{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:37:24Z","timestamp":1789792644627,"version":"4.0.1"},"reference-count":90,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre","doi-asserted-by":"publisher","award":["UMO-2018\/31\/B\/ST8\/02460"],"award-info":[{"award-number":["UMO-2018\/31\/B\/ST8\/02460"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"award":["UMO-2018\/31\/B\/ST8\/02460"],"award-info":[{"award-number":["UMO-2018\/31\/B\/ST8\/02460"]}],"id":[{"id":"https:\/\/ror.org\/03ha2q922","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>We present cystamine-modified polydopamine (PDA) coatings as tunable gatekeepers for mesoporous silica nanoparticles (MSNs) in drug delivery. Unlike conventional post-functionalization strategies, cystamine moieties were incorporated directly into the PDA network, enabling tunable shell composition and redox responsiveness by simply adjusting the dopamine-to-cystamine ratio. By varying the cystamine:dopamine ratio, pH- and redox-responsive release of doxorubicin (DOX) and sorafenib (SO) was achieved, with release kinetics following the Higuchi model. Cystamine-modified PDA nanoparticles with varying disulfide bridge content were synthesized and comprehensively characterized using SEM, TGA, FTIR, and zeta potential measurements. The cystamine content was found to influence thermal stability, coating performance, and protective properties. Importantly, increasing disulfide content did not necessarily improve release performance, suggesting that excessive crosslinking may partially restrict shell permeabilization and drug diffusion. These findings reveal important structure\u2013property relationships in catechol-based coatings and underline the significance of disulfide linkages in the design of bioinspired stimuli-responsive drug delivery systems.<\/jats:p>","DOI":"10.3390\/molecules31142413","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:50:56Z","timestamp":1783587056000},"page":"2413","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual-Stimuli Responsive Cystamine-Modified Polydopamine Coatings as Payload Gatekeepers"],"prefix":"10.3390","volume":"31","author":[{"given":"Sylwia","family":"Ostrowska","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Pozna\u0144skiego St. 8, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Szukowska","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Pozna\u0144skiego St. 8, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeonho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Gachon University, Seongnam 13120, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3687-911X","authenticated-orcid":false,"given":"Rados\u0142aw","family":"Mr\u00f3wczy\u0144ski","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Pozna\u0144skiego St. 8, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2023, November 15). Cancer. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cancer."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.2174\/092986709788803312","article-title":"Doxorubicin: The good, the bad and the ugly effect","volume":"16","author":"Carvalho","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jpge.2016.04.006","article-title":"Hepatocellular carcinoma treatment with sorafenib: Real-life evaluation of prognostic factors and a practical clue for patient management","volume":"23","author":"Cardoso","year":"2016","journal-title":"GE\u2014Port. J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/FPC.0b013e32833ffb56","article-title":"Doxorubicin pathways: Pharmacodynamics and adverse effects","volume":"21","author":"Thorn","year":"2011","journal-title":"Pharmacogenet. Genom."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/bcpt.12365","article-title":"The adverse effects of sorafenib in patients with advanced cancers","volume":"116","author":"Li","year":"2015","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ijc.33588","article-title":"Cancer statistics for the year 2020: An overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/adhm.201400751","article-title":"Blended Nanoparticle System Based on Miscible Structurally Similar Polymers: A Safe, Simple, Targeted, and Surprisingly High Efficiency Vehicle for Cancer Therapy","volume":"4","author":"Tao","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.addr.2014.05.005","article-title":"Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment","volume":"79","author":"Kanapathipillai","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev-bioeng-071812-152409","article-title":"Multifunctional Nanoparticles for Drug Delivery and Molecular Imaging","volume":"15","author":"Bao","year":"2013","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Gurunathan, S., Kang, M.-H., Qasim, M., and Kim, J.-H. (2018). Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103264"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1155\/2019\/3702518","article-title":"Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine","volume":"2019","author":"Lombardo","year":"2019","journal-title":"J. Nanomater."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.matchemphys.2016.09.058","article-title":"Magnetite nanoparticles synthesized by co-precipitation method: The effects of various iron anions on specifications","volume":"184","author":"Yazdani","year":"2016","journal-title":"Mater. Chem. Phys."