{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:46:49Z","timestamp":1785415609838,"version":"3.56.0"},"reference-count":73,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["CVU 1151430"],"award-info":[{"award-number":["CVU 1151430"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003141","name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["320786"],"award-info":[{"award-number":["320786"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]},{"award":["CVU 1151430"],"award-info":[{"award-number":["CVU 1151430"]}],"id":[{"id":"https:\/\/ror.org\/059ex5q34","id-type":"ROR","asserted-by":"publisher"}]},{"award":["320786"],"award-info":[{"award-number":["320786"]}],"id":[{"id":"https:\/\/ror.org\/059ex5q34","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Krugiodendron ferreum (Vahl) Urb. (KF), commonly known as Ch\u2019iin took\u2019, is a species native to the Yucatan Mexico, whose phytochemical composition remains poorly characterized. Thus, the aim of this study was to evaluate the metabolomic profile, antioxidant capacity, and preliminary cellular activity of KF. An aqueous extract was obtained from KF bark (20 mg\/mL). Antioxidant capacity was evaluated using ORAC and DPPH assays. Total phenolic content was evaluated by the Folin\u2013Ciocalteu method. The phenolic profile was determined by UPLC-PDA-MS, and preliminary cellular activity was evaluated by estimating cell number based on the quantification of DAPI-stained nuclei after 72 h of treatment with extract concentrations ranging from 3 to 3000 \u03bcg\/mL. The extract showed an antioxidant capacity of 1765 \u00b1 59.1 Trolox equivalents\/mL and 85.9 \u00b1 0.34% of DPPH radical scavenging activity. The total polyphenol content was 1163 \u00b1 61.5 mg GAE\/L, and its phenolic profile was mainly characterized by catechin 3-O-rhamnoside, taxifolin 3-O-rhamnoside, and myricetin-3-O-rhamnoside. Cell activity analysis revealed that both the 3 and 300 \u03bcg\/mL concentrations increased the number of cells and the area covered by them compared with the control group at 48 and 72 h. The 3000 \u03bcg\/mL concentration showed no difference compared with the water control. Our results suggest that KF contains polyphenolic compounds and antioxidant properties without affecting cellular response.<\/jats:p>","DOI":"10.3390\/molecules31142478","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:05:07Z","timestamp":1784163907000},"page":"2478","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolomic Profile, Antioxidant Capacity, and Preliminary Cellular Activity of Krugiodendron ferreum (Vahl) Urb., a Traditional Plant from Yucatan"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2749-6518","authenticated-orcid":false,"given":"Brenda","family":"Pacheco-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Centro De Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco, A.C. Subsede Sureste, Parque Cient\u00edfico Tecnol\u00f3gico de Yucat\u00e1n, Sierra Papacal-Chuburn\u00e1 Puerto, M\u00e9rida 97302, Yucatan, Mexico"},{"name":"Unidad de Investigaci\u00f3n, Hospital Regional de Alta Especialidad de la Pen\u00ednsula de Yucat\u00e1n, Servicios de Salud del Instituto Mexicano del Seguro Social para el Bienestar (IMSS-BIENESTAR), M\u00e9rida 97130, Yucatan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2469-3238","authenticated-orcid":false,"given":"Teresa","family":"Ayora-Talavera","sequence":"additional","affiliation":[{"name":"Centro De Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco, A.C. Subsede Sureste, Parque Cient\u00edfico Tecnol\u00f3gico de Yucat\u00e1n, Sierra Papacal-Chuburn\u00e1 Puerto, M\u00e9rida 97302, Yucatan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-2865","authenticated-orcid":false,"given":"Julia","family":"Cano-Sosa","sequence":"additional","affiliation":[{"name":"Centro De Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco, A.C. Subsede Sureste, Parque