{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:55:43Z","timestamp":1787507743806,"version":"build-2736575974"},"reference-count":174,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["YQJH2024227"],"award-info":[{"award-number":["YQJH2024227"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["YQJH2024227"],"award-info":[{"award-number":["YQJH2024227"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"\u201cBasic Research Support Program for Outstanding Young Teachers\u201d of Heilongjiang Provincial Undergraduate Universities","award":["YQJH2024227"],"award-info":[{"award-number":["YQJH2024227"]}]},{"name":"2025 Heilongjiang Provincial Natural Science Foundation Joint Fund Cultivation Project","award":["PL2025H240"],"award-info":[{"award-number":["PL2025H240"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Autophagy is an essential mechanism through which cells break down and reuse intracellular proteins and organelles to preserve cellular homeostasis. Under physiological conditions, autophagy primarily exerts a cytoprotective effect; however, aberrant activation or deficiency of autophagy pathways can disturb cellular balance and even trigger apoptosis, thereby contributing to the occurrence and progression of multiple diseases. Flavonoids are natural bioactive components widely distributed in plants, characterized by distinct benefits of synergistic regulation via multiple targets and pathways. This review summarizes the primary mechanisms of flavonoids, focusing on their potential underlying mechanisms against various diseases\u2014including atherosclerosis, cardiovascular diseases, liver diseases, lung diseases, Parkinson\u2019s disease, leukemia, and malignant tumors\u2014via regulating autophagy (including selective autophagy), and sorts out the latest advances in related experimental research over the past five years. In conclusion, flavonoids can effectively ameliorate the pathological processes of multiple diseases by modulating autophagy pathways with favorable biosafety. Nevertheless, low bioavailability remains the core bottleneck restricting their clinical translation. Further optimization of pharmaceutical formulations is warranted to enhance their uptake efficacy in vivo, and rigorous clinical trials are needed to assess their prolonged effectiveness and potential drug interactions, so as to offer new feasible approaches and research directions for the prophylaxis and therapy of various diseases.<\/jats:p>","DOI":"10.3390\/molecules31122055","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:52:08Z","timestamp":1781229128000},"page":"2055","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Research Progress and Prospects of Flavonoids in the Treatment of Diseases by Regulating Autophagy: A Narrative Review"],"prefix":"10.3390","volume":"31","author":[{"given":"Shuang","family":"Xue","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingtong","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyue","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbiao","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Niu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41419-023-06154-8","article-title":"Autophagy: Regulator of Cell Death","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev-cellbio-120219-035530","article-title":"Mechanisms of Selective Autophagy","volume":"37","author":"Lamark","year":"2021","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12929-023-00899-2","article-title":"The role of autophagy in viral infections","volume":"30","author":"Chen","year":"2023","journal-title":"J. Biomed. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Leonte, D., Ungureanu, D., and Zaharia, V. (2023). Flavones and Related Compounds: Synthesis and Biological Activity. Molecules, 28.","DOI":"10.20944\/preprints202308.0268.v1"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1080\/13880209.2025.2467374","article-title":"Antidepressant Activity of Flavones from Traditional Chinese Medicine: A Meta-Analysis","volume":"63","author":"Wang","year":"2025","journal-title":"Pharm. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"\u00c1lvarez-Mercado, A.I., Rojano-Alfonso, C., Mic\u00f3-Carnero, M., Caballeria-Casals, A., Peralta, C., and Casillas-Ram\u00edrez, A. (2021). New Insights into the Role of Autophagy in Liver Surgery in the Setting of Metabolic Syndrome and Related Diseases. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.670273"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"137393","DOI":"10.1016\/j.ijbiomac.2024.137393","article-title":"Polysaccharides Targeting Autophagy to Alleviate Metabolic Syndrome","volume":"283","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.7150\/thno.49860","article-title":"Selective Autophagy of Intracellular Organelles: Recent Research Advances","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.devcel.2019.10.025","article-title":"Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal","volume":"52","author":"Jia","year":"2020","journal-title":"Dev. Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.tem.2021.08.010","article-title":"Lipophagy: A New Player in CNS Disorders","volume":"32","author":"Haidar","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"D1670","DOI":"10.1093\/nar\/gkae973","article-title":"Generic Diagramming Platform (GDP): A Comprehensive Database of High-Quality Biomedical Graphics","volume":"53","author":"Jiang","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Manghwar, H., Hu, W., and Liu, F. (2022). Degradation Mechanism of Autophagy-Related Proteins and Research Progress. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137301"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1080\/15548627.2023.2287932","article-title":"Deacetylation of ATG7 Drives the Induction of Macroautophagy and LC3-Associated Microautophagy","volume":"20","author":"Xu","year":"2024","journal-title":"Autophagy"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.semcancer.2019.08.031","article-title":"Autophagy as a Mechanism for Anti-Angiogenic Therapy Resistance","volume":"66","author":"Chandra","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41580-023-00585-z","article-title":"Autophagy and Autophagy-Related Pathways in Cancer","volume":"24","author":"Debnath","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.3748\/wjg.v26.i39.5997","article-title":"Herbal Cake-Partitioned Moxibustion Inhibits Colonic Autophagy in Crohn\u2019s Disease via Signaling Involving Distinct Classes of Phosphatidylinositol 3-Kinases","volume":"26","author":"Wang","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7435","DOI":"10.1007\/s00018-021-03988-3","article-title":"The Lysosome as an Imperative Regulator of Autophagy and Cell Death","volume":"78","author":"Mahapatra","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"118549","DOI":"10.1016\/j.ejmech.2025.118549","article-title":"Flavonoids as Promising Drug Leads: Structural Diversity, Synthetic Strategies, and Drug-Likeness Optimization","volume":"305","author":"Yang","year":"2026","journal-title":"Eur. J. Med. