, M., Bro\u017cek, A., K\u0119dzia, W., Formanowicz, D., and Opydo-Szymaczek, J. (2021). Relation between inflammation, oxidative stress, and macronutrient intakes in normal and excessive body weight adolescent girls with clinical features of polycystic ovary syndrome. Nutrients, 13.","DOI":"10.3390\/nu13030896"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Mizgier, M., Watrowski, R., Opydo-Szymaczek, J., Jod\u0142owska-Siewert, E., Lombardi, G., K\u0119dzia, W., and Jarz\u0105bek-Bielecka, G. (2021). Association of macronutrients composition, physical activity and serum androgen concentration in young women with polycystic ovary syndrome. Nutrients, 14.","DOI":"10.3390\/nu14010073"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e202401037","DOI":"10.1002\/cbdv.202401037","article-title":"Bisphenol A in Water Systems: Risks to Polycystic Ovary Syndrome and Biochar-Based Adsorption Remediation: A Review","volume":"21","author":"Michenzi","year":"2024","journal-title":"Chem. Biodivers."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13048-024-01432-1","article-title":"Examining the oleoylethanolamide supplement effects on glycemic status, oxidative stress, inflammation, and anti-mullerian hormone in polycystic ovary syndrome","volume":"17","author":"Shivyari","year":"2024","journal-title":"J. Ovarian Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/978-3-319-20825-1_11","article-title":"Endocannabinoids and the endocrine system in health and disease","volume":"231","author":"Hillard","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/0269881111408458","article-title":"The role of the endocannabinoid system in the neuroendocrine regulation of energy balance","volume":"26","author":"Cardinal","year":"2012","journal-title":"J. Psychopharmacol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/biof.1168","article-title":"Endocannabinoids and energy homeostasis: An update","volume":"40","author":"Cristino","year":"2014","journal-title":"Biofactors"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Li, X., Xu, S., Xie, L., Kuang, H., Liu, J., and Li, Y. (2026). Effectiveness and safety of auricular therapy for polycystic ovary syndrome: A systematic review and meta-analysis. Front. Endocrinol., 17.","DOI":"10.3389\/fendo.2026.1726938"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/12\/1996\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:49:55Z","timestamp":1780980595000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/12\/1996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,7]]},"references-count":85,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["molecules31121996"],"URL":"https:\/\/doi.org\/10.3390\/molecules31121996","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,7]]}}}