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Current management relies mainly on pharmacotherapy and lifestyle interventions, but these approaches are limited by poor bioavailability and adverse effects. Nanoparticles (NPs) can deliver therapeutic drugs to cardiac muscle tissue through passive or active targeting, protecting the drugs they carry from premature degradation. They also show good biocompatibility and minimize damage to healthy tissues. This review summarizes the applications of NPs in cardiomyopathy and their active and passive targeting strategies, and provides a brief overview based on the mechanisms reported in individual published studies. It aims to provide therapeutic strategies for clinical management of cardiomyopathy and a theoretical foundation for future translational research.<\/jats:p>","DOI":"10.3390\/molecules31173137","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:30:02Z","timestamp":1788798602000},"page":"3137","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanoparticle-Based Targeted Drug-Delivery Systems for Cardiomyopathy: Mechanisms and Therapeutic Advances"],"prefix":"10.3390","volume":"31","author":[{"given":"Boshen","family":"Liang","sequence":"first","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidan","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3826-9910","authenticated-orcid":false,"given":"Xiaonan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujun","family":"Xie","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Jia","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haopeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangbo","family":"Luo","sequence":"additional","affiliation":[{"name":"First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510400, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"ref_1","first-page":"910","article-title":"Key priorities for the implementation of the 2023 ESC Guidelines for the management of cardiomyopathies in low-resource settings","volume":"11","author":"Jurcut","year":"2025","journal-title":"Eur. 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