{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:19:11Z","timestamp":1787980751456,"version":"build-2784847793"},"reference-count":84,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Polyphenols are a complex class of plant secondary metabolites that exert numerous beneficial effects on human health. The content of individual polyphenolic compounds varies considerably among plant species. Over the past few decades, polyphenols have attracted increasing interest because of their antioxidant and antimicrobial properties. They have also demonstrated beneficial effects in the prevention and treatment of various diseases, including cardiovascular and nervous system disorders, as well as different types of neoplasms. Because polyphenols have been shown to regulate plasma lipid levels and exhibit neuroprotective potential, they have gained attention as possible therapeutic and prophylactic agents for stroke, a neurological condition with a strong cardiovascular component. Quercetin is one of the most extensively studied plant-derived compounds in this context. A growing body of preclinical evidence suggests that it may contribute to stroke prevention and significantly support post-stroke recovery. This review compiles findings from in vitro studies, animal models, and clinical trials and presents the current state of knowledge regarding the biochemical and molecular mechanisms through which quercetin protects against cerebral ischemia.<\/jats:p>","DOI":"10.3390\/molecules31173010","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:47:13Z","timestamp":1787849233000},"page":"3010","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beneficial Role of Quercetin in Prevention and Treatment of Ischemic Stroke: Mechanisms of Action and Administration Strategies"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6768-4919","authenticated-orcid":false,"given":"Aleksandra","family":"Szychowska","sequence":"first","affiliation":[{"name":"The Nicolaus Copernicus Provincial Multispecialty Center for Oncology and Traumatology in Lodz, 93-513 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3529-1989","authenticated-orcid":false,"given":"Miko\u0142aj","family":"Grabarczyk","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Lodz, 90-153 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3814-193X","authenticated-orcid":false,"given":"Weronika","family":"Szczepa\u0144ska","sequence":"additional","affiliation":[{"name":"J. Gromkowski Voivodship Specialist Hospital in Wroclaw, 51-149 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2502-7213","authenticated-orcid":false,"given":"Ewa","family":"Smoli\u0144ska","sequence":"additional","affiliation":[{"name":"Central Teaching Hospital, Medical University of Lodz, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1305-1494","authenticated-orcid":false,"given":"Andrzej","family":"Glabinski","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke, Medical University of Lodz, Zeromskiego 113 Street, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0189-7652","authenticated-orcid":false,"given":"Piotr","family":"Szpakowski","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke, Medical University of Lodz, Zeromskiego 113 Street, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"ref_1","first-page":"160","article-title":"New Pharmacological Approaches Using Polyphenols on the Physiopathology of Neuropathic Pain","volume":"18","author":"Vela","year":"2017","journal-title":"Curr. Drug Targets"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: Food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"La Rosa, G., Lonardo, M.S., Cacciapuoti, N., Muscariello, E., Guida, B., Faraonio, R., Santillo, M., and Damiano, S. (2023). Dietary Polyphenols, Microbiome, and Multiple Sclerosis: From Molecular Anti-Inflammatory and Neuroprotective Mechanisms to Clinical Evidence. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087247"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1080\/15216540701230529","article-title":"Plant polyphenols: How to translate their in vitro antioxidant actions to in vivo conditions","volume":"59","author":"Fraga","year":"2007","journal-title":"IUBMB Life"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Grubi\u0107 Kezele, T., and \u0106urko-Cofek, B. (2022). Neuroprotective Panel of Olive Polyphenols: Mechanisms of Action, Anti-Demyelination, and Anti-Stroke Properties. Nutrients, 14.","DOI":"10.3390\/nu14214533"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Shakoor, H., Feehan, J., Apostolopoulos, V., Platat, C., Al Dhaheri, A.S., Ali, H.I., Ismail, L.C., Bosevski, M., and Stojanovska, L. (2021). Immunomodulatory effects of dietary polyphenols. Nutrients, 13.","DOI":"10.3390\/nu13030728"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Montan\u00e9, X., Kowalczyk, O., Reig-Vano, B., Bajek, A., Roszkowski, K., Tomczyk, R., Pawliszak, W., Giamberini, M., Mocek-P\u0142\u00f3ciniak, A., and Tylkowski, B. (2020). Current perspectives of the applications of polyphenols and flavonoids in cancer therapy. Molecules, 25.","DOI":"10.3390\/molecules25153342"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Nam, J.S., Sharma, A.R., Nguyen, L.T., Chakraborty, C., Sharma, G., and Lee, S.S. (2016). Application of bioactive quercetin in oncotherapy: From nutrition to nanomedicine. Molecules, 21.","DOI":"10.3390\/molecules21010108"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1292\/jvms.17-0693","article-title":"Quercetin attenuates neuronal cells damage in a middle cerebral artery occlusion animal model","volume":"80","author":"Park","year":"2018","journal-title":"J. Vet. Med. