{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T05:03:21Z","timestamp":1784351001157,"version":"3.55.0"},"reference-count":58,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangxi Science and Technology Project","award":["AB16380030"],"award-info":[{"award-number":["AB16380030"]}]},{"name":"Guangxi Natural Science Foundation","award":["2024JJA160299"],"award-info":[{"award-number":["2024JJA160299"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Epoxy resin (EP) exhibits pronounced intrinsic brittleness arising from the highly crosslinked network formed after curing, thereby restricting its application in load-bearing structures. Although TiO2 nanoparticles possess the potential for impact-strength improvement, they are highly prone to aggregation, which compromises stress-transfer efficiency within the composite. To overcome this challenge, a ball-milling strategy is adopted to anchor TiO2 nanoparticles onto three-dimensional graphene oxide (3DGO), leading to the successful fabrication of a 3DGO@TiO2 hybrid filler. At an ultralow loading of 0.03 wt%, the 3DGO@TiO2 epoxy resin composite shows a 221.5% increase in impact strength to 19.55 kJ\/m2 and 33.53% and 32.34% increases in tensile and flexural strength to 64.32 MPa and 96.17 MPa, respectively, relative to neat EP. Morphological analyses indicate that the 3DGO spatial confinement reduces TiO2 aggregate characteristic length by 55.1% from 1123 nm to 504 nm. Molecular dynamics simulations show that the hybrid filler decreases fractional free volume to 17.6%, induces denser matrix packing, and increases the calculated physical interfacial energy to 1023 kcal\/mol, which is 2.2 times that of the pure TiO2 epoxy resin system. This work confirms that 3DGO simultaneously optimizes nanofiller dispersion and physical confinement, offering a novel strategy for high-performance epoxy composites at ultralow loadings.<\/jats:p>","DOI":"10.3390\/molecules31142489","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:55:59Z","timestamp":1784249759000},"page":"2489","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Achieving Exceptional Mechanical Properties of Epoxy Resins at Ultralow Loadings via a 3DGO@TiO2 Hybrid Filler"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6164-4545","authenticated-orcid":false,"given":"Lizhe","family":"Liang","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyuan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s42823-023-00547-7","article-title":"The epoxy resin system: Function and role of curing agents","volume":"34","author":"Aziz","year":"2024","journal-title":"Carbon Lett."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"168051","DOI":"10.1016\/j.cej.2025.168051","article-title":"Corncob-inspired synthesis of carbon fiber\/PO43\u2212 intercalated NiFe-LDH hybrid for simultaneously improving flame retardancy and mechanical properties of epoxy resin composites","volume":"522","author":"Lou","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"111057","DOI":"10.1016\/j.compscitech.2025.111057","article-title":"Enhanced mechanical properties of aramid fiber\/epoxy composites through reinforcing interfacial adhesion based on strong hydrogen bonding interactions","volume":"262","author":"Wang","year":"2025","journal-title":"Compos. Sci. Technol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"\u015eomoghi, R., Semenescu, A., Pas\u0103re, V., Chivu, O.R., Ni\u021boi, D.F., Marcu, D.F., and Florea, B. (2024). The Impact of ZnO Nanofillers on the Mechanical and Anti-Corrosion Performances of Epoxy Composites. Polymers, 16.","DOI":"10.3390\/polym16142054"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1134\/S107042721501019X","article-title":"Use of modified nanoparticles of potassium polytitanate and physical methods of modification of epoxy compositions for improving their operational properties","volume":"88","author":"Mostovoi","year":"2015","journal-title":"Russ. J. Appl. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e55828","DOI":"10.1002\/app.55828","article-title":"Carbonated castor oil as a bioplasticiser and toughening agent for bisphenol a based epoxy","volume":"141","author":"Dhore","year":"2024","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"109857","DOI":"10.1016\/j.compositesb.2022.109857","article-title":"Synergistic fracture toughness enhancement of epoxy-amine matrices via combination of network topology modification and silica nanoparticle reinforcement","volume":"238","author":"Gao","year":"2022","journal-title":"Compos. Part B Eng."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.compositesb.2015.09.017","article-title":"Effect of cross-linking on dynamic mechanical and fracture behavior of epoxy variants","volume":"85","author":"Rahul","year":"2016","journal-title":"Compos. Part B Eng."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1021\/acs.chemrev.0c00938","article-title":"Dynamic Covalent Polymer Networks: A Molecular Platform for Designing Functions beyond Chemical Recycling and Self-Healing","volume":"121","author":"Zheng","year":"2021","journal-title":"Chem. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.mattod.2021.07.003","article-title":"Vitrimers: Current research trends and their emerging applications","volume":"51","author":"Zheng","year":"2021","journal-title":"Mater. Today"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"124518","DOI":"10.1016\/j.polymer.2022.124518","article-title":"A new strategy to improve the toughness of epoxy thermosets by introducing the thermoplastic epoxy","volume":"240","author":"Chen","year":"2022","journal-title":"Polymer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"108884","DOI":"10.1016\/j.compscitech.2021.108884","article-title":"A nano-TiO2\/regenerated cellulose biohybrid enables simultaneously improved strength and toughness of solid epoxy resins","volume":"212","author":"Yang","year":"2021","journal-title":"Compos. Sci. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1007\/s10904-023-02615-x","article-title":"Thermal, Mechanical and Flame Retardant Properties of Antimony Trioxide-Titania Aerogel Composite (ATAC) Reinforced Epoxy Matrix","volume":"33","author":"Mareeswaran","year":"2023","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101355","DOI":"10.1016\/j.coco.2022.101355","article-title":"High content of spherical nanosilica filled epoxy resin master batch with low viscosity and superior thermomechanical performance","volume":"36","author":"Wang","year":"2022","journal-title":"Compos. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"130256","DOI":"10.1016\/j.matchemphys.2024.130256","article-title":"Evaluation of corrosion resistance of citric acid secondary doped poly(o-toluidine)\/titanium dioxide epoxy coatings","volume":"332","author":"Liu","year":"2025","journal-title":"Mater. Chem. Phys."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s12633-026-03667-7","article-title":"Enhancement of Epoxy-derived Polymer Nanocomposites Strengthened with Titanium Dioxide (TiO2) and Silicon Oxide (SiO2) Nanoparticles","volume":"18","author":"Abdelhady","year":"2026","journal-title":"Silicon"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Fekia\u010d, J.J., Krbata, M., Kohutiar, M., Jan\u00edk, R., Kako\u0161ov\u00e1, L., Breznick\u00e1, A., Eckert, M., and Miku\u0161, P. (2025). Comprehensive Review: Optimization of Epoxy Composites, Mechanical Properties, & Technological Trends. Polymers, 17.","DOI":"10.3390\/polym17030271"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1007\/s11771-024-5788-z","article-title":"Novel multifunctional epoxy based graphitic carbon nitride\/silanized TiO2 nanocomposite as protective coatings for steel surface against corrosion and flame in the shipping industry","volume":"31","author":"Xavier","year":"2024","journal-title":"J. Cent. South Univ."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"131149","DOI":"10.1016\/j.matchemphys.2025.131149","article-title":"Combined self-healing and thermoformability with shape memory effect in epoxy nanocomposite vitrimer from disulfide bond grafted TiO2 nanoparticles in the presence of a soft phase","volume":"344","author":"Ahamed","year":"2025","journal-title":"Mater. Chem. Phys."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"104012","DOI":"10.1016\/j.rineng.2025.104012","article-title":"Influence of adding tungsten carbide and titanium dioxide nanoparticles on the impact strength of epoxy based composite materials used in marine applications","volume":"25","author":"Ghani","year":"2025","journal-title":"Results Eng."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1007\/s00396-025-05471-y","article-title":"Enhancement in structural and mechanical properties of epoxy reinforced with silane-treated titanium dioxide","volume":"303","author":"Raju","year":"2025","journal-title":"Colloid Polym. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijbiomac.2022.04.229","article-title":"A lignin-based epoxy\/TiO2 hybrid nanoparticle for multifunctional bio-based epoxy with improved mechanical, UV absorption and antibacterial properties","volume":"210","author":"Yang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"112771","DOI":"10.1016\/j.compositesb.2025.112771","article-title":"Development of self-healed, thermoformable, and fracture resistance epoxy nanocomposites added with disulfide bond grafted TiO2 nanoparticles","volume":"306","author":"Saikia","year":"2025","journal-title":"Compos. Part B Eng."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1002\/pc.70549","article-title":"Improving the Mechanical Properties and Ultraviolet Aging Resistance of Bamboo-Based Fiber Composites Using Titanium Dioxide Nanoparticles","volume":"47","author":"Ren","year":"2026","journal-title":"Polym. Compos."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"133332","DOI":"10.1016\/j.chemosphere.2021.133332","article-title":"Incorporation of SiO2 functionalized gC3N4 sheets with TiO2 nanoparticles to enhance the anticorrosion performance of metal specimens in aggressive Cl\u2212 environment","volume":"290","author":"Steffi","year":"2022","journal-title":"Chemosphere"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"132241","DOI":"10.1016\/j.colsurfa.2023.132241","article-title":"Fabrication of silane-based surface coating with Ag\/TiO2 hybridization and its anti-corrosion performance on metal surface","volume":"676","author":"Shi","year":"2023","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"113474","DOI":"10.1016\/j.compositesb.2026.113474","article-title":"Preparation and properties of in-situ prepared flame retardant nanoparticles\/epoxy resin composites with high heat resistance and toughness","volume":"316","author":"Bu","year":"2026","journal-title":"Compos. Part B Eng."