{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:07:11Z","timestamp":1788858431620,"version":"build-2803163510"},"reference-count":25,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Laboratoire Innotech International"},{"id":[{"id":"https:\/\/ror.org\/021sh3243","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Diosmin, a flavonoid, is widely used to alleviate the symptoms of chronic venous disease (CVD), while compression stockings remain a key component of its conservative management. This study used an ex vivo model of human skin explants to evaluate the vasomotor and anti-inflammatory effects of a class II elastic venous compression model (EVC2), applied alone or in combination with diosmetin-3-O-\u03b2-D-glucuronide (DT), the major circulating metabolite of diosmin. The explants were exposed to substance P to induce neurogenic inflammation, after which they were treated with EVC2, DT at a concentration of 2700 pg\/mL, or both. Compared with substance P alone, all treatments led to a significant reduction in capillary dilation and IL-8 secretion, as well as a change in endothelial CD34 expression. While the combination improved all parameters, only significant additional effects were observed for reducing low CD34 expression versus DT alone (77% for score 0, no CD34 expression, p = 0.043; 62.1% for score 1, low CD34 expression, p = 0.013), and for decreasing IL-8 versus EVC2 alone (41.2%, p = 0.033). These findings suggest vasomotor and anti-inflammatory effects of DT and mechanical compression, and highlight their combined effects on inflammatory parameters in CVD.<\/jats:p>","DOI":"10.3390\/molecules31183142","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:10:22Z","timestamp":1788855022000},"page":"3142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ex Vivo Study of the Vasomotor and Anti-Inflammatory Activity of Class 2 Elastic Venous Compression Devices Combined with Diosmetin-3-O-\u03b2-D-Glucuronide"],"prefix":"10.3390","volume":"31","author":[{"given":"Yasmine","family":"Belabed","sequence":"first","affiliation":[{"name":"Laboratoire Innotech International, 22 Avenue Aristide Briand, 94110 Arcueil, France"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"given":"Sylvie","family":"Boisnic","sequence":"additional","affiliation":[{"name":"GREDECO (Group of Research and Evaluation in Dermatology and Cosmetology), 69 Rue de la Tour, 75016 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Nathaniel","family":"Stroumza","sequence":"additional","affiliation":[{"name":"GREDECO (Group of Research and Evaluation in Dermatology and Cosmetology), 69 Rue de la Tour, 75016 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Charlotte P. J.","family":"Talbot","sequence":"additional","affiliation":[{"name":"Laboratoire Innotech International, 22 Avenue Aristide Briand, 94110 Arcueil, France"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Yoann","family":"Molinard","sequence":"additional","affiliation":[{"name":"Laboratoire Innotech International, 22 Avenue Aristide Briand, 94110 Arcueil, France"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Frederic","family":"Carrois","sequence":"additional","affiliation":[{"name":"Laboratoire Innotech International, 22 Avenue Aristide Briand, 94110 Arcueil, France"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s12325-019-0881-7","article-title":"The Seriousness of Chronic Venous Disease: A Review of Real-World Evidence","volume":"36","author":"Davies","year":"2019","journal-title":"Adv. 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