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1080\/10286020.2021.1949302","article-title":"Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats","volume":"24","author":"Yang","year":"2022","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"115653","DOI":"10.1016\/j.biopha.2023.115653","article-title":"Quercetin improves cerebral ischemia\/reperfusion injury by promoting microglia\/macrophages M2 polarization via regulating PI3K\/Akt\/NF-\u03baB signaling pathway","volume":"168","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1017\/S0007114508945694","article-title":"Flavonoid intake and the risk of ischaemic stroke and CVD mortality in middle-aged Finnish men: The Kuopio Ischaemic Heart Disease Risk Factor Study","volume":"100","author":"Mursu","year":"2008","journal-title":"Br. J. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s13318-018-0517-3","article-title":"Improved Oral Absorption of Quercetin from Quercetin Phytosome\u00ae, a New Delivery System Based on Food Grade Lecithin","volume":"44","author":"Riva","year":"2019","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"9727539","DOI":"10.1155\/2023\/9727539","article-title":"A Pharmacokinetic Study of Different Quercetin Formulations in Healthy Participants: A Diet-Controlled, Crossover, Single- and Multiple-Dose Pilot Study","volume":"2023","author":"Solnier","year":"2023","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1161\/STROKEAHA.122.040073","article-title":"Projected Global Trends in Ischemic Stroke Incidence, Deaths and Disability-Adjusted Life Years From 2020 to 2030","volume":"54","author":"Pu","year":"2023","journal-title":"Stroke"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"I","DOI":"10.1177\/2396987321989865","article-title":"European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke","volume":"6","author":"Berge","year":"2021","journal-title":"Eur. Stroke J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"I","DOI":"10.1177\/23969873221100032","article-title":"European Stroke Organisation (ESO) guideline on pharmacological interventions for long-term secondary prevention after ischaemic stroke or transient ischaemic attack","volume":"7","author":"Dawson","year":"2022","journal-title":"Eur. Stroke J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/CIRCRESAHA.116.308398","article-title":"Stroke Risk Factors, Genetics, and Prevention","volume":"120","author":"Boehme","year":"2017","journal-title":"Circ. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1161\/STROKEAHA.119.025171","article-title":"Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study","volume":"50","author":"Aparicio","year":"2019","journal-title":"Stroke"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5471347","DOI":"10.1155\/2021\/5471347","article-title":"Role of Polyphenols as Antioxidant Supplementation in Ischemic Stroke","volume":"2021","author":"Zhou","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Pacifici, F., Rovella, V., Pastore, D., Bellia, A., Abete, P., Donadel, G., Santini, S., Beck, H., Ricordi, C., and Di Daniele, N. (2021). Polyphenols and Ischemic Stroke: Insight into One of the Best Strategies for Prevention and Treatment. Nutrients, 13.","DOI":"10.3390\/nu13061967"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7467962","DOI":"10.1155\/2017\/7467962","article-title":"Dietary Polyphenols in the Prevention of Stroke","volume":"2017","author":"Arranz","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"104663","DOI":"10.1016\/j.jff.2021.104663","article-title":"Bioavailability of dietary isoquercitrin-\u03b3-cyclodextrin molecular inclusion complex in Sprague\u2013Dawley rats and healthy humans","volume":"85","author":"Kapoor","year":"2021","journal-title":"J. Funct. Foods"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Shala, A.L., Arduino, I., Salihu, M.B., and Denora, N. (2023). Quercetin and Its Nano-Formulations for Brain Tumor Therapy\u2014Current Developments and Future Perspectives for Paediatric Studies. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15030963"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Wu, C., Zhang, J., Yang, S., Peng, C., Lv, M., Liang, J., Li, X., Xie, L., Wei, Y., and Chen, H. (2024). Preparation and Pharmacokinetics of Brain-Targeted Nanoliposome Loaded with Rutin. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252111404"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1186\/s12951-025-03415-w","article-title":"Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability","volume":"23","author":"Liu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"20240349","DOI":"10.1002\/EXP.20240349","article-title":"Engineered Exosome-Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia","volume":"5","author":"Yang","year":"2025","journal-title":"Exploration"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.abb.2010.06.036","article-title":"\u03b1-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans","volume":"501","author":"Murota","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12970-019-0303-x","article-title":"Effects of enzymatically modified isoquercitrin in supplementary protein powder on athlete body composition: A randomized, placebo-controlled, double-blind trial","volume":"16","author":"Omi","year":"2019","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Owczarek-Januszkiewicz, A., Magiera, A., and Olszewska, M.A. (2022). Enzymatically Modified Isoquercitrin: Production, Metabolism, Bioavailability, Toxicity, Pharmacology, and Related Molecular Mechanisms. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314784"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"10279","DOI":"10.2147\/IJN.S537566","article-title":"Recent Advancements in Lipid Nanoparticles-Based Phytoactives Delivery Systems for Neurodegenerative Diseases","volume":"20","author":"Dirir","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Chen, J., Chen, J., Yu, P., Yang, C., Xia, C., Deng, J., Yu, M., Xiang, Z., Gan, L., and Zhu, B. (2024). A Novel Quercetin Encapsulated Glucose Modified Liposome and Its Brain-Target Antioxidative Neuroprotection Effects. Molecules, 29.","DOI":"10.3390\/molecules29030607"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1208\/s12249-024-02736-7","article-title":"Quercetin-Loaded Nanostructured Lipid Carrier In Situ Gel for Brain Targeting Through Intranasal Route: Formulation, In Vivo Pharmacokinetic and Pharmacodynamic Studies","volume":"25","author":"Sonawane","year":"2024","journal-title":"AAPS PharmSciTech"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"100206","DOI":"10.1016\/j.onano.2024.100206","article-title":"Development of QCT loaded TPGS coated solid lipid nanoparticles for improved in vivo neuroprotective activity in LPS administered adult zebrafish model: A QbD-based approach","volume":"17","author":"Garg","year":"2024","journal-title":"OpenNano"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"13182","DOI":"10.1007\/s12035-025-05137-4","article-title":"Intra-nasal Delivery of Quercetin-Loaded Nanostructured Lipid Carriers (NLCs) in the Management of Alzheimer\u2019s Disease: Formulation, In Vitro and In Vivo Assessment","volume":"62","author":"Satpathy","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_36","first-page":"243","article-title":"Nanostructured lipid carriers as a drug delivery system: A comprehensive review with therapeutic applications","volume":"3","author":"Mall","year":"2025","journal-title":"Intell. Pharm."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1080\/10717544.2021.1927244","article-title":"Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions","volume":"28","author":"Li","year":"2021","journal-title":"Drug Deliv."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.redox.2016.06.006","article-title":"Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme induction","volume":"9","author":"Li","year":"2016","journal-title":"Redox Biol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Li, M.-T., Ke, J., Guo, S.-F., Wu, Y., Bian, Y.-F., Shan, L.-L., Liu, Q.-Y., Huo, Y.-J., Guo, C., and Liu, M.-Y. (2021). The Protective Effect of Quercetin on Endothelial Cells Injured by Hypoxia and Reoxygenation. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.732874"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"112039","DOI":"10.1016\/j.biopha.2021.112039","article-title":"Cytoprotective effects of the flavonoid quercetin by activating mitochondrial BKCa channels in endothelial cells","volume":"142","author":"Kampa","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e31002","DOI":"10.1016\/j.heliyon.2024.e31002","article-title":"Quercetin improves the protection of hydroxysafflor yellow a against cerebral ischemic injury by modulating of blood-brain barrier and src-p-gp-mmp-9 signalling","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Huwait, E.A., Saddeek, S.Y., Al-Massabi, R.F., Almowallad, S.J., Pushparaj, P.N., and Kalamegam, G. (2021). Antiatherogenic Effects of Quercetin in the THP-1 Macrophage Model In Vitro, with Insights Into Its Signaling Mechanisms Using In Silico Analysis. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.698138"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00011-020-01402-5","article-title":"Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation","volume":"69","author":"Le","year":"2020","journal-title":"Inflamm. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cbi.2018.02.017","article-title":"Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia\/reperfusion injury via Nrf2-mediated inhibition of the NOX4\/ROS\/NF-\u03baB pathway","volume":"284","author":"Dai","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"135614","DOI":"10.1016\/j.neulet.2020.135614","article-title":"Role of ferroptosis in neurological diseases","volume":"747","author":"Yao","year":"2021","journal-title":"Neurosci. Lett."