{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:02:30Z","timestamp":1789448550933,"version":"build-2803163510"},"reference-count":50,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Aquatic antibiotic pollution represented by ofloxacin (OFX) causes serious ecological hazards and endangers public health due to the high persistence and bioaccumulation of antibiotic residues. Conventional water treatment techniques are insufficient for OFX elimination, limited by low removal efficiency, high energy consumption, and poor operational stability. Herein, a novel MoS2\/CuS heterojunction composite was fabricated via a hydrothermal method and applied to an ultrasound-driven piezocatalysis-coupled peroxymonosulfate (PMS) advanced oxidation system for OFX wastewater remediation. The introduction of CuS effectively remedies the inherent shortcomings of pristine MoS2, including insufficient active sites and rapid photogenerated carrier recombination. The constructed heterojunction induces a strong interfacial built-in electric field, which significantly accelerates the migration of piezoelectric charges. The synergistic photo-piezoelectric effect further promotes continuous PMS activation and facilitates the massive generation of reactive oxygen species (ROS). The influences of key operating parameters and common water inorganic anions on OFX degradation performance were systematically investigated. Radical trapping experiments confirmed the synergistic mechanism between piezocatalysis and PMS activation during the catalytic reaction. The optimized MoS2\/CuS heterojunction exhibits remarkable OFX degradation efficiency and excellent cyclic stability. This work provides a feasible strategy for the rational design and fabrication of high-efficiency piezocatalysts and offers a promising technical route for the remediation of refractory antibiotic wastewater via piezocatalysis-coupled PMS advanced oxidation.<\/jats:p>","DOI":"10.3390\/molecules31183210","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:24:33Z","timestamp":1789129473000},"page":"3210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Catalysis over MoS2\/CuS in Ultrasound-Assisted Peroxymonosulfate System: Performance and Mechanism for Degradation of Multiple Organic Contaminants"],"prefix":"10.3390","volume":"31","author":[{"given":"Chu","family":"Dai","sequence":"first","affiliation":[{"name":"College of Advanced Energy Materials, Hubei University of Education, Wuhan 430205, China"},{"name":"Hubei Engineering Technology Research Center of Environmental Purification Materials, Institute of Materials Research and Engineering, Hubei University of Education, Wuhan 430205, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"College of Advanced Energy Materials, Hubei University of Education, Wuhan 430205, China"},{"name":"Hubei Engineering Technology Research Center of Environmental Purification Materials, Institute of Materials Research and Engineering, Hubei University of Education, Wuhan 430205, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhui","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Advanced Energy Materials, Hubei University of Education, Wuhan 430205, China"},{"name":"Hubei Engineering Technology Research Center of Environmental Purification Materials, Institute of Materials Research and Engineering, Hubei University of Education, Wuhan 430205, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Qi","sequence":"additional","affiliation":[{"name":"College of Advanced Energy Materials, Hubei University of Education, Wuhan 430205, China"},{"name":"Hubei Engineering Technology Research Center of Environmental Purification Materials, Institute of Materials Research and Engineering, Hubei University of Education, Wuhan 430205, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9871-5243","authenticated-orcid":false,"given":"Chen","family":"Tian","sequence":"additional","affiliation":[{"name":"Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141060","DOI":"10.1016\/j.jhazmat.2026.141060","article-title":"Abscisic acid confers antibiotic stress tolerance in cucumber by alleviating antibiotic phytotoxicity and decreasing the levels of antibiotic and antibiotic resistance genes","volume":"502","author":"Wang","year":"2026","journal-title":"J. Hazard. Mater."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107047","DOI":"10.1016\/j.envint.2021.107047","article-title":"Environmental contamination in a high-income country (France) by antibiotics, antibiotic-resistant bacteria, and antibiotic resistance genes: Status and possible causes","volume":"159","author":"Haenni","year":"2022","journal-title":"Environ. Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"109305","DOI":"10.1016\/j.envint.2025.109305","article-title":"From river to groundwater: Antibiotics pollution, resistance prevalence, and source tracking","volume":"196","author":"Wu","year":"2025","journal-title":"Environ. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"117136","DOI":"10.1016\/j.watres.2021.117136","article-title":"Fluoroquinolone Antibiotics Sensitized Photodegradation of Isoproturon","volume":"198","author":"Lu","year":"2021","journal-title":"Water Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"148539","DOI":"10.1016\/j.cej.2024.148539","article-title":"Synthesis of a trivalent copper complex for efficient degradation of antibiotic ofloxacin","volume":"479","author":"Hong","year":"2024","journal-title":"Chem. Eng. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"7124","DOI":"10.1039\/D3RA07557E","article-title":"Ball milling synthesis of Fe3O4 nanoparticles-functionalized porous boron nitride with enhanced cationic dye removal performance","volume":"14","author":"Li","year":"2024","journal-title":"RSC Adv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.envint.2005.05.024","article-title":"Residues and source identification of persistent organic pollutants in farmland soils irrigated by effluents from biological treatment plants","volume":"31","author":"Chen","year":"2005","journal-title":"Environ. Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"152490","DOI":"10.1016\/j.cej.2024.152490","article-title":"Strategies for the quantification and characterization of nanoplastics in AOPs research","volume":"493","author":"Garcia","year":"2024","journal-title":"Chem. Eng. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1021\/acssuschemeng.1c07605","article-title":"Superstructures with Atomic-Level Arranged Perovskite and Oxide Layers for Advanced Oxidation with an Enhanced Non-Free Radical Pathway","volume":"10","author":"Yang","year":"2022","journal-title":"ACS Sustain. Chem. Eng."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10643380500326564","article-title":"Advanced Oxidation Processes for Organic Contaminant Destruction Based on the Fenton Reaction and Related Chemistry","volume":"36","author":"Pignatello","year":"2006","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"119921","DOI":"10.1016\/j.apcatb.2021.119921","article-title":"Carbonized polyaniline activated peroxymonosulfate (PMS) for phenol degradation: Role of PMS adsorption and singlet oxygen generation","volume":"286","author":"Liu","year":"2021","journal-title":"Appl. Catal. B Environ."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1021\/acs.est.4c10364","article-title":"Cytotoxicity and Genotoxicity toward Mammalian Cells Induced by Organic Iodine in Peroxymonosulfate (PMS) Processes: Activated PMS Is Better than Nonactivated PMS in Mitigating Toxicity","volume":"59","author":"Du","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"119142","DOI":"10.1016\/j.watres.2022.119142","article-title":"Revealing the fundamental role of MoO2 in promoting efficient and stable activation of persulfate by iron carbon based catalysts: Efficient Fe2+\/Fe3+ cycling to generate reactive species","volume":"225","author":"Liu","year":"2022","journal-title":"Water Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"162834","DOI":"10.1016\/j.cej.2025.162834","article-title":"Regulation of reactive oxygen species in peroxymonosulfate activation by metal\u2013organic framework-derived materials","volume":"513","author":"Yu","year":"2010","journal-title":"Chem. Eng. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e10707","DOI":"10.1002\/advs.202510707","article-title":"Size-Dependent Ultrasound Activation of Thrombin Catalytic Activity by Mechano-Nanoswitches","volume":"13","author":"Xiao","year":"2026","journal-title":"Adv. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2005141","DOI":"10.1002\/adfm.202005141","article-title":"Additive Manufacturing of Piezoelectric Materials","volume":"30","author":"Chen","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Hao, X., Chen, X., Zhou, X., Zhang, L., Tao, J., Wang, C., Wu, T., and Dai, W. (2021). Performance Optimization for PbTe-Based Thermoelectric Materials. Front. Energy Res., 9.","DOI":"10.3389\/fenrg.2021.754532"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1039\/D0EN00284D","article-title":"A tribo-positive Fe@MoS2 piezocatalyst for the durable degradation of tetracycline: Degradation mechanism and toxicity assessment","volume":"7","author":"Meng","year":"2020","journal-title":"Environ. Sci. Nano"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"26257","DOI":"10.1021\/acsami.4c04152","article-title":"MoS2@MWCNTs with Rich Vacancy Defects for Effective Piezocatalytic Degradation of Norfloxacin via Innergenerated-H2O2: Enhanced Nonradical Pathway and Synergistic Mechanism with Radical Pathway","volume":"16","author":"Wang","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"120205","DOI":"10.1016\/j.jece.2025.120205","article-title":"Homologous element substitution boosts MoS2 out-of-plane piezoelectricity for piezocatalytic environmental remediation","volume":"13","author":"Liu","year":"2025","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Zhang, L., Wang, Q., Li, J., and Wang, C. (2021). The Role of ZnO as a Dopant and an Intergranular Phase in the Electrical Properties of Ca0.6Sr0.4TiO3 Ceramics. Front. Energy Res., 13.","DOI":"10.3389\/fenrg.2021.807300"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Wang, Q., Zhang, L., Liu, X., and Li, S. (2021). Two-Dimensional Semiconductor Heterojunctions for Optoelectronics and Electronics. Front. Energy Res., 9.","DOI":"10.3389\/fenrg.2021.802055"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"114435","DOI":"10.1016\/j.jphotochem.2022.114435","article-title":"Photo-\/electro-\/piezo-catalytic elimination of environmental pollutants","volume":"437","author":"Wang","year":"2023","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"132496","DOI":"10.1016\/j.colsurfa.2023.132496","article-title":"Insight for FeS2\/MoS2@SiO2 nanoreactor with spatial separation of H2O2 activation sites and pollutant adsorption sites: Enhanced H2O2 activation efficiency and pollutant degradation performance in Fenton reaction","volume":"678","author":"Hui","year":"2023","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"18551","DOI":"10.1039\/C6TA08628D","article-title":"Noble metal-free ultrathin MoS2 nanosheet-decorated CdS nanorods as an efficient photocatalyst for spectacular hydrogen evolution under solar light irradiation","volume":"4","author":"Kumar","year":"2016","journal-title":"J. Mater. Chem. A"},{"key":"ref_26","first-page":"115511","article-title":"Z-scheme heterojunction between CuS and PCN-222 for efficient photothermal catalytic CO2 reduction","volume":"587","author":"Xue","year":"2010","journal-title":"Mol. Catal."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"155153","DOI":"10.1016\/j.cej.2024.155153","article-title":"CuS hollow nanocages with rough surface to enhanced photothermal property for ultra-sensitive detection of furazolidone metabolites","volume":"498","author":"Zhang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"105204","DOI":"10.1088\/2053-1591\/ab3ad2","article-title":"Optical tuning of absorption coefficient and dielectric properties of amorphous Cu doped \u03b1-Fe2O3 in the THz range","volume":"6","author":"Wang","year":"2019","journal-title":"Mater. Res. Express"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"111059","DOI":"10.1016\/j.matchar.2021.111059","article-title":"Effects on microstructural refinement of mechanical properties in steelcopper joints laser welded with alternating magnetic field augmentation","volume":"175","author":"Hu","year":"2021","journal-title":"Mater. Charact."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1021\/acsmaterialslett.4c00789","article-title":"New Nanocomposites Derived from Cation-Nonstoichiometric Bax(Co, Fe, Zr, Y)O3\u2212\u03b4 as Efficient Electrocatalysts for Water Oxidation in Alkaline Solution","volume":"6","author":"Abdelghafar","year":"2024","journal-title":"ACS Mater. Lett."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"15544","DOI":"10.1021\/acsami.5c01107","article-title":"Fluid Mechanical and Visible-Light-Driven Piezophotocatalysis in MoS2\/Carbon-Rich Carbon Nitride Heterostructures for Enhanced Green Energy Production and Environmental Remediation","volume":"17","author":"Wu","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Pan, S.G. (2016). Preparation and Characterization of CuS-Graphene Composite. Proceedings of the 2nd Annual International Conference on Advanced Material Engineering (AME 2016), Wuhan, China, 15\u201317 April 2016, Atlantis Press.","DOI":"10.2991\/ame-16.2016.15"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/1556-276X-9-167","article-title":"Ultrasound exfoliation of inorganic analogues of graphene","volume":"9","author":"Henych","year":"2014","journal-title":"Nanoscale Res. Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"48487","DOI":"10.1039\/D5RA08754F","article-title":"3D coral-like Ni\u2013Mo\u2013S\/NF bifunctional electrocatalyst for concurrent glycerol valorization to formate and energy-efficient H2 evolution","volume":"15","author":"Liu","year":"2025","journal-title":"RSC Adv."