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jmst.2024.08.022","article-title":"Construction of rGO-MXene@FeNi\/epoxy composites with regular honeycomb structures for high-efficiency electromagnetic interference shielding","volume":"217","author":"Song","year":"2025","journal-title":"J. Mater. Sci. Technol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"111151","DOI":"10.1016\/j.compscitech.2025.111151","article-title":"Role of the aspect ratio of graphene oxide (GO) on the interface and mechanical properties of vitrimer\/GO nanocomposites","volume":"265","author":"Shen","year":"2025","journal-title":"Compos. Sci. Technol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"111436","DOI":"10.1016\/j.compscitech.2025.111436","article-title":"High-performance epoxy composites based on 3D interconnected hybrid filler network interface engineering: Synergistic enhancement of thermal and mechanical properties","volume":"274","author":"Zhou","year":"2026","journal-title":"Compos. Sci. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"112351","DOI":"10.1016\/j.compositesb.2025.112351","article-title":"Three-dimensional nano-structural design for enhanced damping performance of carbon fiber reinforced polymer composites with balanced mechanical performance","volume":"298","author":"Zhou","year":"2025","journal-title":"Compos. Part B Eng."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1016\/j.jmrt.2026.03.259","article-title":"Synergistically enhanced mechanical and tribological properties of epoxy composites via 3D graphyne architectures welded with graphene quantum dots","volume":"42","author":"Min","year":"2026","journal-title":"J. Mater. Res. Technol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"11985","DOI":"10.1002\/pc.28613","article-title":"Three-dimensional graphene architecture reinforced epoxy composite with double-sided adhesive molybdenum disulfide transition interlayer for maintaining excellent interfacial and tribological properties","volume":"45","author":"Min","year":"2024","journal-title":"Polym. Compos."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"108172","DOI":"10.1016\/j.triboint.2022.108172","article-title":"Fabrication of RGO\/CNTs\/MXene 3D skeleton structure for enhancing thermal and tribological properties of epoxy composites","volume":"179","author":"Zhang","year":"2023","journal-title":"Tribol. Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"142997","DOI":"10.1016\/j.cej.2023.142997","article-title":"A novel cerium organic network modified graphene oxide prepared multifunctional waterborne epoxy-based coating with excellent mechanical and passive\/active anti-corrosion properties","volume":"465","author":"Li","year":"2023","journal-title":"Chem. Eng. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"143086","DOI":"10.1016\/j.cej.2023.143086","article-title":"Enhanced mechanical and tribological properties of epoxy composites reinforced by novel hyperbranched polysiloxane functionalized graphene\/MXene hybrid","volume":"466","author":"Chen","year":"2023","journal-title":"Chem. Eng. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"110363","DOI":"10.1016\/j.compscitech.2023.110363","article-title":"Enhancement mechanism of epoxy resin by polyacrylic acid-modified 3D porous graphene: A microscopic and molecular dynamics perspective","volume":"245","author":"Yu","year":"2024","journal-title":"Compos. Sci. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"134666","DOI":"10.1016\/j.energy.2025.134666","article-title":"Modulation of titanium dioxide\/graphene interface by Mg2+ doping: Titanium dioxide coatings with conductive, corrosion-resistant and superhydrophobic features","volume":"317","author":"Liu","year":"2025","journal-title":"Energy"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"120770","DOI":"10.1016\/j.carbon.2025.120770","article-title":"Spatially selective heterointerface engineering enables high-efficiency low-frequency microwave absorption in graphene\/TiO2 composites","volume":"245","author":"Qi","year":"2025","journal-title":"Carbon"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"148813","DOI":"10.1016\/j.cej.2024.148813","article-title":"Coupling urchin-like TiO2 nanospheres with nitrogen and sulfur co-doped graphene quantum dots for visible-light-induced degradation of toluene","volume":"482","author":"Tang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"113468","DOI":"10.1016\/j.compositesb.2026.113468","article-title":"Advancing carbon fiber reinforced epoxy composites with enhanced mechanical properties and liquid oxygen compatibility","volume":"314","author":"Long","year":"2026","journal-title":"Compos. Part B Eng."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"113564","DOI":"10.1016\/j.compositesb.2026.113564","article-title":"Dual enhancements of flame retardancy and mechanical property of vinyl ester resin composite via using reactive ammonium polyphosphate","volume":"316","author":"Chu","year":"2026","journal-title":"Compos. Part B Eng."