{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:20:00Z","timestamp":1783336800446,"version":"3.54.6"},"reference-count":150,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Tomatoes (Solanum lycopersicum L.) are one of the most important dietary sources of carotenoids, especially lycopene, a bioactive compound associated with antioxidant, anti-inflammatory and cardioprotective effects. This review synthesizes recent data on the phytochemical composition of tomatoes, with a focus on lycopene, its main biological mechanisms and health benefits, including the reduction in oxidative stress. The manuscript also highlights the influence of thermal processing and food matrix on the bioavailability of lycopene, as well as the role of innovative formulation and nanoencapsulation systems in increasing its stability and absorption. Modern extraction and analysis methods are also presented, including ultrasound, microwave and supercritical-fluid-assisted techniques, along with HPLC chromatographic methods. A distinctive element is the analysis of lycopene-based food supplements available on the markets in Romania, Europe and the United States, from the perspective of composition, standardization and safety. Current data support the potential of lycopene as a valuable nutraceutical ingredient, but further clinical studies are needed to confirm therapeutic benefits.<\/jats:p>","DOI":"10.3390\/molecules31132243","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:37:55Z","timestamp":1782391075000},"page":"2243","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tomato-Derived Lycopene: From Phytochemistry and Extraction Technologies to Bioavailability and Nutraceutical Applications"],"prefix":"10.3390","volume":"31","author":[{"given":"Andra-Monica","family":"Anghel (\u015etefan)","sequence":"first","affiliation":[{"name":"Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, \u201cDun\u0103rea de Jos\u201d University, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4014-213X","authenticated-orcid":false,"given":"Elena","family":"Enachi","sequence":"additional","affiliation":[{"name":"Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, \u201cDun\u0103rea de Jos\u201d University, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-5057","authenticated-orcid":false,"given":"Alina-Georgiana","family":"Cristea (Hohot\u0103)","sequence":"additional","affiliation":[{"name":"Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, \u201cDun\u0103rea de Jos\u201d University, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1949-4218","authenticated-orcid":false,"given":"F\u0103nic\u0103","family":"B\u0103l\u0103nescu","sequence":"additional","affiliation":[{"name":"Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, \u201cDun\u0103rea de Jos\u201d University, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9173-4832","authenticated-orcid":false,"given":"Oana","family":"Cioanc\u0103","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"H\u0103ncianu","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Robu","sequence":"additional","affiliation":[{"name":"Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, \u201cDun\u0103rea de Jos\u201d University, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.61180\/vegsci.2022.v49.i2.01","article-title":"Tomato breeding for processing in India: Current status and prospects","volume":"49","author":"Tiwari","year":"2022","journal-title":"Veg. Sci."},{"key":"ref_2","unstructured":"Food and Agriculture Organization of the United Nations (FAO) (2025, October 15). FAOSTAT: Crops and Livestock Products (Tomatoes). 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