Cient\u00edfico Tecnol\u00f3gico de Yucat\u00e1n, Sierra Papacal-Chuburn\u00e1 Puerto, M\u00e9rida 97302, Yucatan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4637-2657","authenticated-orcid":false,"given":"Neith","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Centro De Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco, A.C. Subsede Sureste, Parque Cient\u00edfico Tecnol\u00f3gico de Yucat\u00e1n, Sierra Papacal-Chuburn\u00e1 Puerto, M\u00e9rida 97302, Yucatan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6402-0850","authenticated-orcid":false,"given":"Emanuel","family":"Herrera-Pool","sequence":"additional","affiliation":[{"name":"Centro De Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco, A.C. Subsede Sureste, Parque Cient\u00edfico Tecnol\u00f3gico de Yucat\u00e1n, Sierra Papacal-Chuburn\u00e1 Puerto, M\u00e9rida 97302, Yucatan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3535-930X","authenticated-orcid":false,"given":"\u00c1ngel Virgilio","family":"Dom\u00ednguez-May","sequence":"additional","affiliation":[{"name":"TecNM, Instituto Tecnol\u00f3gico Superior del Sur del Estado de Yucat\u00e1n (ITSSY), Oxkutzcab 97880, Yucatan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia G.","family":"Noriega","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Nutrici\u00f3n y Ciencias M\u00e9dicas Salvador Zubir\u00e1n, Ciudad de M\u00e9xico 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8996-3481","authenticated-orcid":false,"given":"Martha","family":"Guevara-Cruz","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Nutrici\u00f3n y Ciencias M\u00e9dicas Salvador Zubir\u00e1n, Ciudad de M\u00e9xico 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4027-2329","authenticated-orcid":false,"given":"Isabel","family":"Medina-Vera","sequence":"additional","affiliation":[{"name":"Departamento Metodolog\u00eda de Investigaci\u00f3n, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico 04530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3363-1477","authenticated-orcid":false,"given":"Azalia","family":"Avila-Nava","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Regional de Alta Especialidad de la Pen\u00ednsula de Yucat\u00e1n, Servicios de Salud del Instituto Mexicano del Seguro Social para el Bienestar (IMSS-BIENESTAR), M\u00e9rida 97130, Yucatan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sen, T., and Samanta, S.K. (2014). Medicinal Plants, Human Health and Biodiversity: A Broad Review. Biotechnological Applications of Biodiversity, Springer.","DOI":"10.1007\/10_2014_273"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1002\/fsn3.3308","article-title":"Phytobioactive Compounds as Therapeutic Agents for Human Diseases: A Review","volume":"11","author":"Riaz","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Angeles Flores, G., Cusumano, G., Venanzoni, R., and Angelini, P. (2025). Biodiversity-Driven Natural Products and Bioactive Metabolites. Plants, 15.","DOI":"10.3390\/plants15010104"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e155","DOI":"10.1016\/S2542-5196(22)00317-5","article-title":"Evaluating Natural Medicinal Resources and Their Exposure to Global Change","volume":"7","author":"Theodoridis","year":"2023","journal-title":"Lancet Planet. Health"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez, F.M.H. (2023). Traditional Use of Biodiversity for Nutrition and Health in the Americas: A Case Study from Mexico. Ethnic Knowledge and Perspectives of Medicinal Plants, Apple Academic Press.","DOI":"10.1201\/9781003352983-2"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Garc\u00eda, C.M., Ruiz-Ruiz, J.C., Peraza-Echeverr\u00eda, L., Peraza-S\u00e1nchez, S.R., Torres-Tapia, L.W., P\u00e9rez-Brito, D., Tapia-Tussell, R., Herrera-Chal\u00e9, F.G., Segura-Campos, M.R., and Quijano-Ramayo, A. (2019). Antioxidant, Antihypertensive, Anti-Hyperglycemic, and Antimicrobial Activity of Aqueous Extracts from Twelve Native Plants of the Yucatan Coast. