{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T01:30:51Z","timestamp":1786325451357,"version":"build-2736575974"},"reference-count":58,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF-2026-1970"],"award-info":[{"award-number":["ORF-2026-1970"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]},{"award":["ORF-2026-1970"],"award-info":[{"award-number":["ORF-2026-1970"]}],"id":[{"id":"https:\/\/ror.org\/02f81g417","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Lung cancer remains a leading cause of cancer-related mortality worldwide, underscoring the need for safer and more effective therapeutic strategies. In this study, zinc oxide nanoparticles (ZnO NPs) were synthesized via a green, biogenic approach using Lantana camara L. flower aqueous extract and evaluated for their anticancer potential against human non-small cell lung cancer (NSCLC) NCI-H460 cells. The biosynthesized ZnO NPs were characterized using UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), Transmission electron microscopy (TEM), energy-dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and particle size analysis, confirming the formation of nanocrystalline ZnO. LC-MS profiling of the Lantana camara flower extract revealed the presence of several bioactive phytochemicals, including phenolic compounds, terpenoids, fatty acids, and alkaloids, which may contribute to the reduction and stabilization of ZnO NPs during green synthesis. Cytotoxicity assessment of ZnO NPs using MTT and trypan blue exclusion assays revealed a dose-dependent reduction in cell viability, with an IC50 value of 50 \u00b5g\/mL. Mechanistic investigations demonstrated that ZnO NP exposure induced significant oxidative stress, evidenced by increased nitric oxide, lipid peroxidation, and reactive oxygen species levels, along with depletion of intracellular glutathione. Apoptotic cell death was further confirmed by nuclear DNA fragmentation, mitochondrial membrane depolarization, and G0\/G1 phase cell cycle arrest. Quantitative real-time PCR analysis revealed upregulation of the pro-apoptotic genes Bax and p53, accompanied by downregulation of the anti-apoptotic gene Bcl-2, indicating activation of a mitochondrial-dependent intrinsic apoptotic pathway. Collectively, these findings suggest that Lantana camara L. flower-mediated ZnO nanoparticles induced apoptotic responses associated with oxidative stress in NSCLC cells, highlighting their ability as an eco-friendly nanoplatform for further anticancer investigations.<\/jats:p>","DOI":"10.3390\/molecules31162770","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T01:20:03Z","timestamp":1786324803000},"page":"2770","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxidative Stress-Associated Apoptotic Responses Induced by Lantana camara L. Flower\u2013Derived Zinc Oxide Nanoparticles in Human Non-Small Cell Lung Cancer (NCI-H460) Cells"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8266-5177","authenticated-orcid":false,"given":"Essa M.","family":"Sabi","sequence":"first","affiliation":[{"name":"Clinical Biochemistry Unit, Department of Pathology, College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7473-8281","authenticated-orcid":false,"given":"Ahmed H.","family":"Mujamammi","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Unit, Department of Pathology, College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5817-1564","authenticated-orcid":false,"given":"Khalil I.","family":"Zarea","sequence":"additional","affiliation":[{"name":"Department of Physical Sciences, Chemistry Division, College of Science, Jazan University, P.O. Box 114, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5385-7567","authenticated-orcid":false,"given":"Ziyad M.","family":"Althafar","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratories Sciences, College of Applied Medical Sciences in Alquwayiyah, Shaqra University, Riyadh 11961, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9595-8649","authenticated-orcid":false,"given":"Khalid M.","family":"Sumaily","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Unit, Department of Pathology, College of Medicine, King Saud University, P.O. 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National Cancer Institute Lung and Bronchus Cancer\u2014Cancer Stat Facts, Available online: https:\/\/seer.cancer.gov\/statfacts\/html\/lungb.html."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/1878-0261.13764","article-title":"Recent Trends and Therapeutic Potential of Phytoceutical-Based Nanoparticle Delivery Systems in Mitigating Non-Small Cell Lung Cancer","volume":"19","author":"Paudel","year":"2025","journal-title":"Mol. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.63682\/jns.v13i1.9176","article-title":"New Advances and Applications of Phyto-Constituent Based NLCs in Drug Delivery for Lung Cancer","volume":"13","author":"Hasnain","year":"2025","journal-title":"J. Neonatal Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"100326","DOI":"10.1016\/j.hybadv.2024.100326","article-title":"Synthesis of Enzyme-Enriched Zinc Oxide Nanoparticles Using Lantana Camara L. Fruit Extract for Detoxification of Phenol and Derivatives","volume":"7","author":"Lakshmi","year":"2024","journal-title":"Hybrid. Adv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"116294","DOI":"10.1016\/j.biopha.2024.116294","article-title":"Etiology of Lung Carcinoma and Treatment through Medicinal Plants, Marine Plants and Green Synthesized Nanoparticles: A Comprehensive Review","volume":"173","author":"Chaudhary","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Choudhary, F., Naikoo, U.M., Rizwan, A., Kaur, J., Abdin, M.Z., and Farooqi, H. (2025). Innovation in Lung Cancer Management from Herbal Nanomedicine to Artificial Intelligence. J. Nanotheranostics, 6.","DOI":"10.3390\/jnt6030019"},{"key":"ref_9","first-page":"479","article-title":"Green Synthesis of Silver Nanoparticles Using Leaves of Lantana Camara: Impact of Extract Quantity, Reaction Time on Shape, Size and Antibacterial Activity","volume":"17","author":"Ratan","year":"2025","journal-title":"J. Appl. Nat. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jfutfo.2024.01.001","article-title":"Recent Advcances on Plant-Based Bioengineered Nanoparticles Using Secondary Metabolites and Their Potential in Lung Cancer Management","volume":"5","author":"Islam","year":"2025","journal-title":"J. Future Foods"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e00595","DOI":"10.1016\/j.btre.2021.e00595","article-title":"Green Synthesis of Zinc Oxide Nanoparticles Using Leaf Extracts of Raphanus Sativus Var. Longipinnatus and Evaluation of Their Anticancer Property in A549 Cell Lines","volume":"29","author":"Umamaheswari","year":"2021","journal-title":"Biotechnol. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Aldalbahi, A., Alterary, S., Ali Abdullrahman Almoghim, R., Awad, M.A., Aldosari, N.S., Fahad Alghannam, S., Nasser Alabdan, A., Alharbi, S., Ali Mohammed Alateeq, B., and Abdulrahman Al Mohsen, A. (2020). Greener Synthesis of Zinc Oxide Nanoparticles: Characterization and Multifaceted Applications. Molecules, 25.","DOI":"10.3390\/molecules25184198"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3311\/PPch.22159","article-title":"Phytochemical Profiles, in Vitro Antioxidants, and Anti-Inflammatory Activities of Flowers and Leaves of Lantana Camara L. Grown in South of Tunisia","volume":"68","author":"Maaloul","year":"2024","journal-title":"Period. Polytech. Chem. Eng."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"El Hajj, J., Karam, L., Jaber, A., Cheble, E., Akoury, E., Kobeissy, P.H., Ibrahim, J.N., and Yassin, A. (2024). Evaluation of Antiproliferative Potentials Associated with the Volatile Compounds of Lantana Camara Flowers: Selective In Vitro Activity. Molecules, 29.","DOI":"10.20944\/preprints202410.1666.v1"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e279899","DOI":"10.1590\/1519-6984.279899","article-title":"In Vitro Anti-Leukemia, Antioxidant, and Anti-Inflammatory Properties of Lantana Camara","volume":"84","author":"Hoang","year":"2024","journal-title":"Braz. J. Biol."},{"key":"ref_16","first-page":"2047","article-title":"Anticancer Potential of Silver Nanoparticles by Using Lantana Camara Leaf","volume":"3","author":"Dumale","year":"2025","journal-title":"Int. J. Pharm. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"947","DOI":"10.5530\/pres.20252180","article-title":"Phytochemical Profiling, HPLC Analysis and Antioxidant Activity of Lantana Camara Flower and Leaf Extracts","volume":"17","author":"Mahesh","year":"2025","journal-title":"Pharmacogn. Res."},{"key":"ref_18","first-page":"2434","article-title":"Exploring the Perspective of Lantana Camara L. Flowers for Urolithiasis by In Vitro and In Vivo Studies","volume":"9","author":"Arra","year":"2025","journal-title":"Trop. J. Nat. Product Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"100837","DOI":"10.1016\/j.hermed.2023.100837","article-title":"Effect of Lantana Camara Ethanolic Leaf Extract on Survival and Migration of MDA-MB-231 Triple-Negative Breast Cancer Cell Line","volume":"43","author":"Pal","year":"2024","journal-title":"J. Herb. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"286","DOI":"10.22270\/ajprd.v13i6.1655","article-title":"Exploring Lantana Camara: A Comprehensive Insight into Its Bioactive Constituents and Therapeutic Potential","volume":"13","author":"Mehta","year":"2025","journal-title":"Asian J. Pharm. Res. Dev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.47419\/bjbabs.v6i1.276","article-title":"Hepatoprotective Effect of Lantana Camara L. Flower Extracts Against Acetaminophen-Induced Liver Injury in Wistar Rats","volume":"6","author":"Stephen","year":"2025","journal-title":"Baghdad J. Biochem. Appl. Biol. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s12032-025-02862-7","article-title":"Role of Nanomedicines in Lung Cancer Treatment and Diagnosis: Opportunities and Challenges","volume":"42","author":"Shah","year":"2025","journal-title":"Med. