{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:22:57Z","timestamp":1783081377474,"version":"3.54.6"},"reference-count":62,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Naphthalene (Nap) is widely distributed in the environment and has attracted concern due to its recalcitrance to biodegradation and acute toxic effects. Although several laccases can degrade naphthalene, it remains unclear whether laccase is involved in dioxygenation or ring fission of polycyclic aromatic hydrocarbons (PAHs). We demonstrated that laccase has a naphthalene dioxygenase function with a distinct joint approach to oxygen and the alternative regioselective ring-fission process. These results supplement the family of dioxygenase with laccase, a mild method for the ring opening of aromatics, and an operable scale-up application for remediation from PAH pollution and for regioselective oxygenation and ring opening.<\/jats:p>","DOI":"10.3390\/molecules31132352","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:39:11Z","timestamp":1783078751000},"page":"2352","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Free Radicals in the Mimetic Naphthalene Dioxygenase Function of Trametes versicolor Laccase Application for Biosynthesis of Isatin and Indirubin"],"prefix":"10.3390","volume":"31","author":[{"given":"Lin","family":"Wang","sequence":"first","affiliation":[{"name":"School of Life Sciences and Medical Engineering, Anhui University, Hefei 230039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Medical Engineering, Anhui University, Hefei 230039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Medical Engineering, Anhui University, Hefei 230039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boya","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Medical Engineering, Anhui University, Hefei 230039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Medical Engineering, Anhui University, Hefei 230039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuecai","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Medical Engineering, Anhui University, Hefei 230039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zai","family":"Zheng","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Medical Engineering, Anhui University, Hefei 230039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoshui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Microscale Magnetic Resonance, Department of Modern Physics, University of Science and Technology of China, Hefei 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihu","family":"Su","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Microscale Magnetic Resonance, Department of Modern Physics, University of Science and Technology of China, Hefei 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1783-1658","authenticated-orcid":false,"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7230-2675","authenticated-orcid":false,"given":"Ruochun","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Medical Engineering, Anhui University, Hefei 230039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18525","DOI":"10.1021\/acs.jafc.5c05285","article-title":"A Comprehensive Analysis of the Fates of Pesticide Residues in Edible Agricultural Products during Food Processing","volume":"73","author":"Xiao","year":"2025","journal-title":"J. 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