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0213493"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.22403\/UQROOMX\/TYP21\/04","article-title":"M\u00e9dicos Tradicionales Mayas y El Uso de Plantas Medicinales, Un Conocimiento Cultural Que Contin\u00faa Vigente En El Municipio de Tzucacab, Yucat\u00e1n, M\u00e9xico","volume":"13","author":"Cordero","year":"2017","journal-title":"Teor\u00eda Y Prax."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Arguello, K.M., Valle, N.T., G\u00f3mez, L.H., and Islebe, G. (2024). Current Use Value of Medicine Plants in Three 1 Maya Communities of the Yucatan. Res. Sq., 1\u201316.","DOI":"10.21203\/rs.3.rs-5119210\/v1"},{"key":"ref_9","first-page":"94","article-title":"Rese\u00f1a Del Libro: Plantas Medicinales Del Estado de Yucat\u00e1n","volume":"43","year":"1982","journal-title":"Bol. Soc. Bot\u00e1n. M\u00e9xico Bot. Sci."},{"key":"ref_10","unstructured":"Garc\u00eda, H., Sierra, A., and Pereira, G.B. (1996). Medicina Maya Tradicional: Confrontaci\u00f3n Con El Sistema Conceptual Chino, Educaci\u00f3n, Cultura y Ecolog\u00eda."},{"key":"ref_11","unstructured":"Villalobos Perera, P.A. (2021). Plantas Utilizadas Para El Tratamiento de Litiasis Renal En La Regi\u00f3n Centro de Yucat\u00e1n. [Master\u2019s Thesis, Cinvestav]."},{"key":"ref_12","first-page":"65","article-title":"Technical Properties of Sixteen Types of Woods from the State of Tamaulipas, Which Influence on the Manufacture of Particleboards and Fiberboards","volume":"14","year":"2008","journal-title":"Rev. Chapingo Ser. Cienc. For. Ambiente"},{"key":"ref_13","first-page":"7","article-title":"Plantas Usadas Para Tratar La Litiasis Renal o C\u00e1lculo Renal En La Regi\u00f3n Centro Del Estado DeYucat\u00e1n, M\u00e9xico","volume":"15","year":"2023","journal-title":"Desde Herb. CICY"},{"key":"ref_14","unstructured":"Gonz\u00e1lez-S\u00e1nchez, M.A., and Moo-Puc, R.E. (2018). Actividad Antimicrobiana in Vitro de Un Extracto Etan\u00f3lico de Corteza de Krugiodendron Ferreum (Chintok) En Aislados Orales. Patrimonio y Sustentabilidad, TECCIS A.C."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"114369","DOI":"10.1016\/j.jep.2021.114369","article-title":"Antibacterial and Antibiofilm Activities of Mayan Medicinal Plants against Methicillin-Susceptible and -Resistant Strains of Staphylococcus Aureus","volume":"279","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"121265","DOI":"10.1016\/j.jep.2026.121265","article-title":"In-Vitro and in-Silico Anti-Staphylococcal Effects of the Mayan Medicinal Plant Krugiodendron Ferreum (Vahl) Urb. (X-Chintok): Disarming Its Resistance Mechanisms and Virulence Factors","volume":"362","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1021\/acs.jnatprod.6b00525","article-title":"Cytotoxic Ceanothane- and Lupane-Type Triterpenoids from the Roots of Ziziphus jujuba","volume":"79","author":"Kang","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11101-015-9404-6","article-title":"Chemical Constituents and Biological Activities of South American Rhamnaceae","volume":"14","author":"Cespedes","year":"2015","journal-title":"Phytochem. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.foodchem.2009.03.103","article-title":"Effects of Extraction Temperature on the Phenolic and Parthenolide Contents, and Colour of Aqueous Feverfew (Tanacetum parthenium) Extracts","volume":"117","author":"Marete","year":"2009","journal-title":"Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ngan Nguyen Huynh, K., Van Thi Nguyen, N., and Tuyet Ngan, D. (2024). Natural Phenolic Compounds: A Review of Extraction and Analysis. Exploring Natural Phenolic Compounds-Recent Progress and Practical Applications, IntechOpen.","DOI":"10.5772\/intechopen.1007974"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Tanase, C., Co\u0219arc\u0103, S., and Muntean, D.