{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:46:00Z","timestamp":1790279160146,"version":"4.1.0"},"reference-count":47,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SECIHTI","award":["CVU 740702"],"award-info":[{"award-number":["CVU 740702"]}],"id":[{"id":"https:\/\/ror.org\/059ex5q34","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Molecules"],"abstract":"<jats:p>Randia monantha, commonly known as crucetillo, is a medicinal plant traditionally used in Mexico to treat conditions such as diabetes, venomous animal bites, and cancer; however, its effects on cancer cell viability remain underexplored. In this study, hexane, ethyl acetate, and methanolic extracts from the leaves and fruits of Randia monantha were phytochemically characterized and evaluated for their effects on cell viability in HeLa cervical cancer and DU-145 prostate cancer cell lines using the MTT assay. Phytochemical analyses revealed differences in metabolite composition across solvents of varying polarity and plant tissues. Methanolic leaf extracts contained higher levels of terpenoids and polyphenols and produced the greatest reduction in HeLa cell viability, with an estimated IC50 of 4.87 \u00b5g\/mL after 48 h of treatment. In contrast, DU-145 cells exhibited a different response pattern depending on the extract evaluated. Correlation analysis suggested that flavonoids were associated with reduced HeLa cell viability. Overall, leaf extracts produced greater reductions in cancer cell viability than fruit extracts, highlighting leaves as a promising but comparatively underexplored source of bioactive compounds in Randia monantha.<\/jats:p>","DOI":"10.3390\/molecules31173095","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:21:21Z","timestamp":1788452481000},"page":"3095","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phytochemical Characterization and Effects of Randia monantha Benth. Leaf and Fruit Extracts on the Viability of Human Cancer Cell Lines"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0695-5304","authenticated-orcid":false,"given":"Eugenia","family":"Delgado-Tiburcio","sequence":"first","affiliation":[{"name":"Botany Department, Colegio de Postgraduados, Campus Montecillo, km 36.5 Carretera M\u00e9xico-Texcoco, Texcoco 56230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7570-2609","authenticated-orcid":false,"given":"Ivonne","family":"P\u00e9rez-Bautista","sequence":"additional","affiliation":[{"name":"Botany Department, Colegio de Postgraduados, Campus Montecillo, km 36.5 Carretera M\u00e9xico-Texcoco, Texcoco 56230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8577-7991","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Soto-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Botany Department, Colegio de Postgraduados, Campus Montecillo, km 36.5 Carretera M\u00e9xico-Texcoco, Texcoco 56230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4922-3710","authenticated-orcid":false,"given":"Lucero","family":"Ruiz-Posadas","sequence":"additional","affiliation":[{"name":"Botany Department, Colegio de Postgraduados, Campus Montecillo, km 36.5 Carretera M\u00e9xico-Texcoco, Texcoco 56230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0301-9121","authenticated-orcid":false,"given":"Guadalupe","family":"Jimenez-Gutierrez","sequence":"additional","affiliation":[{"name":"Genomic Medicine Laboratory, Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra, Mexico City 14389, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axelle","family":"Renodon-Corni\u00e8re","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 en Sciences Biologiques et Biotechnologies (US2B), UMR 6286, F-44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Sara","family":"Herrera-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Southeast Unit, Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco (CIATEJ), Carretera km 5.5, Sierra Papacal\u2013Chuburn\u00e1, Chuburn\u00e1, Merida 97302, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4744-4437","authenticated-orcid":false,"given":"Ahtziri","family":"Carranza-Aranda","sequence":"additional","affiliation":[{"name":"Department of Philosophical, Methodological, and Instrumental Disciplines, University Center for Health Sciences (CUCS), University of Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Genomic Medicine Laboratory, Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra, Mexico City 14389, Mexico"},{"name":"Department of Bioengineering, School of Engineering and Sciences, Tecnologico de Monterrey, Mexico City Campus, Mexico City 14380, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-6552","authenticated-orcid":false,"given":"Jos\u00e9","family":"Padr\u00f3n","sequence":"additional","affiliation":[{"name":"BioLab, Instituto Universitario de Bio-Org\u00e1nica \u201cAntonio Gonz\u00e1lez\u201d (IUBO-AG), Universidad de La Laguna, Astrof\u00edsico Francisco S\u00e1nchez 2, E-38206 La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz","family":"Guerrero-Lagunes","sequence":"additional","affiliation":[{"name":"Botany Department, Colegio de Postgraduados, Campus Montecillo, km 36.5 Carretera M\u00e9xico-Texcoco, Texcoco 56230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2991\/jegh.k.191008.001","article-title":"Current Cancer Epidemiology","volume":"9","author":"Mattiuzzi","year":"2019","journal-title":"J. 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