{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:31:00Z","timestamp":1786422660012,"version":"build-2736575974"},"reference-count":46,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cornus mas L. fruits are a valuable source of bioactive natural products with potential applications in functional foods and food preservation. In the present study, supercritical carbon dioxide (Sc-CO2) extraction was applied for the recovery of lipophilic fractions from Cornus mas fruits under different operating conditions of pressure, temperature, and extraction time. The influence of extraction parameters on the extraction yield was investigated using a design of experiments (DoE) approach. The chemical composition of the obtained extracts was characterized via high-resolution gas chromatography (HRGC), revealing a fatty acid profile dominated by linoleic acid (58\u201363%) and oleic acid (22\u201324%), followed by palmitic acid (8\u20139%), stearic acid (2\u20134%), arachidic acid (about 2%), and behenic acid (about 1%). The extracts were further evaluated for antimicrobial activity against selected Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, as well as against the yeast Candida albicans. The results demonstrated that supercritical CO2 extraction represents an effective green technology for the selective recovery of lipophilic bioactive compounds from Cornus mas fruits. The extracts exhibited measurable antimicrobial activity in broth microdilution assays against selected Gram-positive and Gram-negative bacteria, as well as Candida albicans, supporting their potential as natural antimicrobial agents. The combination of green extraction technology, analytical characterization, and bioactivity evaluation contributes to the valorization of Cornus mas fruits as a source of food-derived natural products.<\/jats:p>","DOI":"10.3390\/molecules31162757","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T01:20:03Z","timestamp":1786324803000},"page":"2757","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Supercritical CO2 Extraction and Characterization of Lipophilic Natural Products from Cornus mas Fruits: Composition and Antimicrobial Activity"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7509-5446","authenticated-orcid":false,"given":"Elisa","family":"Visentin","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Chimiche e Farmaceutiche, Universit\u00e0 degli Studi di Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6524-3041","authenticated-orcid":false,"given":"Nicola","family":"De Zordi","sequence":"additional","affiliation":[{"name":"Societ\u00e0 Agricola Moldoi s.r.l., Localit\u00e0 Maras Moldoi, n.151\/A, 32037 Sospirolo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2227-7935","authenticated-orcid":false,"given":"Angelo","family":"Cortesi","sequence":"additional","affiliation":[{"name":"Dipartimento di Ingegneria e Architettura, Universit\u00e0 degli Studi di Trieste, Via A. Valerio 10, 34127 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3071-3258","authenticated-orcid":false,"given":"Ramona","family":"Iseppi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Vita, Universit\u00e0 degli Studi di Modena e Reggio Emilia, Via Campi 287, 41125 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5299-8197","authenticated-orcid":false,"given":"Eva","family":"Pericolini","sequence":"additional","affiliation":[{"name":"Dipartimento Chirurgico, Medico, Odontoiatrico e di Scienze Morfologiche con Interesse Trapiantologico, Oncologico e di Medicina Rigenerativa, Via Campi 287, 41125 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4213-9089","authenticated-orcid":false,"given":"Cristina","family":"Forzato","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche e Farmaceutiche, Universit\u00e0 degli Studi di Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Enache, I.-M., St\u0103nciuc, N., Vasile, A.M., Dinic\u0103, R.M., \u021aupu, E., and Vizireanu, C. (2025). Cornus mas: From Plant Taxonomy and Distribution Area to Highly Valorization of Phytochemicals by Microencapsulation in Biopolymeric Matrices Containing Probiotics. Plants, 14.","DOI":"10.3390\/plants14213298"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Przybylska, D., Kucharska, A.Z., Pi\u00f3recki, N., and Soza\u0144ski, T. (2024). The Health-Promoting Quality Attributes, Polyphenols, Iridoids and Antioxidant Activity during the Development and Ripening of Cornelian Cherry (Cornus mas L.). 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