-L. (2019). A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity. Molecules, 24.","DOI":"10.3390\/molecules24061182"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1002\/efd2.21","article-title":"Recent Advances on the Stability of Dietary Polyphenols","volume":"3","author":"Xiao","year":"2022","journal-title":"eFood"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wang, C.-C., Chen, H.-F., Wu, J.-Y., and Chen, L.-G. (2019). Stability of Principal Hydrolysable Tannins from Trapa taiwanensis Hulls. Molecules, 24.","DOI":"10.3390\/molecules24020365"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"139776","DOI":"10.1016\/j.foodchem.2024.139776","article-title":"Study on the Extraction, Purification, Stability, Free Radical Scavenging Kinetics, Polymerization Degree and Characterization of Proanthocyanidins from Pinus koraiensis Seed Scales","volume":"454","author":"Li","year":"2024","journal-title":"Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Male\u0161, I., Dragovi\u0107-Uzelac, V., Jerkovi\u0107, I., Zori\u0107, Z., Pedisi\u0107, S., Repaji\u0107, M., Garofuli\u0107, I.E., and Dobrin\u010di\u0107, A. (2022). Non-Volatile and Volatile Bioactives of Salvia officinalis L., Thymus serpyllum L. and Laurus nobilis L. Extracts with Potential Use in the Development of Functional Beverages. Antioxidants, 11.","DOI":"10.3390\/antiox11061140"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Guti\u00e9rrez-Grijalva, E.P., Zamudio-Sosa, V.E., Contreras-Angulo, L.A., Leyva-L\u00f3pez, N., and Heredia, J.B. (2022). Bioaccessibility of Phenolic Compounds from Mistletoe Infusions and Effect of In Vitro Digestion on Its Antioxidant and Pancreatic Lipase Inhibitory Activity. Foods, 11.","DOI":"10.3390\/foods11213319"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00226-024-01549-y","article-title":"Antioxidant, Antiproliferative, Anti-Inflammatory, and Enzyme Inhibition Potentials of Ficus Carica Wood Bark and Related Bioactive Phenolic Metabolites","volume":"58","author":"Yahiaoui","year":"2024","journal-title":"Wood Sci. Technol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ali, A., Khalil, A.A.K., Khuda, F., Nazir, N., Ullah, R., Bari, A., Haider, A., Jamal, S.B., Ahmad, S., and Khan, Z. (2021). Phytochemical and Biological Screening of Leaf, Bark and Fruit Extracts from Ilex dipyrena Wall. Life, 11.","DOI":"10.3390\/life11080837"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Karim, M.R., Miletti-Gonzalez, K.E., Aryee, A.N.A., and Besong, S.A. (2025). Phytochemical Analysis and Antioxidant Activities of Prunus africana Bark, Leea indica and Paullinia pinnata Leaf Extracts. Antioxidants, 14.","DOI":"10.3390\/antiox14060666"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.tjnut.2024.11.007","article-title":"Health Benefits and Future Research of Phytochemicals: A Literature Review","volume":"155","author":"Yang","year":"2025","journal-title":"J. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s44371-026-00781-8","article-title":"Phytochemicals from Natural Sources Classification Physiological Roles and Health Benefits","volume":"3","author":"Kafi","year":"2026","journal-title":"Discov. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"H\u00e4sler Gunnarsdottir, S., Sommerauer, L., Schnabel, T., Oostingh, G.J., and Schuster, A. (2023). Antioxidative and Antimicrobial Evaluation of Bark Extracts from Common European Trees in Light of Dermal Applications. Antibiotics, 12.","DOI":"10.3390\/antibiotics12010130"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Navarro-Hoyos, M., Alvarado-Corella, D., Moreira-Gonzalez, I., Arnaez-Serrano, E., and Monagas-Juan, M. (2018). Polyphenolic Composition and Antioxidant Activity of Aqueous and Ethanolic Extracts from Uncaria tomentosa Bark and Leaves. Antioxidants, 7.","DOI":"10.3390\/antiox7050065"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Sun, S., Yu, Y., Jo, Y., Han, J.H., Xue, Y., Cho, M., Bae, S.-J., Ryu, D., Park, W., and Ha, K.