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"176264","DOI":"10.1016\/j.ejphar.2023.176264","article-title":"Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2\/HO-1 signaling pathway","volume":"963","author":"Peng","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuroscience.2015.09.012","article-title":"Synergistic neuroprotection by epicatechin and quercetin: Activation of convergent mitochondrial signaling pathways","volume":"308","author":"Nichols","year":"2015","journal-title":"Neuroscience"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.4103\/1673-5374.189186","article-title":"A possible therapeutic potential of quercetin through inhibition of \u03bc-calpain in hypoxia induced neuronal injury: A molecular dynamics simulation study","volume":"11","author":"Pandey","year":"2016","journal-title":"Neural Regen. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuroscience.2020.01.015","article-title":"Quercetin Reduces Ischemic Brain Injury by Preventing Ischemia-induced Decreases in the Neuronal Calcium Sensor Protein Hippocalcin","volume":"430","author":"Park","year":"2020","journal-title":"Neuroscience"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.mehy.2012.04.005","article-title":"An in-silico strategy to explore neuroprotection by quercetin in cerebral ischemia: A novel hypothesis based on inhibition of matrix metalloproteinase (MMPs) and acid sensing ion channel 1a (ASIC1a)","volume":"79","author":"Pandey","year":"2012","journal-title":"Med. Hypotheses"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.sjbs.2021.09.077","article-title":"Cerebroprotective effect of Aloe Emodin: In silico and in vivo studies","volume":"29","author":"Pasala","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neuroscience.2017.02.025","article-title":"Quercetin inhibits acid-sensing ion channels through a putative binding site in the central vestibular region","volume":"348","author":"Mukhopadhyay","year":"2017","journal-title":"Neuroscience"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"153363","DOI":"10.1016\/j.phymed.2020.153363","article-title":"Quercitrin inhibits platelet activation in arterial thrombosis","volume":"80","author":"Oh","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/BF03033172","article-title":"Cell culture protection and in vivo neuroprotective capacity of flavonoids","volume":"5","author":"Dajas","year":"2003","journal-title":"Neurotox. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF03033562","article-title":"Reduction of ischemic brain damage and increase of glutathione by a liposomal preparation of quercetin in permanent focal ischemia in rats","volume":"13","author":"Rivera","year":"2008","journal-title":"Neurotox. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s00701-010-0889-x","article-title":"Quercetin reduces the elevated matrix metalloproteinases-9 level and improves functional outcome after cerebral focal ischemia in rats","volume":"153","author":"Lee","year":"2011","journal-title":"Acta Neurochir."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e2200817","DOI":"10.1002\/adhm.202200817","article-title":"A Water-Soluble Quercetin Conjugate with Triple Targeting Exerts Neuron-Protective Effect on Cerebral Ischemia by Mitophagy Activation","volume":"11","author":"Cen","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Ghosh, A., Sarkar, S., Mandal, A.K., and Das, N. (2013). Neuroprotective Role of Nanoencapsulated Quercetin in Combating Ischemia-Reperfusion Induced Neuronal Damage in Young and Aged Rats. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057735"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.biopha.2018.12.144","article-title":"Neurotherapeutic potential of kolaviron on neurotransmitter dysregulation, excitotoxicity, mitochondrial electron transport chain dysfunction and redox imbalance in 2-VO brain ischemia\/reperfusion injury","volume":"111","author":"Ojo","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0006-8993(03)03009-9","article-title":"Quercetin, a natural flavonoid, attenuates vacuolar formation in the optic tract in rat chronic cerebral hypoperfusion model","volume":"980","author":"Takizawa","year":"2003","journal-title":"Brain Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1007\/s11064-011-0458-6","article-title":"Quercetin Protects Against Oxidative Stress Associated Damages in a Rat Model of Transient Focal Cerebral Ischemia and Reperfusion","volume":"36","author":"Ahmad","year":"2011","journal-title":"Neurochem. Res."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Alattar, A., Alshaman, R., Althobaiti, Y.S., Soliman, G.M., Ali, H.S., Khubrni, W.S., Koh, P.O., Rehman, N.U., and Shah, F.A. (2023). Quercetin Alleviated Inflammasome-Mediated Pyroptosis and Modulated the mTOR\/P70S6\/P6\/eIF4E\/4EBP1 Pathway in Ischemic Stroke. Pharmaceuticals, 16.","DOI":"10.3390\/ph16081182"},{"key":"ref_63","first-page":"491","article-title":"Partial role of multiple pathways in infarct size limiting effect of quercetin and rutin against cerebral ischemia-reperfusion injury in rats","volume":"17","author":"Annapurna","year":"2013","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1111\/1750-3841.15474","article-title":"Isolation and characterization of components responsible for neuroprotective effects of Allium cepa outer scale extract against ischemia reperfusion induced cerebral injury in mice","volume":"85","author":"Singh","year":"2020","journal-title":"J. Food Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12951-021-00879-4","article-title":"Surface-modified engineered exosomes attenuated cerebral ischemia\/reperfusion injury by targeting the delivery of quercetin towards