{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:36:21Z","timestamp":1785429381744,"version":"3.56.0"},"reference-count":84,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Educational Research Project for Young and Middle-aged Teachers in Fujian Province","award":["JZ240015"],"award-info":[{"award-number":["JZ240015"]}]},{"DOI":"10.13039\/501100008766","name":"China Agriculture Research System","doi-asserted-by":"publisher","award":["CARS-44"],"award-info":[{"award-number":["CARS-44"]}],"id":[{"id":"10.13039\/501100008766","id-type":"DOI","asserted-by":"publisher"}]},{"award":["CARS-44"],"award-info":[{"award-number":["CARS-44"]}],"id":[{"id":"https:\/\/ror.org\/03p5eky76","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Undergraduate Innovation and Entrepreneurship Training Program of Fujian Province","award":["202510389444"],"award-info":[{"award-number":["202510389444"]}]},{"name":"Undergraduate Innovation and Entrepreneurship Training Program of Fujian Province","award":["202510389380"],"award-info":[{"award-number":["202510389380"]}]},{"name":"Undergraduate Innovation and Entrepreneurship Training Program of Fujian Province","award":["202410389184"],"award-info":[{"award-number":["202410389184"]}]},{"name":"College of Bee Science, Fujian Agriculture and Forestry University"},{"id":[{"id":"https:\/\/ror.org\/04kx2sy84","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Bee pollen is a mixture of pollen, nectar, and bee saliva. It is rich in bioactive substances, including polysaccharides, flavonoids, carbohydrates, proteins, vitamins, and minerals, conferring high nutritional and pharmacological value. The flavonoids in bee pollen are considered the main components responsible for its active function. Based on a systematic elaboration of the physicochemical properties and classification of bee pollen flavonoids, this review summarizes the preclinical research progress of bee pollen flavonoids in inflammation-related diseases, with a focus on prostatitis, colitis, and neuroinflammation, and analyzes the key bottlenecks limiting their application. It should be noted that the current evidence is primarily derived from pharmacological studies at the cellular and animal levels, and the clinical efficacy in human diseases has not yet been confirmed; their potential effects are mainly established on the basis of biological plausibility and preclinical potential. This review aims to provide a reference for subsequent fundamental research and translational exploration of bee pollen flavonoids and to offer insights for the design of future clinical trials.<\/jats:p>","DOI":"10.3390\/molecules31132379","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:43:14Z","timestamp":1783345394000},"page":"2379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Flavonoids from Bee Pollen: Functional Components, Applications, and Limitations"],"prefix":"10.3390","volume":"31","author":[{"given":"Ying","family":"Zhu","sequence":"first","affiliation":[{"name":"College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6385-6023","authenticated-orcid":false,"given":"Shuting","family":"Pu","sequence":"additional","affiliation":[{"name":"College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zun","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofang","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0351-3763","authenticated-orcid":false,"given":"Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1444-3980","authenticated-orcid":false,"given":"Peiying","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Li","sequence":"additional","affiliation":[{"name":"College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songkun","family":"Su","sequence":"additional","affiliation":[{"name":"College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/9781119312994.apr0625","article-title":"Exine and aperture patterns on the pollen surface: Their formation and roles in plant reproduction","volume":"1","author":"Wang","year":"2018","journal-title":"Annu. 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