-T. (2025). Impact of Extraction Techniques on Phytochemical Composition and Bioactivity of Natural Product Mixtures. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1615338"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s13595-019-0916-x","article-title":"Quantitative and Qualitative Composition of Bark Polyphenols Changes Longitudinally with Bark Maturity in Abies alba Mill","volume":"77","author":"Brennan","year":"2020","journal-title":"Ann. For. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.foodres.2011.03.009","article-title":"Stability of Phytochemicals as Sources of Anti-Inflammatory Nutraceuticals in Beverages\u2014A Review","volume":"50","author":"Harbourne","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Gasmi, A., Mujawdiya, P.K., Noor, S., Lysiuk, R., Darmohray, R., Piscopo, S., Lenchyk, L., Antonyak, H., Dehtiarova, K., and Shanaida, M. (2022). Polyphenols in Metabolic Diseases. Molecules, 27.","DOI":"10.3390\/molecules27196280"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5812401","DOI":"10.1155\/2017\/5812401","article-title":"Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials","volume":"2017","author":"Badimon","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of Oxidative Stress in the Pathogenesis of Nonalcoholic Fatty Liver Disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5607\/en.2015.24.4.325","article-title":"The Role of Oxidative Stress in Neurodegenerative Diseases","volume":"24","author":"Kim","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/hr.2010.264","article-title":"The Role of Oxidative Stress in the Pathophysiology of Hypertension","volume":"34","author":"Rodrigo","year":"2011","journal-title":"Hypertens. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8267234","DOI":"10.1155\/2019\/8267234","article-title":"Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated Diseases","volume":"2019","author":"Vona","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41581-023-00775-0","article-title":"Oxidative Stress and the Role of Redox Signalling in Chronic Kidney Disease","volume":"20","author":"Kishi","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Pacheco-Hern\u00e1ndez, B., Ayora-Talavera, T., Cano-Sosa, J., Noriega, L.G., Pacheco-L\u00f3pez, N.A., Vargas-Morales, J.M., Medina-Vera, I., Guevara-Cruz, M., Chim-Ak\u00e9, R., and Guti\u00e9rrez-Solis, A.L. (2025). Antioxidant and Anti-Inflammatory Effects of Traditional Medicinal Plants for Urolithiasis: A Scoping Review. Plants, 14.","DOI":"10.3390\/plants14132032"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Sabiha, S., Hasan, K., Lima, K., Malmir, M., Serrano, R., Moreira da Silva, I., Rocha, J., Islam, N., and Silva, O. (2024). Quality Studies on Cynometra iripa Leaf and Bark as Herbal Medicines. Molecules, 29.","DOI":"10.3390\/molecules29112629"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/fsn3.2679","article-title":"LC-ESI-QTOF\/MS Characterization of Antimicrobial Compounds with Their Action Mode Extracted from Vine Tea (Ampelopsis grossedentata) Leaves","volume":"10","author":"Umair","year":"2022","journal-title":"Food Sci. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/pca.2452","article-title":"Characterisation of Diarylheptanoid- and Flavonoid-type Phenolics in Corylus avellana L. Leaves and Bark by HPLC\/DAD\u2013ESI\/MS","volume":"24","author":"Alberti","year":"2013","journal-title":"Phytochem. Anal."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.biochi.2015.02.003","article-title":"Isolation and Structural Characterization of 2R, 3R Taxifolin 3-O-Rhamnoside from Ethyl Acetate Extract of Hydnocarpus Alpina and Its Hypoglycemic Effect by Attenuating Hepatic Key Enzymes of Glucose Metabolism in Streptozotocin-Induced Diabetic Rats","volume":"111","author":"Balamurugan","year":"2015","journal-title":"Biochimie"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.tiv.2007.11.015","article-title":"In Vitro Antioxidant and Antigenotoxic Potentials of Myricetin-3-o-Galactoside and Myricetin-3-o-Rhamnoside from Myrtus Communis: Modulation of Expression of Genes Involved in Cell Defence System Using CDNA Microarray","volume":"22","author":"Hayder","year":"2008","journal-title":"Toxicol. Vitr."