{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:12:15Z","timestamp":1790723535935,"version":"4.1.0"},"reference-count":70,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Bee products, including propolis, royal jelly, honey, bee pollen, and bee bread, are natural functional foods recognized for their nutritional value and health-promoting properties. In the present study, propolis, royal jelly, honey, bee pollen, and bee bread collected from Mersin, one of T\u00fcrkiye\u2019s major beekeeping regions, were comprehensively characterized in terms of their phytochemical composition, antioxidant potential, enzyme inhibition effects, and physicochemical properties. The antioxidant capacities of the samples were evaluated by determining total phenolic content (TPC), total flavonoid content (TFC), and their radical scavenging and reducing abilities using the DPPH, ABTS, and DMPD radical scavenging assays and CUPRAC, FRAP, and Fe3+-reducing assays. Enzyme inhibition effects were assessed against human carbonic anhydrase I and II (hCA I and hCA II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), \u03b1-glycosidase, and \u03b1-amylase. Furthermore, the phytochemical profiles of all bee products were determined by LC\u2013MS\/MS through the targeted analysis of 53 phenolic compounds and related metabolites. Furthermore, the honey sample was evaluated for its principal physicochemical quality parameters, including hydroxymethylfurfural (HMF), sugar composition (glucose, fructose, sucrose, and maltose), naphthalene residue, diastase activity, proline content, free acidity, pH, moisture content, and electrical conductivity. Consistent with its phytochemical composition, propolis showed the strongest antioxidant activity among the investigated bee products under the same experimental conditions. These findings highlight the antioxidant potential of Mersin bee products and indicate their potential as natural sources of bioactive compounds, with possible applications in functional food and nutraceutical research. Further comprehensive studies are warranted to better characterize their bioactive constituents and explore their potential applications.<\/jats:p>","DOI":"10.3390\/molecules31183246","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:34:01Z","timestamp":1789378441000},"page":"3246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In-Depth Biological Activities, Chemical Profiling by LC-MS\/MS of Mersin, T\u00fcrkiye Bee Products (Pollen, Honey, Propolis, Royal Jelly and Bee Bread)"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0788-4999","authenticated-orcid":false,"given":"Ebubekir","family":"\u0130zol","sequence":"first","affiliation":[{"name":"Bee and Natural Products R&D and P&D Application and Research Center, Bingol University, 12000 Bing\u00f6l, T\u00fcrkiye"},{"name":"Department of Bee and Bee Products, Institute of Science, Bing\u00f6l University, 12000 Bing\u00f6l, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"software","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-7227","authenticated-orcid":false,"given":"Mustafa Abdullah","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Dicle University, 21280 Diyarbak\u0131r, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University, 04100 A\u011fr\u0131, T\u00fcrkiye"},{"name":"Department of Chemistry, Faculty of Sciences, Atat\u00fcrk University, 25240 Erzurum, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"ref_1","first-page":"518","article-title":"Mersin merkez il\u00e7elerinin (Akdeniz, Toroslar, Yeni\u015fehir, Mezitli) ar\u0131 bitkileri \u00fczerine bir ara\u015ft\u0131rma","volume":"6","year":"2021","journal-title":"MAS J. 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