{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:16:24Z","timestamp":1788412584132,"version":"build-2803163510"},"reference-count":35,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82360762"],"award-info":[{"award-number":["82360762"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["82360762"],"award-info":[{"award-number":["82360762"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Science and Technology Plan Project of Guiyang City","award":["[2024]2-35"],"award-info":[{"award-number":["[2024]2-35"]}]},{"name":"Guizhou Provincial Major Scientific and Technological Program","award":["[2024]015"],"award-info":[{"award-number":["[2024]015"]}]},{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine","award":["GMUSKL-202547"],"award-info":[{"award-number":["GMUSKL-202547"]}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Science and Technology Department","doi-asserted-by":"publisher","award":["CXPTXM [2025]010\/[2025]021\/KXJZ[2025]014"],"award-info":[{"award-number":["CXPTXM [2025]010\/[2025]021\/KXJZ[2025]014"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Three previously undescribed phenolic dimers, including a pair of enantiomeric stilbene dimers (1a\/1b) and one optically pure stilbene dimer (2), were separated from the fruits of the Miao medicine Hypericum patulum Thunb. Structural clarification and assignment of absolute configurations were achieved through 1D\/2D NMR spectroscopy, optical rotation measurements, and analysis of experimental electronic circular dichroism (ECD) spectra. Their antioxidant and anti-\u03b1-glucosidase activities were evaluated. The new stilbene dimers exhibited potent antioxidant activity in both DPPH and ABTS free radical scavenging assays. Moreover, (\u2212)-caesalstilbene C (1b) demonstrated the highest anti-DPPH and anti-ABTS activities among all isolated compounds. Compounds 1\u20132 also showed significant \u03b1-glucosidase-inhibitory activity, comparable to the positive control acarbose. These findings provide a foundation for developing novel antioxidants or \u03b1-glucosidase inhibitors as lead compounds in the search for new antidiabetic agents.<\/jats:p>","DOI":"10.3390\/molecules31173072","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:45:13Z","timestamp":1788241513000},"page":"3072","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["New Stilbene Dimer Compounds from the Fruits of Hypericum patulum and Their Antioxidant and Anti-\u03b1-Glucosidase Activities"],"prefix":"10.3390","volume":"31","author":[{"given":"Yang","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University, Guian New Area, Guiyang 561113, China"},{"name":"School of Pharmacy, Guizhou Medical University, Guian New Area, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Lian","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University, Guian New Area, Guiyang 561113, China"},{"name":"School of Pharmacy, Guizhou Medical University, Guian New Area, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University, Guian New Area, Guiyang 561113, China"},{"name":"School of Pharmacy, Guizhou Medical University, Guian New Area, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Hai","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University, Guian New Area, Guiyang 561113, China"},{"name":"School of Pharmacy, Guizhou Medical University, Guian New Area, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8636-7599","authenticated-orcid":false,"given":"Xue","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University, Guian New Area, Guiyang 561113, China"},{"name":"School of Pharmacy, Guizhou Medical University, Guian New Area, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7205-9579","authenticated-orcid":false,"given":"Jia","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University, Guian New Area, Guiyang 561113, China"},{"name":"School of Pharmacy, Guizhou Medical University, Guian New Area, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0479-6259","authenticated-orcid":false,"given":"Yong-Jun","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University, Guian New Area, Guiyang 561113, China"},{"name":"School of Pharmacy, Guizhou Medical University, Guian New Area, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"ref_1","first-page":"14","article-title":"Morphological and phytochemical diversity among Hypericum species of the Mediterranean Basin","volume":"5","author":"Crockett","year":"2011","journal-title":"Med. 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