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Simon, J., Flahaut, E., and Golzio, M. (2019). Overview of carbon nanotubes for biomedical applications. Materials, 12.","DOI":"10.3390\/ma12040624"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40169-017-0175-0","article-title":"Cancer nanomedicine: A review of recent success in drug delivery","volume":"6","author":"Tran","year":"2017","journal-title":"Clin. Transl. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1039\/b806051g","article-title":"Gold nanoparticles in nanomedicine: Preparations, imaging, diagnostics, therapies and toxicity","volume":"38","author":"Boisselier","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1600032","DOI":"10.1002\/smtd.201600032","article-title":"Golden Opportunities: Plasmonic Gold Nanostructures for Biomedical Applications based on the Second Near-Infrared Window","volume":"1","author":"Park","year":"2017","journal-title":"Small Methods"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kim, J.H., Moon, M.J., Kim, D.Y., Heo, S.H., and Jeong, Y.Y. (2018). Hyaluronic acid-based nanostructures for cancer therapy: Recent advances and challenges. Polymers, 10.","DOI":"10.3390\/polym10101133"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.20892\/j.issn.2095-3941.2020.0496","article-title":"Stimuli-Responsive Nanocarriers for Therapeutic Applications in Cancer","volume":"18","author":"Zhao","year":"2021","journal-title":"Cancer Biol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7152","DOI":"10.1016\/j.ijhydene.2011.03.015","article-title":"Sulfonated poly(ether sulfone)-based silica nanocomposite membranes for high-temperature polymer electrolyte fuel cell applications","volume":"36","author":"Krishnan","year":"2011","journal-title":"Int. J. Hydrogen Energy"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Vallet-Reg\u00ed, M., Colilla, M., Izquierdo-Barba, I., and Manzano, M. (2017). Mesoporous silica nanoparticles for drug delivery: Current insights. Molecules, 23.","DOI":"10.3390\/molecules23010047"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1021\/acs.chemmater.6b00877","article-title":"Size-Controlled Functionalized Mesoporous Silica Nanoparticles for Tunable Drug Release and Enhanced Anti-Tumoral Activity","volume":"28","author":"Bouchoucha","year":"2016","journal-title":"Chem. Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jconrel.2021.10.005","article-title":"Current trends in smart mesoporous silica-based nanovehicles for photoactivated cancer therapy","volume":"339","author":"Wang","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Watermann, A., and Brieger, J. (2017). Mesoporous silica nanoparticles as drug delivery vehicles in cancer. Nanomaterials, 7.","DOI":"10.3390\/nano7070189"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.nano.2014.09.014","article-title":"Mesoporous silica nanoparticles in drug delivery and biomedical applications","volume":"11","author":"Wang","year":"2015","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.1039\/C7CS00219J","article-title":"Diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems","volume":"46","author":"Wen","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1021\/acsabm.8b00050","article-title":"\u201cThree-in-One\u201d multifunctional gatekeeper gated mesoporous silica nanoparticles for intracellular pH-activated targeted cancer therapy","volume":"1","author":"Zhang","year":"2018","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1475-2867-13-89","article-title":"Acidic extracellular microenvironment and cancer","volume":"13","author":"Kato","year":"2013","journal-title":"Cancer Cell Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3109\/1354750X.2012.715672","article-title":"Glutathione levels in human tumors","volume":"17","author":"Gamcsik","year":"2012","journal-title":"Biomarkers"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"121110","DOI":"10.1016\/j.biomaterials.2021.121110","article-title":"Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy","volume":"277","author":"Niu","year":"2021","journal-title":"Biomaterials"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1126\/science.1147241","article-title":"Mussel-inspired surface chemistry for multifunctional coatings","volume":"318","author":"Lee","year":"2007","journal-title":"Science"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2000228","DOI":"10.1002\/mabi.202000228","article-title":"Polydopamine-incorporated nanoformulations for biomedical applications","volume":"20","author":"Zheng","year":"2020","journal-title":"Macromol. Biosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7541","DOI":"10.1021\/acsami.7b08392","article-title":"Polydopamine-based multifunctional (nano)materials for cancer therapy","volume":"10","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"119423","DOI":"10.1016\/j.apcatb.2020.119423","article-title":"Efficient photocatalytic production of hydrogen by exploiting the polydopamine-semiconductor interface","volume":"280","author":"Kim","year":"2021","journal-title":"Appl. Catal. B Environ."