{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T04:44:00Z","timestamp":1786164240718,"version":"build-2736575974"},"reference-count":47,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Aloe vera is a renowned phytotherapeutic plant characterized by a highly dynamic chemical profile and endowed with a broad spectrum of biological activities. Industrial processing of A. vera focuses almost exclusively on the inner parenchyma (AG), discarding the epidermal tissue (AS) as waste. This study addresses the valorization of this byproduct through a comparative evaluation of the phytochemical and biological profiles of hydroalcoholic extracts obtained from both AG and AS. In vitro studies revealed that AS extract exhibited better antioxidant and anti-inflammatory activities than AG and good wound-healing properties, driven by its rich content of anthraquinones and polyphenols. Both extracts were successfully incorporated into a mucoadhesive xanthan gum matrix to engineer an advanced emulgel with suitable viscosity for prolonged mucosal adherence in Gastro-Esophageal Reflux Disease (GERD) management. Rheological profiling against commercial references confirmed that the xanthan-AS formulation provided comparable rheological properties, fully preserving the extract\u2019s anti-inflammatory activity. Ultimately, this study highlights the pharmaceutical potential of A. vera skin, offering a sustainable strategy to transform an industrial byproduct into an innovative formulation for potential GERD management.<\/jats:p>","DOI":"10.3390\/molecules31152735","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:45:47Z","timestamp":1786027547000},"page":"2735","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sustainable Valorization of Aloe vera Skin: Development of a New Emulgel with Anti-Inflammatory Properties"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1386-3601","authenticated-orcid":false,"given":"Jessica","family":"Ceramella","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Information, Modeling, Electronics and Systems (D.I.M.E.S.), University of Calabria, Via Pietro Bucci, Cubo 39C, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2435-8931","authenticated-orcid":false,"given":"Maria Stefania","family":"Sinicropi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1776-0271","authenticated-orcid":false,"given":"Francesca Romana","family":"Lupi","sequence":"additional","affiliation":[{"name":"Department of Information, Modeling, Electronics and Systems (D.I.M.E.S.), University of Calabria, Via Pietro Bucci, Cubo 39C, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7550-9571","authenticated-orcid":false,"given":"Vincenzo","family":"Sicari","sequence":"additional","affiliation":[{"name":"Department of Agriculture, University \u201cMediterranea\u201d of Reggio Calabria, Via dell\u2019Universit\u00e0, 89125 Reggio Calabria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5355-0119","authenticated-orcid":false,"given":"Antonio","family":"Gattuso","sequence":"additional","affiliation":[{"name":"Department of Agriculture, University \u201cMediterranea\u201d of Reggio Calabria, Via dell\u2019Universit\u00e0, 89125 Reggio Calabria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Fernandes","sequence":"additional","affiliation":[{"name":"MedInUP\/RISE-Health, Pharmacology and Therapeutics Unit, Department of Biomedicine, Faculty of Medicine, University of 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4780-452X","authenticated-orcid":false,"given":"Giancarlo","family":"Statti","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4396-9965","authenticated-orcid":false,"given":"Mary","family":"Fucile","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7600-7434","authenticated-orcid":false,"given":"Carlo Maria","family":"Scornajenghi","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, Sapienza University of Rome, Via del 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