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This study aimed to evaluate the cytotoxic and proapoptotic effects of Andean berry juice (ABJ) in human SW480 and SW620 colon cancer cell lines, which represent early-stage and metastatic colorectal cancer, respectively. The juice was prepared from freeze-dried fruits, and several concentrations were assayed in cells. Bioactive compounds in ABJ showed the strongest reductions in metabolic activity and proliferation observed in SW620 cells. ABJ treatments promoted early apoptosis while inducing cell cycle arrest in the S phase (SW480) and in the G2\/M (SW620). Mild mitochondrial depolarization was observed, while increased reactive oxygen species (ROS) accumulation was detected in both cell lines. More proteins involved in the apoptotic process were modulated in SW620 cells, whereas SW480 displayed greater fold changes in regulatory and stress-response proteins. Proteomics and bioinformatics analyses suggested that extrinsic apoptosis predominated in SW480 cells, whereas intrinsic apoptosis was observed in SW620 cells. These results highlighted the cytotoxic and pro-apoptotic potential of the combined activity of polyphenolic compounds from ABJ, demonstrating distinct mechanisms in vitro.<\/jats:p>","DOI":"10.3390\/molecules31122147","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:33:54Z","timestamp":1781768034000},"page":"2147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Andean Berry (Vaccinium meridionale Swartz) Juice Promotes Cytotoxic and Proapoptotic Effects in Human Early-Stage and Metastatic Colorectal Cancer Cells"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8033-3520","authenticated-orcid":false,"given":"Ivan","family":"Luzardo-Ocampo","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, Institute for Obesity Research, Ave. Eugenio Garza Sada 2501 Sur., Col., Tecnol\u00f3gico, Monterrey 64700, Nuevo Leon, Mexico"},{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Ave. Eugenio Garza Sada 2501 Sur., Col., Tecnol\u00f3gico, Monterrey 64700, Nuevo Leon, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4328-6670","authenticated-orcid":false,"given":"Myriam","family":"Agudelo-Quintero","sequence":"additional","affiliation":[{"name":"Research and Graduate Program in Food Science, School of Chemistry, Universidad Aut\u00f3noma de Quer\u00e9taro, Cerro de las Campanas S\/N, Quer\u00e9taro 76000, Queretaro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2422-3439","authenticated-orcid":false,"given":"Sandra S.","family":"Arango-Varela","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica, Facultad de Ciencias Exactas y Aplicadas, Instituto Tecnol\u00f3gico Metropolitano (ITM), Calle 73 No. 76A-354 V\u00eda al Volador, Medell\u00edn 050012, Antioquia, Colombia"},{"name":"Grupo de Investigaci\u00f3n Biolog\u00eda M\u00e9dica, Facultad de Ciencias Exactas y Aplicadas, Instituto Tecnol\u00f3gico Metropolitano (ITM), Calle 73 No. 76A-354 V\u00eda al Volador, Medell\u00edn 050012, Antioquia, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6371-3038","authenticated-orcid":false,"given":"Silvia A.","family":"Quijano","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Ecolog\u00eda y Conservaci\u00f3n de la Biodiversidad (EcoBio), Facultad de Ciencias B\u00e1sicas, Universidad Santiago de Cali, Cali 760001, Valle del Cauca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4664-6336","authenticated-orcid":false,"given":"Maria E.","family":"Maldonado-Celis","sequence":"additional","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Universidad de Antioquia, Carrera 75 No. 65-87, Medell\u00edn 050034, Antioquia, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2824-4678","authenticated-orcid":false,"given":"Jorge A.","family":"Lopera-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica, Facultad de Ciencias Exactas y Aplicadas, Instituto Tecnol\u00f3gico Metropolitano (ITM), Calle 73 No. 76A-354 V\u00eda al Volador, Medell\u00edn 050012, Antioquia, Colombia"},{"name":"Grupo de Investigaci\u00f3n Biolog\u00eda M\u00e9dica, Facultad de Ciencias Exactas y Aplicadas, Instituto Tecnol\u00f3gico Metropolitano (ITM), Calle 73 No. 76A-354 V\u00eda al Volador, Medell\u00edn 050012, Antioquia, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109979","DOI":"10.1016\/j.isci.2024.109979","article-title":"Hallmarks of Cancer Resistance","volume":"27","author":"Tufail","year":"2024","journal-title":"iScience"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1470-2045(24)00600-4","article-title":"Colorectal Cancer Incidence Trends in Younger versus Older Adults: An Analysis of Population-Based Cancer Registry Data","volume":"26","author":"Sung","year":"2025","journal-title":"Lancet Oncol."},{"key":"ref_3","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. 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