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8647","DOI":"10.1002\/chem.201402532","article-title":"Polydopamine\u2014an organocatalyst rather than an innocent polymer","volume":"20","author":"Bunge","year":"2014","journal-title":"Chem. A Eur. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1021\/acscentsci.7b00605","article-title":"Rapid, selective heavy metal removal from water by a metal\u2013organic framework\/polydopamine composite","volume":"4","author":"Sun","year":"2018","journal-title":"ACS Cent. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"24420","DOI":"10.1038\/srep24420","article-title":"Strong Antibacterial Polydopamine Coatings Prepared by a Shaking-assisted Method","volume":"6","author":"Su","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.apsusc.2018.05.155","article-title":"Polydopamine grafted on an advanced Fe3O4\/lignin hybrid material and its evaluation in biosensing","volume":"455","author":"Nowicki","year":"2018","journal-title":"Appl. Surf. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ijbiomac.2019.02.008","article-title":"Bio-inspired magnetite\/lignin\/polydopamine-glucose oxidase biosensing nanoplatform. From synthesis, via sensing assays to comparison with others glucose testing techniques","volume":"127","author":"Kuznowicz","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1039\/C7BM00187H","article-title":"Recent progress in the biomedical applications of polydopamine nanostructures","volume":"5","author":"Batul","year":"2017","journal-title":"Biomater. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Gisbert-Garzar\u00e1n, M., and Vallet-Reg\u00ed, M. (2021). Redox-responsive mesoporous silica nanoparticles for cancer treatment: Recent updates. Nanomaterials, 11.","DOI":"10.3390\/nano11092222"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1021\/acs.accounts.8b00583","article-title":"Material-independent surface chemistry beyond polydopamine coating","volume":"52","author":"Lee","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.7150\/thno.16047","article-title":"Polydopamine Coated Single-Walled Carbon Nanotubes as a Versatile Platform with Radionuclide Labeling for Multimodal Tumor Imaging and Therapy","volume":"6","author":"Zhao","year":"2016","journal-title":"Theranostics"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jconrel.2019.07.036","article-title":"Functionalized theranostic nanocarriers with bio-inspired polydopamine for tumor imaging and chemo-photothermal therapy","volume":"309","author":"Farokhi","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"12999","DOI":"10.1073\/pnas.0605552103","article-title":"Single-molecule mechanics of mussel adhesion","volume":"103","author":"Lee","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1002\/adfm.201000932","article-title":"The Contribution of DOPA to substrate\u2013peptide adhesion and internal cohesion of mussel-inspired synthetic peptide films","volume":"20","author":"Anderson","year":"2010","journal-title":"Adv. Funct. Mater."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1016\/j.biomaterials.2009.12.020","article-title":"General functionalization route for cell adhesion on non-wetting surfaces","volume":"31","author":"Ku","year":"2010","journal-title":"Biomaterials"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2217\/nnm.11.76","article-title":"Attenuation of The In Vivo Toxicity of Biomaterials by Polydopamine Surface Modification","volume":"6","author":"Hong","year":"2011","journal-title":"Nanomedicine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"9384","DOI":"10.1021\/nn404117j","article-title":"Mussel-inspired polydopamine: A biocompatible and ultrastable coating for nanoparticles in vivo","volume":"7","author":"Liu","year":"2013","journal-title":"ACS Nano"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.tiv.2017.07.022","article-title":"In vitro genotoxicity and cytotoxicity of polydopamine-coated magnetic nanostructures","volume":"44","author":"Walawender","year":"2017","journal-title":"Toxicol. In Vitro"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1002\/pi.5193","article-title":"Chemistry of polydopamine analogues","volume":"65","author":"Markiewicz","year":"2016","journal-title":"Polym. Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/adma.200801222","article-title":"Facile conjugation of biomolecules onto surfaces via mussel adhesive protein inspired coatings","volume":"21","author":"Lee","year":"2009","journal-title":"Adv. Mater."},{"key":"ref_52","first-page":"522","article-title":"Nanoparticles modified by polydopamine: Working as \u201cdrug\u201d carriers","volume":"5","author":"Jin","year":"2020","journal-title":"Bioact. Mater."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1080\/10717544.2017.1309475","article-title":"Polydopamine and peptide decorated doxorubicin-loaded mesoporous silica nanoparticles as a targeted drug delivery system for bladder cancer therapy","volume":"24","author":"Wei","year":"2017","journal-title":"Drug Deliv."