{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:06:58Z","timestamp":1789034818408,"version":"build-2803163510"},"reference-count":47,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004881","name":"Coordination of Health Research-IMSS","doi-asserted-by":"publisher","award":["FIS\/IMSS\/PROT\/PRIO\/14\/029"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/PRIO\/14\/029"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"publisher"}]},{"award":["FIS\/IMSS\/PROT\/PRIO\/14\/029"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/PRIO\/14\/029"]}],"id":[{"id":"https:\/\/ror.org\/059qgvg50","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Salvia elegans Vahl. is used to treat inflammatory conditions; however, its direct anti-inflammatory activity has been scarcely investigated. This study evaluated the ethyl acetate extract (SeAcOEt) in vivo and in vitro, using the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema model, and the effects of selected isolated metabolites on inflammatory signaling by measuring NF-\u03baB\/AP-1-dependent SEAP reporter activity in LPS-stimulated RAW-Blue\u2122 macrophages. Phytochemical characterization was performed using thin-layer chromatography, column chromatography, high-performance liquid chromatography (HPLC), mass spectrometry, and nuclear magnetic resonance (NMR). SeAcOEt yielded the following three fractions: SeFA, containing the terpene mixture rosifoliol (1)\/agarospirol (2); SeFB, ursolic acid (3) and 7\u03b1-hydroxysandaracopimaric acid (4); and SeFC, jaceosidin (5) and isosakuranetin-5-O-rutinoside (6). SeAcOEt inhibited TPA-induced ear edema by 87.3%, whereas SeFB showed the highest activity (97.4%), comparable to indomethacin. The terpene mixture and 7\u03b1-hydroxysandaracopimaric acid reduced NF-\u03baB\/AP-1-dependent SEAP reporter activity in LPS-stimulated RAW-Blue\u2122 macrophages. The anti-inflammatory activity of S. elegans could be associated with the combined contribution of phytochemicals enriched in the bioactive fraction SeFB rather than with a single active constituent. This study expands the phytochemical knowledge of S. elegans by reporting 7\u03b1-hydroxysandaracopimaric acid and provides pharmacological evidence supporting the traditional use of this species for inflammatory conditions.<\/jats:p>","DOI":"10.3390\/molecules31183180","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:13:03Z","timestamp":1789031583000},"page":"3180","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Rosifoliol\/Agarospirol and 7\u03b1-Hydroxysandaracopimaric Acid from Salvia elegans Vahl on Local Inflammation and LPS-Activated RAW-Blue Cells"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9056-3568","authenticated-orcid":false,"given":"Maribel","family":"Herrera-Ruiz","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social (IMSS), Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-1670","authenticated-orcid":false,"given":"Manas\u00e9s","family":"Gonz\u00e1lez-Cortazar","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social (IMSS), Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2506-2721","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"S\u00e1nchez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social (IMSS), Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8370-5089","authenticated-orcid":false,"given":"Gabriela Belen","family":"Mart\u00ednez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social (IMSS), Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2233-5958","authenticated-orcid":false,"given":"Alejandro","family":"Zamilpa","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social (IMSS), Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2768-0566","authenticated-orcid":false,"given":"Yury Maritza","family":"Zapata-Lopera","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social (IMSS), Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-8274","authenticated-orcid":false,"given":"Enrique","family":"Jim\u00e9nez-Ferrer","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social (IMSS), Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB Signaling in Inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. 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