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8606","DOI":"10.1039\/D2RA07863E","article-title":"Cancer Nanomedicine: A Review of Nano-Therapeutics and Challenges Ahead","volume":"13","author":"Nirmala","year":"2023","journal-title":"RSC Adv."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Alhujaily, M., Albukhaty, S., Yusuf, M., Mohammed, M.K.A., Sulaiman, G.M., Al-Karagoly, H., Alyamani, A.A., Albaqami, J., and AlMalki, F.A. (2022). Recent Advances in Plant-Mediated Zinc Oxide Nanoparticles with Their Significant Biomedical Properties. Bioengineering, 9.","DOI":"10.3390\/bioengineering9100541"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"13900","DOI":"10.1039\/D5NJ01211B","article-title":"Biosynthesized ZnO Nanoparticles Potentiate Cytotoxicity: In Vitro and in Silico Analysis","volume":"49","author":"Aggarwal","year":"2025","journal-title":"New J. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1007\/s44174-025-00371-9","article-title":"Biogenic Synthesis of Copper Nanoparticles from Lantana Camara Flower Extract: Antioxidant and Anticancer Activities","volume":"4","author":"Vigneshwaran","year":"2025","journal-title":"Biomed. Mater. Devices"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1016\/j.jmrt.2022.06.166","article-title":"Plant-Mediated Synthesis of NiO(II) from Lantana Camara Flowers: A Study of Photo-Catalytic, Electrochemical, and Biological Activities","volume":"19","author":"Mahadevaswamy","year":"2022","journal-title":"J. Mater. Res. Technol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"102350","DOI":"10.1016\/j.pbi.2023.102350","article-title":"Flavonols Modulate Plant Development, Signaling, and Stress Responses","volume":"72","author":"Daryanavard","year":"2023","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Antunes Filho, S., dos Santos, M.S., dos Santos, O.A.L., Backx, B.P., Soran, M.L., Opri\u015f, O., Lung, I., Stegarescu, A., and Bououdina, M. (2023). Biosynthesis of Nanoparticles Using Plant Extracts and Essential Oils. Molecules, 28.","DOI":"10.3390\/molecules28073060"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40824-021-00212-y","article-title":"Bio-Nano Interactions: Binding Proteins, Polysaccharides, Lipids and Nucleic Acids onto Magnetic Nanoparticles","volume":"25","author":"Berensmeier","year":"2021","journal-title":"Biomater. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2724302","DOI":"10.1155\/2022\/2724302","article-title":"Solanum Procumbens-Derived Zinc Oxide Nanoparticles Suppress Lung Cancer In Vitro through Elevation of ROS","volume":"2022","author":"Riyad","year":"2022","journal-title":"Bioinorg. Chem. Appl."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1007\/s42452-025-07669-9","article-title":"Synthesis of Zinc Oxide Nanoparticles Using the Leaves Extract of Rhamnus Prinoides and Its Antibacterial Activities","volume":"7","author":"Birhan","year":"2025","journal-title":"Discov. Appl. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Alqahtani, A.A., Attia, G.H., Elgamal, A., Aleraky, M., Youns, M., Ibrahim, A.M., Abdou, R., Shaikh, I.A., and El Raey, M.A. (2022). Cytotoxic Activity of Zinc Oxide Nanoparticles Mediated by Euphorbia Retusa. Crystals, 12.","DOI":"10.3390\/cryst12070903"},{"key":"ref_34","first-page":"1843","article-title":"Green Synthesis, Optimization, and Characterization of Zinc Oxide Nanoparticle Using Lantana Camara L. Leaf Extract","volume":"12","author":"Agrawal","year":"2023","journal-title":"1843 Pharma Innov. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"26663","DOI":"10.1039\/D3RA03736C","article-title":"Sustainable Bioactivity Enhancement of ZnO\u2013Ag Nanoparticles in Antimicrobial, Antibiofilm, Lung Cancer, and Photocatalytic Applications","volume":"13","author":"Dutta","year":"2023","journal-title":"RSC Adv."},{"key":"ref_36","first-page":"94","article-title":"In Vitro Cytotoxic Activity of Lantana Camara Linn","volume":"36","author":"Raghu","year":"2004","journal-title":"Indian J. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.33640\/2405-609X.3158","article-title":"Biosynthesis, Characterization and Antiproliferative Activity of Green Synthesized Gold Nanoparticles Using Lantadene A Extracted from Lantana Camara","volume":"7","author":"Dawood","year":"2021","journal-title":"Karbala Int. J. Mod. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/jat.4522","article-title":"Biological Mechanism of ZnO Nanomaterials","volume":"44","author":"Li","year":"2024","journal-title":"J. Appl. Toxicol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"215535","DOI":"10.1016\/j.ccr.2023.215535","article-title":"Enhancing Cancer Treatment via \u201cZn2+ Interference\u201d with Zn-Based Nanomaterials","volume":"500","author":"Wang","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Rupa, E.J., Nahar, J., Al-Amin, M., Park, J.K., Murugesan, M., Awais, M., Lee, S.J., Kim, I.M., Ling, L., and Yang, D.C. (2023). Cissus Antractica-ZnO NPs Induce Apoptosis in A549 Cells through ROS-Generated P53\/Bcl-2\/Bax Signaling Pathways and Inhibition of Inflammatory Cytokines. Coatings, 13.","DOI":"10.20944\/preprints202308.1217.v2"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"102329","DOI":"10.1016\/j.rineng.2024.102329","article-title":"Green Synthesis of Bimetallic AgZnO Nanoparticles: Synergistic Anticancer Effects through Regulation of Gene Expression for Lung Cancer Treatment","volume":"22","author":"Eskandari","year":"2024","journal-title":"Results Eng."