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"125432","DOI":"10.1016\/j.ijheatmasstransfer.2024.125432","article-title":"Phase change material microcapsules doped with phosphorus-based flame retardant filled titanium dioxide nanotubes for enhancing the energy storage and temperature regulation performance of buildings","volume":"225","author":"Lin","year":"2024","journal-title":"Int. J. Heat Mass Transf."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"119848","DOI":"10.1016\/j.jece.2025.119848","article-title":"Liquid-like PDMS brushes\/TiO2 microcapsule-driven coatings with integrated self-healing, photodegradation, and antifouling functions","volume":"13","author":"Ren","year":"2025","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Li, X., Yu, B., Chen, J., Huo, D., Liu, J., and Nan, D. (2024). Optimized Functionalization of Graphene Oxide for Enhanced Mechanical Properties in Epoxy Resin Composites. Coatings, 14.","DOI":"10.3390\/coatings14050609"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"100375","DOI":"10.1016\/j.flatc.2022.100375","article-title":"Bottom-up synthesis of few-layered graphene powders and their applications as efficient lubricating and electromagnetic shielding additives","volume":"33","author":"Pan","year":"2022","journal-title":"FlatChem"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"163831","DOI":"10.1016\/j.apsusc.2025.163831","article-title":"The performance of a novel nano-SiO2 dispersion solutions for the chemical-mechanical polishing of sapphire","volume":"709","author":"Chu","year":"2025","journal-title":"Appl. Surf. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"9017","DOI":"10.1016\/j.ceramint.2022.11.057","article-title":"Graphene nanoplatelets\/barium titanate hybrid nanoparticles via ball milling for enhanced dielectric and mechanical properties of fluorosilicone rubber composites","volume":"49","author":"Tan","year":"2023","journal-title":"Ceram. Int."},{"key":"ref_49","unstructured":"(2012). Plastics\u2014Determination of Tensile Properties\u2014Part 2: Test Conditions for Moulding and Extrusion Plastics (Standard No. ISO 527-2:2012)."},{"key":"ref_50","unstructured":"(2008). Plastics-Determination of Flexural Properties. General Administration of Quality Supervision, Inspection and Quarantine of the People\u2019s Republic of China (Standard No. GB\/T 9341-2008)."},{"key":"ref_51","unstructured":"(2008). Plastics-Determination of Charpy Impact Properties-Part 1: Non-Instrumented Impact Test. General Administration of Quality Supervision, Inspection and Quarantine of the People\u2019s Republic of China (Standard No. GB\/T 1043.1-2008)."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Zhang, N., Mao, Y., Wu, S., and Xu, W. (2022). Effects of the Ball Milling Process on the Particle Size of Graphene Oxide and Its Application in Enhancing the Thermal Conductivity of Wood. Forests, 13.","DOI":"10.3390\/f13081325"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"106890","DOI":"10.1016\/j.polymertesting.2020.106890","article-title":"Molecular dynamics simulation and thermo-mechanical characterization for optimization of three-phase epoxy\/TiO2\/SiO2 nano-composites","volume":"93","author":"Takari","year":"2021","journal-title":"Polym. Test."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"109008","DOI":"10.1016\/j.compscitech.2021.109008","article-title":"High-performance, multi-functional and well-dispersed graphene\/epoxy nanocomposites via internal antiplasticization and \u03c0-\u03c0F interactions","volume":"215","author":"Ma","year":"2021","journal-title":"Compos. Sci. Technol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"106588","DOI":"10.1016\/j.compositesa.2021.106588","article-title":"In-situ preparation of layered zinc N, N\u2019-piperazine (bismethylene phosphonate) functionalizing reduced graphene oxide for epoxy resin with reduced fire hazards and improved thermal\/mechanical properties","volume":"149","author":"Wang","year":"2021","journal-title":"Compos. Part A Appl. Sci. Manuf."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"13106","DOI":"10.1002\/pc.71147","article-title":"Biomimetic Octopus-Like Graphene-Based Toughener for Simultaneous Enhancement of Mechanical and Thermal Properties in Epoxy Composites","volume":"47","author":"Xue","year":"2026","journal-title":"Polym. Compos."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e57610","DOI":"10.1002\/app.57610","article-title":"Dopamine-Functionalized Graphene Oxide as Multifunctional Epoxy Modifier: Synergistic Enhancement of Toughness and Thermal Conductivity","volume":"142","author":"Jiang","year":"2025","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s13726-024-01374-x","article-title":"Comprehensive investigation of epoxy\/graphene oxide\/copper nanocomposites: Experimental study and modeling-optimization of mechanical characteristics","volume":"34","author":"Mahouri","year":"2025","journal-title":"Iran. Polym. J."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/14\/2489\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:27:12Z","timestamp":1784348832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/14\/2489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":58,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["molecules31142489"],"URL":"https:\/\/doi.org\/10.3390\/molecules31142489","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]}}}