{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:19:59Z","timestamp":1787545199644,"version":"build-2736575974"},"reference-count":161,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006472","name":"Grigore T. Popa University of Medicine and Pharmacy","doi-asserted-by":"publisher","award":["Project INNODOC-MED, SMIS 351058"],"award-info":[{"award-number":["Project INNODOC-MED, SMIS 351058"]}],"id":[{"id":"10.13039\/501100006472","id-type":"DOI","asserted-by":"publisher"}]},{"award":["Project INNODOC-MED, SMIS 351058"],"award-info":[{"award-number":["Project INNODOC-MED, SMIS 351058"]}],"id":[{"id":"https:\/\/ror.org\/03hd30t45","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Diabetes mellitus represents a growing global health challenge, establishing oral antidiabetic drugs as a therapeutic class of paramount importance. Consequently, to ensure drug safety, therapeutic efficacy, and accurate therapeutic drug monitoring, robust, selective and highly reproducible analytical methods are indispensable. This review provides a comprehensive overview of instrumental analytical techniques developed between 1985 and 2026 for quantifying oral antidiabetic agents. Based on a literature search across major databases\u2014including PubMed, ScienceDirect and Springer\u2014we systematically evaluated the application of UV-VIS spectrophotometry, liquid chromatography, and advanced electroanalytical methods. The reviewed literature encompasses methodologies ranging from routine quality control of bulk powders and pharmaceutical formulations to complex bioanalytical and pharmacokinetic applications. Liquid chromatography\u2013tandem mass spectrometry (LC-MS\/MS) emerged as the gold standard for precise bioanalysis due to its superior selectivity and sensitivity in complex biological matrices. Conversely, UV-VIS spectrophotometry and electrochemical methods remain highly relevant for cost-effective routine quality control in industrial manufacturing. Methodologies are categorized by drug therapeutic class, including biguanides, sulfonylureas, DPP-4 inhibitors, SGLT2 inhibitors, meglitinides, highlighting key validation parameters such as linearity, accuracy, and limits of detection. Finally, this review outlines future directions in the field of antidiabetic drug quantification.<\/jats:p>","DOI":"10.3390\/molecules31162915","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:05:19Z","timestamp":1787241919000},"page":"2915","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Antidiabetic Agents: From Routine Quality Control to Bioanalysis"],"prefix":"10.3390","volume":"31","author":[{"given":"Ana-Maria","family":"Toma","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Department of Analytical Chemistry, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16th Universitatii Street, 700116 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7546-1992","authenticated-orcid":false,"given":"Larisa","family":"P\u0103duraru","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Analytical Chemistry, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16th Universitatii Street, 700116 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3023-0205","authenticated-orcid":false,"given":"Romeo Petru","family":"Dobrin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medicine III, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16th Universitatii Street, 700116 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3741-6184","authenticated-orcid":false,"given":"Nela","family":"Bibire","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Analytical Chemistry, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16th Universitatii Street, 700116 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-3361","authenticated-orcid":false,"given":"M\u0103d\u0103lina","family":"Vieriu","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Analytical Chemistry, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16th Universitatii Street, 700116 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4107-9566","authenticated-orcid":false,"given":"Mihai","family":"Apostu","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Analytical Chemistry, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16th Universitatii Street, 700116 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/S0140-6736(24)02317-1","article-title":"Worldwide Trends in Diabetes Prevalence and Treatment from 1990 to 2022: A Pooled Analysis of 1108 Population-Representative Studies with 141 Million Participants","volume":"404","author":"Zhou","year":"2024","journal-title":"Lancet"},{"key":"ref_2","unstructured":"International Diabetes Federation (2025). IDF Diabetes Atlas, International Diabetes Federation. [11th ed.]. Available online: https:\/\/diabetesatlas.org\/resources\/idf-diabetes-atlas-2025\/."},{"key":"ref_3","unstructured":"Sapra, A., and Bhandari, B.P. (2026, May 24). 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