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1002\/smll.201500610","article-title":"Zinc sulfide nanosheet-based hybrid superlattices with tunable architectures showing enhanced photoelectrochemical properties","volume":"11","author":"Wang","year":"2015","journal-title":"Small"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00339-015-9163-7","article-title":"Co-precipitation synthesis and characterization of faceted MoS2 nanorods with controllable morphologies","volume":"119","author":"Vattikuti","year":"2015","journal-title":"Appl. Phys. A"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ibrahim, A.M., Jia, X., Su, C., Cai, J., Shen, P., and Liu, D. (2022). Effect of Ammonium Sulfide on Sulfidization Flotation of Malachite. Minerals, 12.","DOI":"10.3390\/min12101193"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"122231","DOI":"10.1016\/j.seppur.2022.122231","article-title":"Enhanced radical generation and utilization efficiency by interfacial enrichment and electronic regulation of CuMnO2\/CeO2: Processes and mechanism","volume":"303","author":"Dai","year":"2022","journal-title":"Sep. Purif. Technol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"9902","DOI":"10.1039\/D1CC03857E","article-title":"Better fuels for photocatalytic micromotors: A case study of triethanolamine","volume":"57","author":"Duan","year":"2021","journal-title":"Chem. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"10442","DOI":"10.1021\/acs.est.1c01578","article-title":"Does Tert-Butyl Alcohol Really Terminate the Oxidative Activity of OH in Inorganic Redox Chemistry?","volume":"55","author":"Gao","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1016\/j.jece.2017.07.051","article-title":"Efficient oxidation of arsenic in aqueous solution using zero valent iron- activated persulfate process","volume":"5","author":"Hussain","year":"2017","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"19984","DOI":"10.1039\/D2TA02066A","article-title":"Solar thermal-activated photocatalysis for hydrogen production and aqueous triethanolamine polymerization","volume":"10","author":"Wang","year":"2022","journal-title":"J. Mater. Chem. A"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e15018","DOI":"10.1002\/advs.202515018","article-title":"Hot Electron-Assisted Noble-Metal-Free Synergistic Photothermal Catalyst for Solar-Driven Wastewater Remediation and Microbial Disinfection","volume":"13","author":"Sharma","year":"2026","journal-title":"Adv. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1039\/c4pp00256c","article-title":"Photocatalytic degradation of ofloxacin and evaluation of the residual antimicrobial activity","volume":"14","author":"Peres","year":"2015","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.scitotenv.2013.04.054","article-title":"Light-induced catalytic transformation of ofloxacin by solar Fenton in various water matrices at a pilot plant: Mineralization and characterization of major intermediate products","volume":"461\u2013462","author":"Michael","year":"2013","journal-title":"Sci. Total Environ."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jhazmat.2016.01.046","article-title":"Simultaneous degradation of ofloxacin and recovery of Cu(II) by photoelectrocatalysis with highly ordered TiO2 nanotubes","volume":"308","author":"Liu","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"128392","DOI":"10.1016\/j.cej.2020.128392","article-title":"Effect of inorganic anions on the performance of advanced oxidation processes for degradation of organic contaminants","volume":"411","author":"Wang","year":"2021","journal-title":"Chem. Eng. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"122361","DOI":"10.1016\/j.cej.2019.122361","article-title":"Treatment of membrane filtration concentrate of coking wastewater using PMS\/chloridion oxidation process","volume":"379","author":"Wang","year":"2020","journal-title":"Chem. Eng. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"27241","DOI":"10.1007\/s11356-022-24134-x","article-title":"Carbonate and bicarbonate ions impacts on the reactivity of ferrate(VI) for 3,4-dichlorophenol removal","volume":"30","author":"Zheng","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6774","DOI":"10.1038\/s41467-026-73425-1","article-title":"A polymer-coated nanowire sponge-based contact electrocatalytic system for simultaneous disinfection and removal of multiple micropollutants","volume":"17","author":"Lin","year":"2026","journal-title":"Nat. Commun."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/18\/3210\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:16:35Z","timestamp":1789445795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/18\/3210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":50,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["molecules31183210"],"URL":"https:\/\/doi.org\/10.3390\/molecules31183210","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]}}}