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Taheri, Y., Suleria, H.A.R., Martins, N., Sytar, O., Beyatli, A., Yeskaliyeva, B., Seitimova, G., Salehi, B., Semwal, P., and Painuli, S. (2020). Myricetin Bioactive Effects: Moving from Preclinical Evidence to Potential Clinical Applications. BMC Complement. Med. Ther., 20.","DOI":"10.1186\/s12906-020-03033-z"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s13765-016-0150-2","article-title":"Myricetin: Biological Activity Related to Human Health","volume":"59","author":"Park","year":"2016","journal-title":"Appl. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0031-9422(00)90537-5","article-title":"Catechin-3-O-Rhamnoside Chain Extender Units in Polymeric Procyanidins from Mangrove Bark","volume":"35","author":"Achmadi","year":"1993","journal-title":"Phytochemistry"},{"key":"ref_53","first-page":"629","article-title":"Antimicrobial and Antioxidant Activity of Catechin-3-o-Rhamnoside Isolated from the Stem Bark of Lannea kerstingii Engl. And K. Krause (Anacardiaceae)","volume":"34","author":"Stanislaus","year":"2021","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Chouaibi, M. (2025). Bioactive Phytochemicals from Celery (Apium graveolens L.) By-Products. Bioactive Phytochemicals in By-Products from Leaf, Stem, Root and Tuber Vegetables, Springer.","DOI":"10.1007\/978-3-031-80700-8_8"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.foodchem.2019.04.097","article-title":"Metabolites Profiling of Ziziphus Leaf Taxa via UHPLC\/PDA\/ESI-MS in Relation to Their Biological Activities","volume":"293","author":"Sakna","year":"2019","journal-title":"Food Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.biopha.2018.09.069","article-title":"Syringic Acid (SA)\u2014A Review of Its Occurrence, Biosynthesis, Pharmacological and Industrial Importance","volume":"108","author":"Srinivasulu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Martins, N.O., de Brito, I.M., Ara\u00fajo, S.S.O., Negri, G., de Ara\u00fajo Carlini, E., and Mendes, F.R. (2018). Antioxidant, Anticholinesterase and Antifatigue Effects of Trichilia catigua (Catuaba). BMC Complement. Altern. Med., 18.","DOI":"10.1186\/s12906-018-2222-9"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Dienait\u0117, L., Pukalskien\u0117, M., Pereira, C.V., Matias, A.A., and Venskutonis, P.R. (2020). Valorization of European Cranberry Bush (Viburnum opulus L.) Berry Pomace Extracts Isolated with Pressurized Ethanol and Water by Assessing Their Phytochemical Composition, Antioxidant, and Antiproliferative Activities. Foods, 9.","DOI":"10.3390\/foods9101413"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s11101-024-09949-5","article-title":"Unlocking the Therapeutic Potential of Cinchonains: A Comprehensive Review","volume":"24","author":"Fahsi","year":"2025","journal-title":"Phytochem. Rev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"158292","DOI":"10.1016\/j.phymed.2026.158292","article-title":"Cinchonain Ia Inhibits Uric Acid Reabsorption by Binding to the TRP-459 Residue of the GLUT9 Protein","volume":"157","author":"Li","year":"2026","journal-title":"Phytomedicine"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Makhubu, F.N., Siviya, L.E., Rauwane, M.E., Laurie, S.M., Madala, N.E., and Figlan, S. (2025). Biochemical Responses of Atacama and Blesbok Sweet Potato (Ipomoea batatas L.) Cultivars to Early Drought Stress. Plants, 14.","DOI":"10.3390\/plants14223532"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Herrador, S., Corral-Sarasa, J., Gonz\u00e1lez-Garc\u00eda, P., Morillas-Morota, Y., Olivieri, E., Jim\u00e9nez-S\u00e1nchez, L., and D\u00edaz-Casado, M.E. (2025). Natural Hydroxybenzoic