{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:02:08Z","timestamp":1785438128519,"version":"3.56.0"},"reference-count":51,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chongqing Shapingba Technological Innovation Project","award":["2025012"],"award-info":[{"award-number":["2025012"]}]},{"name":"Chongqing Medical Young Top-notch Talent Project","award":["YXQN202459"],"award-info":[{"award-number":["YXQN202459"]}]},{"name":"Science and Technology Research Program of Chongqing Municipal Education Commission","award":["KJQN202502820"],"award-info":[{"award-number":["KJQN202502820"]}]},{"award":["KJQN202502820"],"award-info":[{"award-number":["KJQN202502820"]}],"id":[{"id":"https:\/\/ror.org\/031nm5713","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Chongqing Medical Scientific Research Project","award":["2026QNXM040"],"award-info":[{"award-number":["2026QNXM040"]}]},{"name":"Chongqing Medical and Pharmaceutical College","award":["ygzbhly2024101"],"award-info":[{"award-number":["ygzbhly2024101"]}]},{"name":"Chongqing Medical and Pharmaceutical College","award":["ygz2023117"],"award-info":[{"award-number":["ygz2023117"]}]},{"name":"Chongqing Medical and Pharmaceutical College","award":["ygzrc2023102"],"award-info":[{"award-number":["ygzrc2023102"]}]},{"award":["ygzbhly2024101"],"award-info":[{"award-number":["ygzbhly2024101"]}],"id":[{"id":"https:\/\/ror.org\/05gvw2741","id-type":"ROR","asserted-by":"publisher"}]},{"award":["ygz2023117"],"award-info":[{"award-number":["ygz2023117"]}],"id":[{"id":"https:\/\/ror.org\/05gvw2741","id-type":"ROR","asserted-by":"publisher"}]},{"award":["ygzrc2023102"],"award-info":[{"award-number":["ygzrc2023102"]}],"id":[{"id":"https:\/\/ror.org\/05gvw2741","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Collaborative Research Fund for Young Scientists Supported by Chongqing Bishan District Bureau of Science and Technology and Chongqing University of Chinese Medicine","award":["BSLHZX025"],"award-info":[{"award-number":["BSLHZX025"]}]},{"award":["BSLHZX025"],"award-info":[{"award-number":["BSLHZX025"]}],"id":[{"id":"https:\/\/ror.org\/023rhb549","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A convenient one-pot strategy was adopted to fabricate Cu-4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) nanosheets through the coordination of HEPES with copper ions under alkaline conditions, and the obtained nanosheets possessed dual laccase-mimetic and oxidase-mimetic activities for phenolic pollutant analysis and show potential for dye decolorization\/removal. The Cu-HEPES nanosheets displayed significant dual enzyme-mimetic activities, effectively catalyzing the oxidation conversion for phenolic compounds, specifically 2,4-dichlorophenol (2,4-DCP), to yield quinone imine products characterized by a unique absorption signal at 500 nm. Meanwhile, Cu-HEPES nanosheets also facilitated the conversion of 3,3\u2032,5,5\u2032-tetramethylbenzidine to yield a yellow-green substance with a distinctive absorption signal at 458 nm. The Cu-HEPES nanosheets displayed a satisfactory affinity (Km = 23.2 \u03bcM) for 2,4-DCP, facilitating its use in accurately detecting 2,4-DCP (linear range from 3.3 to 16.6 \u00b5M) with a detection limit of 0.3 \u00b5M. Subsequently, the devised colorimetric sensing platform was applied to measure 2,4-DCP levels in real tap water samples, yielding satisfactory spiked recoveries ranging from 92.7% to 106.9%. Finally, the synthesized Cu-HEPES nanosheets were preliminarily evaluated for the simultaneous decolorization\/removal of malachite green and Congo red, suggesting their potential applicability in aqueous systems containing multiple organic dyes.<\/jats:p>","DOI":"10.3390\/molecules31152639","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:13:47Z","timestamp":1785320027000},"page":"2639","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cu-HEPES Nanosheets with Dual Enzyme-Mimetic Activities for Colorimetric Detection of 2,4-Dichlorophenol"],"prefix":"10.3390","volume":"31","author":[{"given":"Jia-Yuan","family":"He","sequence":"first","affiliation":[{"name":"Traditional Chinese Medicine College, Chongqing University of Chinese Medicine, Chongqing 402760, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2229-9125","authenticated-orcid":false,"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing Medical and Pharmaceutical College, Chongqing 401331, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"135824","DOI":"10.1016\/j.chemosphere.2022.135824","article-title":"Recent advances in the utilization of immobilized laccase for the degradation of phenolic compounds in aqueous solutions: A review","volume":"307","author":"Chen","year":"2022","journal-title":"Chemosphere"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"146778","DOI":"10.1016\/j.ijbiomac.2025.146778","article-title":"Immobilization of laccase on biochar for the remediation of organic pollutants: A comprehensive review","volume":"322","author":"Chen","year":"2025","journal-title":"Int. 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