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"110103","DOI":"10.1016\/j.msec.2019.110103","article-title":"Polydopamine-coated mesoporous silica nanoparticles for multi-responsive drug delivery and combined chemo-photothermal therapy","volume":"105","author":"Lei","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"110427","DOI":"10.1016\/j.colsurfb.2019.110427","article-title":"Polydopamine coated hollow mesoporous silica nanoparticles as pH-sensitive nanocarriers for overcoming multidrug resistance","volume":"183","author":"Shao","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"9974","DOI":"10.1021\/acs.langmuir.8b01091","article-title":"pH and ultrasound dual-responsive polydopamine-coated mesoporous silica nanoparticles for controlled drug delivery","volume":"34","author":"Li","year":"2018","journal-title":"Langmuir"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Pada, A.-K., Desai, D., Sun, K., Prakirth Govardhanam, N., T\u00f6rnquist, K., Zhang, J., and Rosenholm, J.M. (2019). Comparison of Polydopamine-Coated Mesoporous Silica Nanorods and Spheres for the Delivery of Hydrophilic and Hydrophobic Anticancer Drugs. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143408"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijpharm.2013.12.045","article-title":"Mussel-inspired polydopamine coated mesoporous silica nanoparticles as pH-sensitive nanocarriers for controlled release","volume":"463","author":"Zheng","year":"2014","journal-title":"Int. J. Pharm."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1039\/C9BM00276F","article-title":"Folic acid-modified Prussian blue\/polydopamine nanoparticles as an MRI agent for use in targeted chemo\/photothermal therapy","volume":"7","author":"Lin","year":"2019","journal-title":"Biomater. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"123602","DOI":"10.1016\/j.ijbiomac.2023.123602","article-title":"Folic-acid adorned alginate-polydopamine modified paclitaxel\/Zn-CuO nanocomplex for pH triggered drug release and synergistic antitumor efficacy","volume":"234","author":"Singh","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"127609","DOI":"10.1016\/j.colsurfa.2021.127609","article-title":"Folic acid decorated pH sensitive polydopamine coated honeycomb structured nickel oxide nanoparticles for targeted delivery of quercetin to triple negative breast cancer cells","volume":"630","author":"Binu","year":"2021","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Menichetti, A., Mordini, D., and Montalti, M. (2024). Polydopamine Nanosystems in Drug Delivery: Effect of Size, Morphology, and Surface Charge. Nanomaterials, 14.","DOI":"10.3390\/nano14030303"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Ren, S., Xiao, X., Lv, J., Lv, S., Wang, X., Liu, R., and Kong, Q. (2024). Advances in the study of polydopamine nanotechnology in central nervous system disorders. Front. Mater., 11.","DOI":"10.3389\/fmats.2024.1396397"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"132879","DOI":"10.1016\/j.colsurfa.2023.132879","article-title":"CD-44 Active cystamine-bridged hyaluronic acid\u2013polydopamine nanoparticles for chemo-photothermal cancer therapy","volume":"682","author":"Hemalatha","year":"2024","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1021\/acssuschemeng.8b03675","article-title":"Novel pH-Responsive Smart Fabric: From Switchable Wettability to Controllable On-Demand Oil\/Water Separation","volume":"7","author":"Zeng","year":"2019","journal-title":"ACS Sustain. Chem. Eng."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1021\/acs.analchem.0c05004","article-title":"Glutathione Content Detection of Single Cells under Ingested Doxorubicin by Functionalized Glass Nanopores","volume":"93","author":"Hu","year":"2021","journal-title":"Anal. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jcis.2013.01.001","article-title":"Hybrid nanoparticles for drug delivery and bioimaging: Mesoporous silica nanoparticles functionalized with carboxyl groups and a near-infrared fluorescent dye","volume":"395","author":"Xie","year":"2013","journal-title":"J. Colloid Interface Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/anie.201005061","article-title":"Mesoporous silica nanoparticles end-capped with collagen: Redox-responsive nanoreservoirs for targeted drug delivery","volume":"50","author":"Luo","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Ostrowska, S., Szukowska, M., Kim, S., Kim, Y., Wawrzyniak, D., and Mr\u00f3wczy\u0144ski, R. (2025). Doxorubicin and sorafenib release from mesoporous silica nanoparticles coated with polydopamine\u2014influence of mechanical and chemical stimuli on the process. Front. Coat. Dye Interface Eng., 3.","DOI":"10.3389\/frcdi.2025.1531144"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1208\/s12248-010-9185-1","article-title":"DDSolver: An add-in program for modeling and comparison of drug dissolution profiles","volume":"12","author":"Zhang","year":"2010","journal-title":"AAPS J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"10556","DOI":"10.1002\/anie.201204663","article-title":"Targeted cargo delivery in senescent cells using galactose-capped mesoporous silica nanoparticles","volume":"51","author":"Agostini","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"8592","DOI":"10.1039\/D0TC01499K","article-title":"A novel L-cysteine regulated polydopamine nanoparticle-based electrochemiluminescence image