and Hydroxycinnamic Acids Derivatives: Mechanisms of Action and Therapeutic Applications. Antioxidants, 14.","DOI":"10.3390\/antiox14060711"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Baldi, S., Trist\u00e1n Asensi, M., Pallecchi, M., Sofi, F., Bartolucci, G., and Amedei, A. (2023). Interplay between Lignans and Gut Microbiota: Nutritional, Functional and Methodological Aspects. Molecules, 28.","DOI":"10.3390\/molecules28010343"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Hefer, M., Huskic, I.M., Petrovic, A., Raguz-Lucic, N., Kizivat, T., Gjoni, D., Horvatic, E., Udiljak, Z., Smolic, R., and Vcev, A. (2023). A Mechanistic Insight into Beneficial Effects of Polyphenols in the Prevention and Treatment of Nephrolithiasis: Evidence from Recent In Vitro Studies. Crystals, 13.","DOI":"10.3390\/cryst13071070"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.vetpar.2016.06.004","article-title":"In Vitro Anthelmintic Activity of the Zizyphus joazeiro Bark against Gastrointestinal Nematodes of Goats and Its Cytotoxicity on Vero Cells","volume":"226","author":"Gomes","year":"2016","journal-title":"Vet. Parasitol."},{"key":"ref_66","first-page":"451679","article-title":"Immunobiologic and Antiinflammatory Properties of a Bark Extract from Ampelozizyphus amazonicus Ducke","volume":"2013","author":"Fernandes","year":"2013","journal-title":"BioMed Res. Int."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"103074","DOI":"10.1016\/j.copbio.2024.103074","article-title":"Impact of Hormesis to Deepen Our Understanding of the Mechanisms Underlying the Bioactivities of Polyphenols","volume":"86","author":"Murakami","year":"2024","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_68","unstructured":"Duno de Stefano, R., Carnevali Fern\u00e1ndez-Concha, G., Ram\u00edrez Morillo, I.M., Tapia Mu\u00f1oz, J.L., Can Itz\u00e1, L.L., Hern\u00e1ndez-Aguilar, S., and Embray, T. (2026, May 30). Flora de La Pen\u00ednsula de Yucat\u00e1n. Available online: https:\/\/www.cicy.mx\/sitios\/flora%20digital\/."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"426","DOI":"10.17584\/rcch.2019v13i3.8948","article-title":"Characterization of Three Arracacia xanthorrhiza Bancroft Genotypes Using Morphological and Color Parameters","volume":"13","year":"2019","journal-title":"Rev. Colomb. Cienc. Hort\u00edcolas"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jff.2014.05.009","article-title":"Extract of Cactus (Opuntia Ficus Indica) Cladodes Scavenges Reactive Oxygen Species in Vitro and Enhances Plasma Antioxidant Capacity in Humans","volume":"10","author":"Zou","year":"2014","journal-title":"J. Funct. Foods"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1053\/j.jrn.2020.04.006","article-title":"Oxalate Content and Antioxidant Activity of Different Ethnic Foods","volume":"31","author":"Canton","year":"2021","journal-title":"J. Ren. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"105658","DOI":"10.1016\/j.ultsonch.2021.105658","article-title":"Effect of Solvent Polarity on the Ultrasound Assisted Extraction and Antioxidant Activity of Phenolic Compounds from Habanero Pepper Leaves (Capsicum chinense) and Its Identification by UPLC-PDA-ESI-MS\/MS","volume":"76","author":"Pacheco","year":"2021","journal-title":"Ultrason. Sonochem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","article-title":"Proposed Minimum Reporting Standards for Chemical Analysis","volume":"3","author":"Sumner","year":"2007","journal-title":"Metabolomics"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/14\/2478\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:21:39Z","timestamp":1784262099000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/14\/2478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":73,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["molecules31142478"],"URL":"https:\/\/doi.org\/10.3390\/molecules31142478","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]}}}