impaired neurons","volume":"19","author":"Guo","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"108436","DOI":"10.1016\/j.jnutbio.2020.108436","article-title":"Quercetin protects against cerebral ischemia\/reperfusion and oxygen glucose deprivation\/reoxygenation neurotoxicity","volume":"83","author":"Wang","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1515\/jbcpp-2020-0490","article-title":"Quercetin promotes behavioral recovery and biomolecular changes of melanocortin-4 receptor in mice with ischemic stroke","volume":"32","author":"Ulya","year":"2021","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S1734-1140(11)70617-X","article-title":"Antiatherogenic effect of quercetin is mediated by proteasome inhibition in the aorta and circulating leukocytes","volume":"63","author":"Pashevin","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"112393","DOI":"10.1016\/j.jep.2019.112393","article-title":"Neuroprotective effect of Convolvulus pluricaulis Choisy in oxidative stress model of cerebral ischemia reperfusion injury and assessment of MAP2 in rats","volume":"249","author":"Shalavadi","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neuroscience.2019.11.043","article-title":"Quercetin Attenuates Decrease of Thioredoxin Expression Following Focal Cerebral Ischemia and Glutamate-induced Neuronal Cell Damage","volume":"428","author":"Park","year":"2020","journal-title":"Neuroscience"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ejphar.2013.10.016","article-title":"Alleviation of transient global ischemia\/reperfusion-induced brain injury in rats with 1,2,3,4,6-penta-O-galloyl-\u03b2-d-glucopyranose isolated from Mangifera indica","volume":"720","author":"Viswanatha","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1007\/s11064-018-2576-x","article-title":"Identification of Proteins Differentially Expressed by Quercetin Treatment in a Middle Cerebral Artery Occlusion Model: A Proteomics Approach","volume":"43","author":"Shah","year":"2018","journal-title":"Neurochem. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1292\/jvms.19-0094","article-title":"Quercetin alleviates the injury-induced decrease of protein phosphatase 2A subunit B in cerebral ischemic animal model and glutamate-exposed HT22 cells","volume":"81","author":"Park","year":"2019","journal-title":"J. Vet. Med. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/sj.ejcn.1600974","article-title":"Quercetin intake and the incidence of cerebrovascular disease","volume":"54","author":"Knekt","year":"2000","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/ajcn\/nqab138","article-title":"Habitual flavonoid intake and ischemic stroke incidence in the Danish Diet, Cancer, and Health Cohort","volume":"114","author":"Parmenter","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1002\/ptr.70354","article-title":"Increasing Dietary Quercetin Intake Reduces Stroke Risk and Improve Long-Term Survival in Chronic Kidney Disease Patients","volume":"40","author":"Liao","year":"2026","journal-title":"Phytother. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"108373","DOI":"10.1016\/j.jstrokecerebrovasdis.2025.108373","article-title":"The relationship between flavonols intake and stroke in the elderly: A cross-sectional study from NHANES (2007\u20132010 and 2017\u20132018)","volume":"34","author":"Cheng","year":"2025","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1111\/j.1538-7836.2004.01067.x","article-title":"Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans","volume":"2","author":"Hubbard","year":"2004","journal-title":"J. Thromb. Haemost."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.3945\/jn.115.211888","article-title":"Supplementation of the Pure Flavonoids Epicatechin and Quercetin Affects Some Biomarkers of Endothelial Dysfunction and Inflammation in (Pre)Hypertensive Adults: A Randomized Double-Blind, Placebo-Controlled, Crossover Trial","volume":"145","author":"Dower","year":"2015","journal-title":"J. Nutr."},{"key":"ref_80","first-page":"777","article-title":"Does Quercetin Improve Cardiovascular Risk factors and Inflammatory Biomarkers in Women with Type 2 Diabetes: A Double-blind Randomized Controlled Clinical Trial","volume":"4","author":"Zahedi","year":"2013","journal-title":"Int. J. Prev. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1017\/S0007114509359127","article-title":"Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: A double-blinded, placebo-controlled cross-over study","volume":"102","author":"Egert","year":"2009","journal-title":"Br. J. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1017\/S0007114515002950","article-title":"Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: A randomised double-blinded placebo-controlled cross-over trial","volume":"114","author":"Burak","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.numecd.2011.08.010","article-title":"Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammation in men with different APOE isoforms","volume":"23","author":"Pfeuffer","year":"2013","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1093\/jn\/137.11.2405","article-title":"Quercetin Reduces Blood Pressure in Hypertensive Subjects","volume":"137","author":"Edwards","year":"2007","journal-title":"J. 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