application","volume":"8","author":"Zhang","year":"2020","journal-title":"J. Mater. Chem. C"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.bios.2016.04.020","article-title":"A novel sandwiched electrochemiluminescence immunosensor for the detection of carcinoembryonic antigen based on carbon quantum dots and signal amplification","volume":"89","author":"Li","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jcis.2020.10.137","article-title":"Overcoming the paracetamol dose challenge with wrinkled mesoporous carbon spheres","volume":"586","author":"Olejnik","year":"2021","journal-title":"J. Colloid Interface Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJMoa0708857","article-title":"Sorafenib in advanced hepatocellular carcinoma","volume":"359","author":"Llovet","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"972913","DOI":"10.1155\/2013\/972913","article-title":"Role of glutathione in cancer progression and chemoresistance","volume":"2013","author":"Traverso","year":"2013","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"5746","DOI":"10.1039\/C5TB00304K","article-title":"Mesoporous silica nanoparticles grafted with a light-responsive protein shell for highly cytotoxic antitumoral therapy","volume":"3","author":"Baeza","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"ref_78","first-page":"323","article-title":"Autofagia\u2014mechanizm prze\u017cycia czy \u015bmierci kom\u00f3rki?","volume":"37","author":"Karwicka","year":"2010","journal-title":"Post\u0119py Biol. Kom\u00f3rki"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.biomaterials.2015.11.037","article-title":"Multi-responsive photothermal-chemotherapy with drug-loaded melanin-like nanoparticles for synergetic tumor ablation","volume":"81","author":"Wang","year":"2016","journal-title":"Biomaterials"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"6907","DOI":"10.1038\/ncomms7907","article-title":"Amplification of oxidative stress by a dual stimuli-responsive hybrid drug enhances cancer cell death","volume":"6","author":"Noh","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"10748","DOI":"10.3390\/molecules200610748","article-title":"Oxidation of disulfides to thiolsulfinates with hydrogen peroxide and a cyclic seleninate ester catalyst","volume":"20","author":"McNeil","year":"2015","journal-title":"Molecules"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"12409","DOI":"10.1039\/C7NR05293F","article-title":"A one step method for the functional and property modification of DOPA based nanocoatings","volume":"9","author":"Lyu","year":"2017","journal-title":"Nanoscale"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1021\/acsomega.8b02537","article-title":"Enzyme-\/redox-responsive mesoporous silica nanoparticles based on functionalized dopamine as nanocarriers for cancer therapy","volume":"4","author":"Zhu","year":"2019","journal-title":"ACS Omega"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"129676","DOI":"10.1016\/j.matlet.2021.129676","article-title":"Polydopamine\/keratin complexes as gatekeepers of mesoporous silica nanoparticles for pH and GSH dual responsive drug delivery","volume":"293","author":"Du","year":"2021","journal-title":"Mater. Lett."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"28656","DOI":"10.1021\/acsami.5b10534","article-title":"pH and Glutathione Dual-Responsive Dynamic Cross-Linked Supramolecular Network on Mesoporous Silica Nanoparticles for Controlled Anticancer Drug Release","volume":"7","author":"Li","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.1039\/C9TB01400D","article-title":"Glutathione triggered degradation of polydopamine to facilitate controlled drug release for synergic combinational cancer treatment","volume":"7","author":"Hao","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"ref_87","first-page":"12","article-title":"Release kinetics\u2014concepts and applications","volume":"8","author":"Setty","year":"2019","journal-title":"Int. J. Pharm. Res. Technol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.colsurfb.2013.06.054","article-title":"Amphiphilic polycarbonate conjugates of doxorubicin with pH-sensitive hydrazone linker for controlled release","volume":"11","author":"Jiang","year":"2013","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"11012","DOI":"10.1039\/C9NR01385G","article-title":"Hyaluronic acid conjugated polydopamine functionalized mesoporous silica nanoparticles for synergistic targeted chemo-photothermal therapy","volume":"11","author":"Chen","year":"2019","journal-title":"Nanoscale"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/nm1314","article-title":"Dopamine covalently modifies and functionally inactivates parkin","volume":"11","author":"LaVoie","year":"2005","journal-title":"Nat. Med."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/14\/2413\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:51:56Z","timestamp":1783587116000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/14\/2413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":90,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["molecules31142413"],"URL":"https:\/\/doi.org\/10.3390\/molecules31142413","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]}}}