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"108960","DOI":"10.1016\/j.plaphy.2024.108960","article-title":"Accumulation characteristics of plant flavonoids and effects of cultivation measures on their biosynthesis: A review","volume":"215","author":"Ma","year":"2024","journal-title":"Plant Physiol. Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1248\/bpb.b25-00486","article-title":"Chronotropic, Inotropic, and Lusitropic Effects of Flavonoids","volume":"49","author":"Noguchi","year":"2026","journal-title":"Biol. Pharm. Bull."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.2147\/DDDT.S515004","article-title":"Therapeutic Potential of Flavonoids and Flavonoid-Rich Compounds in Irritable Bowel Syndrome","volume":"19","author":"Xia","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Chen, S., Wang, X., Cheng, Y., Gao, H., and Chen, X. (2023). A Review of Classification, Biosynthesis, Biological Activities and Potential Applications of Flavonoids. Molecules, 28.","DOI":"10.3390\/molecules28134982"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Yoon, J.H., Kim, M.Y., and Cho, J.Y. (2023). Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021498"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Charri\u00e8re, K., Schneider, V., Perrignon-Sommet, M., Lizard, G., Benani, A., Jacquin-Piques, A., and Vejux, A. (2024). Exploring the Role of Apigenin in Neuroinflammation: Insights and Implications. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25095041"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s10020-024-00977-7","article-title":"The Therapeutic Potential of Apigenin in Amyotrophic Lateral Sclerosis through ALDH1A2\/Nrf2\/ARE Signaling","volume":"30","author":"Liang","year":"2024","journal-title":"Mol. Med."},{"key":"ref_26","first-page":"240","article-title":"Apigenin Ameliorates Hepatic Lipid Accumulation by Activating the Autophagy-Mitochondria Pathway","volume":"29","author":"Hsu","year":"2021","journal-title":"J. Food Drug Anal."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Lijun, Z., Liping, W., Dandan, Z., Wenjie, Z., Renjie, X., Xueyan, J., Wenqing, C., Chen, L., and Lu, Z. (2025). Apigenin Mitigates Intestinal Barrier Dysfunction in Sepsis by Modulating the AKT Signaling Pathway. BMC Gastroenterol., 25.","DOI":"10.1186\/s12876-025-04196-0"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.31083\/j.jin2203064","article-title":"Apigenin Alleviates Allodynia and Hyperalgesia in a Mouse Model of Chemotherapy-Induced Peripheral Neuropathy via Regulating Microglia Activation and Polarization","volume":"22","author":"Xie","year":"2023","journal-title":"J. Integr. Neurosci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7996","DOI":"10.1038\/s41598-023-34654-2","article-title":"Apigenin Attenuates Atherosclerosis and Non-Alcoholic Fatty Liver Disease through Inhibition of NLRP3 Inflammasome in Mice","volume":"13","author":"Lu","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/biof.1720","article-title":"Analytical Determinations of Luteolin","volume":"47","author":"Tesio","year":"2021","journal-title":"Biofactors"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/biof.1699","article-title":"Luteolin as a Modulator of Skin Aging and Inflammation","volume":"47","author":"Gendrisch","year":"2021","journal-title":"Biofactors"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s43440-024-00610-8","article-title":"Luteolin for Neurodegenerative Diseases: A Review","volume":"76","author":"Jayawickreme","year":"2024","journal-title":"Pharmacol. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Han, Z., Chen, H., Xu, Y., and Xue, L. (2024). Luteolin Attenuates CCl4-Induced Hepatic Injury by Inhibiting Ferroptosis via SLC7A11. BMC Complement. Med. Ther., 24.","DOI":"10.1186\/s12906-024-04486-2"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1007\/s11064-024-04203-y","article-title":"Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection","volume":"49","author":"Younis","year":"2024","journal-title":"Neurochem. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3892\/ijmm.2024.5401","article-title":"Luteolin Enhances Drug Chemosensitivity by Downregulating the FAK\/PI3K\/AKT Pathway in Paclitaxel-Resistant Esophageal Squamous Cell Carcinoma","volume":"54","author":"Yang","year":"2024","journal-title":"Int. J. Mol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Taweesap, P., Potue, P., Khamseekaew, J., Iampanichakul, M., Jan-O, B., Pakdeechote, P., and Maneesai, P. (2025). Luteolin Relieves Metabolic Dysfunction-Associated Fatty Liver Disease Caused by a High-Fat Diet in Rats through Modulating the AdipoR1\/AMPK\/PPAR\u03b3 Signaling Pathway. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26083804"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.2147\/DDDT.S402864","article-title":"Luteolin Alleviates Liver Fibrosis in Rat Hepatic Stellate Cell HSC-T6: A Proteomic Analysis","volume":"17","author":"Batudeligen","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3349\/ymj.2022.63.3.220","article-title":"Luteolin Protects Cardiomyocytes Cells against Lipopolysaccharide-Induced Apoptosis and Inflammatory Damage by Modulating Nlrp3","volume":"63","author":"Liu","year":"2022","journal-title":"Yonsei Med. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4155\/ppa-2021-0027","article-title":"Baicalein: Promising Therapeutic Applications with Special Reference to Published Patents","volume":"11","author":"Gupta","year":"2022","journal-title":"Pharm. Pat. Anal."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Morshed, A.K.M.H., Paul, S., Hossain, A., Basak, T., Hossain, M.S., Hasan, M.M., Hasibuzzaman, M.A., Rahaman, T.I., Mia, M.A.R., and Shing, P. (2023). Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives. Cancers, 15.","DOI":"10.3390\/cancers15072128"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e14230","DOI":"10.1111\/jfbc.14230","article-title":"Baicalein: A Review on Its Anti-Cancer Effects and Mechanisms in Lung Carcinoma","volume":"46","author":"Chandrashekar","year":"2022","journal-title":"J. Food Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jare.2024.02.023","article-title":"Baicalein Induces Apoptosis by Inhibiting the Glutamine-mTOR Metabolic Pathway in Lung Cancer","volume":"68","author":"Li","year":"2025","journal-title":"J. Adv. Res."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Chen, M., Peng, L., Gong, P., Zheng, X., Sun, T., Zhang, X., and Huo, J. (2022). Baicalein Induces Mitochondrial Autophagy to Prevent Parkinson\u2019s Disease in Rats via miR-30b and the SIRT1\/AMPK\/mTOR Pathway. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.646817"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Liu, N., Cui, X., Guo, T., Wei, X., Sun, Y., Liu, J., Zhang, Y., Ma, W., Yan, W., and Chen, L. (2024). Baicalein Ameliorates Insulin Resistance of HFD\/STZ Mice through Activating PI3K\/AKT Signal Pathway of Liver and Skeletal Muscle in a GLP-1R-Dependent Manner. Antioxidants, 13.","DOI":"10.3390\/antiox13101246"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2519607","DOI":"10.1080\/15476278.2025.2519607","article-title":"Baicalein Alleviates Lithium-Pilocarpine-Induced Status Epilepticus by Regulating DNMT1\/GABRD Pathway in Rats","volume":"21","author":"Wu","year":"2025","journal-title":"Organogenesis"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Lv, W., Han, S., Li, K., Yan, A., Wang, W., Lu, W., Han, J., and Zhang, C. (2025). Baicalein Ameliorates DSS-Induced Ulcerative Colitis in Mice by Inhibiting Ferroptosis and Regulating Gut Microbiota. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1564783"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Peng, B., Hu, Q., He, R., Hou, H., Lian, D., Chen, Y., Li, H., Song, L., Gao, Y., and Chen, T. (2023). Baicalein Alleviates Fibrosis and Inflammation in Systemic Sclerosis by Regulating B-Cell Abnormalities. BMC Complement. Med. Ther., 23.","DOI":"10.1186\/s12906-023-03885-1"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"102350","DOI":"10.1016\/j.pbi.2023.102350","article-title":"Flavonols Modulate Plant Development, Signaling, and Stress Responses","volume":"72","author":"Daryanavard","year":"2023","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Hsieh, Y.H., Hsu, P.H., Hu, A., Cheng, Y.J., Shih, T.L., and Chen, J.J. (2024). Synthesis of Flavonols and Assessment of Their Biological Activity as Anticancer Agents. Molecules, 29.","DOI":"10.3390\/molecules29092041"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Georgiou, N., Kakava, M.G., Routsi, E.A., Petsas, E., Stavridis, N., Freris, C., Zoupanou, N., Moschovou, K., Kiriakidi, S., and Mavromoustakos, T. (2023). Quercetin: A Potential Polydynamic Drug. Molecules, 28.","DOI":"10.3390\/molecules28248141"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Chiang, M.C., Tsai, T.Y., and Wang, C.J. (2023). The Potential Benefits of Quercetin for Brain Health: A Review of Anti-Inflammatory and Neuroprotective Mechanisms. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076328"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Boo, H.J., Yoon, D., Choi, Y., Kim, Y., Cha, J.S., and Yoo, J. (2025). Quercetin: Molecular Insights into Its Biological Roles. Biomolecules, 15.","DOI":"10.3390\/biom15030313"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2327495","DOI":"10.1080\/0886022X.2024.2327495","article-title":"Quercetin Improves Diabetic Kidney Disease by Inhibiting Ferroptosis and Regulating the Nrf2 in Streptozotocin-Induced Diabetic Rats","volume":"46","author":"Zhang","year":"2024","journal-title":"Ren. Fail."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Seo, S.Y., Ju, W.S., Kim, K., Kim, J., Yu, J.O., Ryu, J.S., Kim, J.S., Lee, H.A., Koo, D.B., and Choo, Y.K. (2024). Quercetin Induces Mitochondrial Apoptosis and Downregulates Ganglioside GD3 Expression in Melanoma Cells. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25105146"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e1185","DOI":"10.1002\/iid3.1185","article-title":"Quercetin Attenuates Inflammation in LPS-Induced Lung Epithelial Cells via the Nrf2 Signaling Pathway","volume":"12","author":"Lv","year":"2024","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s10020-023-00720-8","article-title":"Quercetin Inhibits the Metabolism of Arachidonic Acid by Inhibiting the Activity of CYP3A4, Thereby Inhibiting the Progression of Breast Cancer","volume":"29","author":"Tang","year":"2023","journal-title":"Mol. Med."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Periferakis, A., Periferakis, K., Badarau, I.A., Petran, E.M., Popa, D.C., Caruntu, A., Costache, R.S., Scheau, C., Caruntu, C., and Costache, D.O. (2022). Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315054"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Yang, Y., Chen, Z., Zhao, X., Xie, H., Du, L., Gao, H., and Xie, C. (2022). Mechanisms of Kaempferol in the Treatment of Diabetes: A Comprehensive and Latest Review. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.990299"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Nizi\u0144ski, P., Krajewska, A., Oniszczuk, T., Polak, B., and Oniszczuk, A. (2025). Hepatoprotective Effect of Kaempferol-A Review. Molecules, 30.","DOI":"10.3390\/molecules30091913"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"9580","DOI":"10.1080\/10408398.2022.2067121","article-title":"Kaempferol: A Flavonoid with Wider Biological Activities and Its Applications","volume":"63","author":"Bangar","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Qu, Y., Li, X., Xu, F., Zhao, S., Wu, X., Wang, Y., and Xie, J. (2021). Kaempferol Alleviates Murine Experimental Colitis by Restoring Gut Microbiota and Inhibiting the LPS-TLR4-NF-\u03baB Axis. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.679897"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jare.2024.10.037","article-title":"Kaempferol Alleviates Myocardial Ischemia Injury by Reducing Oxidative Stress via the HDAC3-Mediated Nrf2 Signaling Pathway","volume":"75","author":"Yue","year":"2025","journal-title":"J. Adv. Res."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Tie, F., Ding, J., Hu, N., Dong, Q., Chen, Z., and Wang, H. (2021). Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168847"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1080\/13880209.2021.1961823","article-title":"Kaempferol-Induced GPER Upregulation Attenuates Atherosclerosis via the PI3K\/AKT\/Nrf2 Pathway","volume":"59","author":"Feng","year":"2021","journal-title":"Pharm. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/13880209.2021.1877734","article-title":"Kaempferol Suppresses Acetaminophen-Induced Liver Damage by Upregulation\/Activation of SIRT1","volume":"59","author":"BinMowyna","year":"2021","journal-title":"Pharm. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Zhou, J., Zhou, H., Zhu, J., and Fang, S. (2025). Kaempferol Inhibits Cardiomyocyte Pyroptosis via Promoting O-GlcNAcylation of GSDME and Improved Acute Myocardial Infarction. BMC Pharmacol. Toxicol., 26.","DOI":"10.1186\/s40360-025-00908-0"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zhang, S., Tang, F., Zhou, Z., Li, L., Tang, Y., Fu, K., Tan, Y., and Li, L. (2025). Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26146666"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s10787-025-01671-8","article-title":"Rutin: A Pain-Relieving Flavonoid","volume":"33","author":"Forouzanfar","year":"2025","journal-title":"Inflammopharmacology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e13921","DOI":"10.1111\/acel.13921","article-title":"Rutin Is a Potent Senomorphic Agent to Target Senescent Cells and Can Improve Chemotherapeutic Efficacy","volume":"23","author":"Liu","year":"2024","journal-title":"Aging Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e70011","DOI":"10.1111\/srt.70011","article-title":"Rutin Alleviates Psoriasis-Related Inflammation in Keratinocytes by Regulating the JAK2\/STAT3 Signaling","volume":"30","author":"Wu","year":"2024","journal-title":"Ski. Res. Technol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Huo, M., Xia, A., Cheng, W., Zhou, M., Wang, J., Shi, T., Cai, C., Jin, W., Zhou, M., and Liao, Y. (2022). Rutin Promotes Pancreatic Cancer Cell Apoptosis by Upregulating miRNA-877-3p Expression. Molecules, 27.","DOI":"10.3390\/molecules27072293"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1038\/s41598-023-31647-z","article-title":"Rutin Alleviates Colon Lesions and Regulates Gut Microbiota in Diabetic Mice","volume":"13","author":"Cai","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Chen, L., Li, S., Li, W., Yu, Y., Sun, Q., Chen, W., Zhou, H., Wang, C., Li, L., and Xu, M. (2024). Rutin Prevents EqHV-8 Induced Infection and Oxidative Stress via Nrf2\/HO-1 Signaling Pathway. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1386462"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Birsa, M.L., and Sarbu, L.G. (2024). Novel Dithiocarbamic Flavanones with Antioxidant Properties-A Structure-Activity Relationship Study. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252413698"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Cichon, N., Szelenberger, R., Stela, M., Podogrocki, M., Gorniak, L., and Bijak, M. (2025). Flavanones as Modulators of Gut Microbiota and Cognitive Function. Molecules, 30.","DOI":"10.3390\/molecules30102203"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Taheri, A., Mobaser, S.E., Golpour, P., Nourbakhsh, M., Tavakoli-Yaraki, M., Yarahmadi, S., and Nourbakhsh, M. (2023). Hesperetin Attenuates the Expression of Markers of Adipose Tissue Fibrosis in Pre-Adipocytes. BMC Complement. Med. Ther., 23.","DOI":"10.1186\/s12906-023-04152-z"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Zhao, S., Nan, Y., Yao, R., Wang, L., Zeng, X., Aadil, R.M., and Shabbir, M.A. (2023). Antibacterial Activity and Transcriptomic Analysis of Hesperetin against Alicyclobacillus acidoterrestris Vegetative Cells. Foods, 12.","DOI":"10.3390\/foods12173276"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Wang, J., Yao, Y., Yao, T., Shi, Q., Zeng, Y., and Li, L. (2024). Hesperetin Alleviated Experimental Colitis via Regulating Ferroptosis and Gut Microbiota. Nutrients, 16.","DOI":"10.3390\/nu16142343"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.3390\/cimb45020102","article-title":"Hesperetin Induces Autophagy and Delayed Apoptosis by Modulating the AMPK\/Akt\/mTOR Pathway in Human Leukemia Cells In Vitro","volume":"45","author":"Lin","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1038\/s41598-025-33274-2","article-title":"Hesperetin Alleviates Sepsis-Associated Acute Respiratory Distress Syndrome via the PI3K\/Akt\/PTEN Axis","volume":"16","author":"Ruan","year":"2026","journal-title":"Sci. Rep."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Sajeev, A., Aswani, B.S., Alqahtani, M.S., Abbas, M., Sethi, G., and Kunnumakkara, A.B. (2025). Harnessing Liquiritigenin: A Flavonoid-Based Approach for the Prevention and Treatment of Cancer. Cancers, 17.","DOI":"10.3390\/cancers17142328"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.gendis.2021.06.008","article-title":"Liquiritigenin Promotes Osteogenic Differentiation and Prevents Bone Loss via Inducing Auto-Lysosomal Degradation and Inhibiting Apoptosis","volume":"10","author":"Qiu","year":"2021","journal-title":"Genes Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4196\/kjpp.2024.28.4.379","article-title":"Polygonatum sibiricum Component Liquiritigenin Restrains Breast Cancer Cell Invasion and Migration by Inhibiting HSP90 and Chaperone-Mediated Autophagy","volume":"28","author":"Xu","year":"2024","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13020-024-00886-1","article-title":"The SIRT1\/Nrf2 Signaling Pathway Mediates the Anti-Pulmonary Fibrosis Effect of Liquiritigenin","volume":"19","author":"Hua","year":"2024","journal-title":"Chin. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3892\/ol.2025.15172","article-title":"Silymarin Induces Multiple Myeloma Cell Apoptosis by Inhibiting the JAK2\/STAT3 Signaling Pathway","volume":"30","author":"Liu","year":"2025","journal-title":"Oncol. Lett."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.virol.2022.04.005","article-title":"Flavonols and Dihydroflavonols Inhibit the Main Protease Activity of SARS-CoV-2 and the Replication of Human Coronavirus 229E","volume":"571","author":"Zhu","year":"2022","journal-title":"Virology"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Wadhwa, K., Pahwa, R., Kumar, M., Kumar, S., Sharma, P.C., Singh, G., Verma, R., Mittal, V., Singh, I., and Kaushik, D. (2022). Mechanistic Insights into the Pharmacological Significance of Silymarin. Molecules, 27.","DOI":"10.3390\/molecules27165327"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Okiljevi\u0107, B., Marti\u0107, N., Govedarica, S., Andreji\u0107 Vi\u0161nji\u0107, B., Bosanac, M., Baljak, J., Pavli\u0107, B., Milanovi\u0107, I., and Ra\u0161kovi\u0107, A. (2024). Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16040520"},{"key":"ref_89","first-page":"4521","article-title":"Silymarin Suppresses Proliferation of Human Hepatocellular Carcinoma Cells under Hypoxia through Downregulation of the HIF-1\u03b1\/VEGF Pathway","volume":"15","author":"Yu","year":"2023","journal-title":"Am. J. Transl. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1267\/ahc.22-00059","article-title":"Protective Effect of Silymarin on Liver in Experimental in the Sepsis Model of Rats","volume":"56","author":"Gedikli","year":"2023","journal-title":"Acta Histochem. Cytochem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"42723","DOI":"10.1021\/acsomega.2c04140","article-title":"Silymarin-Functionalized Selenium Nanoparticles Prevent LPS-Induced Inflammatory Response in RAW264.7 Cells through Downregulation of the PI3K\/Akt\/NF-\u03baB Pathway","volume":"7","author":"Mi","year":"2022","journal-title":"ACS Omega"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Liu, Z., Qiu, D., Yang, T., Su, J., Liu, C., Su, X., Li, A., Sun, P., Li, J., and Yan, L. (2023). Research Progress of Dihydroquercetin in the Treatment of Skin Diseases. Molecules, 28.","DOI":"10.3390\/molecules28196989"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Yuan, L., Sun, Y., Zhou, N., Wu, W., Zheng, W., and Wang, Y. (2022). Dihydroquercetin Attenuates Silica-Induced Pulmonary Fibrosis by Inhibiting Ferroptosis Signaling Pathway. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.845600"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Wang, M., Han, H., Wan, F., Zhong, R., Do, Y.J., Oh, S.I., Lu, X., Liu, L., Yi, B., and Zhang, H. (2022). Dihydroquercetin Supplementation Improved Hepatic Lipid Dysmetabolism Mediated by Gut Microbiota in High-Fat Diet (HFD)-Fed Mice. Nutrients, 14.","DOI":"10.3390\/nu14245214"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e29807","DOI":"10.1016\/j.heliyon.2024.e29807","article-title":"Dihydroquercetin Regulates HIF-1\u03b1\/AKT\/NR2B Signalling to Improve Impaired Brain Function in Rats with Metabolic Syndrome","volume":"10","author":"Fu","year":"2024","journal-title":"Heliyon"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Iwasa, M., Kato, H., Iwashita, K., Yamakage, H., Kato, S., Saito, S., Ihara, M., Nishimura, H., Kawamoto, A., and Suganami, T. (2023). Taxifolin Suppresses Inflammatory Responses of High-Glucose-Stimulated Mouse Microglia by Attenuating the TXNIP\u2013NLRP3 Axis. Nutrients, 15.","DOI":"10.3390\/nu15122738"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Farhan, M. (2022). Green Tea Catechins: Nature\u2019s Way of Preventing and Treating Cancer. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810713"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Diniz, L.R.L., Elshabrawy, H.A., Souza, M.T.S., Duarte, A.B.S., Datta, S., and de Sousa, D.P. (2021). Catechins: Therapeutic Perspectives in COVID-19-Associated Acute Kidney Injury. Molecules, 26.","DOI":"10.3390\/molecules26195951"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Ferrari, E., and Naponelli, V. (2025). Catechins and Human Health: Breakthroughs from Clinical Trials. Molecules, 30.","DOI":"10.3390\/molecules30153128"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.7150\/ijms.122441","article-title":"Green Tea Containing Inulin and Catechins Ameliorates High-Fat Diet-Induced Metabolic Dysfunction-Associated Fatty Liver Disease in Mice","volume":"22","author":"Lee","year":"2025","journal-title":"Int. J. Med. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e14364","DOI":"10.1111\/cns.14364","article-title":"Targeting the AKT-P53\/CREB Pathway with Epicatechin for Improved Prognosis of Traumatic Brain Injury","volume":"30","author":"Wang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3892\/mmr.2023.13095","article-title":"Catechin Hydrate Ameliorates Cerulein-Induced Chronic Pancreatitis via the Inactivation of TGF-\u03b2\/Smad2 Signaling","volume":"28","author":"Kweon","year":"2023","journal-title":"Mol. Med. Rep."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Elbarbry, F., Jones, G., and Ung, A. (2022). Catechin Reduces Blood Pressure in Spontaneously Hypertensive Rats through Modulation of Arachidonic Acid Metabolism. Molecules, 27.","DOI":"10.3390\/molecules27238432"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3000605231167314","DOI":"10.1177\/03000605231167314","article-title":"Proanthocyanidins May Be Potential Therapeutic Agents for the Treatment of Carotid Atherosclerosis: A Review","volume":"51","author":"Huang","year":"2023","journal-title":"J. Int. Med. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.3724\/abbs.2024042","article-title":"Proanthocyanidins Isolated from Lotus Seed Skin Mitigate Glycolipid Metabolism Disorder through the p38\/Nrf2\/NF-\u03baB Signaling Pathway","volume":"56","author":"Yi","year":"2024","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"25643","DOI":"10.1038\/s41598-024-76743-w","article-title":"Proanthocyanidins Protects 3-NPA-Induced Ovarian Function Decline by Activating SESTRIN2-NRF2-Mediated Oxidative Stress in Mice","volume":"14","author":"Huang","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Li, H., Zhang, Y., Hao, Y., Xu, P., Wang, X., Zhu, B., Lu, C., and Xu, K. (2023). Proanthocyanidins Inhibit Osteoblast Apoptosis via the PI3K\/AKT\/Bcl-xL Pathway in the Treatment of Steroid-Induced Osteonecrosis of the Femoral Head in Rats. Nutrients, 15.","DOI":"10.3390\/nu15081936"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e13921","DOI":"10.1111\/srt.13921","article-title":"Proanthocyanidins Alleviate Henoch-Sch\u00f6nlein Purpura by Mitigating Inflammation and Oxidative Stress through Regulation of the TLR4\/MyD88\/NF-\u03baB Pathway","volume":"30","author":"Li","year":"2024","journal-title":"Ski. Res. Technol."