{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:30:38Z","timestamp":1786696238307,"version":"build-2736575974"},"reference-count":28,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The electrochemical sensing of similar catecholamines remains challenging due to their overlapping redox behavior and similar reactivity, which often results in poorly selective reaction pathways. Herein, we report a bioinspired tyrosinase electro-catalytic system that enables the modulation of the catecholamine reactivity through the integration of enzymatic oxidation with electrochemical transformation. The biocatalytic platform consisted of electroactive lignin nanoparticles (LNPs) supporting tyrosinase drop cast on the graphene-based screen-printed electrode. The overall reaction included the oxidation of catecholamines to ortho-quinones, followed by nucleophile addition of cysteine under control of the redox environment. Overall, coupling enzymatic catalysis with electrochemical regulation enabled selectivity in the oxidative functionalization of catecholamines, providing a sustainable strategy for tuning reactivity in advanced bioinspired catalytic systems.<\/jats:p>","DOI":"10.3390\/molecules31162839","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:08:29Z","timestamp":1786694909000},"page":"2839","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electro-Biocatalytic Reactivity of Catecholamine at a Lignin Nanoparticle\u2013Tyrosinase Interface"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6487-6115","authenticated-orcid":false,"given":"Valeria","family":"Gigli","sequence":"first","affiliation":[{"name":"Research Centre for Innovation in Circular Economy and Sustainability (CRIECS), University of Tuscia, 02100 Rieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8142-4154","authenticated-orcid":false,"given":"Elisabetta","family":"Tomaino","sequence":"additional","affiliation":[{"name":"Department of Biological and Ecological Sciences, University of Tuscia, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6561-2222","authenticated-orcid":false,"given":"Davide","family":"Piccinino","sequence":"additional","affiliation":[{"name":"Centro Integrato di Ateneo, Sezione Grandi Attrezzature, University of Tuscia, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0856-2986","authenticated-orcid":false,"given":"Lorenzo","family":"Botta","sequence":"additional","affiliation":[{"name":"Department of Biological and Ecological Sciences, University of Tuscia, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5448-0658","authenticated-orcid":false,"given":"Eliana","family":"Capecchi","sequence":"additional","affiliation":[{"name":"Department of Biological and Ecological Sciences, University of Tuscia, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Saladino","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Drug Technologies, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"eadp7460","DOI":"10.1126\/sciadv.adp7460","article-title":"Nanoplasmonic aptasensor for sensitive, selective, and real-time detection of dopamine from unprocessed whole blood","volume":"10","author":"Biswas","year":"2024","journal-title":"Sci. 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