{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:45:50Z","timestamp":1791233150214,"version":"4.1.0"},"reference-count":188,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Heilongjiang Province Joint Fund Cultivation Project","award":["PL2025T010"],"award-info":[{"award-number":["PL2025T010"]}]},{"name":"Heilongjiang Provincial Postdoctoral Scientific Research Foundation","award":["LBH-Q18115"],"award-info":[{"award-number":["LBH-Q18115"]}]},{"DOI":"10.13039\/501100009009","name":"Heilongjiang Province Traditional Chinese Medicine Scientific Research Project","doi-asserted-by":"publisher","award":["ZHY2024-012"],"award-info":[{"award-number":["ZHY2024-012"]}],"id":[{"id":"10.13039\/501100009009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Lonicera japonica Thunb. (honeysuckle), a traditional herb with \u201cfood-medicine homology\u201d status in Chinese medicine, is valued for its antipyretic and detoxifying properties. This review systematically summarizes its chemical composition\u2014over 507 identified compounds, including phenylpropanoids, flavonoids, triterpenoids, saponins, and the plant-specific miR2911\u2014as well as its multi-target pharmacological mechanisms and emerging translational applications, with particular emphasis on the gut\u2013brain axis-mediated neuroprotective effects. Despite low oral bioavailability, honeysuckle polysaccharides and chlorogenic acid have been shown to exert significant neuroprotection in Alzheimer\u2019s disease models by modulating gut microbiota composition, increasing short-chain fatty acid production, and restoring intestinal barrier integrity\u2014a mechanism that challenges conventional direct-action paradigms. We also outline the applications of honeysuckle in functional foods, pharmaceuticals, animal husbandry, and cosmetics, and propose future directions including precision fermentation and mechanism-driven clinical trials. By integrating phytochemistry, pharmacology, and biotechnology, this review provides a roadmap for the evidence-based development of honeysuckle as a precise medicinal and edible resource.<\/jats:p>","DOI":"10.3390\/molecules31162792","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:32:16Z","timestamp":1786444336000},"page":"2792","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Honeysuckle as a Food-Medicine Resource: A Review of Its Multi-Target Pharmacological Effects and Emerging Applications"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0641-7954","authenticated-orcid":false,"given":"Jie","family":"Gao","sequence":"first","affiliation":[{"name":"Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liheng","family":"Li","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine, Harbin 150040, China"},{"name":"Heilongjiang Key Laboratory of Chinese Medicine Informatics, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"117278","DOI":"10.1016\/j.jep.2023.117278","article-title":"Traditional Uses, Botany, Phytochemistry, and Pharmacology of Lonicerae japonicae Flos and Lonicerae flos: A Systematic Comparative Review","volume":"322","author":"Li","year":"2024","journal-title":"J. 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