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Zaa, C.A., Marcelo, \u00c1.J., An, Z., Medina-Franco, J.L., and Velasco-Vel\u00e1zquez, M.A. (2023). Anthocyanins: Molecular Aspects on Their Neuroprotective Activity. Biomolecules, 13.","DOI":"10.3390\/biom13111598"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Ngamsamer, C., Sirivarasai, J., and Sutjarit, N. (2022). The Benefits of Anthocyanins against Obesity-Induced Inflammation. Biomolecules, 12.","DOI":"10.3390\/biom12060852"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Deepa, P., Hong, M., Sowndhararajan, K., and Kim, S. (2023). A Review of the Role of an Anthocyanin, Cyanidin-3-O-\u03b2-glucoside in Obesity-Related Complications. Plants, 12.","DOI":"10.3390\/plants12223889"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1038\/s41598-025-94918-x","article-title":"Cyanidin-3-Glucoside Upregulated NDRG2 through the PI3K\/AKT Pathway to Alleviate EMT and ECM in Renal Fibrosis","volume":"15","author":"Lu","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Zhu, L., Cao, F., Hu, Z., Zhou, Y., Guo, T., Yan, S., Xie, Q., Xia, X., Yuan, H., and Li, G. (2024). Cyanidin-3-O-Glucoside Alleviates Alcoholic Liver Injury via Modulating Gut Microbiota and Metabolites in Mice. Nutrients, 16.","DOI":"10.3390\/nu16050694"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Wang, B., Cui, S., Mao, B., Zhang, Q., Tian, F., Zhao, J., Tang, X., and Chen, W. (2022). Cyanidin Alleviated CCl4-Induced Acute Liver Injury by Regulating the Nrf2 and NF-\u03baB Signaling Pathways. Antioxidants, 11.","DOI":"10.3390\/antiox11122383"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3892\/mmr.2021.11977","article-title":"Cyanidin-3-O-\u03b2-glucoside Protects against Pulmonary Artery Hypertension Induced by Monocrotaline via the TGF-\u03b21\/p38 MAPK\/CREB Signaling Pathway","volume":"23","author":"Ouyang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Wang, Y., Chen, J., Wang, Y., Zheng, F., Qu, M., Huang, Z., Yan, J., Bao, F., Li, X., and Sun, C. (2022). Cyanidin-3-O-Glucoside Extracted from the Chinese Bayberry (Myrica rubra Sieb. et Zucc.) Alleviates Antibiotic-Associated Diarrhea by Regulating Gut Microbiota and Down-Regulating Inflammatory Factors in NF-\u03baB Pathway. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.970530"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Sharma, A., Choi, H.K., Kim, Y.K., and Lee, H.J. (2021). Delphinidin and Its Glycosides\u2019 War on Cancer: Preclinical Perspectives. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111500"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1111\/cas.14133","article-title":"Delphinidin Suppresses Breast Carcinogenesis through the HOTAIR\/microRNA-34a Axis","volume":"110","author":"Han","year":"2019","journal-title":"Cancer Sci."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Bajorat, R., Grest, S.L., Bergt, S., Klawitter, F., Vollmar, B., Reuter, D.A., and Bajorat, J. (2024). Administration of Delphinidin to Improve Survival and Neurological Outcome in Mice After Cardiac Arrest and Resuscitation. Antioxidants, 13.","DOI":"10.3390\/antiox13121469"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"413","DOI":"10.4196\/kjpp.2020.24.5.413","article-title":"Delphinidin Enhances Radio-Therapeutic Effects via Autophagy Induction and JNK\/MAPK Pathway Activation in Non-Small Cell Lung Cancer","volume":"24","author":"Kang","year":"2020","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/13880209.2021.2017469","article-title":"Delphinidin-3-O-Glucoside, an Active Compound of Hibiscus sabdariffa Calyces, Inhibits Oxidative Stress and Inflammation in Rabbits with Atherosclerosis","volume":"60","author":"Sun","year":"2022","journal-title":"Pharm. Biol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Jasim, H.A., Nahar, L., Jasim, M.A., Moore, S.A., Ritchie, K.J., and Sarker, S.D. (2021). Chalcones: Synthetic Chemistry Follows Where Nature Leads. Biomolecules, 11.","DOI":"10.3390\/biom11081203"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Hussein, O.J., Elkhalifa, D., Hassan, A.F., Alali, F., Al Moustafa, A.E., and Khalil, A. (2025). The Role of Natural Chalcones and Their Derivatives in Targeting Prostate Cancer: Recent Updates. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262412082"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Leu, W.J., Chu, J.C., Hsu, J.L., Du, C.M., Jiang, Y.H., Hsu, L.C., Huang, W.J., and Guh, J.H. (2020). Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps-Structure-Activity-Relationship and Mechanism Studies. Molecules, 25.","DOI":"10.3390\/molecules25245960"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Darwish, M.I.M., Moustafa, A.M., Youssef, A.M., Mansour, M., Yousef, A.I., El Omri, A., Shawki, H.H., Mohamed, M.F., Hassaneen, H.M., and Abdelhamid, I.A. (2023). Novel Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis. Molecules, 28.","DOI":"10.3390\/molecules28083338"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Jebari-Benslaiman, S., Galicia-Garc\u00eda, U., Larrea-Sebal, A., Olaetxea, J.R., Alloza, I., Vandenbroeck, K., Benito-Vicente, A., and Mart\u00edn, C. (2022). Pathophysiology of Atherosclerosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063346"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1002\/ptr.70097","article-title":"Pharmacological Diversity of Flavonoids and Their Clinical Application Prospects in Neurological Disorders","volume":"39","author":"Cheng","year":"2025","journal-title":"Phytother. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3892\/mmr.2025.13515","article-title":"Advances in Research on Flavonoids in Tumor Immunotherapy (Review)","volume":"31","author":"Yan","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/13880209.2025.2509020","article-title":"Apigenin Attenuates the Atherosclerotic Lesions through Enhancing Selective Autophagy\/Lipophagy and Promoting RCT Process","volume":"63","author":"Hu","year":"2025","journal-title":"Pharm. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Xie, C., Shi, Y., Chen, Z., Zhou, X., Luo, P., Hong, C., Tian, N., Wu, Y., Zhou, Y., and Lin, Y. (2022). Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.787278"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"6631562","DOI":"10.1155\/2021\/6631562","article-title":"Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy","volume":"2021","author":"Zhang","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Bahar, M.E., Hwang, J.S., Lai, T.H., Byun, J.H., Kim, D.H., and Kim, D.R. (2024). The Survival of Human Intervertebral Disc Nucleus Pulposus Cells under Oxidative Stress Relies on the Autophagy Triggered by Delphinidin. Antioxidants, 13.","DOI":"10.3390\/antiox13070759"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"6651839","DOI":"10.1155\/2021\/6651839","article-title":"Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-\u03b21\/Smad3 and p38\/PPAR\u03b1 Pathways","volume":"2021","author":"Ji","year":"2021","journal-title":"PPAR Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"112167","DOI":"10.1016\/j.biopha.2021.112167","article-title":"Liquiritigenin Protects against Arsenic Trioxide-Induced Liver Injury by Inhibiting Oxidative Stress and Enhancing mTOR-Mediated Autophagy","volume":"143","author":"Zhang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Katsaros, I., Sotiropoulou, M., Vailas, M., Papachristou, F., Papakyriakopoulou, P., Grigoriou, M., Kostomitsopoulos, N., Giatromanolaki, A., Valsami, G., and Tsaroucha, A. (2024). The Effect of Quercetin on Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Beclin1, P62, and LC3: An Experimental Study. Nutrients, 16.","DOI":"10.3390\/nu16244282"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"36637","DOI":"10.1038\/s41598-025-20512-w","article-title":"Exercise Training and Silymarin Consumption Can Ameliorate Mitophagy Signaling Flux in Hepatocytes of Rats with Dexamethasone-Induced Non-Alcoholic Fatty Liver Disease","volume":"15","author":"Nasiri","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_137","first-page":"1329","article-title":"Proanthocyanidin Alleviates Liver Ischemia\/Reperfusion Injury by Suppressing Autophagy and Apoptosis via the PPAR\u03b1\/PGC1\u03b1 Signaling Pathway","volume":"11","author":"Yao","year":"2023","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"167259","DOI":"10.1016\/j.bbadis.2024.167259","article-title":"Cyanidin-3-O-Glucoside Alleviates Ethanol-Induced Liver Injury by Promoting Mitophagy in a Gao-Binge Mouse Model of Alcohol-Associated Liver Disease","volume":"1870","author":"He","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_139","first-page":"602","article-title":"Apigenin Attenuates Myocardial Ischemia-Reperfusion Injury through miR-448\/SIRT1 Axis","volume":"28","author":"Tian","year":"2025","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Dai, X., Liang, B., and Sun, Y. (2025). Luteolin Ameliorates Rat Model of Metabolic Syndrome-Induced Cardiac Injury by Apoptosis Suppression and Autophagy Promotion via NR4A2\/p53 Regulation. BMC Complement. Med. Ther., 25.","DOI":"10.1186\/s12906-025-04749-6"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41401-020-0496-1","article-title":"Baicalein Attenuates Cardiac Hypertrophy in Mice via Suppressing Oxidative Stress and Activating Autophagy in Cardiomyocytes","volume":"42","author":"Liu","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1080\/15384101.2021.1932029","article-title":"Quercetin Prevents Isoprenaline-Induced Myocardial Fibrosis by Promoting Autophagy via Regulating miR-223-3p\/FOXO3","volume":"20","author":"Hu","year":"2021","journal-title":"Cell Cycle"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The Evolving Tumor Microenvironment: From Cancer Initiation to Metastatic Outgrowth","volume":"41","author":"Joyce","year":"2023","journal-title":"Cancer Cell"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Wu, L., Lin, Y., Gao, S., Wang, Y., Pan, H., Wang, Z., Pozzolini, M., Yang, F., Zhang, H., and Yang, Y. (2023). Luteolin Inhibits Triple-Negative Breast Cancer by Inducing Apoptosis and Autophagy through SGK1-FOXO3a-BNIP3 Signaling. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1200843"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1080\/15548627.2024.2439657","article-title":"Baicalein Tethers CD274\/PD-L1 for Autophagic Degradation to Boost Antitumor Immunity","volume":"21","author":"Hao","year":"2025","journal-title":"Autophagy"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3892\/or.2025.8890","article-title":"Effect of Quercetin on Inhibiting Gefitinib-Activated Non-Small Cell Lung Cancer-Induced Cell Pyroptosis in Cardiomyocytes via Modulating Mitochondrial Autophagy Mediated by the SHP2\/ROS\/AMPK\/XBP-1\/DJ-1 Signaling Pathway","volume":"53","author":"Zhang","year":"2025","journal-title":"Oncol. Rep."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"102022","DOI":"10.1016\/j.mcp.2025.102022","article-title":"Silymarin Plus Doxorubicin Exerts the Anti-Hepatocellular Carcinoma Effects via Wnt, Apoptosis, Autophagy and Angiogenesis Pathways","volume":"81","author":"Yuan","year":"2025","journal-title":"Mol. Cell. Probes"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Chen, Y., Liu, Y., Zhou, J., Bao, T., Wang, J., and Ao, M. (2025). Adamantyl-Substituted Chalcone CA13 Induces Cytoprotective Autophagy and JNK-Dependent Apoptosis in Lung Cancer Cells. Biomolecules, 16.","DOI":"10.3390\/biom16010054"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Mendez-Callejas, G., Pi\u00f1eros-Avila, M., Celis, C.A., Torrenegra, R., Espinosa-Benitez, A., Pestana-Nobles, R., and Yosa-Reyes, J. (2024). Natural 2\u2032,4-Dihydroxy-4\u2032,6\u2032-Dimethoxy Chalcone Isolated from Chromolaena tacotana Inhibits Breast Cancer Cell Growth through Autophagy and Mitochondrial Apoptosis. Plants, 13.","DOI":"10.3390\/plants13050570"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Mendez-Callejas, G., Pi\u00f1eros-Avila, M., Yosa-Reyes, J., Pestana-Nobles, R., Torrenegra, R., Camargo-Ubate, M.F., Bello-Castro, A.E., and Celis, C.A. (2023). A Novel Tri-Hydroxy-Methylated Chalcone Isolated from Chromolaena tacotana with Anti-Cancer Potential Targeting Pro-Survival Proteins. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015185"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"117284","DOI":"10.1016\/j.biopha.2024.117284","article-title":"Chalcones Induce Apoptosis, Autophagy and Reduce Spreading in Osteosarcoma 3D Models","volume":"179","author":"Rossi","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"e70071","DOI":"10.1002\/fsn3.70071","article-title":"Luteolin Inhibits Dexamethasone-Induced Osteoporosis by Autophagy Activation Through miR-125b-5p\/SIRT3\/AMPK\/mTOR Axis, an In Vitro and In Vivo Study","volume":"13","author":"Tang","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1177\/15353702231211977","article-title":"Quercetin Suppresses Ovariectomy-Induced Osteoporosis in Rat Mandibles by Regulating Autophagy and the NLRP3 Pathway","volume":"248","author":"Xiong","year":"2023","journal-title":"Exp. Biol. Med."