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10616-018-0287-4","article-title":"Expression of P53, BAX, and BCL-2 in Human Malignant Melanoma and Squamous Cell Carcinoma Cells after Tea Tree Oil Treatment in Vitro","volume":"71","author":"Ramadan","year":"2019","journal-title":"Cytotechnology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jsps.2021.01.008","article-title":"Anticancer Efficacies of Krameria Lappacea Extracts against Human Breast Cancer Cell Line (MCF-7): Role of Oxidative Stress and ROS Generation","volume":"29","year":"2021","journal-title":"Saudi Pharm. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.3892\/or.2015.4256","article-title":"Induction of Apoptosis by an Ethanol Extract of Poria Cocos Wolf. in Human Leukemia U937 Cells","volume":"34","author":"Choi","year":"2015","journal-title":"Oncol. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.18632\/oncotarget.28031","article-title":"Interactions of Multidomain Pro-Apoptotic and Anti-Apoptotic Proteins in Cancer Cell Death","volume":"12","author":"Chota","year":"2021","journal-title":"Oncotarget"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/15548627.2018.1509171","article-title":"Necrotic, Apoptotic and Autophagic Cell Fates Triggered by Nanoparticles","volume":"15","author":"Mohammadinejad","year":"2019","journal-title":"Autophagy"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/sj.cdd.4401879","article-title":"Neural Precursor Cells Possess Multiple P53-Dependent Apoptotic Pathways","volume":"13","author":"Akhtar","year":"2006","journal-title":"Cell Death Differ."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"6121328","DOI":"10.1155\/2018\/6121328","article-title":"Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells","volume":"2018","author":"Yuan","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Nelson, V.K., Sahoo, N.K., Sahu, M., Sudhan, H.H., Pullaiah, C.P., and Muralikrishna, K.S. (2020). In Vitro Anticancer Activity of Eclipta Alba Whole Plant Extract on Colon Cancer Cell HCT-116. BMC Complement. Med. Ther., 20.","DOI":"10.1186\/s12906-020-03118-9"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3109\/08923973.2010.543687","article-title":"The Effect of MS14 on Innate and Cellular Immune Responses in BALB\/c Mice","volume":"33","author":"Yaraee","year":"2011","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for Lipid Peroxides in Animal Tissues by Thiobarbituric Acid Reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"ref_53","first-page":"1395","article-title":"In Vitro Cytotoxic Potential of Swietenia Macrophylla King Seeds against Human Carcinoma Cell Lines","volume":"5","author":"Goh","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"101479","DOI":"10.1016\/j.jscs.2022.101479","article-title":"Determination of Secondary Metabolites Including Curcumin in Rheum Ribes L. and Surveying of Its Antioxidant and Anticancer Activity","volume":"26","author":"Noori","year":"2022","journal-title":"J. Saudi Chem. Soc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.3892\/ijmm.2013.1313","article-title":"Small-Molecule Coh-Sr4 Inhibits Adipocyte Differentiation via Ampk Activation","volume":"31","author":"Figarola","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"ref_56","first-page":"2957","article-title":"Medicinal Supplement Genipin Induces P53 and Bax-Dependent Apoptosis in Colon Cancer Cells","volume":"16","author":"Ye","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s40199-014-0072-7","article-title":"Osteogenic Potential of Punica Granatum through Matrix Mineralization, Cell Cycle Progression and Runx2 Gene Expression in Primary Rat Osteoblasts","volume":"22","author":"Siddiqui","year":"2014","journal-title":"DARU J. Pharm. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"\u00d6zdemir, D., and A\u011fca, C.A. (2025). Deciphering the Anti-Cancer Efficacy of the Combination of Small-Molecule Inhibitor KAN0438757 and Curcumin in Lung Cancer Cell Lines. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47110892"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/16\/2770\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T01:21:10Z","timestamp":1786324870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/16\/2770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,9]]},"references-count":58,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["molecules31162770"],"URL":"https:\/\/doi.org\/10.3390\/molecules31162770","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,9]]}}}