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Han, M., Lu, Y., Tao, Y., Zhang, X., Dai, C., Zhang, B., Xu, H., and Li, J. (2023). Luteolin Protects Pancreatic \u03b2 Cells against Apoptosis through Regulation of Autophagy and ROS Clearance. Pharmaceuticals, 16.","DOI":"10.3390\/ph16070975"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Sheng, H., Zhang, D., Zhang, J., Zhang, Y., Lu, Z., Mao, W., Liu, X., and Zhang, L. (2022). Kaempferol Attenuated Diabetic Nephropathy by Reducing Apoptosis and Promoting Autophagy through AMPK\/mTOR Pathways. Front. Med., 9.","DOI":"10.3389\/fmed.2022.986825"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Alshaman, R., Kolieb, E., El-Sayed, R.M., Gouda, S.G., Alattar, A., Zaitone, S.A., Abdelmaogood, A.K.K., Elabbasy, L.M., Eltrawy, A.H., and Sayd, F.Y. (2024). Computational and Experimental Approaches Exploring the Role of Hesperetin in Improving Autophagy in Rat Diabetic Retinopathy. Biomedicines, 12.","DOI":"10.3390\/biomedicines12030552"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Tian, C., Feng, Y., Chen, T., Zhang, Z., He, X., Jiang, L., and Liu, M. (2023). EGCG Restores Keratinocyte Autophagy to Promote Diabetic Wound Healing through the AMPK\/ULK1 Pathway. Front. Biosci., 28.","DOI":"10.31083\/j.fbl2812324"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1177\/15353702221110646","article-title":"Epigallocatechin-3-Gallate Attenuates Myocardial Fibrosis in Diabetic Rats by Activating Autophagy","volume":"247","author":"Jia","year":"2022","journal-title":"Exp. Biol. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"101911","DOI":"10.1016\/j.redox.2021.101911","article-title":"Kaempferol Alleviates LD-Mitochondrial Damage by Promoting Autophagy: Implications in Parkinson\u2019s Disease","volume":"41","author":"Han","year":"2021","journal-title":"Redox Biol."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Lang, L., Liu, S., Zhang, W., Zhang, J., and Liu, H. (2026). Quercetin Regulates Autophagy and Attenuates Airway Inflammation in a Murine Model of Asthma: Association with PI3K\/Akt\/mTOR Signaling Pathway Modulation. Front. Pharmacol., 17.","DOI":"10.3389\/fphar.2026.1755094"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Feng, M., Zhou, X., Yang, T., Chen, Z., Yang, G., Jiang, X., and Yuan, W. (2026). Quercetin Prevents Age-Related Hearing Loss in C57BL\/6J Mice by Activating Mitophagy and Inhibiting the NLRP3 Inflammasome. PLoS ONE, 21.","DOI":"10.1371\/journal.pone.0342423"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e71083","DOI":"10.1096\/fj.202502311R","article-title":"Hesperetin Alleviates Bleomycin-Induced Pulmonary Fibrosis by Modulating Cellular Senescence and Promoting Impaired Autophagy in a CISD2-Dependent Manner","volume":"39","author":"Lin","year":"2025","journal-title":"FASEB J."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"e70829","DOI":"10.1002\/jbt.70829","article-title":"Ameliorative Role of Silymarin in Methotrexate-Induced Pulmonary Damage: A Multi-Pathway Molecular Approach","volume":"40","author":"Genc","year":"2026","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Shen, M., You, Y., Xu, C., and Chen, Z. (2024). Epigallocatechin-3-Gallate Attenuates Lipopolysacharide-Induced Pneumonia via Modification of Inflammation, Oxidative Stress, Apoptosis, and Autophagy. BMC Complement. Med. Ther., 24.","DOI":"10.1186\/s12906-024-04436-y"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Yang, C.C., Wu, C.J., Chien, C.Y., and Chien, C.T. (2021). Green Tea Polyphenol Catechins Inhibit Coronavirus Replication and Potentiate the Adaptive Immunity and Autophagy-Dependent Protective Mechanism to Improve Acute Lung Injury in Mice. Antioxidants, 10.","DOI":"10.3390\/antiox10060928"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Qin, H., Song, Z., Zhao, C., Yang, J., Xia, F., Wang, L., Ali, A., and Zheng, W. (2022). Liquiritigenin Inhibits Lipid Accumulation in 3T3-L1 Cells via mTOR-Mediated Regulation of the Autophagy Mechanism. Nutrients, 14.","DOI":"10.3390\/nu14061287"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"393","DOI":"10.46497\/ArchRheumatol.2022.9034","article-title":"Grape Seed Proanthocyanidin Extract Induces Apoptotic and Autophagic Cell Death in Rheumatoid Arthritis Fibroblast-Like Synoviocytes","volume":"37","author":"Heo","year":"2022","journal-title":"Arch. Rheumatol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7150\/thno.78370","article-title":"3,4-Dimethoxychalcone, a Caloric Restriction Mimetic, Enhances TFEB-Mediated Autophagy and Alleviates Pyroptosis and Necroptosis after Spinal Cord Injury","volume":"13","author":"Zhang","year":"2023","journal-title":"Theranostics"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Maharajan, N., Ganesan, C.D., Moon, C., Jang, C.H., Oh, W.K., and Cho, G.W. (2021). Licochalcone D Ameliorates Oxidative Stress-Induced Senescence via AMPK Activation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147324"},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Rahmani, A.H., Alsahli, M.A., Almatroudi, A., Almogbel, M.A., Khan, A.A., Anwar, S., and Almatroodi, S.A. (2022). The Potential Role of Apigenin in Cancer Prevention and Treatment. Molecules, 27.","DOI":"10.3390\/molecules27186051"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1002\/ptr.8217","article-title":"Luteolin: A Promising Multifunctional Natural Flavonoid for Human Diseases","volume":"38","author":"Zhu","year":"2024","journal-title":"Phytother. Res."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Chmiel, M., and Stompor-Gor\u0105cy, M. (2023). Promising Role of the Scutellaria baicalensis Root Hydroxyflavone-Baicalein in the Prevention and Treatment of Human Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054732"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"143630","DOI":"10.1016\/j.foodchem.2025.143630","article-title":"Improving Quercetin Bioavailability: A Systematic Review and Meta-Analysis of Human Intervention Studies","volume":"477","author":"Liu","year":"2025","journal-title":"Food Chem."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"112024","DOI":"10.1016\/j.biopha.2021.112024","article-title":"Silymarin (Milk Thistle Extract) as a Therapeutic Agent in Gastrointestinal Cancer","volume":"142","author":"Fallah","year":"2021","journal-title":"Biomed. Pharmacother."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/12\/2055\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:12:19Z","timestamp":1782274339000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/12\/2055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":174,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["molecules31122055"],"URL":"https:\/\/doi.org\/10.3390\/molecules31122055","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]}}}